High Glucose Suppresses Keratinocyte Migration Through the Inhibition of p38 MAPK/Autophagy Pathway.

abstract：:Signaling pathways of red blood cells' (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool for correction of hemorheological disorders, which accompany a n...

journal_title：Frontiers in physiology

authors： Semenov AN,Shirshin EA,Muravyov AV,Priezzhev AV

更新日期：2019-08-14 00:00:00

abstract：:Background: High altitude (HA) exposure can lead to changes in resting heart rate variability (HRV), which may be linked to acute mountain sickness (AMS) development. Compared with traditional HRV measures, non-linear HRV appears to offer incremental and prognostic data, yet its utility and relationship to AMS have be...

journal_title：Frontiers in physiology

authors： Boos CJ,Bye K,Sevier L,Bakker-Dyos J,Woods DR,Sullivan M,Quinlan T,Mellor A

更新日期：2018-04-16 00:00:00

abstract：:Defects in mitochondrial ribosomal proteins (MRPs) cause various diseases in humans. Because of the essential role of MRPs in synthesizing the essential subunits of oxidative phosphorylation (OXPHOS) complexes, identifying all of the protein components involved in the mitochondrial translational machinery is critical....

journal_title：Frontiers in physiology

authors： Koc EC,Cimen H,Kumcuoglu B,Abu N,Akpinar G,Haque ME,Spremulli LL,Koc H

更新日期：2013-07-30 00:00:00

abstract：:The sympathetic nervous system (SNS) contribution to long-term setting of blood pressure (BP) and hence hypertension has been a continuing controversy over many decades. However, the contribution of increased sympathetic vasomotor tone to the heart, kidney, and blood vessels has been suggested as a major influence on ...

journal_title：Frontiers in physiology

authors： Head GA,Jackson KL,Gueguen C

更新日期：2019-12-12 00:00:00

abstract：:Coronary microembolization (CME) is an important clinical problem, and it is related to poor outcome. The specific molecular mechanisms of CME are not fully understood. In the present study, we established a mice model of CME. Isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography coupl...

journal_title：Frontiers in physiology

authors： Chen A,Chen Z,Xia Y,Lu D,Jia J,Hu K,Sun A,Zou Y,Qian J,Ge J

更新日期：2018-09-19 00:00:00

abstract：:Red blood cell nitric oxide synthase (RBC-NOS) dependent NO production positively affects RBC deformability which is known to improve oxygen supply to the working tissue. Whole-body electrostimulation (WB-EMS) has been shown to improve maximum strength, sprinting and jumping performance, and to increase deformability ...

journal_title：Frontiers in physiology

authors： Filipovic A,Bizjak D,Tomschi F,Bloch W,Grau M

更新日期：2019-05-09 00:00:00

abstract：:Current scientific debates center on the impact of lipids and mitochondrial function on diverse aspects of human health, nutrition and disease, among them the association of lipotoxicity with the onset of insulin resistance in skeletal muscle, and with heart dysfunction in obesity and diabetes. Mitochondria play a fun...

journal_title：Frontiers in physiology

authors： Aon MA,Bhatt N,Cortassa SC

更新日期：2014-07-31 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2019.00116.]. ...

journal_title：Frontiers in physiology

authors： Satti R,Abid NU,Bottaro M,De Rui M,Garrido M,Raoufy MR,Montagnese S,Mani AR

更新日期：2019-05-28 00:00:00

abstract：:Rising atmospheric carbon dioxide (CO2) concentration is likely to influence insect-plant interactions. Aphid, as a typical phloem-feeding herbivorous insect, has shown consistently more positive responses in fitness to elevated CO2 concentrations than those seen in leaf-chewing insects. But, little is known about the...

journal_title：Frontiers in physiology

authors： Jiang S,Dai Y,Lu Y,Fan S,Liu Y,Bodlah MA,Parajulee MN,Chen F

更新日期：2018-11-12 00:00:00

abstract：:Studies have revealed a robust and independent correlation between chronic kidney disease (CKD) and cardiovascular (CV) events, including death, heart failure, and myocardial infarction. Recent clinical trials extend this range of adverse CV events, including malignant ventricular arrhythmias and sudden cardiac death ...

