Redox Aspects of Chaperones in Cardiac Function.

abstract：:Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease ge...

journal_title：Frontiers in physiology

authors： Zheng T,Ni Y,Li J,Chow BKC,Panagiotou G

更新日期：2017-09-28 00:00:00

abstract：:Huntington's disease (HD) is an inherited neurodegenerative disorder typified by involuntary body movements, and psychiatric and cognitive abnormalities. Many HD patients also exhibit metabolic changes including progressive weight loss and appetite dysfunction. Here we have investigated metabolic function in pre-manif...

journal_title：Frontiers in physiology

authors： Wang R,Ross CA,Cai H,Cong WN,Daimon CM,Carlson OD,Egan JM,Siddiqui S,Maudsley S,Martin B

更新日期：2014-06-23 00:00:00

abstract：:The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epith...

journal_title：Frontiers in physiology

authors： Brecker M,Khakhina S,Schubert TJ,Thompson Z,Rubenstein RC

更新日期：2020-09-08 00:00:00

abstract：:Liver cirrhosis (LC) is the final usual outcome of liver damage induced by various chronic liver diseases. Because of asymptomatic nature of LC, it is usually diagnosed at late and advanced stages, and patients are easy to miss the best timing for treatment. Thus, the early detection of LC is needed. In the prospectiv...

journal_title：Frontiers in physiology

authors： Yoo HJ,Jung KJ,Kim M,Kim M,Kang M,Jee SH,Choi Y,Lee JH

更新日期：2019-11-19 00:00:00

abstract：Context:Strength-endurance mainly depends on the power output, which is often expressed relative to the individual's maximal power capability (Pmax). However, an individual can develop the same power, but in different combinations of force and velocity (force-velocity condition). Also, at matched power output, changing...

journal_title：Frontiers in physiology

authors： Rivière JR,Peyrot N,Cross MR,Messonnier LA,Samozino P

更新日期：2020-10-09 00:00:00

abstract：:Aphidius gifuensis is one of the most important aphid natural enemies and has been successfully used to control Myzys persicae and other aphid species. High temperature in summer is one of the key barriers for the application of A. gifuensis in the field and greenhouse. In this work, we investigated the biological per...

journal_title：Frontiers in physiology

authors： Kang ZW,Liu FH,Liu X,Yu WB,Tan XL,Zhang SZ,Tian HG,Liu TX

更新日期：2017-11-28 00:00:00

abstract：:Pulmonary edema (PE) is an issue widely noted in acute exposure to hypoxia as seen in high altitude climbers, yet the etiology of this is not defined. Previous studies in rats showed that both hypoxia and strong sympathetic activation may induce PE. As acute exposure to hypoxia is accompanied by sympathetic activation...

journal_title：Frontiers in physiology

authors： Bölter C,Gabriel P,Appelt P,Salameh A,Schierle K,Rassler B

更新日期：2019-07-05 00:00:00

abstract：:[This corrects the article on p. 165 in vol. 7, PMID: 27242539.]. ...

journal_title：Frontiers in physiology

authors： Nielsen AL,Chen S,Fleischer SJ

更新日期：2017-08-11 00:00:00

abstract：:Familial hypertrophic cardiomyopathy (HCM), due to point mutations in genes for sarcomere proteins such as myosin, occurs in 1/500 people and is the most common cause of sudden death in young individuals. Similar mutations in skeletal muscle, e.g., in the MYH7 gene for slow myosin found in both the cardiac ventricle a...

journal_title：Frontiers in physiology

authors： Månsson A

更新日期：2014-09-15 00:00:00

abstract：:Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy metabolism is unclear. The aim of the present study was to inves...

journal_title：Frontiers in physiology

authors： Lavoie S,Steullet P,Kulak A,Preitner F,Do KQ,Magistretti PJ

更新日期：2016-04-21 00:00:00

abstract：:This study aimed to investigate the influence of different exercise training modalities [(i) a concurrent training based on physical activity recommendation from the World Health Organization group (PAR group), (ii) a high intensity interval training group (HIIT group), and (iii) a high intensity interval training add...

journal_title：Frontiers in physiology

authors： Amaro-Gahete FJ,De-la-O A,Jurado-Fasoli L,Dote-Montero M,Gutiérrez Á,Ruiz JR,Castillo MJ

