Gamified, Automated Virtual Reality Exposure Therapy for Fear of Spiders: A Single-Subject Trial Under Simulated Real-World Conditions.

Abstract:

Background:Virtual Reality exposure therapy (VRET) is an evidence-based treatment of phobias and recent research suggests that this applies also to self-contained, automated interventions requiring no therapist guidance. With the advent and growing adoption of consumer VR technology, automated VR intervention have the potential to close the considerable treatment gap for specific phobias through dissemination as consumer applications, self-help at clinics, or as blended treatment. There is however a lack of translational effectiveness studies on VRET treatment effects under real-world conditions. Methods:We conducted a single-arm (n = 25), single-subject study of automated, gamified VRET for fear of spiders, under simulated real-world conditions. After setup and reading instructions, participants completed the automated, single-session treatment by themselves. Self-rated fear of spiders and quality of life served as outcome measures, measured twice before, and one and two weeks after treatment, and at a six-month follow-up. Session characteristics and user experience measures were collected at the end of the session. Results:Mixed-effects modeling revealed a significant and large (d = 1.26) effect of treatment-onset on phobia symptoms (p < .001), and a small (d = 0.49) effect on quality of life (p = .025). Results were maintained at a six-month follow-up (p > .053). The intervention was tolerable and practical. There were no significant correlations between any user experience measure and decrease in phobia symptoms (p > .209). Conclusions:An automated VRET intervention for fear of spiders showed equivalent effects on phobia symptoms under effectiveness conditions as previously reported under efficacy conditions. These results suggest that automated VRET applications are promising self-help treatments also when provided under real-world conditions. Pre-registration:Open Science Foundation, https://doi.org/10.17605/OSF.IO/78GUB.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Lindner P,Miloff A,Bergman C,Andersson G,Hamilton W,Carlbring P

doi

10.3389/fpsyt.2020.00116

subject

Has Abstract

pub_date

2020-03-03 00:00:00

pages

116

issn

1664-0640

journal_volume

11

pub_type

杂志文章
  • The Autonomic Progress Bar Motivates Treatment Completion for Patients of Stimulant Use Disorder and Cannabis Use Disorder.

    abstract::Background: The intrinsic motivation behind the "need to complete" is more influential than external incentives. We introduced a novel progress-bar tool to motivate the completion of programs designed to treat stimulant and cannabis use disorders. We further examined the effectiveness of the progress bar's scoring app...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00944

    authors: Chen IC,Teng G,Chen CJ,Lan TH,Liu HJ

    更新日期:2020-01-13 00:00:00

  • Systematic Review of Gut Microbiota and Major Depression.

    abstract::Background: Recently discovered relationships between the gastrointestinal microbiome and the brain have implications for psychiatric disorders, including major depressive disorder (MDD). Bacterial transplantation from MDD patients to rodents produces depression-like behaviors. In humans, case-control studies have exa...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00034

    authors: Cheung SG,Goldenthal AR,Uhlemann AC,Mann JJ,Miller JM,Sublette ME

    更新日期:2019-02-11 00:00:00

  • Increased Amplitude of Low-Frequency Fluctuation in Right Angular Gyrus and Left Superior Occipital Gyrus Negatively Correlated With Heroin Use.

    abstract::Abnormal amplitude of low-frequency fluctuation has been implicated in heroin addiction. However, previous studies lacked consistency and didn't consider the impact of confounding factors such as methadone and alcohol. Fifty-one heroin-dependent (HD) individuals and 40 healthy controls underwent resting-state function...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00492

    authors: Luo J,Yang R,Yang W,Duan C,Deng Y,Zhang J,Chen J,Liu J

    更新日期:2020-07-03 00:00:00

  • A Medicinal Herb Scutellaria lateriflora Inhibits PrP Replication in vitro and Delays the Onset of Prion Disease in Mice.

    abstract::Transmissible spongiform encephalopathies (TSE) are characterized by the misfolding of the host encoded prion protein (PrP(C)) into a pathogenic isoform (PrP(Sc)) which leads to the accumulation of β-sheet-rich fibrils and subsequent loss of neurons and synaptic functions. Although many compounds have been identified ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2012.00009

    authors: Eiden M,Leidel F,Strohmeier B,Fast C,Groschup MH

    更新日期:2012-02-17 00:00:00

  • The Detection of Malingering: A New Tool to Identify Made-Up Depression.

