Mechanisms Linking Olfactory Impairment and Risk of Mortality.

abstract：:Glutamate-induced excitotoxicity is common in the pathogenesis of many neurological diseases. A pulsed electromagnetic field (PEMF) exerts therapeutic effects on the nervous system, but its specific mechanism associated with excitotoxicity is still unknown. We investigated the role of PEMF exposure in regulating gluta...

journal_title：Frontiers in neuroscience

authors： Li X,Xu H,Lei T,Yang Y,Jing D,Dai S,Luo P,Xu Q

更新日期：2017-02-06 00:00:00

abstract：:The effects of transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex functions, such as working memory (WM), have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral pr...

journal_title：Frontiers in neuroscience

authors： Lukasik KM,Lehtonen M,Salmi J,Meinzer M,Joutsa J,Laine M

更新日期：2018-01-10 00:00:00

abstract：:A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual m...

journal_title：Frontiers in neuroscience

authors： Svob Strac D,Pivac N,Smolders IJ,Fogel WA,De Deurwaerdere P,Di Giovanni G

更新日期：2016-11-10 00:00:00

abstract：:Women with epilepsy commonly have premature onset of menopause. The decrease in estrogen levels is associated with increased occurrence of neurodegenerative processes and cognitive decline. Previously, we found that estradiol (E2) replacement in ovariectomized (OVX) female rats significantly reduced the seizure-relate...

journal_title：Frontiers in neuroscience

authors： Iacobas DA,Iacobas S,Nebieridze N,Velíšek L,Velíšková J

更新日期：2018-06-20 00:00:00

abstract：:Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (HDC, SLITRK1, BTBD9, and SLC6A4) in an effort to identify possibly causal variants using a targeted re-...

journal_title：Frontiers in neuroscience

authors： Alexander J,Potamianou H,Xing J,Deng L,Karagiannidis I,Tsetsos F,Drineas P,Tarnok Z,Rizzo R,Wolanczyk T,Farkas L,Nagy P,Szymanska U,Androutsos C,Tsironi V,Koumoula A,Barta C,TSGeneSEE.,Sandor P,Barr CL,Tischfield

更新日期：2016-09-21 00:00:00

abstract：:The human cerebellum has recently been discovered to contribute to cognition and emotion beyond the planning and execution of movement, suggesting its functional heterogeneity. We aimed to identify the functional parcellation of the cerebellum using information from resting-state functional magnetic resonance imaging ...

journal_title：Frontiers in neuroscience

authors： Wang C,Kipping J,Bao C,Ji H,Qiu A

更新日期：2016-05-02 00:00:00

abstract：:The structure of gene coexpression networks reflects the activation and interaction of multiple cellular systems. Since the pathology of neuropsychiatric disorders is influenced by diverse cellular systems and pathways, we investigated gene coexpression networks in major depression, and searched for putative unifying ...

journal_title：Frontiers in neuroscience

authors： Gaiteri C,Sibille E

更新日期：2011-08-30 00:00:00

abstract：:How speech signals are analyzed and represented remains a foundational challenge both for cognitive science and neuroscience. A growing body of research, employing various behavioral and neurobiological experimental techniques, now points to the perceptual relevance of both phoneme-sized (10-40 Hz modulation frequency...

journal_title：Frontiers in neuroscience

authors： Chait M,Greenberg S,Arai T,Simon JZ,Poeppel D

更新日期：2015-06-16 00:00:00

abstract：:Introduction: Spasticity is a typical motor disorder in patients affected by stroke. Typically post-stroke rehabilitation consists of repetition of mobilization exercises on impaired limbs, aimed to reduce muscle hypertonia and mitigate spastic reflexes. It is currently strongly debated if the treatment's effectivenes...

journal_title：Frontiers in neuroscience

authors： Crea S,Cempini M,Mazzoleni S,Carrozza MC,Posteraro F,Vitiello N

更新日期：2017-05-12 00:00:00

abstract：:The analysis of spontaneous functional connectivity (sFC) reveals the statistical connections between regions of the brain consistent with underlying functional communication networks within the brain. In this work, we describe the implementation of a complete all-to-all network analysis of resting state neuronal acti...

