Abstract:
:Tripartite motif-containing 67 (TRIM67), an E3 ubiquitin ligase, belongs to the TRIM protein family. The relationship between TRIM67 and tumorigenesis is not fully clear. Here, we elucidated TRIM67 function in non-small cell lung cancer (NSCLC). TRIM67 immunostaining results were correlated with clinicopathological features. Moreover, the function of TRIM67 in cultured NSCLC cells was evaluated by MTT, colony formation, and Transwell assays. TRIM67 expression was associated with tumor size, lymph node metastasis, p-TNM stage, cancer cell differentiation, and poor prognosis. We altered TRIM67 expression in A549 and H1299 cell lines, and the results showed that TRIM67 promoted cell proliferation, migration, invasion and EMT by positively regulating the Notch pathway. Collectively, the results showed that TRIM67 promotes NSCLC progression through the Notch pathway and that TRIM67 expression is associated with clinicopathological features, indicating that TRIM67 may play an important role in promoting the development of NSCLC and could be applied as not only an important prognostic biomarker but also a therapeutic target in NSCLC.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Jiang J,Ren H,Xu Y,Wudu M,Wang Q,Liu Z,Su H,Jiang X,Zhang Y,Zhang B,Qiu Xdoi
10.7150/jca.38286subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1240-1249issue
5issn
1837-9664pii
jcav11p1240journal_volume
11pub_type
杂志文章abstract:OBJECTIVES:To study whether radical nephrectomy (RN) with lymph node dissection (LND) can benefit pT3 renal cell carcinoma (RCC) patients versus no LND under the 2018 American Joint Committee on Cancer TNM classification system. Subjects/Patients and Methods: We performed a retrospective cohort study of clinicopatholog...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30375
更新日期:2019-05-26 00:00:00
abstract::Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in b...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.8242
更新日期:2014-01-15 00:00:00
abstract::Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16069
更新日期:2016-10-22 00:00:00
abstract::Trend analysis is the analysis using statistical models to estimate and predict potential trends over time, space or any independent continuous-variable. It has been widely used in epidemiology and public health, but much less so in clinical oncology and basic cancer research. Methodological imitations of the chosen s...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.43521
更新日期:2020-03-04 00:00:00
abstract::Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28917
更新日期:2019-01-29 00:00:00
abstract:PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15696
更新日期:2016-07-08 00:00:00
abstract::Objective: This study aimed to evaluate the efficacy and safety of doxorubicin-loaded drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres microspheres (CSM) in treating unresectable intrahepatic cholangiocarcinoma (ICC). Methods: 88 unresectable ICC patients who received DEB-TACE treatment ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39410
更新日期:2020-05-18 00:00:00
abstract::Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC). Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respe...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22085
更新日期:2018-03-08 00:00:00
abstract:OBJECTIVE:The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS:The mineralization of ovarian cancer cell lines SKOV3 was induced ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22932
更新日期:2018-02-28 00:00:00
abstract:BACKGROUND:Medullary thyroid cancer (MTC) commonly presents with lymph node (LN) metastases, and has a worse prognosis than papillary thyroid cancer (PTC). Tumor size and LN involvement have been shown to affect stage of disease; however, to our knowledge, ours is the first study that attempts to correlate anterior nec...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.200
更新日期:2011-04-08 00:00:00
abstract::Purpose: Hypoxia-inducible factor-1alpha (HIF-1A) is a transcription factor that plays an "angiogenic switch" role especially under hypoxia microenvironment in solid tumor. However, the functions and clinical significance of HIF-1A in gallbladder cancer (GBC) are still controversial, and it has not been studied in nor...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46749
更新日期:2021-01-01 00:00:00
abstract::Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.11566
更新日期:2015-05-12 00:00:00
abstract::Background: The purpose of this study was to examine and compare the prognostic value of different immunization-based scoring systems in patients with soft tissue sarcoma (STS). Methods: We conducted a retrospective study evaluating a cohort of 165 patients diagnosed with STS between July 2007 and July 2014. The relat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17356
