Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.

abstract：:The grand challenge to physiology, as was first described in an essay published in the inaugural issue of Frontiers in Physiology in 2010, remains to integrate function from molecules to intact organisms. In order to make sense of the vast volume of information derived from, and increasingly dependent upon, reductioni...

journal_title：Frontiers in physiology

authors： Billman GE

更新日期：2020-03-10 00:00:00

abstract：:Dendrolimus punctatus Walker is a serious pest affecting conifers in southern China. As extensive pesticide spraying is currently required to control D. punctatus, new control strategies are urgently needed. Chemosensory genes represent potential molecular targets for development of alternative pest control strategies...

journal_title：Frontiers in physiology

authors： Zhang SF,Liu HH,Kong XB,Wang HB,Liu F,Zhang Z

更新日期：2017-07-07 00:00:00

abstract：:The extensive literature dealing with the Golgi system emphasizes its role in protein secretion and modification, usually without specifying from which evolutionary ancient cell physiological necessity such secretion originated. Neither does it specify which functional requirements the secreted proteins must meet. Fro...

journal_title：Frontiers in physiology

authors： De Loof A,Schoofs L

更新日期：2020-10-15 00:00:00

abstract：:Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in all cells by a highly regulated pathway that involves a mitochondrial multiprotein complex. Defects in either the structural and/or regulatory...

journal_title：Frontiers in physiology

authors： Hernández-Camacho JD,Bernier M,López-Lluch G,Navas P

更新日期：2018-02-05 00:00:00

abstract：:Heat shock proteins are molecular chaperones that are involved in numerous normal cellular processes and stress responses, and heat shock factors are transcriptional activators of heat shock proteins. Heat shock factors and heat shock proteins are coordinated in various biological processes. The regulatory function of...

journal_title：Frontiers in physiology

authors： Jin J,Li Y,Zhou Z,Zhang H,Guo J,Wan F

更新日期：2020-09-15 00:00:00

abstract：:Consumption of acidic foods and drinks and other factors that cause enamel wear are responsible for the daily enamel loss and degradation. Use of some toothpastes that have been showed to possess different properties of remineralisation and/or repair of the enamel surface may help to protect tooth enamel. The aim of t...

journal_title：Frontiers in physiology

authors： Lelli M,Putignano A,Marchetti M,Foltran I,Mangani F,Procaccini M,Roveri N,Orsini G

更新日期：2014-09-05 00:00:00

abstract：:Ontologies and standards are very important parts of today's bioscience research. With the rapid increase of biological knowledge, they provide mechanisms to better store and represent data in a controlled and structured way, so that scientists can share the data, and utilize a wide variety of software and tools to ma...

journal_title：Frontiers in physiology

authors： Mi H,Thomas PD

更新日期：2011-02-21 00:00:00

abstract：:This paper introduces the use of low frequencies forced oscillation technique (FOT) in the presence of breathing signal. The hypothesis tested is to evaluate the sensitivity of FOT to various degrees of obstruction in COPD patients. The measurements were performed in the frequency range 0-2 Hz. The use of FOT to evalu...

journal_title：Frontiers in physiology

authors： Ghita M,Copot D,Ghita M,Derom E,Ionescu C

更新日期：2019-11-19 00:00:00

abstract：:Chitosan is a cheap resource, which is widely used in biomedical applications due to its biocompatible and antibacterial properties. In this study, composite nanofibrous membranes of chitosan (CS) and poly(vinyl alcohol) (PVA) loaded with antibiotics at different ratios were successfully fabricated by electrospinning....

journal_title：Frontiers in physiology

authors： Wang M,Roy AK,Webster TJ

更新日期：2017-01-11 00:00:00

abstract：:One of the central issues of the whole process of biogenesis is how to understand the progressive constitution of a large (in spatial and temporal terms) system that transcends the individual sphere of proto-metabolic organizations and includes collective networks, both synchronous (i.e., proto-ecosystem webs) and asy...

journal_title：Frontiers in physiology

authors： Moreno A

更新日期：2019-09-24 00:00:00

abstract：:Previous research has quantified the peak movement demands of elite rugby league match-play, but the peak accelerometer load or the semi-professional peak demands remain unknown. The aim of this research was to determine the peak movement demands of professional and semi-professional rugby league competition. Wearable...

