Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart.

abstract：:Molecular chaperones are stress proteins that allow the correct folding or unfolding as well as the assembly or disassembly of macromolecular cellular components. Changes in expression and post-translational modifications of chaperones have been linked to a number of age- and stress-related diseases including cancer, ...

journal_title：Frontiers in physiology

authors： Penna C,Sorge M,Femminò S,Pagliaro P,Brancaccio M

更新日期：2018-03-16 00:00:00

abstract：:An increase in calorie consumption is associated with the recent rise in obesity prevalence. However, our current understanding of the effects of nutrient excess on major metabolic pathways appears insufficient to develop safe and effective metabolic interventions to prevent obesity. Hence, we sought to identify syste...

journal_title：Frontiers in physiology

authors： Sansbury BE,Bhatnagar A,Hill BG

更新日期：2014-11-25 00:00:00

abstract：:Cell function and survival are controlled by intracellular signals, and modulated by surrounding cells and the extracellular environment. Connexin channels participate in these processes by mediating cell-to-cell communication. In bone cells, gap junction channels were detected in the early 1970s, and are present amon...

journal_title：Frontiers in physiology

authors： Plotkin LI

更新日期：2014-04-04 00:00:00

abstract：:Hepatocellular carcinomas (HCCs) have different etiology and heterogenic genomic alterations lead to high complexity. The molecular features of HCC have largely been studied by gene expression and proteome profiling focusing on the correlations between the expression of specific markers and clinical data. Integration ...

journal_title：Frontiers in physiology

authors： D'Alessandro LA,Meyer R,Klingmüller U

更新日期：2013-02-25 00:00:00

abstract：:Sarcopenia is defined as the progressive loss of muscle mass with age, and poses a serious threat to the physiological and psychological health of the elderly population with consequential economic and social burdens. Chronic low-grade inflammation plays a central role in the development of sarcopenia such that it alt...

journal_title：Frontiers in physiology

authors： Xia Z,Cholewa J,Zhao Y,Shang HY,Yang YQ,Araújo Pessôa K,Su QS,Lima-Soares F,Zanchi NE

更新日期：2017-06-22 00:00:00

abstract：:The integrated pest management (IPM) strategy was developed and used in combination with pesticides and beneficial biological control agents. To further develop IPM efficiency, it is important to evaluate the side effects of pesticides on biological control agents. Aphidius gifuensis is one of the most important aphid...

journal_title：Frontiers in physiology

authors： Kang ZW,Liu FH,Pang RP,Tian HG,Liu TX

更新日期：2018-12-11 00:00:00

abstract：:Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were develope...

journal_title：Frontiers in physiology

authors： de Souza ILL,Barros BC,de Oliveira GA,Queiroga FR,Toscano LT,Silva AS,Silva PM,Interaminense LFL,Cavalcante FA,da Silva BA

更新日期：2017-10-04 00:00:00

abstract：:Ontologies and standards are very important parts of today's bioscience research. With the rapid increase of biological knowledge, they provide mechanisms to better store and represent data in a controlled and structured way, so that scientists can share the data, and utilize a wide variety of software and tools to ma...

journal_title：Frontiers in physiology

authors： Mi H,Thomas PD

更新日期：2011-02-21 00:00:00

abstract：:Secondary shifts develop in post-translational phosphorylation of sarcomeric proteins in multiple animal models of inherited cardiomyopathy. These signaling alterations together with the primary mutation are predicted to contribute to the overall cardiac phenotype. As a result, identification and integration of post-t...

journal_title：Frontiers in physiology

authors： Westfall MV

更新日期：2016-09-14 00:00:00

abstract：:Nowadays, the common octopus (Octopus vulgaris) culture is hampered by massive mortalities occurring during early life-cycle stages (paralarvae). Despite the causes of the high paralarvae mortality are not yet well-defined and understood, the nutritional stress caused by inadequate diets is pointed out as one of the m...

journal_title：Frontiers in physiology

authors： Varó I,Cardenete G,Hontoria F,Monroig Ó,Iglesias J,Otero JJ,Almansa E,Navarro JC

