Abstract:
:Objective: Selective serotonin reuptake inhibitors like sertraline have been shown in observational studies and anecdotal reports to improve language development in young children with fragile X syndrome (FXS). A previous controlled trial of sertraline in young children with FXS found significant improvement in expressive language development as measured by the Mullen Scales of Early Learning (MSEL) among those with comorbid autism spectrum disorder (ASD) in post hoc analysis, prompting the authors to probe whether sertraline is also indicated in nonsyndromic ASD. Methods: The authors evaluated the efficacy of 6 months of treatment with low-dose sertraline in a randomized, double-blind, placebo-controlled trial in 58 children with ASD aged 24 to 72 months. Results: 179 subjects were screened for eligibility, and 58 were randomized to sertraline (32) or placebo (26). Eight subjects from the sertraline arm and five from the placebo arm discontinued. Intent-to-treat analysis showed no significant difference from placebo on the primary outcomes (MSEL expressive language raw score and age equivalent combined score) or secondary outcomes. Sertraline was well tolerated, with no difference in side effects between sertraline and placebo groups. No serious adverse events possibly related to study treatment occurred. Conclusion: This randomized controlled trial of sertraline treatment showed no benefit with respect to primary or secondary outcome measures. For the 6-month period, treatment in young children with ASD appears safe, although the long-term side effects of low-dose sertraline in early childhood are unknown. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT02385799.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
Potter LA,Scholze DA,Biag HMB,Schneider A,Chen Y,Nguyen DV,Rajaratnam A,Rivera SM,Dwyer PS,Tassone F,Al Olaby RR,Choudhary NS,Salcedo-Arellano MJ,Hagerman RJdoi
10.3389/fpsyt.2019.00810subject
Has Abstractpub_date
2019-11-06 00:00:00pages
810issn
1664-0640journal_volume
10pub_type
杂志文章abstract::Several studies investigated the role of resilience as a mediating factor for psychopathological phenotypes. The aim of the current study is to explore the putative role of resilience as a mediator between different vulnerability factors and depressive symptoms. One hundred and fifty patients with a major depressive d...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00010
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abstract::Introduction: People with psychosis show impairments in cognitive flexibility, a phenomenon that is still poorly understood. In this study, we tested if there were differences in cognitive and metacognitive processes related to rigidity in patients with psychosis. We compared individuals with dichotomous interpersonal...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
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abstract::Objective: To evaluate perceived needs and difficulties related to instruments for assessing work ability in individuals with mental disorders. Method: We conducted an online survey of 104 German-speaking medico-legal experts (forensic psychiatric and psychology experts, insurance physicians) and therapists. Results: ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00453
更新日期:2018-09-25 00:00:00
abstract:Objectives:Schizophrenia (SZ) is a complex psychiatric disorder that has a strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) is one of the genes thought to be pivotal in regulating the glutamatergic system. Studies have suggested that variations in DTNBP1 confer susceptibility to SZ and clinical symptoms. H...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
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更新日期:2020-05-25 00:00:00
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journal_title:Frontiers in psychiatry
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journal_title:Frontiers in psychiatry
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journal_title:Frontiers in psychiatry
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journal_title:Frontiers in psychiatry
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pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00612
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abstract::Our study aims to explore the risk factors for suicidal ideation and their interaction among the elderly in nursing homes in Hunan province, China. A cross-sectional study was conducted among the elderly in nursing homes in Hunan Province. Twenty-four nursing homes were selected by multistage cluster random sampling, ...
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pub_type: 杂志文章
doi:10.3389/fpsyt.2012.00053
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journal_title:Frontiers in psychiatry
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doi:10.3389/fpsyt.2019.00768
更新日期:2019-10-25 00:00:00
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journal_title:Frontiers in psychiatry
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doi:10.3389/fpsyt.2019.00381
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journal_title:Frontiers in psychiatry
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journal_title:Frontiers in psychiatry
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journal_title:Frontiers in psychiatry
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doi:10.3389/fpsyt.2019.00149
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