journal_title：Frontiers in physiology

authors： Kiuchi MG,Ho JK,Nolde JM,Gavidia LML,Carnagarin R,Matthews VB,Schlaich MP

更新日期：2020-01-14 00:00:00

abstract：:Activation of autonomic neural pathways by chronic hypertensive stimuli plays a significant role in pathogenesis of hypertension. Here, we proposed that even a single acute hypertensive stimulus will activate neural and immune pathways that may be important in initiation of memory imprinting seen in chronic hypertensi...

journal_title：Frontiers in physiology

authors： Zubcevic J,Santisteban MM,Perez PD,Arocha R,Hiller H,Malphurs WL,Colon-Perez LM,Sharma RK,de Kloet A,Krause EG,Febo M,Raizada MK

更新日期：2017-08-31 00:00:00

abstract：:The use of aquatic invertebrates in biomedical research and as environmental sentinels has dramatically grown in recent decades, with an increased need in understanding of comparative pathology. The Unionids freshwater mussels are a group of worldwide distributed bivalves residing small ditches and ponds, lakes, canal...

journal_title：Frontiers in physiology

authors： Carella F,Villari G,Maio N,De Vico G

更新日期：2016-11-01 00:00:00

abstract：:Skeletal muscle differentiation is an essential process for the maintenance of muscle development and homeostasis. Reactive oxygen species (ROS) are critical signaling molecules involved in muscle differentiation. Palmitoyl protein thioesterase 1 (PPT1), a lysosomal enzyme, is involved in removing thioester-linked fat...

journal_title：Frontiers in physiology

authors： Yun HR,Jo YH,Kim J,Nguyen NNY,Shin Y,Kim SS,Choi TG

更新日期：2020-10-15 00:00:00

abstract：:Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphorylations can exhibit...

journal_title：Frontiers in physiology

authors： Salhi HE,Hassel NC,Siddiqui JK,Brundage EA,Ziolo MT,Janssen PM,Davis JP,Biesiadecki BJ

更新日期：2016-12-15 00:00:00

abstract：:Although motor output of the postural function clearly influences postural performance in young and older subjects, no relationship has been formally established between them. However, the relationship between lower-extremity muscle strength/power and postural performance is often pointed out, especially in older subj...

journal_title：Frontiers in physiology

authors： Paillard T

更新日期：2017-08-15 00:00:00

abstract：:Aim: Acute ingestion of alcohol is often accompanied by cardiovascular dysregulation, malaise and even syncope. The full hemodynamic and cutaneous responses to the combination of alcohol and sugar (i.e., alcopops), a common combination in young people, and the mechanisms for the propensity to orthostatic intolerance a...

journal_title：Frontiers in physiology

authors： Maufrais C,Charriere N,Montani JP

更新日期：2017-11-10 00:00:00

abstract：:Airway hyperresponsiveness (AHR), a characteristic of asthma that involves an excessive reduction in airway caliber, is a complex mechanism reflecting multiple processes that manifest over a large range of length and time scales. At one extreme, molecular interactions determine the force generated by airway smooth mus...

journal_title：Frontiers in physiology

authors： Lauzon AM,Bates JH,Donovan G,Tawhai M,Sneyd J,Sanderson MJ

更新日期：2012-06-11 00:00:00

abstract：:Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called "β-adrenergic desensitization"). Adrenergic responsiven...

journal_title：Frontiers in physiology

authors： Ferrara N,Komici K,Corbi G,Pagano G,Furgi G,Rengo C,Femminella GD,Leosco D,Bonaduce D

更新日期：2014-01-09 00:00:00

abstract：:Human diseases have been investigated in the context of single genes as well as complex networks of genes. Though single gene approaches have been extremely successful in the past, most human diseases are complex and better characterized by multiple interacting genes commonly known as networks or pathways. With the ad...

journal_title：Frontiers in physiology

authors： Sahoo D

更新日期：2012-07-23 00:00:00

abstract：:Background:Plutella xylostella has become a notorious pest of cruciferous crops all over the world. Delta-endotoxins of Bacillus thuringiensis are widely used insecticidal proteins for controlling P. xylostella. However, the interaction mechanism of B. thuringiensis with the immune system of P. xylostella, at the geno...

