Alpha-Synuclein Continues to Enhance SNARE-Dependent Vesicle Docking at Exorbitant Concentrations.

abstract：:Event-driven neuromorphic spiking sensors such as the silicon retina and the silicon cochlea encode the external sensory stimuli as asynchronous streams of spikes across different channels or pixels. Combining state-of-art deep neural networks with the asynchronous outputs of these sensors has produced encouraging res...

journal_title：Frontiers in neuroscience

authors： Anumula J,Neil D,Delbruck T,Liu SC

更新日期：2018-02-09 00:00:00

abstract：:The advent of large scale neural computational platforms has highlighted the lack of algorithms for synthesis of neural structures to perform predefined cognitive tasks. The Neural Engineering Framework (NEF) offers one such synthesis, but it is most effective for a spike rate representation of neural information, and...

journal_title：Frontiers in neuroscience

authors： Tapson JC,Cohen GK,Afshar S,Stiefel KM,Buskila Y,Wang RM,Hamilton TJ,van Schaik A

更新日期：2013-08-30 00:00:00

abstract：:The motor neuron degenerative disease spinal muscular atrophy (SMA) remains one of the most frequently inherited causes of infant mortality. Afflicted patients loose the survival motor neuron 1 (SMN1) gene but retain one or more copies of SMN2, a homolog that is incorrectly spliced. Primary treatment strategies for SM...

journal_title：Frontiers in neuroscience

authors： Borg R,Cauchi RJ

更新日期：2014-10-15 00:00:00

abstract：:Antiepileptic drugs (AEDs) require daily ingestion for maximal seizure prophylaxis. Adverse psychiatric consequences of AEDs present as: (i) reversible changes in mood, anxiety, anger and/or irritability that often necessitate drug discontinuation, and (ii) autism and/or cognitive/psychomotor delays following fetal ex...

journal_title：Frontiers in neuroscience

authors： Bass JS,Tuo AH,Ton LT,Jankovic MJ,Kapadia PK,Schirmer C,Krishnan V

更新日期：2020-11-06 00:00:00

abstract：:Information processing in the cerebral cortex requires the activation of diverse neurons across layers and columns, which are established through the coordinated production of distinct neuronal subtypes and their placement along the three-dimensional axis. Over recent years, our knowledge of the regulatory mechanisms ...

journal_title：Frontiers in neuroscience

authors： Toma K,Hanashima C

更新日期：2015-08-11 00:00:00

abstract：Background:Emerging evidence demonstrates that diet-induced obesity disrupts corticolimbic circuits underlying emotional regulation. Studies directed at understanding how obesity alters brain and behavior are easily confounded by a myriad of complications related to obesity. This study investigated the early neurobiolo...

journal_title：Frontiers in neuroscience

authors： Vega-Torres JD,Azadian M,Rios-Orsini RA,Reyes-Rivera AL,Ontiveros-Angel P,Figueroa JD

更新日期：2020-06-30 00:00:00

abstract：:The GABAergic neurons in the lateral pontine tegmentum (LPT) play key roles in the regulation of sleep and locomotion. The dysfunction of the LPT is related to neurological disorders such as rapid eye movement sleep behavior disorder and ocular flutter. However, the whole-brain neural connectivity to LPT GABAergic neu...

journal_title：Frontiers in neuroscience

authors： Chen ZK,Yuan XS,Dong H,Wu YF,Chen GH,He M,Qu WM,Huang ZL

更新日期：2019-04-24 00:00:00

abstract：:Recent non-invasive brain stimulation techniques in combination with motor training can enhance neuroplasticity and learning. It is reasonable to assume that such neuroplasticity-based interventions constitute a useful rehabilitative tool for patients with Parkinson's Disease (PD). Regarding motor skill training, many...

journal_title：Frontiers in neuroscience

authors： Horiba M,Ueki Y,Nojima I,Shimizu Y,Sahashi K,Itamoto S,Suzuki A,Yamada G,Matsukawa N,Wada I

更新日期：2019-06-19 00:00:00

abstract：:We constructed a near infrared spectroscopy-based real-time feedback system to estimate the subjects' emotional states using the changes in oxygenated hemoglobin concentration [Δ(oxy-Hb)] in the prefrontal cortex (PFC). Using this system, we investigated the influences of continual mild and equivocal stimuli consistin...

journal_title：Frontiers in neuroscience

authors： Hori S,Mori K,Mashimo T,Seiyama A

更新日期：2017-06-09 00:00:00

abstract：:Sensory loss involves irreversible behavioral and neural changes. Paradigms of short-term limb immobilization mimic deprivation of proprioceptive inputs and motor commands, which occur after the loss of limb use. While several studies have shown that short-term immobilization induced motor control impairments, the ori...

