High Glucose Suppresses Keratinocyte Migration Through the Inhibition of p38 MAPK/Autophagy Pathway.


:Wound healing is delayed frequently in patients with diabetes. Proper keratinocyte migration is an essential step during re-epithelialization. Impaired keratinocyte migration is a critical underlying factor responsible for the deficiency of diabetic wound healing, which is mainly attributed to the hyperglycemic state. However, the underlying mechanisms remain largely unknown. Previously, we demonstrated a marked activation of p38/mitogen-activated protein kinase (MAPK) pathway in the regenerated migrating epidermis, which in turn promoted keratinocyte migration. In the present study, we find that p38/MAPK pathway is downregulated and accompanied by inactivation of autophagy under high glucose (HG) environment. In addition, we demonstrate that inactivation of p38/MAPK and autophagy result in the inhibition of keratinocyte migration under HG environment, and the activating p38/MAPK by MKK6(Glu) overexpression rescues cell migration through an autophagy-dependent way. Moreover, diabetic wound epidermis shows a significant inhibition of p38/MAPK and autophagy. Targeting these dysfunctions may provide novel therapeutic approaches.


Front Physiol


Frontiers in physiology


Li L,Zhang J,Zhang Q,Zhang D,Xiang F,Jia J,Wei P,Zhang J,Hu J,Huang Y




Has Abstract


2019-01-28 00:00:00








  • Benchmarking Procedures for High-Throughput Context Specific Reconstruction Algorithms.

    abstract::Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information. Context specific reconstruction based on generic genome scale models like ReconX or HMR has the potential to become a diagnostic and treatment tool t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Pacheco MP,Pfau T,Sauter T

    更新日期:2016-01-22 00:00:00

  • Muscle Responses to Passive Joint Movements in Infants During the First Year of Life.

    abstract::Muscle tone represents one of the important concepts for characterizing changes in the state of the developing nervous system. It can be manifested in the level of activity of flexors and extensors and in muscle reactions to its passive stretching (StR) or shortening (ShR). Here we investigated such reactions in a coh...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Solopova IA,Zhvansky DS,Dolinskaya IY,Keshishian ES,Selionov VA,Sylos-Labini F,Lacquaniti F,Ivanenko Y

    更新日期:2019-09-13 00:00:00

  • Renal erythropoietin-producing cells in health and disease.

    abstract::Erythropoietin (Epo) is an indispensable erythropoietic hormone primarily produced from renal Epo-producing cells (REPs). Epo production in REPs is tightly regulated in a hypoxia-inducible manner to maintain tissue oxygen homeostasis. Insufficient Epo production by REPs causes renal anemia and anemia associated with c...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Souma T,Suzuki N,Yamamoto M

    更新日期:2015-06-03 00:00:00

  • A "Wearable" Test for Maximum Aerobic Power: Real-Time Analysis of a 60-m Sprint Performance and Heart Rate Off-Kinetics.

    abstract::Maximum aerobic power ([Formula: see text]) as an indicator of body fitness is today a very well-known concept not just for athletes but also for the layman. Unfortunately, the accurate measurement of that variable has remained a complex and exhaustive laboratory procedure, which makes it inaccessible to many active p...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Storniolo JL,Pavei G,Minetti AE

    更新日期:2017-11-01 00:00:00

  • Tonic neuromodulation of the inspiratory rhythm generator.

    abstract::The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific challenges. Endogenous continuous ("tonic") neuromodulation can regula...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Peña-Ortega F

    更新日期:2012-07-20 00:00:00

  • Particle Size Dynamics: Toward a Better Understanding of Electronic Cigarette Aerosol Interactions With the Respiratory System.

    abstract::The knowledge of possible acute and long-term health effects of aerosols inhaled from electronic cigarettes (ECs) is still limited partially due to incomplete awareness of physical phenomena related to EC-aerosol dynamics. This short review discusses the basic processes of aerosol transformation (dynamics) upon inhala...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Sosnowski TR,Odziomek M

    更新日期:2018-07-09 00:00:00

  • Primary Motor Cortex Excitability in Karate Athletes: A Transcranial Magnetic Stimulation Study.

    abstract::Purpose: The mechanisms involved in the coordination of muscle activity are not completely known: to investigate adaptive changes in human motor cortex Transcranial magnetic stimulation (TMS) was often used. The sport models are frequently used to study how the training may affect the corticospinal system excitability...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Monda V,Valenzano A,Moscatelli F,Salerno M,Sessa F,Triggiani AI,Viggiano A,Capranica L,Marsala G,De Luca V,Cipolloni L,Ruberto M,Precenzano F,Carotenuto M,Zammit C,Gelzo M,Monda M,Cibelli G,Messina G,Messina A

    更新日期:2017-09-12 00:00:00

  • Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response.

    abstract::Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a "disease of the sarcomere." Despite the discovery of sarcomere protein mutations linked to HCM almost 30 years ago, the cellular mechanisms responsible for the deve...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chowdhury SAK,Warren CM,Simon JN,Ryba DM,Batra A,Varga P,Kranias EG,Tardiff JC,Solaro RJ,Wolska BM

