Obesity as a Risk Factor for Alzheimer's Disease: Implication of Leptin and Glutamate.

abstract：:Asiatic acid (AA), a pentacyclic triterpene derived from the tropical medicinal plant Centella asiatica, has been widely used as an antioxidant and anti-inflammatory agent. Evidence regarding the neuroprotective properties of AA is emerging. However, the protective effects of AA and its mechanism in glaucoma are poorl...

journal_title：Frontiers in neuroscience

authors： Huang W,Gao F,Hu F,Huang J,Wang M,Xu P,Zhang R,Chen J,Sun X,Zhang S,Wu J

更新日期：2018-07-20 00:00:00

abstract：:The mammalian brain is characterized by orderly spatial distribution of its cellular components, commonly referred to as topographical organization. The topography of cortical and subcortical maps is thought to represent functional or computational properties. In the present investigation, we have studied map transfor...

journal_title：Frontiers in neuroscience

authors： Leergaard TB,Bjaalie JG

更新日期：2007-10-15 00:00:00

abstract：:Voltage-gated calcium channels (VGCCs) are important mediators of pain hypersensitivity during inflammatory states, but their role in sensory nerve growth remains underexplored. Here, we assess the role of the N-type calcium channel Cav2.2 in the complete Freund's adjuvant (CFA) model of inflammatory pain. We demonstr...

journal_title：Frontiers in neuroscience

authors： Pitake S,Middleton LJ,Abdus-Saboor I,Mishra SK

更新日期：2019-09-19 00:00:00

abstract：:The characterization of the functional network of the brain dynamics has become a prominent tool to illuminate novel aspects of brain functioning. Due to its excellent time resolution, such research is oftentimes based on electroencephalographic recordings (EEG). However, a particular EEG-reference might cause crucial...

journal_title：Frontiers in neuroscience

authors： Ríos-Herrera WA,Olguín-Rodríguez PV,Arzate-Mena JD,Corsi-Cabrera M,Escalona J,Marín-García A,Ramos-Loyo J,Rivera AL,Rivera-López D,Zapata-Berruecos JF,Müller MF

更新日期：2019-09-12 00:00:00

abstract：:We performed this study to investigate the possibility of a definitive pattern of Galectin-3 (Gal-3) expression in the cerebrospinal fluid (CSF) and serum of Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS) patients. In our study, we collected the CSF and serum samples of 31 AD patients, 19 ALS patient...

journal_title：Frontiers in neuroscience

authors： Ashraf GM,Baeesa SS

更新日期：2018-06-29 00:00:00

abstract：:The dentate gyrus (DG) is a region in the mammalian brain critical for memory encoding with a neuronal architecture and function that deviates considerably from other cortical areas. One of the major differences of the DG compared to other brain regions is the finding that the dentate gyrus generates new principal neu...

journal_title：Frontiers in neuroscience

authors： Piatti VC,Ewell LA,Leutgeb JK

更新日期：2013-04-04 00:00:00

abstract：:This work presents sPyNNaker 4.0.0, the latest version of the software package for simulating PyNN-defined spiking neural networks (SNNs) on the SpiNNaker neuromorphic platform. Operations underpinning realtime SNN execution are presented, including an event-based operating system facilitating efficient time-driven ne...

journal_title：Frontiers in neuroscience

authors： Rhodes O,Bogdan PA,Brenninkmeijer C,Davidson S,Fellows D,Gait A,Lester DR,Mikaitis M,Plana LA,Rowley AGD,Stokes AB,Furber SB

更新日期：2018-11-20 00:00:00

abstract：:Diffusion magnetic resonance imaging (dMRI) allows to reconstruct the main pathways of axons within the white matter of the brain as a set of polylines, called streamlines. The set of streamlines of the whole brain is called the tractogram. Organizing tractograms into anatomically meaningful structures, called tracts,...

journal_title：Frontiers in neuroscience

authors： Sharmin N,Olivetti E,Avesani P

更新日期：2018-02-06 00:00:00

abstract：:There is increasing evidence that metabolic dysfunction plays an important role in Alzheimer's disease (AD). Brain insulin resistance and subsequent impairment of insulin and insulin-like growth factor (IGF) signaling are associated with the neurodegenerative and clinical features of AD. Nevertheless, how the brain in...

journal_title：Frontiers in neuroscience

authors： Bonham LW,Geier EG,Steele NZR,Holland D,Miller BL,Dale AM,Desikan RS,Yokoyama JS,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2018-07-16 00:00:00

abstract：:Transcutaneous Vagus Nerve Stimulation (tVNS) on the auricular branch of the vagus nerve has been receiving attention due to its therapeutic potential for neuropsychiatric disorders. Although the mechanism of tVNS is not yet completely understood, studies have demonstrated the potential role of vagal afferent nerve st...

