Kras as a key oncogene and therapeutic target in pancreatic cancer.

abstract：:Human physiological signals are inherently rhythmic and have a hallmark feature in that even distant intrasignal measurements are related to each other. This relationship is termed long-range correlation and has been recognized as an indicator of the optimal state of the observed physiological systems, among which the...

journal_title：Frontiers in physiology

authors： Ravi DK,Marmelat V,Taylor WR,Newell KM,Stergiou N,Singh NB

更新日期：2020-06-23 00:00:00

abstract：:Malignant hypertension develops in some cases of hypertension but not in others. We hypothesized that an impaired neovascularization and a reduced capillary supply characterizes the malignant course of experimental hypertension. Two-kidney, one-clip renovascular hypertension was induced in rats; controls (sham) were s...

journal_title：Frontiers in physiology

authors： Hartner A,Jagusch L,Cordasic N,Amann K,Veelken R,Jacobi J,Hilgers KF

更新日期：2016-08-30 00:00:00

abstract：:Social attachment formed by filial imprinting in newborn chicks undergoes a process of memory consolidation that involves rearrangement of its neural storage substrates. In the first 3 h after imprinting it depends on the integrity of the intermediate medial mesopallium (IMM) and beyond that time on unidentified memor...

journal_title：Frontiers in physiology

authors： Tiunova AA,Komissarova NV,Anokhin KV

更新日期：2019-03-29 00:00:00

abstract：:Purpose: Aging is associated with changes in muscle energy metabolism. Proton (1H) and phosphorous (31P) magnetic resonance spectroscopy (MRS) has been successfully applied for non-invasive investigation of skeletal muscle metabolism. The aim of this study was to detect differences in adenosine triphosphate (ATP) prod...

journal_title：Frontiers in physiology

authors： Krumpolec P,Klepochová R,Just I,Tušek Jelenc M,Frollo I,Ukropec J,Ukropcová B,Trattnig S,Krššák M,Valkovič L

更新日期：2020-06-29 00:00:00

abstract：:Regulation of energy homeostasis is fundamental for life. In animal species and humans, the Central Nervous System (CNS) plays a critical role in such regulation by integrating peripheral signals and modulating behavior and the activity of peripheral organs. A precise interplay between CNS and peripheral signals is ne...

journal_title：Frontiers in physiology

authors： Kim JD,Leyva S,Diano S

更新日期：2014-12-09 00:00:00

abstract：PURPOSE:The aim of present investigation was to evaluate marginal bone level after 5-year follow-up of implants placed in healed ridges and fresh extraction sockets in maxilla with immediate loading protocol. MATERIALS AND METHODS:Thirty-six patients in need of a single-tooth replacement in the anterior maxilla receiv...

journal_title：Frontiers in physiology

authors： Berberi AN,Sabbagh JM,Aboushelib MN,Noujeim ZF,Salameh ZA

更新日期：2014-01-31 00:00:00

abstract：:Mild normobaric hypoxia (NH) and modest exercise have multiple beneficial effects on health, but the changes in physiological function induced by NH and/or exercise remain unclear. The purpose of this investigation was to examine the specific effects of NH and/or exercise on cardiac function and myocardial structure a...

journal_title：Frontiers in physiology

authors： Li QF,Wang H,Zheng L,Yang F,Li HZ,Li JX,Cheng D,Lu K,Liu Y

更新日期：2020-01-21 00:00:00

abstract：:Purpose: To provide insights into the energy requirements as well as the physiological adaptations of an experienced 50-year-old ultra-marathon male athlete during the world's most challenging mountain ultra-marathon (MUM). Methods: The international race supporting the study was the Tor des Geants®, characterized by ...

journal_title：Frontiers in physiology

authors： Savoldelli A,Fornasiero A,Trabucchi P,Limonta E,La Torre A,Degache F,Pellegrini B,Millet GP,Vernillo G,Schena F

更新日期：2017-12-05 00:00:00

abstract：:Loss of skeletal muscle myofibrillar protein with disease and/or inactivity can severely deteriorate muscle strength and function. Strategies to counteract wasting of muscle myofibrillar protein are therefore desirable and invite for considerations on the potential superiority of specific modes of resistance exercise ...