    更新日期:2020-03-10 00:00:00

  • The Circadian Clock Improves Fitness in the Fruit Fly, Drosophila melanogaster.

    abstract::It is assumed that a properly timed circadian clock enhances fitness, but only few studies have truly demonstrated this in animals. We raised each of the three classical Drosophila period mutants for >50 generations in the laboratory in competition with wildtype flies. The populations were either kept under a conventi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Horn M,Mitesser O,Hovestadt T,Yoshii T,Rieger D,Helfrich-Förster C

    更新日期:2019-11-01 00:00:00

  • Biochemical and Functional Characterization of Glycoside Hydrolase Family 16 Genes in Aedes aegypti Larvae: Identification of the Major Digestive β-1,3-Glucanase.

    abstract::Insect β-1,3-glucanases belong to Glycoside Hydrolase Family 16 (GHF16) and are involved in digestion of detritus and plant hemicellulose. In this work, we investigated the role of GHF16 genes in Aedes aegypti larvae, due to their detritivore diet. Aedes aegypti genome has six genes belonging to GHF16 (Aae GH16.1 - Aa...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Souza RS,Gama MDVF,Schama R,Lima JBP,Diaz-Albiter HM,Genta FA

    更新日期:2019-02-28 00:00:00

  • Adenosine: Direct and Indirect Actions on Gastric Acid Secretion.

    abstract::Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts. Adenosine is formed continuously in intracellular and extracellular locations of all tissues. Extra...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Arin RM,Gorostidi A,Navarro-Imaz H,Rueda Y,Fresnedo O,Ochoa B

    更新日期:2017-09-22 00:00:00

  • Nitric Oxide and Oxidative Stress Changes at Depth in Breath-Hold Diving.

    abstract:Background:Several mechanisms allow humans to resist the extreme conditions encountered during breath-hold diving. Available nitric oxide (NO) is one of the major contributors to such complex adaptations at depth and oxidative stress is one of the major collateral effects of diving. Due to technical difficulties, these...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Cialoni D,Brizzolari A,Samaja M,Bosco G,Paganini M,Pieri M,Lancellotti V,Marroni A

    更新日期:2021-01-07 00:00:00

  • The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release.

    abstract::The microbial community of the gut conveys significant benefits to host physiology. A clear relationship has now been established between gut bacteria and host metabolism in which microbial-mediated gut hormone release plays an important role. Within the gut lumen, bacteria produce a number of metabolites and contain ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Martin AM,Sun EW,Rogers GB,Keating DJ

    更新日期:2019-04-16 00:00:00

  • There Is Little Difference in the Peak Movement Demands of Professional and Semi-Professional Rugby League Competition.

    abstract::Previous research has quantified the peak movement demands of elite rugby league match-play, but the peak accelerometer load or the semi-professional peak demands remain unknown. The aim of this research was to determine the peak movement demands of professional and semi-professional rugby league competition. Wearable...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Johnston RD,Devlin P,Wade JA,Duthie GM

    更新日期:2019-10-14 00:00:00

  • Salbutamol Worsens the Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease.

    abstract:Background:Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bokov P,El Jurdi H,Denjoy I,Peiffer C,Medjahdi N,Holvoet L,Benkerrou M,Delclaux C

    更新日期:2020-02-26 00:00:00

  • Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects.

    abstract::Currently, schizophrenia is considered a multifactorial disease. Over the past 50 years, many investigators have considered the role of toxic free radicals in the etiology of schizophrenia. This is an area of active research which is still evolving. Here, we review the recent data and current concepts on the roles of ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Nasyrova RF,Ivashchenko DV,Ivanov MV,Neznanov NG

    更新日期:2015-05-11 00:00:00

  • Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales.

    abstract::Many natural phenomena display "self-organized criticality" (SOC), (Bak et al., 1987). This refers to spatially extended systems for which patterns of activity characterized by different lengthscales can occur with a probability density that follows a power law with pattern size. Differently from power laws at phase t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Lopez L,Piegari E,Sigaut L,Ponce Dawson S

    更新日期:2012-09-03 00:00:00

  • High-Intensity Interval Training in Normobaric Hypoxia Leads to Greater Body Fat Loss in Overweight/Obese Women than High-Intensity Interval Training in Normoxia.

    abstract::A moderate hypoxic stimulus is considered a promising therapeutic modality for several pathological states including obesity. There is scientific evidence suggesting that when hypoxia and physical activity are combined, they could provide benefits for the obese population. The aim of the present study was to investiga...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Camacho-Cardenosa A,Camacho-Cardenosa M,Burtscher M,Martínez-Guardado I,Timon R,Brazo-Sayavera J,Olcina G

    更新日期:2018-02-07 00:00:00

  • Conjugating Existing Clinical Drugs With Gold Nanoparticles for Better Treatment of Heart Diseases.

    abstract::Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Zhang J,Ma A,Shang L

    更新日期:2018-05-29 00:00:00

  • Prevention, Reduction and Repair of Brain Injury of the Preterm Infant.