    abstract::Major depression is a high-prevalence mental disease with major socio-economic impact, for both the direct and the indirect costs. Major depression symptoms can be faked or exaggerated in order to obtain economic compensation from insurance companies. Critically, depression is potentially easily malingered, as the sym...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00249

    authors: Monaro M,Toncini A,Ferracuti S,Tessari G,Vaccaro MG,De Fazio P,Pigato G,Meneghel T,Scarpazza C,Sartori G

    更新日期:2018-06-08 00:00:00

  • Pathways from cannabis to psychosis: a review of the evidence.

    abstract::The nature of the relationship between cannabis use (CU) and psychosis is complex and remains unclear. Researchers and clinicians remain divided regarding key issues such as whether or not cannabis is an independent cause of psychosis and schizophrenia. This paper reviews the field in detail, examining questions of ca...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2013.00128

    authors: Burns JK

    更新日期:2013-10-14 00:00:00

  • Consequences of CYP2D6 Copy-Number Variation for Pharmacogenomics in Psychiatry.

    abstract::Pharmacogenomics represents a potentially powerful enhancement to the current standard of care for psychiatric patients. However, a variety of biological and technical challenges must be addressed in order to provide adequate clinical decision support for personalized prescribing and dosing based on genomic data. This...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00432

    authors: Jarvis JP,Peter AP,Shaman JA

    更新日期:2019-06-20 00:00:00

  • Bibliometric and Visual Analysis of Research on the Links Between the Gut Microbiota and Depression From 1999 to 2019.

    abstract::Background: There is a crucial link between the gut microbiota and the host central nervous system, and the communication between them occurs via a bidirectional pathway termed the "microbiota-gut-brain axis." The gut microbiome in the modern environment has markedly changed in response to environmental factors. These...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.587670

    authors: Zhu X,Hu J,Deng S,Tan Y,Qiu C,Zhang M,Ni X,Lu H,Wang Z,Li L,Chen H,Huang S,Xiao T,Shang D,Wen Y

    更新日期:2021-01-08 00:00:00

  • Personality and Psychological Factors of Problematic Internet Gamers Seeking Hospital Treatment.

    abstract::Introduction: Previous studies on internet gaming disorder (IGD) have reported an association between personality traits and impulsive or problematic use of the internet or internet games, but the results obtained were inconsistent. Our study's hypothesis was that personality traits are associated with the individual'...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00583

    authors: Seong W,Hong JS,Kim S,Kim SM,Han DH

    更新日期:2019-08-28 00:00:00

  • Functional Correlates of Resting-State Connectivity in the Default Mode Network of Heroin Users on Methadone Treatment and Medication-Free Therapeutic Community Program.

    abstract::The treatment of heroin addiction is a complex process involving changes in addictive behavior and brain functioning. The goal of this study was to explore the brain default mode network (DMN) functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI) and decision-making performance ba...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00381

    authors: Kuo LW,Lin PS,Lin SY,Liu MF,Jan H,Lee HC,Wang SC

    更新日期:2019-06-06 00:00:00

  • Co-design of eHealth Interventions With Children and Young People.

    abstract::Co-design, defined as collective creativity across the entire design process, can lead to the development of interventions that are more engaging, satisfying, and useful to potential users. However, using this methodology within the research arena requires a shift from traditional practice. Co-design of eHealth interv...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00481

    authors: Thabrew H,Fleming T,Hetrick S,Merry S

    更新日期:2018-10-18 00:00:00

  • Language Patterns Discriminate Mild Depression From Normal Sadness and Euthymic State.

    abstract:Objectives:Deviations from typical word use have been previously reported in clinical depression, but language patterns of mild depression (MD), as distinct from normal sadness (NS) and euthymic state, are unknown. In this study, we aimed to apply the linguistic approach as an additional diagnostic key for understandin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00105

    authors: Smirnova D,Cumming P,Sloeva E,Kuvshinova N,Romanov D,Nosachev G

    更新日期:2018-04-10 00:00:00

  • Common Marmosets: A Potential Translational Animal Model of Juvenile Depression.

    abstract::Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, di...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00175

    authors: Galvão-Coelho NL,Galvão ACM,da Silva FS,de Sousa MBC

    更新日期:2017-09-21 00:00:00

  • Maternal Nutrition and Offspring Stress Response-Implications for Future Development of Non-Communicable Disease: A Perspective From India.