更新日期：2017-05-17 00:00:00

abstract：:Introduction: Endothelial progenitor cells (EPCs) display a unique ability to promote angiogenesis and restore endothelial function in injured blood vessels. NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H2O2) serves as a signaling molecule and promotes endothelial cell proliferation and migration as well as prote...

journal_title：Frontiers in physiology

authors： Hakami NY,Ranjan AK,Hardikar AA,Dusting GJ,Peshavariya HM

更新日期：2017-03-23 00:00:00

abstract：:Neural crest (NC) cells are multipotent embryonic cells that form melanocytes, craniofacial bone and cartilage, and the peripheral nervous system in vertebrates. NC cells express many cadherin proteins, which control their specification, epithelial to mesenchymal transition (EMT), migration, and mesenchymal to epithel...

journal_title：Frontiers in physiology

authors： Manohar S,Camacho-Magallanes A,Echeverria C Jr,Rogers CD

更新日期：2020-10-30 00:00:00

abstract：:High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM). Adult male Munic...

journal_title：Frontiers in physiology

authors： Foresto-Neto O,Albino AH,Arias SCA,Faustino VD,Zambom FFF,Cenedeze MA,Elias RM,Malheiros DMAC,Camara NOS,Fujihara CK,Zatz R

更新日期：2020-02-11 00:00:00

abstract：:The need for radiotherapy personalization is now widely recognized, however, it would require considerations not only on the probability of control and survival of the tumor, but also on the possible toxic effects, on the quality of the expected life and the economic efficiency of the treatment. In this paper, we prop...

journal_title：Frontiers in physiology

authors： Belfatto A,Jereczek-Fossa BA,Baroni G,Cerveri P

更新日期：2018-10-15 00:00:00

abstract：:Progressive aging induces several structural and functional alterations in the cardiovascular system, among whom particularly important are a reduced number of myocardial cells and increased interstitial collagen fibers, which result in impaired left ventricular diastolic function. Even in the absence of cardiovascula...

journal_title：Frontiers in physiology

authors： Vigorito C,Giallauria F

更新日期：2014-02-20 00:00:00

abstract：:Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review some of the characteri...

journal_title：Frontiers in physiology

authors： Kumar RK,Foster PS

更新日期：2012-07-31 00:00:00

abstract：:The earliest humans relied on large quantities of metabolic energy from the oxidation of fatty acids to develop larger brains and bodies, prevent and reduce disease risk, extend longevity, in addition to other benefits. This was enabled through the consumption of a high fat and low-carbohydrate diet (LCD). Increased f...

journal_title：Frontiers in physiology

authors： Maffetone P,Laursen PB

更新日期：2020-04-02 00:00:00

abstract：:Many animals use a diverse repertoire of complex acoustic signals to convey different types of information to other animals. The information in each vocalization therefore must be coded by neurons in the auditory system. One way in which the auditory system may discriminate among different vocalizations is by having h...

journal_title：Frontiers in physiology

authors： Dimitrov AG,Cummins GI,Mayko ZM,Portfors CV

更新日期：2014-04-16 00:00:00

abstract：:In the last three decades, all efforts in bone tissue engineering were driven by the dogma that the ideal pore size in bone substitutes lies between 0.3 and 0.5 mm in diameter. Newly developed additive manufacturing methodologies for ceramics facilitate the total control over pore size, pore distribution, bottleneck s...

journal_title：Frontiers in physiology

authors： Ghayor C,Weber FE

更新日期：2018-07-19 00:00:00

abstract：:Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosph...

journal_title：Frontiers in physiology

authors： Liu M,Galli G,Wang Y,Fan Q,Wang Z,Wang X,Xiao W

更新日期：2020-07-15 00:00:00

abstract：:Mitochondrial redox imbalance has been implicated in mechanisms of aging, various degenerative diseases and drug-induced toxicity. Statins are safe and well-tolerated therapeutic drugs that occasionally induce myotoxicity such as myopathy and rhabdomyolysis. Previous studies indicate that myotoxicity caused by statins...