journal_title：Frontiers in neuroscience

authors： Jin Y,Kong J

更新日期：2017-01-20 00:00:00

abstract：:It is necessary to understand the morphology of the vagus nerve (VN) to design and deliver effective and selective vagus nerve stimulation (VNS) because nerve morphology influences fiber responses to electrical stimulation. Specifically, nerve diameter (and thus, electrode-fiber distance), fascicle diameter, fascicula...

journal_title：Frontiers in neuroscience

authors： Pelot NA,Goldhagen GB,Cariello JE,Musselman ED,Clissold KA,Ezzell JA,Grill WM

更新日期：2020-11-04 00:00:00

abstract：:The GABAergic neurons in the lateral pontine tegmentum (LPT) play key roles in the regulation of sleep and locomotion. The dysfunction of the LPT is related to neurological disorders such as rapid eye movement sleep behavior disorder and ocular flutter. However, the whole-brain neural connectivity to LPT GABAergic neu...

journal_title：Frontiers in neuroscience

authors： Chen ZK,Yuan XS,Dong H,Wu YF,Chen GH,He M,Qu WM,Huang ZL

更新日期：2019-04-24 00:00:00

abstract：:Subplate cells are among the first generated neurons in the mammalian cerebral cortex and have been implicated in the establishment of cortical wiring. In rodents some subplate neurons persist into adulthood. Here we would like to highlight several converging findings which suggest a novel secretory function of subpla...

journal_title：Frontiers in neuroscience

authors： Kondo S,Al-Hasani H,Hoerder-Suabedissen A,Wang WZ,Molnár Z

更新日期：2015-03-26 00:00:00

abstract：Background:Non-invasive neuromodulation is an emerging therapy for children with early brain injury but is difficult to apply to preschoolers when windows of developmental plasticity are optimal. Transcranial static magnetic field stimulation (tSMS) decreases primary motor cortex (M1) excitability in adults but effects...

journal_title：Frontiers in neuroscience

authors： Hollis A,Zewdie E,Nettel-Aguirre A,Hilderley A,Kuo HC,Carlson HL,Kirton A

更新日期：2020-05-19 00:00:00

abstract：:Background: Stress-induced cellular changes in limbic brain structures contribute to the development of various psychopathologies. In vivo detection of these microstructural changes may help us to develop objective biomarkers for psychiatric disorders. Diffusion tensor imaging (DTI) is an advanced neuroimaging techniq...

journal_title：Frontiers in neuroscience

authors： Nagy SA,Vranesics A,Varga Z,Csabai D,Bruszt N,Bali ZK,Perlaki G,Hernádi I,Berente Z,Miseta A,Dóczi T,Czéh B

更新日期：2020-06-03 00:00:00

abstract：:Nocturnal secretion of melatonin from the pineal gland may affect central and peripheral timing, in addition to its well-known involvement in the control of seasonal physiology. The Syrian hamster is a photoperiodic species, which displays gonadal atrophy and increased adiposity when adapted to short (winter-like) pho...

journal_title：Frontiers in neuroscience

authors： Chakir I,Dumont S,Pévet P,Ouarour A,Challet E,Vuillez P

更新日期：2015-05-27 00:00:00

abstract：:The neurohormone oxytocin (OXT) has been found to mediate the regulation of complex socioemotional cognition in multiple ways both in humans and other animals. Recent studies have investigated the effects of OXT in different levels of analysis (from genetic to behavioral) chiefly targeting its impact on the social com...

journal_title：Frontiers in neuroscience

authors： Theofanopoulou C

更新日期：2016-06-14 00:00:00

abstract：:Olfaction is a sense involved in a complex set of tasks, influencing eating behavior, increasing awareness of environmental hazards and affecting social communication. Surprisingly, smell disorders are very frequent, especially in the elderly population. Several recent studies conducted mostly in older subjects have d...

journal_title：Frontiers in neuroscience

authors： Van Regemorter V,Hummel T,Rosenzweig F,Mouraux A,Rombaux P,Huart C

更新日期：2020-02-21 00:00:00

abstract：:During the last decades, neuroscientists have increasingly exploited a variety of artificial, de-novo synthesized materials with controlled nano-sized features. For instance, a renewed interest in the development of prostheses or neural interfaces was driven by the availability of novel nanomaterials that enabled the ...

journal_title：Frontiers in neuroscience

authors： Pampaloni NP,Giugliano M,Scaini D,Ballerini L,Rauti R

更新日期：2019-01-15 00:00:00

abstract：:The melanin-concentrating hormone (MCH) system is a robust integrator of exogenous and endogenous information, modulating arousal and energy balance in mammals. Its predominant function in teleosts, however, is to concentrate melanin in the scales, contributing to the adaptive color change observed in several teleost ...