更新日期:2017-02-25 00:00:00
abstract::Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.458
更新日期:2011-01-01 00:00:00
abstract::Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18055
更新日期:2017-04-09 00:00:00
abstract::Background: Hepatitis B virus infection had been identified its relationship with liver diseases, including liver tumors. We aimed to explore diagnostic and prognostic values between the Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC). Methods: We used the GSE14520 dataset to explore diagnosti...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29655
更新日期:2019-08-28 00:00:00
abstract::Liquid biopsy is becoming a promising method for non-invasive cancer detection. In several proof-of-concept studies, long non-coding RNAs (lncRNAs) were found to be potential biomarkers for bladder cancer detection. The objective of this study was to discover a panel of cell-free, urinary lncRNAs as liquid biopsy biom...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37006
更新日期:2020-01-01 00:00:00
abstract::Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16774
更新日期:2017-01-01 00:00:00
abstract::Background: The use of PCI in early operable patients with small cell lung cancer (SCLC) is still controversial. Therefore, we conducted a systematic review with meta-analysis to investigate the effects of PCI in resected SCLC patients. Methods: Relevant studies were identified from PubMed and EMBASE databases, the po...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21465
更新日期:2018-01-01 00:00:00
abstract::Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue si...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44413
更新日期:2020-04-06 00:00:00
abstract::Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that areca nut induced several cytotoxic effects in oral cells, including ROS generation, inflammation, tissue hypoxia, DNA damage, and cell inv...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.29765
更新日期:2019-07-08 00:00:00
abstract::Objective: Both previous and recent literature showed long non-coding RNAs (lncRNAs) were crucial participants in multiple myeloma (MM) evolution. However, the dynamic regulation and mechanism of lncRNAs in MM progression was not fully understood. This study will explore the expression and effects of prostate cancer-a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35098
更新日期:2019-10-20 00:00:00
abstract::Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...
journal_title:Journal of Cancer
pub_type: 杂志文章,收录出版
doi:10.7150/jca.29953
更新日期:2019-06-09 00:00:00
abstract::Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.47260
更新日期:2020-10-18 00:00:00
abstract::Background: Anti-EGFR therapies have been recommended for advanced colorectal cancer (CRC) with wild-type RAS and PIK3CA mutation. However, PIK3CA mutations are a poor prognostic marker and a negative predictor of response to anti-EGFR therapies in RAS wild-type CRC. Therefore, new and advanced treatment strategies ar...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19458
更新日期:2017-08-22 00:00:00
abstract::We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18762
更新日期:2017-05-12 00:00:00
abstract::Purpose: The objective of the study was to evaluate the important role played by androgen and insulin in the development of endometrial carcinoma (EC), and their combined effect on EC risk. Methods: We enrolled 510 type I EC patients and 510 age-, time-, and nationality-matched subjects into this study. Metabolic and ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46391
更新日期:2020-07-25 00:00:00
abstract::The alterations of MET have been detected in non-small-cell lung cancer (NSCLC). However, the prognostic impact of MET gene copy number gain (CNG) has not been consistent among studies. We performed this meta-analysis to evaluate the prognostic value of high MET CNG in patients with NSCLC. A systematic computerized se...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24980
更新日期:2018-04-23 00:00:00
abstract::Purpose: Several new treatment options for patients with metastatic castration resistant prostate cancer (mCRPC) have been approved within the last years - among them cabazitaxel (CAB), abiraterone acetate, enzalutamide, and radium-223. The aim of this study was to assess factors predictive for efficacy of CAB. Method...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17644
更新日期:2017-02-11 00:00:00
abstract::Yes-associated protein (YAP) is a transcriptional coactivator that promotes cell proliferation, migration, and tissue homeostasis in colorectal cancer (CRC). Here, we established 5-Fu resistant CRC cell line (SW620R) and examined the role of YAP in chemotherapy resistance. We showed that YAP promoted cell proliferatio...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44775
更新日期:2020-07-11 00:00:00