journal_title：Frontiers in physiology

authors： La Guardia PG,Alberici LC,Ravagnani FG,Catharino RR,Vercesi AE

更新日期：2013-05-15 00:00:00

abstract：:It is assumed that a properly timed circadian clock enhances fitness, but only few studies have truly demonstrated this in animals. We raised each of the three classical Drosophila period mutants for >50 generations in the laboratory in competition with wildtype flies. The populations were either kept under a conventi...

journal_title：Frontiers in physiology

authors： Horn M,Mitesser O,Hovestadt T,Yoshii T,Rieger D,Helfrich-Förster C

更新日期：2019-11-01 00:00:00

abstract：:Hallucinations - compelling perceptions of stimuli that aren't really there - occur in many psychiatric and neurological disorders, and are triggered by certain drugs of abuse. Despite their clinical importance, the neuronal mechanisms giving rise to hallucinations are poorly understood, in large part due to the absen...

journal_title：Frontiers in physiology

authors： Lee AH,Brandon CL,Wang J,Frost WN

更新日期：2018-06-25 00:00:00

abstract：:The development of durable ventricular assist devices (VADs) has improved mortality rates and quality of life in patients with end stage heart failure. While the use of VADs has increased dramatically in recent years, there is limited experience with VAD implantation in patients with complex congenital heart disease (...

journal_title：Frontiers in physiology

authors： Villa CR,Morales DLS

更新日期：2017-05-09 00:00:00

abstract：:Prone position can reduce mortality in acute respiratory distress syndrome (ARDS), but several studies found variable effects on oxygenation and lung mechanics. It is unclear whether different positive end-expiratory pressure (PEEP) titration techniques modify the effect of prone position. We tested, in an animal mode...

journal_title：Frontiers in physiology

authors： Scaramuzzo G,Ball L,Pino F,Ricci L,Larsson A,Guérin C,Pelosi P,Perchiazzi G

更新日期：2020-03-12 00:00:00

abstract：:Preterm premature rupture of membranes is a leading cause of preterm births. Cytokine induced matrix metalloproteinase1 and interleukin 8 production from amnion mesenchymal cells may contribute to fetal membrane weakening and rupture. Progestins inhibit inflammation induced fetal membrane weakening but their effect on...

journal_title：Frontiers in physiology

authors： Marinello W,Feng L,Allen TK

更新日期：2020-07-24 00:00:00

abstract：:Previous research has quantified the peak movement demands of elite rugby league match-play, but the peak accelerometer load or the semi-professional peak demands remain unknown. The aim of this research was to determine the peak movement demands of professional and semi-professional rugby league competition. Wearable...

journal_title：Frontiers in physiology

authors： Johnston RD,Devlin P,Wade JA,Duthie GM

更新日期：2019-10-14 00:00:00

abstract：Background:Several mechanisms allow humans to resist the extreme conditions encountered during breath-hold diving. Available nitric oxide (NO) is one of the major contributors to such complex adaptations at depth and oxidative stress is one of the major collateral effects of diving. Due to technical difficulties, these...

journal_title：Frontiers in physiology

authors： Cialoni D,Brizzolari A,Samaja M,Bosco G,Paganini M,Pieri M,Lancellotti V,Marroni A

更新日期：2021-01-07 00:00:00

abstract：:Familial hypertrophic cardiomyopathy (HCM), due to point mutations in genes for sarcomere proteins such as myosin, occurs in 1/500 people and is the most common cause of sudden death in young individuals. Similar mutations in skeletal muscle, e.g., in the MYH7 gene for slow myosin found in both the cardiac ventricle a...

journal_title：Frontiers in physiology

authors： Månsson A

更新日期：2014-09-15 00:00:00

abstract：:Rapidly expanding aging populations and a concomitant increase in the prevalence of age-related diseases are global health problems today. Over the past three decades, a large body of work has led to the identification of genes and regulatory networks that affect longevity and health span, often benefiting from the tr...

journal_title：Frontiers in physiology

authors： Hou NS,Taubert S

更新日期：2012-05-18 00:00:00