Eyeblink Conditioning in Schizophrenia: A Critical Review.

Abstract:

:There is accruing evidence of cerebellar abnormalities in schizophrenia. The theory of cognitive dysmetria considers cerebellar dysfunction a key component of schizophrenia. Delay eyeblink conditioning (EBC), a cerebellar-dependent translational probe, is a behavioral index of cerebellar integrity. The circuitry underlying EBC has been well characterized by non-human animal research, revealing the cerebellum as the essential circuitry for the associative learning instantiated by this task. However, there have been persistent inconsistencies in EBC findings in schizophrenia. This article thoroughly reviews published studies investigating EBC in schizophrenia, with an emphasis on possible effects of antipsychotic medication and stimulus and analysis parameters on reports of EBC performance in schizophrenia. Results indicate a consistent finding of impaired EBC performance in schizophrenia, as measured by decreased rates of conditioning, and that medication or study design confounds do not account for this impairment. Results are discussed within the context of theoretical and neurochemical models of schizophrenia.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Kent JS,Bolbecker AR,O'Donnell BF,Hetrick WP

doi

10.3389/fpsyt.2015.00146

subject

Has Abstract

pub_date

2015-12-18 00:00:00

pages

146

issn

1664-0640

journal_volume

6

pub_type

杂志文章,评审
  • Monetary Incentives Increase Metacognitive Confidence in Source Memory Performance in Patients With Schizophrenia.

    abstract:Background:Contemporary psychiatric research focuses its attention on the patient's dysfunction of metacognition in relation to the basic cognitive processes of mental activity. The current study investigated dysfunctional metacognition in relation to self-monitoring of memory in patients diagnosed with schizophrenia. ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00725

    authors: Szczepanowski R,Cichoń E,Pasieczna AH,Gawęda Ł,Rosińczuk J

    更新日期:2020-07-29 00:00:00

  • Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors.

    abstract::Post-traumatic stress disorder (PTSD) is a heterogeneous disorder that affects individuals exposed to trauma (e.g., combat, interpersonal violence, and natural disasters). It is characterized by hyperarousal, intrusive reminders of the trauma, avoidance of trauma-related cues, and negative cognition and mood. This het...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2014.00088

    authors: Briscione MA,Jovanovic T,Norrholm SD

    更新日期:2014-07-21 00:00:00

  • Personality and Psychological Factors of Problematic Internet Gamers Seeking Hospital Treatment.

    abstract::Introduction: Previous studies on internet gaming disorder (IGD) have reported an association between personality traits and impulsive or problematic use of the internet or internet games, but the results obtained were inconsistent. Our study's hypothesis was that personality traits are associated with the individual'...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00583

    authors: Seong W,Hong JS,Kim S,Kim SM,Han DH

    更新日期:2019-08-28 00:00:00

  • Lower Income Levels in Australia Are Strongly Associated With Elevated Psychological Distress: Implications for Healthcare and Other Policy Areas.

    abstract::Background: Australia is a high-income country with increasing income inequality. It is unclear whether Australia's well-developed mental healthcare system is making a difference to population mental health and the Federal Government has targeted outcomes accountability in service funding strategies. In high-income co...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00536

    authors: Isaacs AN,Enticott J,Meadows G,Inder B

    更新日期:2018-10-26 00:00:00

  • Characterizing Treatment-Resistant Anorexia Nervosa.

    abstract::Background: The issue of treatment resistance in eating disorder care is controversial. Prior research has identified multiple failed treatment attempts as a common criterion for severe and enduring anorexia nervosa, but little is known about patients who have multiple failed treatment attempts. This study was designe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.542206

    authors: Smith S,Woodside DB

    更新日期:2021-01-08 00:00:00

  • Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.

    abstract::Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well-established in motor function, the outcome in dopamine-related behaviors remains uncertai...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2014.00067

    authors: Coelho JE,Alves P,Canas PM,Valadas JS,Shmidt T,Batalha VL,Ferreira DG,Ribeiro JA,Bader M,Cunha RA,do Couto FS,Lopes LV

    更新日期:2014-06-13 00:00:00

  • Non-Invasive Brain Stimulation for the Treatment of Symptoms Following Traumatic Brain Injury.