    abstract::Periventricular-intraventricular hemorrhages (PIVH) and (diffuse) white matter injury (WMI) are the most important acquired brain lesions of the very and extremely prematurely born neonate. Both carry a high risk for death or adverse neurodevelopmental outcome. The first part of the review discusses the standard of ca...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: van Bel F,Vaes J,Groenendaal F

    更新日期:2019-03-20 00:00:00

  • Rapamycin Inhibits Cardiac Hypertrophy by Promoting Autophagy via the MEK/ERK/Beclin-1 Pathway.

    abstract::Rapamycin, also known as sirolimus, is an antifungal agent and immunosuppressant drug used to prevent organ rejection in transplantation. However, little is known about the role of rapamycin in cardiac hypertrophy and the signaling pathways involved. Here, the effect of rapamycin was examined using phenylephrine (PE) ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Gu J,Hu W,Song ZP,Chen YG,Zhang DD,Wang CQ

    更新日期:2016-03-18 00:00:00

  • Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits.

    abstract::We examined how systemic blockade of type 1 angiotensin (AT(1)-) receptors affects reflex control of the circulation and the kidney. In conscious rabbits, the effects of candesartan on responses of systemic and renal hemodynamics and renal excretory function to acute hypoxia, mild hemorrhage, and plasma volume expansi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Xu TB,Eppel GA,Head GA,Evans RG

    更新日期:2011-07-19 00:00:00

  • Hormonal regulation of the hypothalamic melanocortin system.

    abstract::Regulation of energy homeostasis is fundamental for life. In animal species and humans, the Central Nervous System (CNS) plays a critical role in such regulation by integrating peripheral signals and modulating behavior and the activity of peripheral organs. A precise interplay between CNS and peripheral signals is ne...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Kim JD,Leyva S,Diano S

    更新日期:2014-12-09 00:00:00

  • Beluga (Delphinapterus leucas) granulocytes and monocytes display variable responses to in vitro pressure exposures.

    abstract::While it is widely known that marine mammals possess adaptations which allow them to make repetitive and extended dives to great depths without suffering ill effects seen in humans, the response of marine mammal immune cells to diving is unknown. Renewed interest in marine mammal dive physiology has arisen due to repo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Thompson LA,Romano TA

    更新日期:2015-05-06 00:00:00

  • Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins.

    abstract::Na(+)/Ca(2+) exchanger (NCX) proteins extrude Ca(2+) from the cell to maintain cellular homeostasis. Since NCX proteins contribute to numerous physiological and pathophysiological events, their pharmacological targeting has been desired for a long time. This intervention remains challenging owing to our poor understan...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Giladi M,Tal I,Khananshvili D

    更新日期:2016-02-09 00:00:00

  • The Spectrum of Scarring in Craniofacial Wound Repair.

    abstract::Fibrosis is intimately linked to wound healing and is one of the largest causes of wound-related morbidity. While scar formation is the normal and inevitable outcome of adult mammalian cutaneous wound healing, scarring varies widely between different anatomical sites. The spectrum of craniofacial wound healing spans a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: desJardins-Park HE,Mascharak S,Chinta MS,Wan DC,Longaker MT

    更新日期:2019-03-29 00:00:00

  • Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation.

    abstract::Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remarkable success, there...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Golestanirad L,Gale JT,Manzoor NF,Park HJ,Glait L,Haer F,Kaltenbach JA,Bonmassar G

    更新日期:2018-07-27 00:00:00

  • Neurally Released GABA Acts via GABAC Receptors to Modulate Ca2+ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum.

    abstract::γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Nevertheless, a role for GABA in enteric synaptic transmission remains elusive. In this study, we characterized the expression and function of GABA in the myenteric plexus of the mouse ileum. A...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Koussoulas K,Swaminathan M,Fung C,Bornstein JC,Foong JPP

    更新日期:2018-02-13 00:00:00

  • Extracellular hemoglobin: the case of a friend turned foe.

    abstract::Hemoglobin (Hb) is a highly conserved molecule present in all life forms and functionally tied to the complexity of aerobic organisms on earth in utilizing oxygen from the atmosphere and delivering to cells and tissues. This primary function sustains the energy requirements of cells and maintains cellular homeostasis....

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Quaye IK

    更新日期:2015-04-20 00:00:00

  • Changes in Physical Fitness After 12 Weeks of Structured Concurrent Exercise Training, High Intensity Interval Training, or Whole-Body Electromyostimulation Training in Sedentary Middle-Aged Adults: A Randomized Controlled Trial.

    abstract::This study aimed to investigate the influence of different exercise training modalities [(i) a concurrent training based on physical activity recommendation from the World Health Organization group (PAR group), (ii) a high intensity interval training group (HIIT group), and (iii) a high intensity interval training add...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Amaro-Gahete FJ,De-la-O A,Jurado-Fasoli L,Dote-Montero M,Gutiérrez Á,Ruiz JR,Castillo MJ

    更新日期:2019-04-24 00:00:00