Systematic Review of Gut Microbiota and Major Depression.


:Background: Recently discovered relationships between the gastrointestinal microbiome and the brain have implications for psychiatric disorders, including major depressive disorder (MDD). Bacterial transplantation from MDD patients to rodents produces depression-like behaviors. In humans, case-control studies have examined the gut microbiome in healthy and affected individuals. We systematically reviewed existing studies comparing gut microbial composition in MDD and healthy volunteers. Methods: A PubMed literature search combined the terms "depression," "depressive disorder," "stool," "fecal," "gut," and "microbiome" to identify human case-control studies that investigated relationships between MDD and microbiota quantified from stool. We evaluated the resulting studies, focusing on bacterial taxa that were different between MDD and healthy controls. Results: Six eligible studies were found in which 50 taxa exhibited differences (p < 0.05) between patients with MDD and controls. Patient characteristics and methodologies varied widely between studies. Five phyla-Bacteroidetes, Firmicutes, Actinobacteria, Fusobacteria, and Protobacteria-were represented; however, divergent results occurred across studies for all phyla. The largest number of differentiating taxa were within phylum Firmicutes, in which nine families and 12 genera differentiated the diagnostic groups. The majority of these families and genera were found to be statistically different between the two groups in two identified studies. Family Lachnospiraceae differentiated the diagnostic groups in four studies (with an even split in directionality). Across all five phyla, nine genera were higher in MDD (Anaerostipes, Blautia, Clostridium, Klebsiella, Lachnospiraceae incertae sedis, Parabacteroides, Parasutterella, Phascolarctobacterium, and Streptococcus), six were lower (Bifidobacterium, Dialister, Escherichia/Shigella, Faecalibacterium, and Ruminococcus), and six were divergent (Alistipes, Bacteroides, Megamonas, Oscillibacter, Prevotella, and Roseburia). We highlight mechanisms and products of bacterial metabolism as they may relate to the etiology of depression. Conclusions: No consensus has emerged from existing human studies of depression and gut microbiome concerning which bacterial taxa are most relevant to depression. This may in part be due to differences in study design. Given that bacterial functions are conserved across taxonomic groups, we propose that studying microbial functioning may be more productive than a purely taxonomic approach to understanding the gut microbiome in depression.


Front Psychiatry


Frontiers in psychiatry


Cheung SG,Goldenthal AR,Uhlemann AC,Mann JJ,Miller JM,Sublette ME




Has Abstract


2019-02-11 00:00:00








  • Advances in Resting State Neuroimaging of Mild Cognitive Impairment.

    abstract::The rapidly increasing number of patients with Alzheimer's disease (AD) worldwide has become a major public concern. Mild cognitive impairment (MCI), characterized with accelerated memory decline than normal aging, is a stage between cognitively unimpaired and dementia. Identification of MCI in the Alzheimer's continu...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Lin L,Xing G,Han Y

    更新日期:2018-12-06 00:00:00

  • The Influence of Depression on the Psychometric Properties of the Maslach Burnout Inventory-Human Services Survey: A Cross-Sectional Study With Nursing Assistants.

    abstract::Background: The Maslach Burnout Inventory-Human Services Survey (MBI-HSS) is the most commonly used instrument to assess burnout. Although various factors have been reported to influence its validity, the influence of major depressive disorder (MDD) has not been previously considered. We developed this study to invest...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Trigo TR,de Freitas CCS,Wang YP,Ribeiro FG,de Lucia MCS,Siqueira JO,Iosifescu DV,Hallak JEC,Fraguas R

    更新日期:2018-12-18 00:00:00

  • Vocational Profile and Correlates of Employment in People With Schizophrenia: The Role of Avolition.

    abstract:Objective:Employment was associated with recovery in individuals with schizophrenia. Our study aimed to delineate the vocational profile and investigate factors associated with likelihood of employment in individuals with schizophrenia. Materials and Methods:276 community dwelling outpatients with schizophrenia were r...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Ang MS,Rekhi G,Lee J

    更新日期:2020-08-27 00:00:00

  • Rethinking a Negative Event: The Affective Impact of Ruminative versus Imagery-Based Processing of Aversive Autobiographical Memories.

    abstract:INTRODUCTION:Ruminative (abstract verbal) processing during recall of aversive autobiographical memories may serve to dampen their short-term affective impact. Experimental studies indeed demonstrate that verbal processing of non-autobiographical material and positive autobiographical memories evokes weaker affective r...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Slofstra C,Eisma MC,Holmes EA,Bockting CLH,Nauta MH

    更新日期:2017-05-30 00:00:00

  • Association of frontal gray matter volume and cerebral perfusion in heroin addiction: a multimodal neuroimaging study.