    abstract:BACKGROUND:Traumatic brain injury (TBI) is a common cause of physical, psychological, and cognitive impairment, but many current treatments for TBI are ineffective or produce adverse side effects. Non-invasive methods of brain stimulation could help ameliorate some common trauma-induced symptoms. OBJECTIVE:This review...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2015.00119

    authors: Dhaliwal SK,Meek BP,Modirrousta MM

    更新日期:2015-08-26 00:00:00

  • Do manual and voxel-based morphometry measure the same? A proof of concept study.

    abstract::Voxel-based morphometry (VBM) is a commonly used method to study volumetric variations on a whole brain basis. However, it is often criticized for potential confounds, mainly based on imperfect spatial registration. We therefore aimed to evaluate if VBM and "gold standard" manual volumetry are measuring the same effec...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2014.00039

    authors: Focke NK,Trost S,Paulus W,Falkai P,Gruber O

    更新日期:2014-04-08 00:00:00

  • Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice.

    abstract::Butyrylcholinesterase (BChE) efficiently hydrolyzes acetylcholine (ACh) at high concentrations when acetylcholinesterase (AChE) is substrate-inhibited. Recent studies have shown that BChE also has a function that is independent of ACh, but it has not been fully explored. Low BChE expression is accompanied with higher ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.564843

    authors: Chen S,Lin Z,Tan KL,Chen R,Su W,Zhao H,Tan Q,Tan W

    更新日期:2020-09-11 00:00:00

  • Metacognitive Training Modulates Default-Mode Network Homogeneity During 8-Week Olanzapine Treatment in Patients With Schizophrenia.

    abstract:Background:Previous studies have revealed the efficacy of metacognitive training for schizophrenia. However, the underlying mechanisms of metacognitive training on brain function alterations, including the default-mode network (DMN), remain unknown. The present study explored treatment effects of metacognitive training...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00234

    authors: Shan X,Liao R,Ou Y,Ding Y,Liu F,Chen J,Zhao J,Guo W,He Y

    更新日期:2020-03-27 00:00:00

  • Yi-nao-jie-yu Prescription Exerts a Positive Effect on Neurogenesis by Regulating Notch Signals in the Hippocampus of Post-stroke Depression Rats.

    abstract::Post-stroke depression (PSD) is one of the most frequent complications of stroke. The Yi-nao-jie-yu prescription (YNJYP) is an herbal prescription widely used as a therapeutic agent against PSD in traditional Chinese medicine. Disruption of adult neurogenesis has attracted attention as a potential cause of cognitive p...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00483

    authors: Tian H,Li X,Tang Q,Zhang W,Li Q,Sun X,Zhao R,Ma C,Liu H,Gao Y,Han F

    更新日期:2018-10-16 00:00:00

  • Inheritance of HLA-Cw7 Associated With Autism Spectrum Disorder (ASD).

    abstract::Autism spectrum disorder (ASD) is a behaviorally defined disorder that is now thought to affect approximately 1 in 69 children in the United States. In most cases, the etiology is unknown, but several studies point to the interaction of genetic predisposition with environmental factors. The immune system is thought to...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00612

    authors: Harville T,Rhodes-Clark B,Bennuri SC,Delhey L,Slattery J,Tippett M,Wynne R,Rose S,Kahler S,Frye RE

    更新日期:2019-09-11 00:00:00

  • Low Density Lipoprotein Receptor-Related Protein and Apolipoprotein E Expression is Altered in Schizophrenia.

    abstract::Our recent microarray study reported altered mRNA expression of several low density lipoprotein receptor-related proteins (LRP) associated with the first 4 years following diagnosis with schizophrenia. Whilst this finding is novel, apolipoprotein E (APOE), which mediates its activity through LRPs, has been reported by...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2010.00019

    authors: Gibbons AS,Thomas EA,Scarr E,Dean B

    更新日期:2010-07-08 00:00:00

  • The Detection of Malingering: A New Tool to Identify Made-Up Depression.

    abstract::Major depression is a high-prevalence mental disease with major socio-economic impact, for both the direct and the indirect costs. Major depression symptoms can be faked or exaggerated in order to obtain economic compensation from insurance companies. Critically, depression is potentially easily malingered, as the sym...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00249

    authors: Monaro M,Toncini A,Ferracuti S,Tessari G,Vaccaro MG,De Fazio P,Pigato G,Meneghel T,Scarpazza C,Sartori G