journal_title：Frontiers in physiology

authors： Li S,Xu X,Shakeel M,Xu J,Zheng Z,Zheng J,Yu X,Zhao Q,Jin F

更新日期：2018-11-15 00:00:00

abstract：:Background: Red yeast rice supplements are broadly accepted as treatment for dyslipidaemia in subjects without high cardiovascular (CV) risk. Their effect on lipid profile is well known, but few data are available on their effect on endothelial function. Objectives: To study the effect of a novel nutraceutical compoun...

journal_title：Frontiers in physiology

authors： Cimaglia P,Vieceli Dalla Sega F,Vitali F,Lodolini V,Bernucci D,Passarini G,Fortini F,Marracino L,Aquila G,Rizzo P,Ferrari R,Campo G

更新日期：2019-03-11 00:00:00

abstract：:Periventricular-intraventricular hemorrhages (PIVH) and (diffuse) white matter injury (WMI) are the most important acquired brain lesions of the very and extremely prematurely born neonate. Both carry a high risk for death or adverse neurodevelopmental outcome. The first part of the review discusses the standard of ca...

journal_title：Frontiers in physiology

authors： van Bel F,Vaes J,Groenendaal F

更新日期：2019-03-20 00:00:00

abstract：:Voltage gated potassium channels (KV) are membrane proteins that allow selective flow of K+ ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated...

journal_title：Frontiers in physiology

authors： Moreno C,de la Cruz A,Valenzuela C

更新日期：2016-11-24 00:00:00

abstract：:Background: Understanding the microscopic dynamics of the beating heart has been challenging due to the technical nature of imaging with micrometer resolution while the heart moves. The development of multiphoton microscopy has made in vivo, cell-resolved measurements of calcium dynamics and vascular function possible...

journal_title：Frontiers in physiology

authors： Jones JS,Small DM,Nishimura N

更新日期：2018-07-31 00:00:00

abstract：:Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy metabolism is unclear. The aim of the present study was to inves...

journal_title：Frontiers in physiology

authors： Lavoie S,Steullet P,Kulak A,Preitner F,Do KQ,Magistretti PJ

更新日期：2016-04-21 00:00:00

abstract：:Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin-APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with high morbidity in ...

journal_title：Frontiers in physiology

authors： Zhou Y,Wang Y,Qiao S,Yin L

更新日期：2017-12-12 00:00:00

abstract：:With the advent of high-throughput technologies, the field of systems biology has amassed an abundance of "omics" data, quantifying thousands of cellular components across a variety of scales, ranging from mRNA transcript levels to metabolite quantities. Methods are needed to not only integrate this omics data but to ...

journal_title：Frontiers in physiology

authors： Blazier AS,Papin JA

更新日期：2012-08-06 00:00:00

abstract：:Huanglian Jiedu decoction (HLJDD) has been used in the clinical treatment of inflammatory conditions. To clarify the mechanism of its comprehensive anti-inflammatory activities, the correlation between lipid homeostasis and the TLR4/MyD88 signaling pathway in zebrafish was established in the present study. In the lipo...

journal_title：Frontiers in physiology

authors： Zhou J,Gu X,Fan X,Zhou Y,Wang H,Si N,Yang J,Bian B,Zhao H

更新日期：2019-09-26 00:00:00

abstract：:The sense of taste is responsible for the detection and ingestion of food to cover energetic requirements in health and disease. The change in taste perception might lead to malnutrition that is usually one of the frequent causes of morbidity and mortality in patients with cancer. In this review, we summarize the mech...

journal_title：Frontiers in physiology

authors： Murtaza B,Hichami A,Khan AS,Ghiringhelli F,Khan NA

更新日期：2017-03-08 00:00:00

abstract：:Polarized (POL) training intensity distribution (TID) emphasizes high-volume low-intensity exercise in zone (Z)1 (< first lactate threshold) with a greater proportion of high-intensity Z3 (>second lactate threshold) compared to Z2 (between first and second lactate threshold). In highly trained rowers there is a lack o...

journal_title：Frontiers in physiology

authors： Treff G,Winkert K,Sareban M,Steinacker JM,Becker M,Sperlich B

更新日期：2017-08-02 00:00:00