journal_title：Frontiers in physiology

authors： Johnston RD,Devlin P,Wade JA,Duthie GM

更新日期：2019-10-14 00:00:00

abstract：Background:Nav1.5 cardiac Na+ channel mutations can cause arrhythmogenic syndromes. Some of these mutations exert a dominant negative effect on wild-type channels. Recent studies showed that Na+ channels can dimerize, allowing coupled gating. This leads to the hypothesis that allosteric interactions between Na+ channel...

journal_title：Frontiers in physiology

authors： Hichri E,Selimi Z,Kucera JP

更新日期：2020-11-05 00:00:00

abstract：:An increase in calorie consumption is associated with the recent rise in obesity prevalence. However, our current understanding of the effects of nutrient excess on major metabolic pathways appears insufficient to develop safe and effective metabolic interventions to prevent obesity. Hence, we sought to identify syste...

journal_title：Frontiers in physiology

authors： Sansbury BE,Bhatnagar A,Hill BG

更新日期：2014-11-25 00:00:00

abstract：:High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM). Adult male Munic...

journal_title：Frontiers in physiology

authors： Foresto-Neto O,Albino AH,Arias SCA,Faustino VD,Zambom FFF,Cenedeze MA,Elias RM,Malheiros DMAC,Camara NOS,Fujihara CK,Zatz R

更新日期：2020-02-11 00:00:00

abstract：:The microbes in the gastrointestinal tract are separated from the host by a single layer of intestinal epithelial cells (IECs) that plays pivotal roles in maintaining homeostasis by absorbing nutrients and providing a physical and immunological barrier to potential pathogens. Preservation of homeostasis requires the c...

journal_title：Frontiers in physiology

authors： Burgueño JF,Fritsch J,Santander AM,Brito N,Fernández I,Pignac-Kobinger J,Conner GE,Abreu MT

更新日期：2019-12-12 00:00:00

abstract：:Glutaraldehyde is a well-known substance used in biomedical research to fix cells. Since hemolytic anemias are often associated with red blood cell shape changes deviating from the biconcave disk shape, conservation of these shapes for imaging in general and 3D-imaging in particular, like confocal microscopy, scanning...

journal_title：Frontiers in physiology

authors： Abay A,Simionato G,Chachanidze R,Bogdanova A,Hertz L,Bianchi P,van den Akker E,von Lindern M,Leonetti M,Minetti G,Wagner C,Kaestner L

更新日期：2019-05-14 00:00:00

abstract：:Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida). In addition, the mites are carriers of microorganisms and microbial adjuvant compounds that stimulate innate signaling pathways. We s...

journal_title：Frontiers in physiology

authors： Erban T,Rybanska D,Harant K,Hortova B,Hubert J

更新日期：2016-02-24 00:00:00

abstract：:Blidingia sp. is a green alga that has spread rapidly in Subei Shoal, China. To explore the potential beneficial effects of Blidingia sp., we investigated the anti-inflammatory activity of its water-methanol extract of Blidingia sp. in a mouse model of lipopolysaccharide (LPS)-induced intestinal inflammation. The resu...

journal_title：Frontiers in physiology

authors： Song W,Li Y,Zhang X,Wang Z

更新日期：2019-06-25 00:00:00

abstract：:Periventricular-intraventricular hemorrhages (PIVH) and (diffuse) white matter injury (WMI) are the most important acquired brain lesions of the very and extremely prematurely born neonate. Both carry a high risk for death or adverse neurodevelopmental outcome. The first part of the review discusses the standard of ca...

journal_title：Frontiers in physiology

authors： van Bel F,Vaes J,Groenendaal F

更新日期：2019-03-20 00:00:00

abstract：:Laodelphax striatellus is naturally infected with the Wolbachia strain wStri, which induces strong cytoplasmic incompatibility of its host. MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that play a critical role in the regulation of gene expression at post-transcriptional level in various biologic...

journal_title：Frontiers in physiology

authors： Liu L,Zhang KJ,Rong X,Li YY,Liu H

更新日期：2019-07-24 00:00:00

abstract：:Divers that are exposed to high pressure (HP) above 1.1 MPa suffer from High Pressure Neurological Syndrome (HPNS), which is implicated with central nervous system (CNS) malfunction. Marine mammals performing extended and deep breath-hold dives are exposed to almost 20 MPa without apparent HPNS symptoms. N-methyl-D-as...