journal_title：Frontiers in neuroscience

authors： Scotto CR,Meugnot A,Casiez G,Toussaint L

更新日期：2020-07-01 00:00:00

abstract：:We present a novel assistive control strategy for a robotic hip exoskeleton for assisting hip flexion/extension, based on a proportional Electromyography (EMG) strategy. The novelty of the proposed controller relies on the use of the Gastrocnemius Medialis (GM) EMG signal instead of a hip flexor muscle, to control the...

journal_title：Frontiers in neuroscience

authors： Grazi L,Crea S,Parri A,Molino Lova R,Micera S,Vitiello N

更新日期：2018-02-14 00:00:00

abstract：:A vast literature implicates the ventral striatum in the processing of reward-related information and in mediating the impact of such information on behavior. It is characterized by heterogeneity at the local circuit, connectivity, and functional levels. A tool for dissecting this complex structure that has received r...

journal_title：Frontiers in neuroscience

authors： van der Meer MA,Kalenscher T,Lansink CS,Pennartz CM,Berke JD,Redish AD

更新日期：2010-09-15 00:00:00

abstract：:The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in ...

journal_title：Frontiers in neuroscience

authors： Fernández E,Rajan N,Bagni C

更新日期：2013-10-24 00:00:00

abstract：:Obesity is known to induce leptin and insulin resistance. Leptin is a peptide hormone synthesized in adipose tissue that mainly regulates food intake. It has been shown that insulin stimulates the production of leptin when adipocytes are exposed to glucose to encourage satiety; while leptin, via a negative feedback, d...

journal_title：Frontiers in neuroscience

authors： Lloret A,Monllor P,Esteve D,Cervera-Ferri A,Lloret MA

更新日期：2019-05-22 00:00:00

abstract：:Aromatase cytochrome P450arom (cyp19) is the only enzyme that has the ability to convert androgens into estrogens. Estrogens, which are produced locally in the vertebrate brain play many fundamental roles in neuroendocrine functions, reproductive functions, socio-sexual behaviors, and neurogenesis. Radial glial cells ...

journal_title：Frontiers in neuroscience

authors： Xing L,Esau C,Trudeau VL

更新日期：2016-01-12 00:00:00

abstract：:Mutations in leucine-rich repeat kinase 2 (LRRK2) instigate an autosomal dominant form of Parkinson's disease (PD). Despite the neuropathological heterogeneity observed in LRRK2-PD, accumulating evidence suggests that alpha-synuclein and tau pathology are observed in a vast majority of cases. Intriguingly, the presenc...

journal_title：Frontiers in neuroscience

authors： Dues DJ,Moore DJ

更新日期：2020-07-08 00:00:00

abstract：:Individuals differ widely in how steeply they discount future rewards. The sources of these stable individual differences in delay discounting (DD) are largely unknown. One candidate is the COMT Val158Met polymorphism, known to modulate prefrontal dopamine levels and affect DD. To identify possible neural mechanisms b...

journal_title：Frontiers in neuroscience

authors： Gianotti LR,Figner B,Ebstein RP,Knoch D

更新日期：2012-05-07 00:00:00

abstract：:Modern high field and ultra high field magnetic resonance imaging (MRI) experiments routinely collect multi-dimensional data with high spatial resolution, whether multi-parametric structural, diffusion or functional MRI. While diffusion and functional imaging have benefited from recent advances in multi-dimensional si...

journal_title：Frontiers in neuroscience

authors： Bazin PL,Alkemade A,van der Zwaag W,Caan M,Mulder M,Forstmann BU

更新日期：2019-10-09 00:00:00

abstract：:Achromatopsia type 2 (ACHM2) is a severe, inherited eye disease caused by mutations in the CNGA3 gene encoding the α subunit of the cone photoreceptor cyclic nucleotide-gated (CNG) channel. Patients suffer from strongly impaired daylight vision, photophobia, nystagmus, and lack of color discrimination. We have previou...

journal_title：Frontiers in neuroscience

authors： Mühlfriedel R,Tanimoto N,Schön C,Sothilingam V,Garcia Garrido M,Beck SC,Huber G,Biel M,Seeliger MW,Michalakis S

更新日期：2017-05-24 00:00:00

abstract：:Animal functional magnetic resonance imaging (fMRI) has provided key insights into the physiological mechanisms underlying healthy and diseased brain states. In non-human primates, resting-state fMRI studies are commonly conducted under isoflurane anesthesia, where anesthetic concentration is used to roughly infer ane...