journal_title：Frontiers in neuroscience

authors： Diniz GB,Bittencourt JC

更新日期：2019-11-26 00:00:00

abstract：:Women and men differ in a wide variety of behavioral traits and in their vulnerability to developing certain mental disorders. This review endeavors to explore how recent preclinical and clinical research findings have enhanced our understanding of the factors that underlie these disparities. We start with a brief ove...

journal_title：Frontiers in neuroscience

authors： Viveros MP,Mendrek A,Paus T,López-Rodríguez AB,Marco EM,Yehuda R,Cohen H,Lehrner A,Wagner EJ

更新日期：2012-06-12 00:00:00

abstract：:Recently, Parkinson's disease-associated α-synuclein (αS) has emerged as an important regulator for SNARE-dependent vesicle fusion. However, it is controversial if excessive accumulation of αS, even in the absence of aggregation, impairs neurotransmission. Here we use a single vesicle fusion assay with ms time resolut...

journal_title：Frontiers in neuroscience

authors： Hawk BJD,Khounlo R,Shin YK

更新日期：2019-03-21 00:00:00

abstract：:We present a spiking neural network model of the thalamic Lateral Geniculate Nucleus (LGN) developed on SpiNNaker, which is a state-of-the-art digital neuromorphic hardware built with very-low-power ARM processors. The parallel, event-based data processing in SpiNNaker makes it viable for building massively parallel n...

journal_title：Frontiers in neuroscience

authors： Sen-Bhattacharya B,Serrano-Gotarredona T,Balassa L,Bhattacharya A,Stokes AB,Rowley A,Sugiarto I,Furber S

更新日期：2017-08-09 00:00:00

abstract：:Neurologic Music Therapy (NMT) is a novel impairment-focused behavioral intervention system whose techniques are based on the clinical neuroscience of music perception, cognition, and production. Auditory Stimulation (RAS) is one of the NMT techniques, which aims to develop and maintain a physiological rhythmic motor ...

journal_title：Frontiers in neuroscience

authors： Buard I,Dewispelaere WB,Thaut M,Kluger BM

更新日期：2019-02-19 00:00:00

abstract：:The recently renewed focus on the human exploration of outer space has boosted the interest toward a variety of questions regarding health of astronauts and cosmonauts. Among the others, sleep has traditionally been considered a central issue. To extend the research chances, human sleep alterations have been investiga...

journal_title：Frontiers in neuroscience

authors： Zivi P,De Gennaro L,Ferlazzo F

更新日期：2020-08-11 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive brain disorder with gradual memory loss that correlates to cognitive deficits in the elderly population. Recent studies have shown the potentials of machine learning algorithms to identify biomarkers and functional brain activity patterns across various AD stages using electro...

journal_title：Frontiers in neuroscience

authors： Fan M,Yang AC,Fuh JL,Chou CA

更新日期：2018-10-04 00:00:00

abstract：:On a large sample of 2288 Han Chinese undergraduates, we investigated how religion and DRD4 are related to human altruistic giving behavior as measured with the Andreoni-Miller Dictator Game. This game enables us to clearly specify (non-)selfishness, efficiency, and fairness motives for sharing. Participants were furt...

journal_title：Frontiers in neuroscience

authors： Jiang Y,Bachner-Melman R,Chew SH,Ebstein RP

更新日期：2015-09-24 00:00:00

abstract：:The brain is the most complex organ in the body, controlling our highest functions, as well as regulating myriad processes which incorporate the entire physiological system. The effects of prospective therapeutic entities on the brain and central nervous system (CNS) may potentially cause significant injury, hence, CN...

journal_title：Frontiers in neuroscience

authors： Grainger AI,King MC,Nagel DA,Parri HR,Coleman MD,Hill EJ

更新日期：2018-08-31 00:00:00

abstract：:Chemical communication via sex pheromones is critical for successful reproduction but the underlying neural mechanisms are not well-understood. The goldfish is a tractable model because sex pheromones have been well-characterized in this species. We used male goldfish forebrain explants in vitro and performed whole-ce...

journal_title：Frontiers in neuroscience

authors： Lado WE,Spanswick DC,Lewis JE,Trudeau VL

更新日期：2014-06-30 00:00:00

abstract：:Throughout the past decade, silicon-based neural probes have become a driving force in neural engineering. Such probes comprise sophisticated, integrated CMOS electronics which provide a large number of recording sites along slender probe shanks. Using such neural probes in a chronic setting often requires them to be ...

journal_title：Frontiers in neuroscience

authors： Chauvière L,Pothof F,Gansel KS,Klon-Lipok J,Aarts AAA,Holzhammer T,Paul O,Singer WJ,Ruther P

更新日期：2019-05-21 00:00:00