journal_title：Frontiers in physiology

authors： Rindom E,Vissing K

更新日期：2016-11-17 00:00:00

abstract：:Consistency of individual differences of animal behavior and personality in reactions to various environmental stresses among their life stages could reflect basic divergences in coping style which may affect survival, social rank, and reproductive success in the wild. However, the physiological mechanisms determining...

journal_title：Frontiers in physiology

authors： Yuan M,Chen Y,Huang Y,Lu W

更新日期：2018-05-30 00:00:00

abstract：:Exercise and physical labor in extreme environmental conditions causes transient decreases in immune cell and cytokine concentrations, likely increasing the susceptibility to opportunistic infection. Baker's yeast beta glucan (BYBG) has been previously demonstrated to be an effective countermeasure in athletes, but it...

journal_title：Frontiers in physiology

authors： McFarlin BK,Venable AS,Carpenter KC,Henning AL,Ogenstad S

更新日期：2017-10-20 00:00:00

abstract：:The pea aphid, Acyrthosiphon pisum (Harris) (Hemiptera: Aphididae), shows wing polyphenism (winged and wingless morphs) in its life cycle. The winged morph is adapted for dispersal; its two developmental adult stages (for dispersal and reproduction) are based on its breeding periods. The two morphs show different phot...

journal_title：Frontiers in physiology

authors： Zhang Y,Wang XX,Jing X,Tian HG,Liu TX

更新日期：2016-08-02 00:00:00

abstract：:Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were develope...

journal_title：Frontiers in physiology

authors： de Souza ILL,Barros BC,de Oliveira GA,Queiroga FR,Toscano LT,Silva AS,Silva PM,Interaminense LFL,Cavalcante FA,da Silva BA

更新日期：2017-10-04 00:00:00

abstract：AIM:The signaling pathways involved in the regulation of cardiac GLUT4 translocation/glucose uptake and CD36 translocation/long-chain fatty acid uptake are not fully understood. We compared in heart/muscle-specific PKC-λ knockout mice the roles of atypical PKCs (PKC-ζ and PKC-λ) in regulating cardiac glucose and fatty ...

journal_title：Frontiers in physiology

authors： Habets DD,Luiken JJ,Ouwens M,Coumans WA,Vergouwe M,Maarbjerg SJ,Leitges M,Bonen A,Richter EA,Glatz JF

更新日期：2012-09-11 00:00:00

abstract：:Chronic kidney disease (CKD) can have an insidious onset because there is a gradual decline in nephron number throughout life. There may be no overt symptoms of renal dysfunction until about two thirds or more of the nephrons have been destroyed and glomerular filtration rate (GFR) falls to below 25% of normal (often ...

journal_title：Frontiers in physiology

authors： Lumbers ER,Kandasamy Y,Delforce SJ,Boyce AC,Gibson KJ,Pringle KG

更新日期：2020-07-16 00:00:00

abstract：:Molecular imaging has emerged in the past few decades as a novel means to investigate atherosclerosis. From a pathophysiological perspective, atherosclerosis is characterized by microscopic inflammation and microcalcification that precede the characteristic plaque buildup in arterial walls detected by traditional asse...

journal_title：Frontiers in physiology

authors： Mayer M,Borja AJ,Hancin EC,Auslander T,Revheim ME,Moghbel MC,Werner TJ,Alavi A,Rajapakse CS

更新日期：2020-10-22 00:00:00

abstract：:Reperfusion of ischemic cardiac tissue is the standard treatment for improving clinical outcome following myocardial infarction but is inevitably associated with ischemia-reperfusion injury (IRI). Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ischemia-reperfusion pri...

journal_title：Frontiers in physiology

authors： Martin-Puig S,Tello D,Aragonés J

更新日期：2015-05-20 00:00:00

abstract：:Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-gly...

journal_title：Frontiers in physiology

authors： Tijardović M,Marijančević D,Bok D,Kifer D,Lauc G,Gornik O,Keser T

更新日期：2019-12-20 00:00:00

abstract：:Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an increasingly serious health and socioeconomic concern for modern societies. Science has made tremendous progress in the understanding of aging itself, which has helped medicine to extend life expectancies. With the increase of the l...

journal_title：Frontiers in physiology

authors： Fulop T,Larbi A,Khalil A,Cohen AA,Witkowski JM

更新日期：2019-12-18 00:00:00

abstract：:Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review some of the characteri...