journal_title：Frontiers in neuroscience

authors： Schmidt BT,Ghuman AS,Huppert TJ

更新日期：2014-06-11 00:00:00

abstract：:The molecular mechanism underlying Parkinson's disease (PD), an increasingly common neurodegenerative disease, remains unclear. Long non-coding RNA (lncRNA) plays essential roles in gene expression and human diseases. We hypothesize that lncRNAs are involved in neuronal degeneration of PD. Using microarray, we identif...

journal_title：Frontiers in neuroscience

authors： Fan Y,Li J,Yang Q,Gong C,Gao H,Mao Z,Yuan X,Zhu S,Xue Z

更新日期：2019-12-13 00:00:00

abstract：:Emotional stimuli have been shown to modulate attentional orienting through signals sent by subcortical brain regions that modulate visual perception at early stages of processing. Fewer studies, however, have investigated a similar effect of emotional stimuli on attentional orienting in the auditory domain together w...

journal_title：Frontiers in neuroscience

authors： Ceravolo L,Frühholz S,Grandjean D

更新日期：2016-05-12 00:00:00

abstract：:Many complex brain disorders, such as autism spectrum disorders, exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek to understand individual differences in brain network structure in terms of covariates that measur...

journal_title：Frontiers in neuroscience

authors： Narayan M,Allen GI

更新日期：2016-04-12 00:00:00

abstract：:The blood-brain barrier (BBB) mediates the communication between the periphery and the central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play a role in neurodegenerative disease. This has stimulated a wealth of information on the molecular impact of insulin in the brain, particularl...

journal_title：Frontiers in neuroscience

authors： Rhea EM,Banks WA

更新日期：2019-06-04 00:00:00

abstract：:It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in mice. The leptin receptors in the hypothalamus are the main target for the homeostat...

journal_title：Frontiers in neuroscience

authors： Fujita Y,Yamashita T

更新日期：2019-08-07 00:00:00

abstract：:Brain functional connectivity network (BFCN) analysis has been widely used in the diagnosis of mental disorders, such as schizophrenia. In BFCN methods, brain network construction is one of the core tasks due to its great influence on the diagnosis result. Most of the existing BFCN construction methods only consider t...

journal_title：Frontiers in neuroscience

authors： Zhu Q,Li H,Huang J,Xu X,Guan D,Zhang D

更新日期：2019-06-14 00:00:00

abstract：:Features and functions of long-range GABAergic projection neurons in the developing cerebral cortex have been reported previously, although until now their significance in the adult cerebral cortex has remained uncertain. The septo-hippocampal circuit is one exception - in this system, long-range mature GABAergic proj...

journal_title：Frontiers in neuroscience

authors： Tamamaki N,Tomioka R

更新日期：2010-12-08 00:00:00

abstract：:Lactate is a versatile metabolite with important roles in modulation of brain glucose utilization rate (CMRglc), diagnosis of brain-injured patients, redox- and receptor-mediated signaling, memory, and alteration of gene transcription. Neurons and astrocytes release and accumulate lactate using equilibrative monocarbo...

journal_title：Frontiers in neuroscience

authors： Hertz L,Gibbs ME,Dienel GA

更新日期：2014-09-09 00:00:00

abstract：:Purinergic signaling is critically involved in neuroinflammation associated with multiple sclerosis (MS) and its major inflammatory animal model, experimental autoimmune encephalomyelitis (EAE). Herein, we explored the expression of ectonucleoside triphosphate diphosphohydrolase1 (NTPDase1/CD39) in the spinal cord, at...

journal_title：Frontiers in neuroscience

authors： Jakovljevic M,Lavrnja I,Bozic I,Milosevic A,Bjelobaba I,Savic D,Sévigny J,Pekovic S,Nedeljkovic N,Laketa D

更新日期：2019-04-26 00:00:00

abstract：:Previous research has provided qualitative evidence for overlap in a number of brain regions across the subjective value network (SVN) and the default mode network (DMN). In order to quantitatively assess this overlap, we conducted a series of coordinate-based meta-analyses (CBMA) of results from 466 functional magnet...

journal_title：Frontiers in neuroscience

authors： Acikalin MY,Gorgolewski KJ,Poldrack RA

更新日期：2017-01-19 00:00:00

abstract：:Rodent models have opened the door to a better understanding of the neurobiology of brain disorders and increased our ability to evaluate novel treatments. Resting-state functional magnetic resonance imaging (rs-fMRI) allows for in vivo exploration of large-scale brain networks with high spatial resolution. Its applic...