journal_title：Frontiers in neuroscience

authors： Zhang Z,Cai DC,Wang Z,Zeljic K,Wang Z,Wang Y

更新日期：2019-04-11 00:00:00

abstract：:Concerns regarding a drought in psychopharmacology have risen from many quarters. From one perspective, the wellspring of bedrock medications for anxiety disorders, depression, and schizophrenia was serendipitously discovered over 30 year ago, the swell of pharmaceutical investment in drug discovery has receded, and t...

journal_title：Frontiers in neuroscience

authors： Macdonald K,Feifel D

更新日期：2013-03-15 00:00:00

abstract：:Accuracy in auditory distance perception can improve with practice and varies for sounds differing in familiarity. Here, listeners were trained to judge the distances of English, Bengali, and backwards speech sources pre-recorded at near (2-m) and far (30-m) distances. Listeners' accuracy was tested before and after t...

journal_title：Frontiers in neuroscience

authors： Wisniewski MG,Mercado E 3rd,Church BA,Gramann K,Makeig S

更新日期：2014-12-09 00:00:00

abstract：:Twenty years ago, the first report on the sound-induced double flash illusion, a visual illusion induced by sound, was published. In this paradigm, participants are presented with different numbers of auditory and visual stimuli. In case of an incongruent number of auditory and visual stimuli, the influence of auditor...

journal_title：Frontiers in neuroscience

authors： Keil J

更新日期：2020-04-03 00:00:00

abstract：:The menstrual cycle has attracted research interest ever since the 1930s. For many researchers the menstrual cycle is an excellent model of ovarian steroid influence on emotion, behavior, and cognition. Over the past years methodological improvements in menstrual cycle studies have been noted, and this review summariz...

journal_title：Frontiers in neuroscience

authors： Sundström Poromaa I,Gingnell M

更新日期：2014-11-24 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) is a powerful noninvasive tool for studying spontaneous resting state functional connectivity (RSFC) in laboratory animals. Brain function can be significantly affected by generally used anesthetics, however, rendering the need for awake imaging. Only a few different awake ...

journal_title：Frontiers in neuroscience

authors： Stenroos P,Paasonen J,Salo RA,Jokivarsi K,Shatillo A,Tanila H,Gröhn O

更新日期：2018-08-20 00:00:00

abstract：:A new paradigm in neuroscience has recently emerged - the brain-gut axis (BGA). The contemporary focus in this paradigm has been gut → brain ("bottom-up"), in which the gut-microbiome, and its perturbations, affects one's psychological state-of-mind and behavior, and is pivotal in neurodegenerative disorders. The emer...

journal_title：Frontiers in neuroscience

authors： Isaiah S,Loots DT,Solomons R,van der Kuip M,Tutu Van Furth AM,Mason S

更新日期：2020-04-21 00:00:00

abstract：:The present study interrogated a quantitative trait locus (QTL) on Chr 4 associated with the population sizes of two types of bipolar cell in the mouse retina. This locus was identified by quantifying the number of rod bipolar cells and Type 2 cone bipolar cells across a panel of recombinant inbred (RI) strains of mic...

journal_title：Frontiers in neuroscience

authors： Kautzman AG,Keeley PW,Ackley CR,Leong S,Whitney IE,Reese BE

更新日期：2018-12-03 00:00:00

abstract：:The neural generators of the frequency-following response (FFR), a neural response widely used to study the human auditory system, remain unclear. There is evidence that the balance between cortical and subcortical contributions to the FFR varies with stimulus frequency. In this study, we tried to clarify whether this...

journal_title：Frontiers in neuroscience

authors： Zhang X,Gong Q

更新日期：2019-02-26 00:00:00

abstract：:D-norpseudoephedrine (NPE), also known as cathine, is found naturally in the shrub Catha edulis "Khat." NPE has been widely used as an appetite suppressant for the treatment of obesity. Although it is known that NPE acts on α1-adrenergic receptors, there is little information about the role of dopamine receptors on NP...

journal_title：Frontiers in neuroscience

authors： Kalyanasundar B,Perez CI,Arroyo B,Moreno MG,Gutierrez R

更新日期：2020-10-16 00:00:00

abstract：Background:Cochlear implants (CIs), which have been designed primarily to support spoken communication of persons with severe to profound hearing loss, are highly effective in supporting speech perception in quiet listening conditions. CI users as a group achieve significantly poorer perception and appraisal of music, ...

journal_title：Frontiers in neuroscience

authors： Gfeller K,Driscoll V,Schwalje A

更新日期：2019-11-21 00:00:00