Ontologies and standards in bioscience research: for machine or for human.

abstract：:Cephalopods are unrivaled in the natural world in their ability to alter their visual appearance. These mollusks have evolved a complex system of dermal units under neural, hormonal, and muscular control to produce an astonishing variety of body patterns. With parallels to the pixels on a television screen, cephalopod...

journal_title：Frontiers in physiology

authors： How MJ,Norman MD,Finn J,Chung WS,Marshall NJ

更新日期：2017-06-19 00:00:00

abstract：Rationale:Pulmonary hypertension (PH) is a rare but fatal disease characterized by elevated pulmonary pressures and vascular remodeling, leading to right ventricular failure and death. Recently, neuroinflammation has been suggested to be involved in the sympathetic activation in experimental PH. Whether PH is associate...

journal_title：Frontiers in physiology

authors： Vaillancourt M,Chia P,Medzikovic L,Cao N,Ruffenach G,Younessi D,Umar S

更新日期：2019-09-20 00:00:00

abstract：:Microbiopsies of human skeletal muscle are increasingly adopted by physiologists for a variety of experimental assays given the reduced invasiveness of this procedure compared to the classic Bergstrom percutaneous biopsy technique. However, a recent report demonstrated lower mitochondrial respiration in saponin-permea...

journal_title：Frontiers in physiology

authors： Hughes MC,Ramos SV,Turnbull PC,Nejatbakhsh A,Baechler BL,Tahmasebi H,Laham R,Gurd BJ,Quadrilatero J,Kane DA,Perry CG

更新日期：2015-12-18 00:00:00

abstract：:Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The development and use of immortalized cell lines, with a stable phenotype, is an important contribution to biological studies as it allows for the investigation of molecular activities without the cont...

journal_title：Frontiers in physiology

authors： Sarkar J,Simanian EJ,Tuggy SY,Bartlett JD,Snead ML,Sugiyama T,Paine ML

更新日期：2014-07-25 00:00:00

abstract：:This study investigates the complex interplay between the cardiac and respiratory systems in 268 healthy neonates born between 35 and 40 weeks of gestation. The aim is to provide a comprehensive description of the developing cardiorespiratory information transfer mechanisms as a function of gestational age (GA). This ...

journal_title：Frontiers in physiology

authors： Lucchini M,Pini N,Burtchen N,Signorini MG,Fifer WP

更新日期：2020-08-27 00:00:00

abstract：:The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications. The current study sought to investigate the antihypertensive effect of a newly synthesized pyrazole derivative ...

journal_title：Frontiers in physiology

authors： Trindade NR,Lopes PR,Naves LM,Fajemiroye JO,Alves PH,Amaral NO,Lião LM,Rebelo ACS,Castro CH,Braga VA,Menegatti R,Pedrino GR

更新日期：2018-08-07 00:00:00

abstract：:This study aims to investigate the embryo development potential of extending the culture of abnormally fertilized zygotes with no pronuclear (0PN), monopronuclear (1PN), and poor-quality day 3 embryos and to determine the associated clinical outcomes. This is a retrospective study performed between January 2014 and Ma...

journal_title：Frontiers in physiology

authors： Chen X,Shi S,Mao J,Zou L,Yu K

更新日期：2020-11-04 00:00:00

abstract：:Cardiac arrest is a prevalent condition with a poor prognosis, attributable in part to persistent myocardial dysfunction following resuscitation. The molecular basis of this dysfunction remains unclear. We induced cardiac arrest in a porcine model of acute sudden death and assessed the impact of ischemia and reperfusi...

journal_title：Frontiers in physiology

authors： Woodward M,Previs MJ,Mader TJ,Debold EP

更新日期：2015-07-16 00:00:00

abstract：:Astronauts exposed to microgravity face sensorimotor challenges affecting balance control when readapting to Earth's gravity upon return from spaceflight. Small amounts of electrical noise applied to the vestibular system have been shown to improve balance control during standing and walking under discordant sensory c...

journal_title：Frontiers in physiology

authors： Temple DR,De Dios YE,Layne CS,Bloomberg JJ,Mulavara AP

更新日期：2018-03-29 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2019.00621.]. ...

