Abstract:
:A coronary angiography-derived index of microvascular resistance (caIMR) is proposed for physiological assessment of microvasular diseases in coronary circulation. The aim of the study is to assess diagnostic performance of caIMR, using wire-derived index of microvascular resistance (IMR) as the reference standard. IMR was demonstrated in 56 patients (57 vessels) with stable/unstable angina pectoris and no obstructive coronary arteries in three centers using the Certus pressure wire. Based on the aortic pressure wave and coronary angiograms from two projections, the caIMR was computed and assessed in blinded fashion against the IMR at an independent core laboratory. Diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive value of the caIMR with a cutoff value of 25 were 84.2% (95% CI: 72.1% to 92.5%), 86.1% (95% CI: 70.5% to 95.3%), 81.0% (95% CI: 58.1% to 94.6%), 88.6% (95% CI: 76.1% to 95.0%), and 77.3% (95% CI: 59.5% to 88.7%) against the IMR with a cutoff value of 25. The receiver-operating curve had area under the curve of 0.919 and the correlation coefficient equaled to 0.746 between caIMR and wire-derived IMR. Hence, caIMR could eliminate the need of a pressure wire, reduce technical error, and potentially increase adoption of physiological assessment of microvascular diseases in patients with ischemic heart disease.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Ai H,Feng Y,Gong Y,Zheng B,Jin Q,Zhang HP,Sun F,Li J,Chen Y,Huo Y,Huo Ydoi
10.3389/fphys.2020.605356subject
Has Abstractpub_date
2020-12-16 00:00:00pages
605356issn
1664-042Xjournal_volume
11pub_type
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journal_title:Frontiers in physiology
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pub_type: 杂志文章
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pub_type: 杂志文章
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abstract::Southeast Asian Ovalocytosis results from a heterozygous deletion of 9 amino acids in the erythrocyte anion exchange protein AE1 (band 3). The report of the first successful birth of an individual homozygous for this mutation showed an association with severe dyserythropoietic anemia. Imaging of the proband's erythroc...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.00357
更新日期:2020-04-28 00:00:00
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journal_title:Frontiers in physiology
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2014.00428
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abstract::The pre-occlusal eruption brings the molars into functional occlusion and initiates tensional strains during mastication. We hypothesized that upon establishment of occlusal contact, the periodontal ligament (PDL) undergoes cell and extracellular matrix maturation to adapt to this mechanical function. The PDL of 12 Wi...
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doi:10.3389/fphys.2020.00174
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abstract::The use of intravenous vitamin C (IVC) for cancer therapy has long been an area of intense controversy. Despite this, high dose IVC has been administered for decades by complementary health care practitioners and physicians, with little evidence base resulting in inconsistent clinical practice. In this review we pose ...
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doi:10.3389/fphys.2018.01182
更新日期:2018-08-23 00:00:00
abstract::At a fundamental level most genes, signaling pathways, biological functions and organ systems are highly conserved between man and all vertebrate species. Leveraging this conservation, researchers are increasingly using the experimental advantages of the amphibian Xenopus to model human disease. The online Xenopus res...
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pub_type: 杂志文章,评审
doi:10.3389/fphys.2019.00154
更新日期:2019-02-26 00:00:00
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doi:10.3389/fphys.2020.00296
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pub_type: 杂志文章
doi:10.3389/fphys.2019.01628
更新日期:2020-01-21 00:00:00
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pub_type: 杂志文章,评审
doi:10.3389/fphys.2019.01542
更新日期:2019-12-19 00:00:00
abstract::F1F0-ATP synthase inhibitory factor 1 (IF1) inhibits the reverse mode of F1F0-ATP synthase, and therefore protects cellular ATP content at the expense of accelerated loss of mitochondrial membrane potential (ΔΨm). There is considerable variability in IF1 expression and its influence on bioenergetics between different ...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.00833
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pub_type: 杂志文章
doi:10.3389/fphys.2018.00347
更新日期:2018-04-24 00:00:00
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pub_type: 杂志文章
doi:10.3389/fphys.2013.00235
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