Corrigendum: Immunology's Coming of Age.

abstract：:Human pregnancy is accompanied by a mild systemic inflammatory response, which includes the activation of monocytes circulating in maternal blood. This response is exaggerated in preeclampsia, a placental-dependent disorder specific to human pregnancies. We and others showed that placental syncytiotrophoblast membrane...

journal_title：Frontiers in immunology

authors： Joerger-Messerli MS,Hoesli IM,Rusterholz C,Lapaire O

更新日期：2014-04-15 00:00:00

abstract：:Hepatitis B virus (HBV) infection is regarded as the main etiological risk factor in the process of hepatocellular carcinoma (HCC), as it promotes an immunosuppressive microenvironment that is partially mediated by the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) signaling pathway. The tumo...

journal_title：Frontiers in immunology

authors： Li B,Yan C,Zhu J,Chen X,Fu Q,Zhang H,Tong Z,Liu L,Zheng Y,Zhao P,Jiang W,Fang W

更新日期：2020-05-28 00:00:00

abstract：:Natural killer (NK) cells play an important role following allogeneic hematopoietic stem cell transplantation (HSCT) exerting graft-versus-leukemia/tumor effect and mediating pathogen-specific immunity. Although NK cells are the first donor-derived lymphocytes reconstituting post-HSCT, their distribution of CD56++CD16...

journal_title：Frontiers in immunology

authors： Huenecke S,Cappel C,Esser R,Pfirrmann V,Salzmann-Manrique E,Betz S,Keitl E,Banisharif-Dehkordi J,Bakhtiar S,Königs C,Jarisch A,Soerensen J,Ullrich E,Klingebiel T,Bader P,Bremm M

更新日期：2017-02-10 00:00:00

abstract：:Innate lymphoid cells (ILCs) are the most recently identified family of the innate immune system and are hypothesized to modulate immune functions prior to the generation of adaptive immune responses. Subsets of ILCs reside in the mucosa and regulate immune responses to external pathogens; however, their role and the ...

journal_title：Frontiers in immunology

authors： Yin S,Yu J,Hu B,Lu C,Liu X,Gao X,Li W,Zhou L,Wang J,Wang D,Lu L,Wang L

更新日期：2018-09-12 00:00:00

abstract：:Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. However, infected humans and ...

journal_title：Frontiers in immunology

authors： Tracy KE,Baumgarth N

更新日期：2017-02-20 00:00:00

abstract：:T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tf...

journal_title：Frontiers in immunology

authors： Pallikkuth S,de Armas L,Rinaldi S,Pahwa S

更新日期：2017-10-23 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small...

journal_title：Frontiers in immunology

authors： Park AM,Khadka S,Sato F,Omura S,Fujita M,Hsu DK,Liu FT,Tsunoda I

更新日期：2020-09-23 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction. Though effective treatments are currently available, many commonly used therapies have important limitations and al...

journal_title：Frontiers in immunology

authors： Gable KL,Guptill JT

更新日期：2020-01-10 00:00:00

abstract：:The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epito...

journal_title：Frontiers in immunology

authors： Gupta S,Agarwal A,Kumar A,Biswas D

更新日期：2018-04-10 00:00:00

abstract：:The classical model of cytokine signaling dominates our view of specific gene activation by cytokines such as the interferons (IFNs). The importance of the model extends beyond cytokines and applies to hormones such as growth hormone (GH) and insulin, and growth factors such as epidermal growth factor (EGF) and fibrob...

journal_title：Frontiers in immunology

authors： Johnson HM,Noon-Song EN,Dabelic R,Ahmed CM

更新日期：2013-07-25 00:00:00

abstract：:The glycans on the plasma membrane of cells manifest as the glycocalyx, which serves as an information-rich frontier that is directly in contact with its immediate milieu. The glycoconjugates (GCs) that adorn most of the mammalian cells are also abundant in gametes, especially the spermatozoa where they perform unique...

journal_title：Frontiers in immunology

authors： Batra V,Dagar K,Nayak S,Kumaresan A,Kumar R,Datta TK

更新日期：2020-08-28 00:00:00

abstract：:Malaria remains a significant health problem in many tropical and sub-tropical regions. The development of vaccines against the clinically active blood-stage of infection needs to consider variability and polymorphism in target antigens, and an adjuvant system able to induce broad spectrum immunity comprising both ant...

journal_title：Frontiers in immunology

authors： Wilson KL,Pouniotis D,Hanley J,Xiang SD,Ma C,Coppel RL,Plebanski M

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Serotype-specific antibody responses to unconjugated pneumococcal polysaccharide vaccine (PPV) evaluated by a World Health Organization (WHO)-standardized enzyme-linked immunosorbent assay (ELISA) are the gold standard for diagnosis of specific polysaccharide antibody deficiency (SAD). The American Academy o...

journal_title：Frontiers in immunology

authors： Schaballie H,Bosch B,Schrijvers R,Proesmans M,De Boeck K,Boon MN,Vermeulen F,Lorent N,Dillaerts D,Frans G,Moens L,Derdelinckx I,Peetermans W,Kantsø B,Jørgensen CS,Emonds MP,Bossuyt X,Meyts I

更新日期：2017-05-12 00:00:00

abstract：:Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery, few approved treatments are available for this complication. Wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic...

journal_title：Frontiers in immunology

authors： Li B,Hu Y,Zhao Y,Cheng M,Qin H,Cheng T,Wang Q,Peng X,Zhang X

更新日期：2017-01-31 00:00:00

abstract：:A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irrad...

journal_title：Frontiers in immunology

authors： Liu J,Zhou J,Wu M,Hu C,Yang J,Li D,Wu P,Chen Y,Chen P,Lin S,Cui Y,Fu S,Wu J