journal_title：Frontiers in physiology

authors： Russo R,Marra R,Andolfo I,De Rosa G,Rosato BE,Manna F,Gambale A,Raia M,Unal S,Barella S,Iolascon A

更新日期：2020-08-11 00:00:00

abstract：:Several clinical studies have investigated the potential benefits of endothelin receptor antagonism in chronic pathologies such as diabetic kidney disease. However, fluid retention and edema have been identified as major side effects of endothelin receptor antagonists. In the present study we hypothesized that avosent...

journal_title：Frontiers in physiology

authors： Baltatu OC,Iliescu R,Zaugg CE,Reckelhoff JF,Louie P,Schumacher C,Campos LA

更新日期：2012-04-18 00:00:00

abstract：:A coronary angiography-derived index of microvascular resistance (caIMR) is proposed for physiological assessment of microvasular diseases in coronary circulation. The aim of the study is to assess diagnostic performance of caIMR, using wire-derived index of microvascular resistance (IMR) as the reference standard. IM...

journal_title：Frontiers in physiology

authors： Ai H,Feng Y,Gong Y,Zheng B,Jin Q,Zhang HP,Sun F,Li J,Chen Y,Huo Y,Huo Y

更新日期：2020-12-16 00:00:00

abstract：:Realistic electrocardiogram (ECG) simulation with numerical models is important for research linking cellular and molecular physiology to clinically observable signals, and crucial for patient tailoring of numerical heart models. However, ECG simulation with a realistic torso model is computationally much harder than ...

journal_title：Frontiers in physiology

authors： Potse M

更新日期：2018-04-20 00:00:00

abstract：INTRODUCTION:Gases, such as nitric oxide (NO), carbon monoxide (CO), or hydrogen sulfide (H2S), termed gasotransmitters, play an increasingly important role in understanding of how electrical signaling of cells is modulated. H2S is well-known to act on various ion channels and receptors. In a previous study we reported...

journal_title：Frontiers in physiology

authors： Sitdikova GF,Fuchs R,Kainz V,Weiger TM,Hermann A

更新日期：2014-11-12 00:00:00

abstract：:Pancreatic cancer is one of the deadliest human malignancies and little progress has been achieved in its treatment over the past decades. Advances in our understanding of the biology of this disease provide new potential opportunities for treatment. Pancreatic cancer is preceded by precursor lesions, the most common ...

journal_title：Frontiers in physiology

authors： Collins MA,Pasca di Magliano M

更新日期：2014-01-21 00:00:00

abstract：:Glucose metabolism is a biologically important metabolic process. Glycogen synthase kinase (GSK-3) is a key enzyme located in the middle of the sugar metabolism pathway that can regulate the energy metabolism process in the body through insulin signaling. This paper mainly explores the regulatory effect of glycogen sy...

journal_title：Frontiers in physiology

authors： Ding YJ,Li GY,Xu CD,Wu Y,Zhou ZS,Wang SG,Li C

更新日期：2020-11-25 00:00:00

abstract：:Xinnao shutong (XNST) capsules have been clinically used in China to treat cerebrovascular diseases. Previous studies have demonstrated that XNST has significant neuroprotective effects against acute cerebral ischemic stroke. The present study investigated the effects and mechanisms of XNST treatment following chronic...

journal_title：Frontiers in physiology

authors： Wang L,Wang R,Chen Z,Zhao H,Luo Y

更新日期：2018-05-15 00:00:00

abstract：:Determining individual health status is of great importance for a better understanding of life history trade-offs between growth, reproduction, and maintenance. However, existing immunological methods are invasive and therefore not suitable for investigating health status in wild populations. Thus, there is an urgent ...

journal_title：Frontiers in physiology

authors： Behringer V,Stevens JM,Leendertz FH,Hohmann G,Deschner T

更新日期：2017-02-06 00:00:00

abstract：:Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosph...

journal_title：Frontiers in physiology

authors： Liu M,Galli G,Wang Y,Fan Q,Wang Z,Wang X,Xiao W

更新日期：2020-07-15 00:00:00

abstract：:The spinal cord demonstrates several forms of plasticity that resemble brain-dependent learning and memory. Among the most studied form of spinal plasticity is spinal memory for noxious (nociceptive) stimulation. Numerous papers have described central pain as a spinally-stored memory that enhances future responses to ...