    更新日期:2018-06-08 00:00:00

  • Modeling Trait Anxiety: From Computational Processes to Personality.

    abstract::Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with ref...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2017.00001

    authors: Raymond JG,Steele JD,Seriès P

    更新日期:2017-01-23 00:00:00

  • Dopamine pathology in schizophrenia: analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra.

    abstract:INTRODUCTION:Despite the importance of dopamine neurotransmission in schizophrenia, very few studies have addressed anomalies in the mesencephalic dopaminergic neurons of the substantia nigra/ventral tegmental area (SN/VTA). Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the production of dopamine, and a pos...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2012.00031

    authors: Perez-Costas E,Melendez-Ferro M,Rice MW,Conley RR,Roberts RC

    更新日期:2012-04-09 00:00:00

  • The Modified Yale Food Addiction Scale 2.0: Validation Among Non-Clinical and Clinical French-Speaking Samples and Comparison With the Full Yale Food Addiction Scale 2.0.

    abstract:Objectives:The modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was designed to assess food addiction using a shorter version than the YFAS 2.0. We lack data about the psychometric properties of the mYFAS 2.0 in patients with obesity, as well as studies comparing the psychometric properties of the mYFAS 2.0 versus th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.480671

    authors: Brunault P,Berthoz S,Gearhardt AN,Gierski F,Kaladjian A,Bertin E,Tchernof A,Biertho L,de Luca A,Hankard R,Courtois R,Ballon N,Benzerouk F,Bégin C

    更新日期:2020-09-08 00:00:00

  • Cognitive Intervention Targeting Autobiographical Memory Impairment in Patients With Schizophrenia Using a Wearable Camera: A Proof-of-Concept Study.

    abstract::Autobiographical memory (AM) impairment in schizophrenia affects the richness of detail in personal memories and is one of the major predictors of patients' social functioning. Despite the empirical evidence attributing these difficulties to a defective encoding process, cognitive remediation interventions targeting A...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00397

    authors: Dassing R,Allé MC,Cerbai M,Obrecht A,Meyer N,Vidailhet P,Danion JM,Mengin AC,Berna F

    更新日期:2020-05-08 00:00:00

  • Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls.

    abstract:INTRODUCTION:Multivariate machine learning methods can be used to classify groups of schizophrenia patients and controls using structural magnetic resonance imaging (MRI). However, machine learning methods to date have not been extended beyond classification and contemporaneously applied in a meaningful way to clinical...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2012.00053

    authors: Greenstein D,Malley JD,Weisinger B,Clasen L,Gogtay N

    更新日期:2012-06-01 00:00:00

  • Mechanisms of auditory verbal hallucination in schizophrenia.

    abstract::Recent work on the mechanisms underlying auditory verbal hallucination (AVH) has been heavily informed by self-monitoring accounts that postulate defects in an internal monitoring mechanism as the basis of AVH. A more neglected alternative is an account focusing on defects in auditory processing, namely a spontaneous ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2013.00155

    authors: Cho R,Wu W

    更新日期:2013-11-27 00:00:00

  • A Randomized Controlled Trial on the Efficacy of a Psychosocial Behavioral Intervention to Improve the Lifestyle of Patients With Severe Mental Disorders: Study Protocol.

    abstract::Patients with severe mental disorders die on average 20 years prior to the general population. This mortality gap is mainly due to the higher prevalence of physical diseases and the adoption of unhealthy lifestyle behaviors.The LIFESTYLE trial aims to evaluate the efficacy of a new psychosocial group intervention (inc...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2018.00235

    authors: Sampogna G,Fiorillo A,Luciano M,Del Vecchio V,Steardo L Jr,Pocai B,Barone M,Amore M,Pacitti F,Dell'Osso L,Di Lorenzo G,Maj M,LIFESTYLE Working Group.