journal_title：Frontiers in physiology

authors： Bliznyuk A,Golan H,Grossman Y

更新日期：2018-11-22 00:00:00

abstract：Background:The development of childhood motor competence demonstrates a high degree of inter-individual variation. Some children's competence levels increase whilst others' competence levels remain unchanged or even decrease over time. However, few studies have examined this developmental change in motor competence acr...

journal_title：Frontiers in physiology

authors： Coppens E,Bardid F,Deconinck FJA,Haerens L,Stodden D,D'Hondt E,Lenoir M

更新日期：2019-10-02 00:00:00

abstract：UNLABELLED:Since Matrix metalloproteinases (MMPs) have been suggested to contribute to dentin caries progression, the hypothesis that MMP inhibition would affect the progression of dentin caries is clinically relevant. Grape seed extracts (GSE) have been previously reported to be natural inhibitors of MMPs. OBJECTIVE:...

journal_title：Frontiers in physiology

authors： Khaddam M,Salmon B,Le Denmat D,Tjaderhane L,Menashi S,Chaussain C,Rochefort GY,Boukpessi T

更新日期：2014-10-31 00:00:00

abstract：:An early event in atherogenesis is the recruitment and infiltration of circulating monocytes and macrophage activation in the subendothelial space. Atherosclerosis subsequently progresses as a unresolved inflammatory disease, particularly in hypercholesterolemic conditions. Although physical exercise training has been...

journal_title：Frontiers in physiology

authors： Rentz T,Wanschel ACBA,de Carvalho Moi L,Lorza-Gil E,de Souza JC,Dos Santos RR,Oliveira HCF

更新日期：2020-11-23 00:00:00

abstract：:This study investigates human performance in a cyclic Fitts task at three different scales of observation, either in the presence (difficult condition) or in the absence (easy condition) of a speed-accuracy trade-off. At the fastest scale, the harmonicity of the back and forth movements, which reflects the dissipation...

journal_title：Frontiers in physiology

authors： Wijnants ML,Cox RF,Hasselman F,Bosman AM,Van Orden G

更新日期：2012-05-23 00:00:00

abstract：Background:Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant hypertension, SHR kidneys remain relatively free of pathology due to having an augmented myogenic constriction (MC). We h...

journal_title：Frontiers in physiology

authors： Nademi S,Lu C,Dickhout JG

更新日期：2020-07-22 00:00:00

abstract：:The paired cranial sensory organs and peripheral nervous system of vertebrates arise from a thin strip of cells immediately adjacent to the developing neural plate. The neural plate border region comprises progenitors for four key populations of cells: neural plate cells, neural crest cells, the cranial placodes, and ...

journal_title：Frontiers in physiology

authors： Thawani A,Groves AK

更新日期：2020-12-07 00:00:00

abstract：:Purpose: To provide insights into the energy requirements as well as the physiological adaptations of an experienced 50-year-old ultra-marathon male athlete during the world's most challenging mountain ultra-marathon (MUM). Methods: The international race supporting the study was the Tor des Geants®, characterized by ...

journal_title：Frontiers in physiology

authors： Savoldelli A,Fornasiero A,Trabucchi P,Limonta E,La Torre A,Degache F,Pellegrini B,Millet GP,Vernillo G,Schena F

更新日期：2017-12-05 00:00:00

abstract：:The vascular myogenic response is characterized by arterial constriction in response to an increase in intraluminal pressure and dilatation to a decrease in pressure. This mechanism is important for the regulation of blood flow, capillary pressure, and arterial pressure. The identity of the mechanosensory mechanism(s)...

journal_title：Frontiers in physiology

authors： Jackson TY,Sun Z,Martinez-Lemus LA,Hill MA,Meininger GA

更新日期：2010-12-29 00:00:00

abstract：:Aging is associated with a decline in cardiac function due to a decreased myocardial reserve. This adverse cardiac remodeling comprises of a variety of changes, including a reduction in mitochondrial function and a decline in the expression of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a...

journal_title：Frontiers in physiology

authors： Whitehead N,Gill JF,Brink M,Handschin C

更新日期：2018-03-21 00:00:00