journal_title：Frontiers in neuroscience

authors： Bajic D,Craig MM,Mongerson CRL,Borsook D,Becerra L

更新日期：2017-12-12 00:00:00

abstract：:There is a need for reliable and objective measures of early and mild symptomology in multiple sclerosis (MS), as deficits can be subtle and difficult to quantify objectively in patients without overt physical deficits. We hypothesized that a speech-in-noise (SiN) task would be sensitive to demyelinating effects on pr...

journal_title：Frontiers in neuroscience

authors： Iva P,Fielding J,Clough M,White O,Godic B,Martin R,Rajan R

更新日期：2020-12-23 00:00:00

abstract：:Recent intriguing evidence suggests that metabolites of amyloid precursor protein (APP), mutated in familial forms of Alzheimer's disease (AD), play critical roles in developmental and postnatal neurogenesis. Of note is soluble APPα (sAPPα) that regulates neural progenitor cell proliferation. The APP family encompasse...

journal_title：Frontiers in neuroscience

authors： Lazarov O,Demars MP

更新日期：2012-06-04 00:00:00

abstract：:Human and animal studies suggest an intriguing link between mitochondrial diseases and depression. Although depression has historically been linked to alterations in monoaminergic pharmacology and adult hippocampal neurogenesis, new data increasingly implicate broader forms of dampened plasticity, including plasticity...

journal_title：Frontiers in neuroscience

authors： Allen J,Romay-Tallon R,Brymer KJ,Caruncho HJ,Kalynchuk LE

更新日期：2018-06-06 00:00:00

abstract：:Blood-oxygen-level dependent (BOLD) signals are widely used in functional magnetic resonance imaging (fMRI) as a proxy measure of brain activation. However, because these signals are blood-related, they are also influenced by other physiological processes. This is especially true in resting state fMRI, during which no...

journal_title：Frontiers in neuroscience

authors： Tong Y,Hocke LM,Lindsey KP,Erdoğan SB,Vitaliano G,Caine CE,Frederick Bd

更新日期：2016-06-30 00:00:00

abstract：:Hypothalamic neurohormones are released in a pulsatile manner. The mechanisms of this pulsatility remain poorly understood and several hypotheses are available, depending upon the neuroendocrine system considered. Among these systems, hypothalamo-neurohypophyseal magnocellular neurons have been early-considered models...

journal_title：Frontiers in neuroscience

authors： Israel JM,Oliet SH,Ciofi P

更新日期：2016-03-31 00:00:00

abstract：:There is increasing interest in understanding how the phase and amplitude of distinct neural oscillations might interact to support dynamic communication within the brain. In particular, previous work has demonstrated a coupling between the phase of low frequency oscillations and the amplitude (or power) of high frequ...

journal_title：Frontiers in neuroscience

authors： Seymour RA,Rippon G,Kessler K

更新日期：2017-09-01 00:00:00

abstract：:The menstrual cycle has attracted research interest ever since the 1930s. For many researchers the menstrual cycle is an excellent model of ovarian steroid influence on emotion, behavior, and cognition. Over the past years methodological improvements in menstrual cycle studies have been noted, and this review summariz...

journal_title：Frontiers in neuroscience

authors： Sundström Poromaa I,Gingnell M

更新日期：2014-11-24 00:00:00

abstract：:Ischemic stroke places an increasing burden on individuals, families, and societies around the world. However, effective therapies or drugs for ischemic stroke are lacking. Therefore, animal models mimicking ischemic stroke in humans are of great value for preclinical experiments. middle cerebral artery occlusion (MCA...

journal_title：Frontiers in neuroscience

authors： Shi XF,Ai H,Lu W,Cai F

更新日期：2019-02-12 00:00:00

abstract：:Although the major causative factors of Alzheimer's disease (AD) are the accumulation of amyloid β and hyperphosphorylated tau, AD can also be caused by metabolic dysfunction. The major clinical symptom of AD is cognitive dysfunction. However, AD is also accompanied by various secondary symptoms such as depression, sl...

journal_title：Frontiers in neuroscience

authors： Kim S,Nam Y,Shin SJ,Park YH,Jeon SG,Kim JI,Kim MJ,Moon M

更新日期：2020-09-24 00:00:00