    abstract::Psychological stress is recognized as a major modifiable risk factor for adult non-communicable disease (NCD) that includes depression, type 2 diabetes mellitus, and cardiovascular disease. Dysregulation of hypothalamic-pituitary-adrenal (HPA) axis activity resulting in either exaggerated or blunted cortisol responses...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00795

    authors: Krishnaveni GV,Srinivasan K

    更新日期:2019-10-29 00:00:00

  • A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.

    abstract::Objective: Selective serotonin reuptake inhibitors like sertraline have been shown in observational studies and anecdotal reports to improve language development in young children with fragile X syndrome (FXS). A previous controlled trial of sertraline in young children with FXS found significant improvement in expres...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00810

    authors: Potter LA,Scholze DA,Biag HMB,Schneider A,Chen Y,Nguyen DV,Rajaratnam A,Rivera SM,Dwyer PS,Tassone F,Al Olaby RR,Choudhary NS,Salcedo-Arellano MJ,Hagerman RJ

    更新日期:2019-11-06 00:00:00

  • Anhedonia and substance dependence: clinical correlates and treatment options.

    abstract::Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, and it refers to both a state symptom in various psychiatric disorders and a personality trait. It has a putative neural substrate, originating in the dopaminergic mesolimbic and mesocortical reward circuit. Anhedonia...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2011.00010

    authors: Hatzigiakoumis DS,Martinotti G,Giannantonio MD,Janiri L

    更新日期:2011-03-17 00:00:00

  • Housing Orientations and Needs of Above-Average Length of Stay Hospitalized Psychiatric Patients.

    abstract::A small number of severely and persistently mentally ill in-patients awaiting residential or long-stay facilities represent an obstacle to the efficient utilization of acute care beds. These facilities are costly and currently reputed to be contrary to recovery principles. In 2013, all acute psychiatric care wards in ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00231

    authors: Rapisarda F,Felx A,Gagnon S,De Benedictis L,Luyet A,Boutin M,Corbière M,Lesage A

    更新日期:2020-04-07 00:00:00

  • Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity Disorder.

    abstract:BACKGROUND:Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder affecting children, adolescents, and adults. Its etiology is not well understood, but it is increasingly believed to result from diverse pathophysiologies that affect the structure and function of specific brain circui...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2016.00128

    authors: Khadka S,Pearlson GD,Calhoun VD,Liu J,Gelernter J,Bessette KL,Stevens MC

    更新日期:2016-07-25 00:00:00

  • Perspectives on Games, Computers, and Mental Health: Questions about Paradoxes, Evidences, and Challenges.

    abstract::In the field of mental health, games and computerized games present questions about paradoxes, evidences, and challenges. This perspective article offers perspectives and personal opinion about these questions, evidences, and challenges with an objective of presenting several ideas and issues in this rapidly developin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2016.00122

    authors: Desseilles M

    更新日期:2016-07-04 00:00:00

  • Eyeblink Conditioning in Schizophrenia: A Critical Review.

    abstract::There is accruing evidence of cerebellar abnormalities in schizophrenia. The theory of cognitive dysmetria considers cerebellar dysfunction a key component of schizophrenia. Delay eyeblink conditioning (EBC), a cerebellar-dependent translational probe, is a behavioral index of cerebellar integrity. The circuitry under...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2015.00146

    authors: Kent JS,Bolbecker AR,O'Donnell BF,Hetrick WP

    更新日期:2015-12-18 00:00:00

  • Neurocognition and Social Cognition Predicting 1-Year Outcomes in First-Episode Psychosis.

    abstract::Cognitive performance at illness onset may predict outcomes in first-episode psychosis (FEP), and the change in cognition may associate with clinical changes. Cognitive testing was administered to 54 FEP participants 2 months after entering treatment and to 39 participants after 1 year. We investigated whether baselin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.603933

    authors: Lindgren M,Holm M,Kieseppä T,Suvisaari J

    更新日期:2020-12-04 00:00:00

  • An Integrative Program to Reduce Stigma in Primary Healthcare Workers Toward People With Diagnosis of Severe Mental Disorders: A Protocol for a Randomized Controlled Trial.

    abstract::Background: People with severe mental disorders (SMDs) have higher disease and death rates than the general population. Stigma (negative attitudes and perceptions) contributes to limited access to health services and a lower quality of medical assistance in this population, and it is manifested as negative attitudes, ...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2019.00110

    authors: Grandón P,Saldivia S,Vaccari P,Ramirez-Vielma R,Victoriano V,Zambrano C,Ortiz C,Cova F