更新日期：2019-04-24 00:00:00

abstract：:Introduction: Heart Rate Variability (HRV) and Pulse Rate Variability (PRV), are non-invasive techniques for monitoring changes in the cardiac cycle. Both techniques have been used for assessing the autonomic activity. Although highly correlated in healthy subjects, differences in HRV and PRV have been observed under ...

journal_title：Frontiers in physiology

authors： Mejía-Mejía E,Budidha K,Abay TY,May JM,Kyriacou PA

更新日期：2020-07-23 00:00:00

abstract：:Odontoblast cells generated from human dental pulp stem/progenitor cells (hDPSCs) secrete reparative dentin in responds to an injury. Endogenous Wnt signaling is also activated during this process, and these Wnt-activated cells are responsible for the following repair response. R-spondin 2 (Rspo2) is a potent stem cel...

journal_title：Frontiers in physiology

authors： Gong Y,Yuan S,Sun J,Wang Y,Liu S,Guo R,Dong W,Li R

更新日期：2020-08-07 00:00:00

abstract：:Kir7.1 encoded by the Kcnj13 gene in the mouse is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. Further investigations of the localisation and function of Kir7.1 would benefit from the availability of a knockout mouse, but perinatal mortality attribu...

journal_title：Frontiers in physiology

authors： Cornejo I,Villanueva S,Burgos J,López-Cayuqueo KI,Chambrey R,Julio-Kalajzić F,Buelvas N,Niemeyer MI,Figueiras-Fierro D,Brown PD,Sepúlveda FV,Cid LP

更新日期：2018-04-23 00:00:00

abstract：:We have been able to reduce substantially patient pool heterogeneity by identifying phenotypic markers that allow the researcher to stratify chronic fatigue syndrome (CFS) patients into subgroups. To date, we have shown that stratifying based on the presence or absence of comorbid psychiatric diagnosis leads to a grou...

journal_title：Frontiers in physiology

authors： Natelson BH

更新日期：2013-05-20 00:00:00

abstract：:The extensive literature dealing with the Golgi system emphasizes its role in protein secretion and modification, usually without specifying from which evolutionary ancient cell physiological necessity such secretion originated. Neither does it specify which functional requirements the secreted proteins must meet. Fro...

journal_title：Frontiers in physiology

authors： De Loof A,Schoofs L

更新日期：2020-10-15 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects. While brain-derived GLP-1 may participate in these central actions, evidence suggests that peripherally derived GLP-1 plays an important role and GLP-1 analogs are kno...

journal_title：Frontiers in physiology

authors： Fu Z,Gong L,Liu J,Wu J,Barrett EJ,Aylor KW,Liu Z

更新日期：2020-05-29 00:00:00

abstract：:The spawning migration of the European eel is an extensive journey over 5000 to 7000 km from the European coast to the Sargasso Sea. Eels do not feed during this journey and on-board fuels must be sufficient to support the journey of 3.5 to 6 month, as well as sexual maturation and the spawning activity. Swimming of e...

journal_title：Frontiers in physiology

authors： Pelster B

更新日期：2015-01-05 00:00:00

abstract：:Data-driven computational neural network models have been used to study mechanisms for generating the motor patterns for breathing and breathing related behaviors such as coughing. These models have commonly been evaluated in open loop conditions or with feedback of lung volume simply represented as a filtered version...

journal_title：Frontiers in physiology

authors： O'Connor R,Segers LS,Morris KF,Nuding SC,Pitts T,Bolser DC,Davenport PW,Lindsey BG

更新日期：2012-07-23 00:00:00

abstract：:Aim: Combined use of herbal medicines in patients underwent dual antiplatelet therapy (DAPT) might cause bleeding or thrombosis because herbal medicines with anti-platelet activities may exhibit interactions with DAPT. In this study, we tried to use a feedback system control (FSC) optimization technique to optimize do...

journal_title：Frontiers in physiology

authors： Liu W,Li YL,Feng MT,Zhao YW,Ding X,He B,Liu X

更新日期：2018-05-04 00:00:00

abstract：:The spinal cord demonstrates several forms of plasticity that resemble brain-dependent learning and memory. Among the most studied form of spinal plasticity is spinal memory for noxious (nociceptive) stimulation. Numerous papers have described central pain as a spinally-stored memory that enhances future responses to ...