    abstract::Structure and function are closely related in the healthy human brain. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent patients results in hypoperfusion of fronto-temp...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Denier N,Schmidt A,Gerber H,Schmid O,Riecher-Rössler A,Wiesbeck GA,Huber CG,Lang UE,Radue EW,Walter M,Borgwardt S

    更新日期:2013-10-21 00:00:00

  • Antecedents of Public Mental Health During the COVID-19 Pandemic: Mediation of Pandemic-Related Knowledge and Self-Efficacy and Moderation of Risk Level.

    abstract::Background: COVID-19 affects not only patients' physical health but also their mental health. For the general public, although their physical health may not be directly affected, their mental health may be affected by stress, anxiety, and social panic caused by COVID-19. Controlling the pandemic should focus on not on...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Wang S,Feng K,Zhang Y,Liu J,Wang W,Li Y

    更新日期:2020-11-12 00:00:00

  • Statistics on cannabis users skew perceptions of cannabis use.

    abstract:UNLABELLED:Collecting information about the prevalence of cannabis use is necessary but not sufficient for understanding the size, dynamics, and outcomes associated with cannabis markets. This paper uses two data sets describing cannabis consumption in the United States and Europe to highlight (1) differences in infere...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Burns RM,Caulkins JP,Everingham SS,Kilmer B

    更新日期:2013-11-06 00:00:00

  • Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies.

    abstract::Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and maj...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Li CT,Yang KC,Lin WC

    更新日期:2019-01-24 00:00:00

  • Effect of the Nature of Subsequent Environment on Oxytocin and Cortisol Secretion in Maltreated Children.

    abstract::Childhood maltreatment (CM), including abuse and neglect, is a crucial factor that distorts child development. CM is associated with alterations in numerous brain regions, and may be associated with hormonal dysregulation. This study aimed to investigate differences in secretion patterns of cortisol (CT) and oxytocin ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Mizushima SG,Fujisawa TX,Takiguchi S,Kumazaki H,Tanaka S,Tomoda A

    更新日期:2015-12-11 00:00:00

  • Pathways from cannabis to psychosis: a review of the evidence.

    abstract::The nature of the relationship between cannabis use (CU) and psychosis is complex and remains unclear. Researchers and clinicians remain divided regarding key issues such as whether or not cannabis is an independent cause of psychosis and schizophrenia. This paper reviews the field in detail, examining questions of ca...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Burns JK

    更新日期:2013-10-14 00:00:00

  • The Clonic Phase of Seizures in Patients Treated with Electroconvulsive Therapy is Related to Age and Stimulus Intensity.

    abstract:BACKGROUND:Electroconvulsive therapy (ECT) is effective in the treatment of major depressive disorder and schizophrenia in patients who are drug-naïve or less-receptive to antipsychotic drugs. Several studies have discussed the correlation between patient characteristics, input-current volume, and seizure duration. Acc...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Wang CC,Lin CH,Chiu YC,Tseng CC

    更新日期:2013-12-23 00:00:00

  • A Randomized Controlled Trial on Mutual Support Group Intervention for Families of People With Recent-Onset Psychosis: A Four-Year Follow-Up.

    abstract::Introduction: Recent research in Western countries has indicated that family interventions in schizophrenia and other psychotic disorders can reduce patient relapse and improve medication compliance. Few studies have addressed Chinese and Asian populations. This study tested the long-term effects of a 9-month family-l...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Chien WT,Bressington D,Chan SWC

    更新日期:2018-12-18 00:00:00

  • Pleasure and addiction.

    abstract::What is the role and value of pleasure in addiction? Foddy and Savulescu (1) have claimed that substance use is just pleasure-oriented behavior. They describe addiction as "strong appetites toward pleasure" and argue that addicts suffer in significant part because of strong social and moral disapproval of lives domina...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Kennett J,Matthews S,Snoek A

    更新日期:2013-09-25 00:00:00

  • Comorbidity of Obsessive-Compulsive Disorder and Schizotypal Personality Disorder: Clinical Response and Treatment Resistance to Pharmacotherapy in a 3-Year Follow-Up Naturalistic Study.

    abstract::The present study aims to analyze the clinical and socio-demographic characteristics of patients with obsessive-compulsive disorder (OCD) in comorbidity with schizotypal personality disorder (SPD), as well as the response rate to pharmacological treatments. OCD+SPD patients had a younger age at onset, a higher probabi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Perris F,Fabrazzo M,De Santis V,Luciano M,Sampogna G,Fiorillo A,Catapano F