journal_title：Frontiers in physiology

authors： Ferguson AR,Huie JR,Crown ED,Grau JW

更新日期：2012-10-04 00:00:00

abstract：:Improving crops yield under water-limited conditions is the most daunting challenge faced by breeders. To this end, accurate, relevant phenotyping plays an increasingly pivotal role for the selection of drought-resilient genotypes and, more in general, for a meaningful dissection of the quantitative genetic landscape ...

journal_title：Frontiers in physiology

authors： Tuberosa R

更新日期：2012-09-19 00:00:00

abstract：:A wide range of adipokines identified over the past years has allowed considering the white adipose tissue as a secretory organ closely integrated into overall physiological and metabolic control. Apelin, a ubiquitously expressed peptide was known to exert different physiological effects mainly on the cardiovascular s...

journal_title：Frontiers in physiology

authors： Bertrand C,Valet P,Castan-Laurell I

更新日期：2015-04-10 00:00:00

abstract：:Background: The possibility of non-invasively assessing load-independent parameters characterizing cardiac function is of high clinical value. Typically, these parameters are assessed during resting conditions. However, for diagnostic purposes, the parameter behavior across a physiologically relevant range of heart ra...

journal_title：Frontiers in physiology

authors： Casas B,Viola F,Cedersund G,Bolger AF,Karlsson M,Carlhäll CJ,Ebbers T

更新日期：2018-10-30 00:00:00

abstract：:Research on the effects of climate change in the marine environment continues to accelerate, yet we know little about the effects of multiple climate drivers in more complex, ecologically relevant settings - especially in sub-tropical and tropical systems. In marine ecosystems, climate change (warming and freshening f...

journal_title：Frontiers in physiology

authors： Turner LM,Havenhand JN,Alsterberg C,Turner AD,K GS,Rai A,Venugopal MN,Karunasagar I,Godhe A

更新日期：2019-04-04 00:00:00

abstract：:Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that includes matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs), and ADAM with thrombospondin motifs (ADAMTSs). In ...

journal_title：Frontiers in physiology

authors： Fan D,Kassiri Z

更新日期：2020-06-16 00:00:00

abstract：:Objective: Ventricular remodeling is considered the basis of heart failure and is involved in myocardial fibrosis. This study aimed to assess perindopril and a galectin-3 inhibitor (modified citrus pectin, MCP) for their effects on ventricular remodeling and myocardial fibrosis in rabbits with ischemic heart failure. ...

journal_title：Frontiers in physiology

authors： Li S,Li S,Hao X,Zhang Y,Deng W

更新日期：2019-03-22 00:00:00

abstract：Background:The underlying mechanisms by which diabetes and dyslipidemia contribute to diabetic nephropathy (DN) are not fully understood. In this study, we aimed to investigate the role of high glucose (HG) on intracellular cholesterol accumulation in glomerular endothelial cells (GEnCs) and its potential mechanism. M...

journal_title：Frontiers in physiology

authors： Wang Y,Xiao S,Zhou S,Zhang R,Liu H,Lin Y,Yu P

更新日期：2020-10-19 00:00:00

abstract：PURPOSE:The aim of present investigation was to evaluate marginal bone level after 5-year follow-up of implants placed in healed ridges and fresh extraction sockets in maxilla with immediate loading protocol. MATERIALS AND METHODS:Thirty-six patients in need of a single-tooth replacement in the anterior maxilla receiv...

journal_title：Frontiers in physiology

authors： Berberi AN,Sabbagh JM,Aboushelib MN,Noujeim ZF,Salameh ZA

更新日期：2014-01-31 00:00:00

abstract：:This study aims to present complex network models which analyze professional swimmers of 50-m freestyle Olympic competitions, comparing characteristics and variables that are considered performance determinants. This comparative research includes Olympic medalists' versus non-medalists' behavior. Using data from 40 at...

journal_title：Frontiers in physiology

authors： Pereira-Ferrero VH,Lewis TG,Ferrero LGP,Duarte LT

更新日期：2019-09-03 00:00:00

abstract：:[This corrects the article on p. 528 in vol. 7, PMID: 27899896.]. ...

journal_title：Frontiers in physiology

authors： Fahlman A,Madigan J

更新日期：2017-01-05 00:00:00