The WNT Framework in Shaping Immune Cell Responses During Bacterial Infections.

Abstract:

:A large proportion of the world is inflicted with health concerns arising from infectious diseases. Moreover, there is a widespread emergence of antibiotic resistance among major infectious agents, partially stemming from their continuous dialog with the host, and their enormous capacity to remodel the latter toward a secure niche. Among the several infection-driven events, moderation of WNT signaling pathway has been identified to be strategically tuned during infections to govern host-pathogen interactions. Primarily known for its role in arbitrating early embryonic developmental events; aberrant activation of the WNT pathway has also been associated with immunological consequences during diverse patho-physiological conditions. Here, we review the different mechanisms by which components of WNT signaling pathways are exploited by discrete bacterial agents for their pathogenesis. Furthermore, recent advances on the cross-talk of WNT with other signaling pathways, the varied modes of WNT-mediated alteration of gene expression, and WNT-dependent post-transcriptional and post-translational regulation of the immune landscape during distinct bacterial infections would be highlighted.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Mukherjee T,Balaji KN

doi

10.3389/fimmu.2019.01985

subject

Has Abstract

pub_date

2019-08-21 00:00:00

pages

1985

issn

1664-3224

journal_volume

10

pub_type

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