更新日期：2019-02-27 00:00:00

abstract：:This is the first case of NBAS disease detected by NBS for primary immunodeficiency. NBS with KRECs is revealing unknown potentialities detecting conditions that benefit from early recognition like NBAS deficiency. Immune phenotyping should be mandatory in patients with NBAS deficiency since they can exhibit severe im...

journal_title：Frontiers in immunology

authors： Ricci S,Lodi L,Serranti D,Moroni M,Belli G,Mancano G,La Barbera A,Forzano G,Mangone G,Indolfi G,Azzari C

更新日期：2019-08-27 00:00:00

abstract：:Graft-vs.-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Significant progresses have been made in defining the dichotomous role of dendritic cells (DCs) in the development of GVHD. Host-derived DCs are important to elicit...

journal_title：Frontiers in immunology

authors： Yu H,Tian Y,Wang Y,Mineishi S,Zhang Y

更新日期：2019-02-01 00:00:00

abstract：:Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk HPV types (i.e., HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) are considered to be the main etiological agents of genital tract cancers, such as cervical, vulvar, vaginal, penile, and anal cancers, and of a subset of head and...

journal_title：Frontiers in immunology

authors： Garbuglia AR,Lapa D,Sias C,Capobianchi MR,Del Porto P

更新日期：2020-02-18 00:00:00

abstract：:We previously reported that adiponectin (AD) promotes naïve T cell differentiation into Th17 cells and participates in synovial inflammation and the bone erosion process in patients with rheumatoid arthritis. Here, we use a T cell lineage adiponectin receptor 1 (AdipoR1) conditional knockout model to investigate the r...

journal_title：Frontiers in immunology

authors： Zhang Q,Wang L,Jiang J,Lin S,Luo A,Zhao P,Tan W,Zhang M

更新日期：2020-08-18 00:00:00

abstract：:Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory reaction may result in systemic manifestations with dire consequences to the host. The extent of activation of the inflammatory response is tightly regulated thro...

journal_title：Frontiers in immunology

authors： Al-Barazie RM,Bashir GH,Qureshi MM,Mohamed YA,Al-Sbiei A,Tariq S,Lammers WJ,Al-Ramadi BK,Fernandez-Cabezudo MJ

更新日期：2018-03-19 00:00:00

abstract：:Bovine neonatal pancytopenia (BNP) was a vaccine-induced alloimmune disease observed in young calves and characterized by hemorrhages, pancytopenia, and severe destruction of the hematopoietic tissues. BNP was induced by alloreactive maternal antibodies present in the colostrum of certain cows vaccinated with a highly...

journal_title：Frontiers in immunology

authors： Kasonta R,Mauritz J,Spohr C,Sauter-Louis C,Duchow K,Cussler K,Holsteg M,Bastian M

更新日期：2018-08-14 00:00:00

abstract：:The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a ...

journal_title：Frontiers in immunology

authors： Simões AE,Di Lorenzo B,Silva-Santos B

更新日期：2018-04-27 00:00:00

abstract：:Background: Disease progression monitoring through CD4 counts alone can be inadequate in HIV infection as ongoing immune activation may result in Serious non-AIDS events (SNAEs). SNAEs involve monocyte activation driven chronic inflammation with significant sequelae observed even during HAART. Here, we attempted to de...

journal_title：Frontiers in immunology

authors： Prabhu VM,Singh AK,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-12-06 00:00:00

abstract：:Inducible Bronchus Associated Lymphoid Tissue (iBALT) is an ectopic lymphoid tissue associated with severe forms of chronic lung diseases, including chronic obstructive pulmonary disease, rheumatoid lung disease, hypersensitivity pneumonitis and asthma, suggesting that iBALT may exacerbate these clinical conditions. H...

journal_title：Frontiers in immunology

authors： Hwang JY,Silva-Sanchez A,Carragher DM,Garcia-Hernandez ML,Rangel-Moreno J,Randall TD

更新日期：2020-09-25 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00

abstract：:The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly increased numbers of B cells. However, it has remained unclear whether th...

journal_title：Frontiers in immunology

authors： Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J

更新日期：2018-03-22 00:00:00

abstract：:Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient responses while preventing immunodeficiencies and autoimmunity. Post-transcriptional regulation of RNA editing, location, stability, and t...

journal_title：Frontiers in immunology

authors： Díaz-Muñoz MD,Turner M

更新日期：2018-05-23 00:00:00

abstract：:A large proportion of the world is inflicted with health concerns arising from infectious diseases. Moreover, there is a widespread emergence of antibiotic resistance among major infectious agents, partially stemming from their continuous dialog with the host, and their enormous capacity to remodel the latter toward a...

journal_title：Frontiers in immunology

authors： Mukherjee T,Balaji KN

更新日期：2019-08-21 00:00:00

abstract：:It is now apparent that immune cells express a functional cholinergic system and that α7 nicotinic acetylcholine receptors (α7 nAChRs) are involved in regulating T cell differentiation and the synthesis of antigen-specific antibodies and proinflammatory cytokines. Here, we investigated the specific function α7 nAChRs ...

journal_title：Frontiers in immunology

authors： Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K

更新日期：2019-05-31 00:00:00

abstract：:The killer-cell Ig-like receptors (KIR) form a multigene entity involved in modulating immune responses through interactions with MHC class I molecules. The complexity of the KIR cluster is reflected by, for instance, abundant levels of allelic polymorphism, gene copy number variation, and stochastic expression profil...

journal_title：Frontiers in immunology

authors： Bruijnesteijn J,van der Wiel MKH,de Groot N,Otting N,de Vos-Rouweler AJM,Lardy NM,de Groot NG,Bontrop RE

更新日期：2018-12-04 00:00:00