    更新日期:2019-06-17 00:00:00

  • A Review of Impaired Neuroplasticity in Schizophrenia Investigated with Non-invasive Brain Stimulation.

    abstract:BACKGROUND:Several lines of evidence implicate dysfunctional neuronal plasticity in the pathophysiology of schizophrenia (SCZ). Aberrant glutamatergic and gamma amino--butyric acid neurotransmission are thought to underlie core cognitive deficits and negative symptoms of SCZ. Non-invasive brain stimulation (NIBS) allow...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Bhandari A,Voineskos D,Daskalakis ZJ,Rajji TK,Blumberger DM

    更新日期:2016-03-29 00:00:00

  • Decision-Making Dysfunctions of Counterfactuals in Depression: Who Might I have Been?

    abstract::Cognitive neuroscience enables us now to decompose major depressive disorder into dysfunctional component processes and relate these processes to specific neural substrates. This approach can be used to illuminate the biological basis of altered psychological processes in depression, including abnormal decision-making...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Howlett JR,Paulus MP

    更新日期:2013-11-08 00:00:00

  • Decision-Making in Suicidal Behavior: The Protective Role of Loss Aversion.

    abstract:Background:Loss aversion is a central and well operationalized trait behavior that describes the tendency for humans to strongly prefer avoiding losses to making equivalent gains. Human decision-making is thus biased toward safer choices. Aim:The aim of this study was to explore the relationship between loss aversion ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Hadlaczky G,Hökby S,Mkrtchian A,Wasserman D,Balazs J,Machín N,Sarchiapone M,Sisask M,Carli V

    更新日期:2018-04-05 00:00:00

  • White Matter Microstructural Changes and Episodic Memory Disturbances in Late-Onset Bipolar Disorder.

    abstract::Background: Bipolar disorder (BD) has been associated with distributed network disruption, but little is known on how different clinical subtypes, particularly those with an earlier and later onset of disease, are related to connectivity changes in white matter (WM) tracts. Methods: Diffusion tensor imaging (DTI) and ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Alves GS,Knöchel C,Paulitsch MA,Reinke B,Carvalho AF,Feddern R,Prvulovic D,Sudo FK,Pantel J,Reif A,Oertel V

    更新日期:2018-10-09 00:00:00

  • Association Analysis of Neuronal Nitric Oxide Synthase 1 Gene Polymorphism With Psychopathological Symptoms in Chronic Ketamine Users.

    abstract::Objective: We previously found that chronic ketamine usages were associated with various psychotic and cognitive symptoms mimicking schizophrenia. The blockade of the NMDA receptor and subsequent nitric oxide synthase 1 (NOS1) dysfunction were found to be closely correlated with schizophrenia including NOS1 gene polym...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Chen J,Zhang M,Zhou C,Ding Y,Fan N,He H

    更新日期:2020-12-23 00:00:00

  • A Novel Approach to Assess Sleep-Related Rhythmic Movement Disorder in Children Using Automatic 3D Analysis.

    abstract::Background: Unlike other episodic sleep disorders in childhood, there are no agreed severity indices for rhythmic movement disorder. While movements can be characterized in detail by polysomnography, in our experience most children inhibit rhythmic movement during polysomnography. Actigraphy and home video allow asses...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Gall M,Kohn B,Wiesmeyr C,van Sluijs RM,Wilhelm E,Rondei Q,Jäger L,Achermann P,Landolt HP,Jenni OG,Riener R,Garn H,Hill CM

    更新日期:2019-10-16 00:00:00

  • Lifestyle Interventions and Prevention of Suicide.

    abstract::Over the past years, there has been a growing interest in the association between lifestyle psychosocial interventions, severe mental illness, and suicide risk. Patients with severe mental disorders have higher mortality rates, poor health states, and higher suicide risk compared to the general population. Lifestyle b...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Berardelli I,Corigliano V,Hawkins M,Comparelli A,Erbuto D,Pompili M

    更新日期:2018-11-06 00:00:00

  • Primary Sjogren's Syndrome Associated With Treatment-Resistant Obsessive-Compulsive Disorder.

    abstract::There is an increasing awareness that autoimmune diseases can present with neuropsychiatric manifestations. We present the case of a 17-year-old female requiring psychiatric hospitalization for obsessive-compulsive disorder and major depressive disorder with mixed affective features, who was subsequently diagnosed wit...

    journal_title:Frontiers in psychiatry



    authors: Ong LTC,Galambos G,Brown DA

    更新日期:2017-07-11 00:00:00

  • Longer Cortical Silent Period Length Is Associated to Binge Eating Disorder: An Exploratory Study.

