Abstract:
:Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease gene expression signature will lead to a therapeutic effect. However, it has also been shown that globally reversing the disease expression signature is not a prerequisite for drug activity. On the other hand, the basic idea of significant anti-correlation in expression profiles could have great value for establishing diet-disease associations and could provide new insights into the role of dietary interventions in disease. Methods: We performed an integrated analysis of publicly available gene expression profiles for foods, diseases and drugs, by calculating pairwise similarity scores for diet and disease gene expression signatures and characterizing their topological features in protein-protein interaction networks. Results: We identified 485 diet-disease pairs where diet could positively influence disease development and 472 pairs where specific diets should be avoided in a disease state. Multiple evidence suggests that orange, whey and coconut fat could be beneficial for psoriasis, lung adenocarcinoma and macular degeneration, respectively. On the other hand, fructose-rich diet should be restricted in patients with chronic intermittent hypoxia and ovarian cancer. Since humans normally do not consume foods in isolation, we also applied different algorithms to predict synergism; as a result, 58 food pairs were predicted. Interestingly, the diets identified as anti-correlated with diseases showed a topological proximity to the disease proteins similar to that of the corresponding drugs. Conclusions: In conclusion, we provide a computational framework for establishing diet-disease associations and additional information on the role of diet in disease development. Due to the complexity of analyzing the food composition and eating patterns of individuals our in silico analysis, using large-scale gene expression datasets and network-based topological features, may serve as a proof-of-concept in nutritional systems biology for identifying diet-disease relationships and subsequently designing dietary recommendations.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Zheng T,Ni Y,Li J,Chow BKC,Panagiotou Gdoi
10.3389/fphys.2017.00753subject
Has Abstractpub_date
2017-09-28 00:00:00pages
753issn
1664-042Xjournal_volume
8pub_type
杂志文章abstract::Divers that are exposed to high pressure (HP) above 1.1 MPa suffer from High Pressure Neurological Syndrome (HPNS), which is implicated with central nervous system (CNS) malfunction. Marine mammals performing extended and deep breath-hold dives are exposed to almost 20 MPa without apparent HPNS symptoms. N-methyl-D-as...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.01633
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2014.00403
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2016.00333
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fphys.2018.01140
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.00623
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.00301
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pub_type: 杂志文章
doi:10.3389/fphys.2017.01063
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00028
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2019.01508
更新日期:2019-12-18 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.606287
更新日期:2020-11-27 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00976
更新日期:2017-11-28 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2014.00350
更新日期:2014-09-15 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2014.00431
更新日期:2014-11-12 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.606706
更新日期:2020-12-10 00:00:00
abstract:Background:The underlying mechanisms by which diabetes and dyslipidemia contribute to diabetic nephropathy (DN) are not fully understood. In this study, we aimed to investigate the role of high glucose (HG) on intracellular cholesterol accumulation in glomerular endothelial cells (GEnCs) and its potential mechanism. M...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.552483
更新日期:2020-10-19 00:00:00
abstract::The two forms of inorganic arsenic, arsenate (AsV) and arsenite (AsIII), are easily taken up by the cells of the plant root. Once in the cell, AsV can be readily converted to AsIII, the more toxic of the two forms. AsV and AsIII both disrupt plant metabolism, but through distinct mechanisms. AsV is a chemical analog o...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2012.00182
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pub_type: 杂志文章
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doi:10.3389/fphys.2019.00062
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pub_type: 杂志文章
doi:10.3389/fphys.2020.576736
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2017.00211
更新日期:2017-04-11 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2020.598898
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journal_title:Frontiers in physiology
pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2012.00350
更新日期:2012-09-03 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00884
更新日期:2017-11-02 00:00:00
abstract::[This corrects the article DOI: 10.3389/fphys.2019.00313.]. ...
journal_title:Frontiers in physiology
pub_type: 已发布勘误
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更新日期:2020-02-25 00:00:00
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pub_type: 杂志文章
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