    更新日期:2019-03-07 00:00:00

  • Decision-Making in Suicidal Behavior: The Protective Role of Loss Aversion.

    abstract:Background:Loss aversion is a central and well operationalized trait behavior that describes the tendency for humans to strongly prefer avoiding losses to making equivalent gains. Human decision-making is thus biased toward safer choices. Aim:The aim of this study was to explore the relationship between loss aversion ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00116

    authors: Hadlaczky G,Hökby S,Mkrtchian A,Wasserman D,Balazs J,Machín N,Sarchiapone M,Sisask M,Carli V

    更新日期:2018-04-05 00:00:00

  • Different Trajectories of Prolonged Grief in Bereaved Family Members After Terror.

    abstract::Introduction: The loss of a loved one in a terror incident is associated with elevated risk for mental health disorders such as prolonged grief disorder (PGD) and posttraumatic stress disorder (PTSD), but the long- term adaptation after such losses are not well understood. This study aims to explore the trajectories o...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.545368

    authors: Kristensen P,Dyregrov K,Gjestad R

    更新日期:2020-10-14 00:00:00

  • Recreational drug use and impulsivity in a population of canadian undergraduate drinkers.

    abstract::The consumption of drugs during young adulthood may be particularly detrimental given important neurodevelopmental changes occurring during this period. As impulsivity may lead to substance use and substance use to the commission of seemingly impulsive acts, an improved understanding of the relationship between alcoho...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2010.00129

    authors: Balodis IM,Potenza MN,Olmstead MC

    更新日期:2010-10-21 00:00:00

  • Changes in the Influence of Alcohol-Paired Stimuli on Alcohol Seeking across Extended Training.

    abstract::Previous work has demonstrated that goal-directed control of alcohol-seeking and other drug-related behaviors is reduced following extended self-administration and drug exposure. Here, we examined how the magnitude of stimulus influences on responding changes across similar training and drug exposure. Rats self-admini...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2016.00169

    authors: Corbit LH,Janak PH

    更新日期:2016-10-10 00:00:00

  • Utility of Machine-Learning Approaches to Identify Behavioral Markers for Substance Use Disorders: Impulsivity Dimensions as Predictors of Current Cocaine Dependence.

    abstract:BACKGROUND:Identifying objective and accurate markers of cocaine dependence (CD) can innovate its prevention and treatment. Existing evidence suggests that CD is characterized by a wide range of cognitive deficits, most notably by increased impulsivity. Impulsivity is multidimensional and it is unclear which of its var...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2016.00034

    authors: Ahn WY,Ramesh D,Moeller FG,Vassileva J

    更新日期:2016-03-10 00:00:00

  • Are Individual Learning Experiences More Important Than Heritable Tendencies? A Pilot Twin Study on Placebo Analgesia.

    abstract::Objective: Predicting who will be a placebo responder is a prerequisite to maximize placebo effects in pain treatment and to minimize them in clinical trials. First evidence exists that genetics could affect placebo effects. However, a classical twin study to estimate the relative contribution of genetic influences co...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00679

    authors: Weimer K,Hahn E,Mönnikes N,Herr AK,Stengel A,Enck P

    更新日期:2019-09-18 00:00:00

  • Prevalence and Related Factors of Insomnia Among Chinese Medical Staff in the Middle and Late Stage of COVID-19.

    abstract::Background: The outbreak of novel coronavirus disease (COVID-19) has brought serious psychological pressure to people, especially medical health staff. At present, there are few studies on insomnia and related factors of medical health staff in the middle and late stage of the epidemic of COVID-19. Therefore, the purp...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.602315

    authors: Liu D,Liu S,Zhu L,Li D,Huang D,Deng H,Guo H,Huang D,Liao Y,Mao Z,Miao Q,Liu W,Xiu M,Zhang X

    更新日期:2020-12-07 00:00:00

  • How Prevalent is "Food Addiction"?

    abstract::Increasing evidence suggests that binge eating-related disorders could be related to addiction-like eating patterns due to the addictive potential of hyperpalatable foods. Subsequently, important implications have been derived for treatment of those disorders and even political actions. However, studies on the prevale...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2011.00061

    authors: Meule A

    更新日期:2011-11-03 00:00:00