journal_title：Frontiers in physiology

authors： Kumar RK,Foster PS

更新日期：2012-07-31 00:00:00

abstract：:Circadian clocks are endogenous oscillators essential for orchestrating daily rhythms in physiology, metabolism and behavior. While mouse models have been instrumental to elucidate the molecular mechanism of circadian rhythm generation, our knowledge about the molecular makeup of circadian oscillators in humans is sti...

journal_title：Frontiers in physiology

authors： Börding T,Abdo AN,Maier B,Gabriel C,Kramer A

更新日期：2019-05-09 00:00:00

abstract：:Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca(2+)- and voltage-activated K(+) (BK or Slo1) channels at the single-channel level. It starts ...

journal_title：Frontiers in physiology

authors： Geng Y,Magleby KL

更新日期：2015-01-21 00:00:00

abstract：:Ticks and tick-borne pathogens affect health and welfare of companion animals worldwide, and some human tick-borne diseases are associated with exposure to domestic animals. Vaccines are the most environmentally friendly alternative to acaracides for the control of tick infestations, and to reduce the risk for tick-bo...

journal_title：Frontiers in physiology

authors： Contreras M,Villar M,de la Fuente J

更新日期：2019-07-26 00:00:00

abstract：:Whether neurally-mediated vasodilatation may contribute to exercise hyperemia has not been completely understood. Bülbring and Burn (1935) found for the first time the existence of sympathetic cholinergic nerve to skeletal muscle contributing to vasodilatation in animals. Blair et al. (1959) reported that atropine-sen...

journal_title：Frontiers in physiology

authors： Matsukawa K,Ishii K,Liang N,Endo K

更新日期：2013-02-15 00:00:00

abstract：:The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems. The evolution of using oxygen for efficient energy production served as a driving fo...

journal_title：Frontiers in physiology

authors： Naudí A,Jové M,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2013-12-17 00:00:00

abstract：:Cells expressing bitter taste receptors (T2Rs or Tas2rs) in extraoral tissues are considered to be chemosensory cells mediating protective responses to potentially harmful or even antiinflammatory or antimicrobial compounds. In a previous study the activity of the Tas2R143/Tas2R135/Tas2r126 cluster promoter in the sto...

journal_title：Frontiers in physiology

authors： Widmayer P,Partsch V,Pospiech J,Kusumakshi S,Boehm U,Breer H

更新日期：2020-02-07 00:00:00

abstract：:Anthropogenic climate change exposes marine organisms to CO2 induced ocean acidification (OA). Marine animals may make physiological and behavioral adaptations to cope with OA. Elevated pCO2 may affect metabolism, feeding, and energy partition of marine crabs, and thereby affect their predator-prey dynamics with musse...

journal_title：Frontiers in physiology

authors： Wang Y,Hu M,Wu F,Storch D,Pörtner HO

更新日期：2018-08-21 00:00:00

abstract：:Following partial hepatectomy, a coordinated series of molecular events occurs to regulate hepatocyte entry into the cell cycle to recover lost mass. In rats during the first 6 h following resection, hepatocytes are primed by a tightly controlled cytokine response to prepare hepatocytes to begin replication. Although ...

journal_title：Frontiers in physiology

authors： Cook DJ,Patra B,Kuttippurathu L,Hoek JB,Vadigepalli R

更新日期：2015-07-07 00:00:00

abstract：:Breast cancer is the most common type of cancer among women and despite recent advances in the medical field, there are still some inherent limitations in the currently used screening techniques. The radiological interpretation of screening X-ray mammograms often leads to over-diagnosis and, as a consequence, to unnec...

journal_title：Frontiers in physiology

authors： Gerasimova E,Audit B,Roux SG,Khalil A,Gileva O,Argoul F,Naimark O,Arneodo A

更新日期：2014-05-08 00:00:00

abstract：:Temperature is an important abiotic factor that drives the evolution of ectotherms owing to its pervasive effects at all levels of organization. Although a species' thermal tolerance is environmentally driven within a spatial cline, it may be constrained over time due to differential phylogenetic inheritance. At the l...

journal_title：Frontiers in physiology

authors： Faria SC,Bianchini A,Lauer MM,Zimbardi ALRL,Tapella F,Romero MC,McNamara JC

更新日期：2020-04-24 00:00:00