journal_title：Frontiers in physiology

authors： Ferguson AR,Huie JR,Crown ED,Grau JW

更新日期：2012-10-04 00:00:00

abstract：:Objective: This study aims to investigate the effect of astragaloside IV on adipose lipolysis and hepatic gluconeogenesis. Methods: High-fat diet (HFD) feeding induced adipose dysfunction with enhanced endogenous glucose production in mice. The effects of Astragaloside IV on lipolysis and hepatic glucose production we...

journal_title：Frontiers in physiology

authors： Du Q,Zhang S,Li A,Mohammad IS,Liu B,Li Y

更新日期：2018-01-23 00:00:00

abstract：:The ingestion of intact protein or essential amino acids (EAA) stimulates mechanistic target of rapamycin complex-1 (mTORC1) signaling and muscle protein synthesis (MPS) following resistance exercise. The purpose of this study was to investigate the response of myofibrillar-MPS to ingestion of branched-chain amino aci...

journal_title：Frontiers in physiology

authors： Jackman SR,Witard OC,Philp A,Wallis GA,Baar K,Tipton KD

更新日期：2017-06-07 00:00:00

abstract：:Comparison of genomic sequences from diverse vertebrate species has revealed numerous highly conserved regions that do not appear to encode proteins or functional RNAs. Often these "conserved non-coding elements," or CNEs, can direct gene expression to specific tissues in transgenic models, demonstrating they have reg...

journal_title：Frontiers in physiology

authors： Turner EE,Cox TC

更新日期：2014-01-21 00:00:00

abstract：:Wound healing is delayed frequently in patients with diabetes. Proper keratinocyte migration is an essential step during re-epithelialization. Impaired keratinocyte migration is a critical underlying factor responsible for the deficiency of diabetic wound healing, which is mainly attributed to the hyperglycemic state....

journal_title：Frontiers in physiology

authors： Li L,Zhang J,Zhang Q,Zhang D,Xiang F,Jia J,Wei P,Zhang J,Hu J,Huang Y

更新日期：2019-01-28 00:00:00

abstract：:We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a contr...

journal_title：Frontiers in physiology

authors： Šket R,Debevec T,Kublik S,Schloter M,Schoeller A,Murovec B,Vogel Mikuš K,Makuc D,Pečnik K,Plavec J,Mekjavić IB,Eiken O,Prevoršek Z,Stres B

更新日期：2018-03-13 00:00:00

abstract：:Unlike other marine teleosts, the Plotosidae catfishes reportedly have an extra-branchial salt secreting dendritic organ (DO). Salinity acclimation [brackishwater (BW) 3aaa, seawater (SWcontrol) 34aaa, and hypersaline water (HSW) 60aaa] for 14 days was used to investigate the osmoregulatory abilities of Plotosus linea...

journal_title：Frontiers in physiology

authors： Malakpour Kolbadinezhad S,Coimbra J,Wilson JM

更新日期：2018-07-03 00:00:00

abstract：:Background: Tissue availability of polyunsaturated fatty acids (PUFA) depends on several factors, including dietary intake, physical exercise, genetic variation, and metabolic turnover. However, there is limited evidence whether running training activity per se may influence indices associated with PUFA metabolism suc...

journal_title：Frontiers in physiology

authors： Davinelli S,Corbi G,Righetti S,Casiraghi E,Chiappero F,Martegani S,Pina R,De Vivo I,Simopoulos AP,Scapagnini G

更新日期：2019-04-26 00:00:00

abstract：:The microbes in the gastrointestinal tract are separated from the host by a single layer of intestinal epithelial cells (IECs) that plays pivotal roles in maintaining homeostasis by absorbing nutrients and providing a physical and immunological barrier to potential pathogens. Preservation of homeostasis requires the c...

journal_title：Frontiers in physiology

authors： Burgueño JF,Fritsch J,Santander AM,Brito N,Fernández I,Pignac-Kobinger J,Conner GE,Abreu MT

更新日期：2019-12-12 00:00:00

abstract：:3-iodothyronamine (T1AM) is an endogenous amine, that has been detected in many rodent tissues, and in human blood. It has been hypothesized to derive from thyroid hormone metabolism, but this hypothesis still requires validation. T1AM is not a ligand for nuclear thyroid hormone receptors, but stimulates with nanomola...

journal_title：Frontiers in physiology

authors： Zucchi R,Accorroni A,Chiellini G

更新日期：2014-10-16 00:00:00