Abstract:
:Throughout the past decade, silicon-based neural probes have become a driving force in neural engineering. Such probes comprise sophisticated, integrated CMOS electronics which provide a large number of recording sites along slender probe shanks. Using such neural probes in a chronic setting often requires them to be mechanically anchored with respect to the skull. However, any relative motion between brain and implant causes recording instabilities and tissue responses such as glial scarring, thereby shielding recordable neurons from the recording sites integrated on the probe and thus decreasing the signal quality. In the current work, we present a comparison of results obtained using mechanically fixed and floating silicon neural probes chronically implanted into the cortex of a non-human primate. We demonstrate that the neural signal quality estimated by the quality of the spiking and local field potential (LFP) recordings over time is initially superior for the floating probe compared to the fixed device. Nonetheless, the skull-fixed probe also allowed long-term recording of multi-unit activity (MUA) and low frequency signals over several months, especially once pulsations of the brain were properly controlled.
journal_name
Front Neuroscijournal_title
Frontiers in neuroscienceauthors
Chauvière L,Pothof F,Gansel KS,Klon-Lipok J,Aarts AAA,Holzhammer T,Paul O,Singer WJ,Ruther Pdoi
10.3389/fnins.2019.00464subject
Has Abstractpub_date
2019-05-21 00:00:00pages
464eissn
1662-4548issn
1662-453Xjournal_volume
13pub_type
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