Abstract:
:Subplate cells are among the first generated neurons in the mammalian cerebral cortex and have been implicated in the establishment of cortical wiring. In rodents some subplate neurons persist into adulthood. Here we would like to highlight several converging findings which suggest a novel secretory function of subplate neurons during cortical development. Throughout the postnatal period in rodents, subplate neurons have highly developed rough endoplasmic reticulum (ER) and are under an ER stress condition. By comparing gene expression between subplate and layer 6, we found that several genes encoding secreted proteins are highly expressed in subplate neurons. One of these secreted proteins, neuroserpin, encoded by the serpini1 gene, is localized to the ER in subplate cells. We propose that subplate might influence cortical circuit formation through a transient secretory function.
journal_name
Front Neuroscijournal_title
Frontiers in neuroscienceauthors
Kondo S,Al-Hasani H,Hoerder-Suabedissen A,Wang WZ,Molnár Zdoi
10.3389/fnins.2015.00100subject
Has Abstractpub_date
2015-03-26 00:00:00pages
100eissn
1662-4548issn
1662-453Xjournal_volume
9pub_type
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