    abstract::Introduction: Although binge eating disorder (BED) is an eating disorder and obesity is a clinical disease, it is known that both conditions present overlapped symptoms related to, at least partially, the disruption of homeostatic and hedonistic eating behavior pathways. Therefore, the understanding of neural substrat...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Antunes LC,Elkfury JL,Parizotti CS,Brietzke AP,Bandeira JS,Torres ILDS,Fregni F,Caumo W

    更新日期:2020-10-14 00:00:00

  • Association Between Plasma Metabolites and Psychometric Scores Among Children With Developmental Disabilities: Investigating Sex-Differences.

    abstract::Background: Developmental disabilities are defined by delays in learning, language, and behavior, yet growing evidence has revealed disturbances in metabolic systems that may also be present. Little is known about whether these metabolic issues contribute to the symptoms or severity of these disabilities, or whether s...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Sotelo-Orozco J,Abbeduto L,Hertz-Picciotto I,Slupsky CM

    更新日期:2020-12-22 00:00:00

  • The Modified Yale Food Addiction Scale 2.0: Validation Among Non-Clinical and Clinical French-Speaking Samples and Comparison With the Full Yale Food Addiction Scale 2.0.

    abstract:Objectives:The modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was designed to assess food addiction using a shorter version than the YFAS 2.0. We lack data about the psychometric properties of the mYFAS 2.0 in patients with obesity, as well as studies comparing the psychometric properties of the mYFAS 2.0 versus th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Brunault P,Berthoz S,Gearhardt AN,Gierski F,Kaladjian A,Bertin E,Tchernof A,Biertho L,de Luca A,Hankard R,Courtois R,Ballon N,Benzerouk F,Bégin C

    更新日期:2020-09-08 00:00:00

  • GABA System in Schizophrenia and Mood Disorders: A Mini Review on Third-Generation Imaging Studies.

    abstract::Third-generation neuroimaging research has been enriched by advances in magnetic resonance spectroscopy (MRS) measuring the concentration of important neurotrasmitters, such as the inhibitory amino acid GABA. Here, we performed a systematic mini-review on brain MRS studies measuring GABA concentration in patients affe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Chiapponi C,Piras F,Piras F,Caltagirone C,Spalletta G

    更新日期:2016-04-19 00:00:00

  • Can a Brief Relaxation Exercise Modulate Placebo or Nocebo Effects in a Visceral Pain Model?

    abstract::Translational research aiming to elucidate mediators and moderators of placebo and nocebo effects is highly relevant. This experimental study tested effects of a brief progressive muscle relaxation (PMR) exercise, designed to alter psychobiological stress parameters, on the magnitude of placebo and nocebo effects in a...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Elsenbruch S,Roderigo T,Enck P,Benson S

    更新日期:2019-03-21 00:00:00

  • Cognitive Flexibility Predicts PTSD Symptoms: Observational and Interventional Studies.

    abstract::Introduction: Post-Traumatic Stress Disorder (PTSD) is a prevalent, severe and tenacious psychopathological consequence of traumatic events. Neurobehavioral mechanisms underlying PTSD pathogenesis have been identified, and may serve as risk-resilience factors during the early aftermath of trauma exposure. Longitudinal...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Ben-Zion Z,Fine NB,Keynan NJ,Admon R,Green N,Halevi M,Fonzo GA,Achituv M,Merin O,Sharon H,Halpern P,Liberzon I,Etkin A,Hendler T,Shalev AY

    更新日期:2018-10-04 00:00:00

  • Parameter-Based Evaluation of Attentional Impairments in Schizophrenia and Their Modulation by Prefrontal Transcranial Direct Current Stimulation.

    abstract:Background:Attentional dysfunctions constitute core cognitive symptoms in schizophrenia, but the precise underlying neurocognitive mechanisms remain to be elucidated. Methods:In this randomized, double-blind, sham-controlled study, we applied, for the first time, a theoretically grounded modeling approach based on Bun...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Gögler N,Papazova I,Oviedo-Salcedo T,Filipova N,Strube W,Funk J,Müller HJ,Finke K,Hasan A

    更新日期:2017-11-29 00:00:00

  • Alteration of Brain Structure With Long-Term Abstinence of Methamphetamine by Voxel-Based Morphometry.

    abstract::Background: A large portion of previous studies that have demonstrated brain gray matter reduction in individuals who use methamphetamine (MA) have focused on short-term abstinence, but few studies have focused on the effects of long-term abstinence of methamphetamine on brain structures. Materials and Methods: Our st...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Zhang Z,He L,Huang S,Fan L,Li Y,Li P,Zhang J,Liu J,Yang R

    更新日期:2018-12-20 00:00:00