    更新日期:2018-06-07 00:00:00

  • Manual Dexterity in Schizophrenia-A Neglected Clinical Marker?

    abstract::Impaired manual dexterity is commonly observed in schizophrenia. However, a quantitative description of key sensorimotor components contributing to impaired dexterity is lacking. Whether the key components of dexterity are differentially affected and how they relate to clinical characteristics also remains unclear. We...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00120

    authors: Térémetz M,Carment L,Brénugat-Herne L,Croca M,Bleton JP,Krebs MO,Maier MA,Amado I,Lindberg PG

    更新日期:2017-07-10 00:00:00

  • Functional Connectivity of Cognitive Brain Networks in Schizophrenia during a Working Memory Task.

    abstract::Task-based connectivity studies facilitate the understanding of how the brain functions during cognition, which is commonly impaired in schizophrenia (SZ). Our aim was to investigate functional connectivity during a working memory task in SZ. We hypothesized that the task-negative (default mode) network and the cognit...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00294

    authors: Godwin D,Ji A,Kandala S,Mamah D

    更新日期:2017-12-22 00:00:00

  • Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.

    abstract::Proton exchange provides a powerful contrast mechanism for magnetic resonance imaging (MRI). MRI techniques sensitive to proton exchange provide new opportunities to map, with high spatial and temporal resolution, compounds important for brain metabolism and function. Two such techniques, chemical exchange saturation ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.532606

    authors: Shaffer JJ Jr,Mani M,Schmitz SL,Xu J,Owusu N,Wu D,Magnotta VA,Wemmie JA

    更新日期:2020-09-24 00:00:00

  • Longer Cortical Silent Period Length Is Associated to Binge Eating Disorder: An Exploratory Study.

    abstract::Introduction: Although binge eating disorder (BED) is an eating disorder and obesity is a clinical disease, it is known that both conditions present overlapped symptoms related to, at least partially, the disruption of homeostatic and hedonistic eating behavior pathways. Therefore, the understanding of neural substrat...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.559966

    authors: Antunes LC,Elkfury JL,Parizotti CS,Brietzke AP,Bandeira JS,Torres ILDS,Fregni F,Caumo W

    更新日期:2020-10-14 00:00:00

  • Astrocytic Regulation of Glutamate Transmission in Schizophrenia.

    abstract::According to the glutamate hypothesis of schizophrenia, the abnormality of glutamate transmission induced by hypofunction of NMDA receptors (NMDARs) is causally associated with the positive and negative symptoms of schizophrenia. However, the underlying mechanisms responsible for the changes in glutamate transmission ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00544

    authors: Mei YY,Wu DC,Zhou N

    更新日期:2018-11-06 00:00:00

  • High Psychiatric Morbidity and Comorbidity Among Female Prisoners in Hunan, China.

    abstract:Background:High prevalence of mental disorders has been found among female prisoners in Western countries, however, little is known about the epidemiology of mental disorders in such populations in China. This study aims to investigate psychiatric morbidity and comorbidity among sentenced prisoners in a female prison i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00271

    authors: Zhong S,Zhu X,Chen Y,Guo H,Luo C,Liang X,Wang F,Chen H,Zhou J,Wang X

    更新日期:2020-04-14 00:00:00

  • Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study.

    abstract:Background:Neuropsychological studies have revealed that patients with schizophrenia (SZ) have facial recognition difficulties and a reduced visual evoked N170 response to human faces. However, detailed neurophysiological evidence of this face processing deficit in SZ with a higher spatial resolution has yet to be acqu...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.554844

    authors: Ohara N,Hirano Y,Oribe N,Tamura S,Nakamura I,Hirano S,Tsuchimoto R,Ueno T,Togao O,Hiwatashi A,Nakao T,Onitsuka T

    更新日期:2020-09-03 00:00:00

  • How Prevalent is "Food Addiction"?

    abstract::Increasing evidence suggests that binge eating-related disorders could be related to addiction-like eating patterns due to the addictive potential of hyperpalatable foods. Subsequently, important implications have been derived for treatment of those disorders and even political actions. However, studies on the prevale...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2011.00061

    authors: Meule A

    更新日期:2011-11-03 00:00:00

  • The Attribution of Mental Health Problems to Jinn: An Explorative Study in a Transcultural Psychiatric Outpatient Clinic.

    abstract:Background:Among Muslim patients, a common cultural concept of distress is the notion that jinn may be the cause of mental health problems, especially in the presence of hallucinations. Objective:This study examines the frequency with which this attribution style is manifest in a specific psychiatric outpatient popula...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00089

    authors: Lim A,Hoek HW,Ghane S,Deen M,Blom JD

    更新日期:2018-03-28 00:00:00