Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female Drosophila.

abstract：:Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequen...

journal_title：Frontiers in physiology

authors： Ding HL,Hooper JE,Batzel P,Eames BF,Postlethwait JH,Artinger KB,Clouthier DE

更新日期：2016-07-14 00:00:00

abstract：:Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), and spinal-bulbar muscular atrophy (SBMA) are devastating diseases characterized by the degeneration of motor neurons. Although the molecular causes underlying these diseases differ, recent findings have highlighted the contribution of intrinsic skele...

journal_title：Frontiers in physiology

authors： Boyer JG,Ferrier A,Kothary R

更新日期：2013-12-18 00:00:00

abstract：:Introduction: Tilt tables enable early mobilization of patients by providing verticalization. But there is a high risk of orthostatic hypotension provoked by verticalization, especially after neurological diseases such as spinal cord injury. Robot-assisted tilt tables might be an alternative as they add passive roboti...

journal_title：Frontiers in physiology

authors： Sarabadani Tafreshi A,Riener R,Klamroth-Marganska V

更新日期：2016-12-09 00:00:00

abstract：:Loss of skeletal muscle myofibrillar protein with disease and/or inactivity can severely deteriorate muscle strength and function. Strategies to counteract wasting of muscle myofibrillar protein are therefore desirable and invite for considerations on the potential superiority of specific modes of resistance exercise ...

journal_title：Frontiers in physiology

authors： Rindom E,Vissing K

更新日期：2016-11-17 00:00:00

abstract：:Clinical investigations prove that blue light irradiation reduces the severity of psoriasis vulgaris. Nevertheless, the mechanisms involved in the management of this condition remain poorly defined. Despite the encouraging results of the clinical studies, no clear guidelines are specified in the literature for the irr...

journal_title：Frontiers in physiology

authors： Félix Garza ZC,Liebmann J,Born M,Hilbers PA,van Riel NA

更新日期：2017-01-26 00:00:00

abstract：:Aim: Tea is usually consumed at two temperatures (as hot tea or as iced tea). However, the importance of drink temperature on the cardiovascular system and on metabolism has not been thoroughly investigated. The purpose of this study was to compare the cardiovascular, metabolic and cutaneous responses to the ingestion...

journal_title：Frontiers in physiology

authors： Maufrais C,Sarafian D,Dulloo A,Montani JP

更新日期：2018-04-06 00:00:00

abstract：:The "Woody" or "Wooden" breast disease is a severe myopathy of pectoralis major muscle recently identified within rapidly growing broiler lines all around the world with a prevalence rate around 20%, or even higher. Although of significant ethical and economic impact, little is known regarding the structural and funct...

journal_title：Frontiers in physiology

authors： Liu J,Puolanne E,Schwartzkopf M,Arner A

更新日期：2020-04-09 00:00:00

abstract：:The multifunctional CD36 scavenger receptor facilitates fatty acid (FA) uptake and oxidation and it has been involved in the pathophysiology related to dysfunctional FA metabolism. The common variant in the CD36 gene, rs1761667 (A/G), whose allele A is characterized by a reduced protein expression, has been associated...

journal_title：Frontiers in physiology

authors： Melis M,Carta G,Pintus S,Pintus P,Piras CA,Murru E,Manca C,Di Marzo V,Banni S,Tomassini Barbarossa I

更新日期：2017-12-06 00:00:00

abstract：:Sulfur is both crucial to life and a potential threat to health. While colonic sulfur metabolism mediated by eukaryotic cells is relatively well studied, much less is known about sulfur metabolism within gastrointestinal microbes. Sulfated compounds in the colon are either of inorganic (e.g., sulfates, sulfites) or or...

journal_title：Frontiers in physiology

authors： Carbonero F,Benefiel AC,Alizadeh-Ghamsari AH,Gaskins HR

更新日期：2012-11-28 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:The sterile insect technique (SIT) may reduce pest populations by allowing sufficient amount of irradiation-induced sterile males to mate with wild females whilst maintaining mating ability comparable to wild males. Although the SIT methods are well understood, the optimal sterilizing dose and processing development s...

journal_title：Frontiers in physiology

authors： Cai J,Yang H,Shi S,Zhong G,Yi X

更新日期：2018-02-20 00:00:00

abstract：:A primary goal of enamel research is to understand and potentially treat or prevent enamel defects related to amelogenesis imperfecta (AI). Rodents are ideal models to assist our understanding of how enamel is formed because they are easily genetically modified, and their continuously erupting incisors display all sta...

journal_title：Frontiers in physiology

authors： Pugach MK,Gibson CW

更新日期：2014-09-17 00:00:00

abstract：:Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such ...

journal_title：Frontiers in physiology

authors： Zhang J,Ma A,Shang L

更新日期：2018-05-29 00:00:00

abstract：:The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their str...

journal_title：Frontiers in physiology

authors： Artigas-Jerónimo S,Villar M,Cabezas-Cruz A,Valdés JJ,Estrada-Peña A,Alberdi P,de la Fuente J

更新日期：2018-11-13 00:00:00

abstract：:Background: Nrg4 expression has been linked to brown adipose tissue activity and browning of white adipocytes in mice. Here, we aimed to investigate whether these observations could be translated to humans by investigating NRG4 mRNA and markers of brown/beige adipocytes in human visceral (VAT) and subcutaneous adipose...

journal_title：Frontiers in physiology

authors： Comas F,Martínez C,Sabater M,Ortega F,Latorre J,Díaz-Sáez F,Aragonés J,Camps M,Gumà A,Ricart W,Fernández-Real JM,Moreno-Navarrete JM

更新日期：2019-01-31 00:00:00

abstract：:Many disease fighting strategies have focused on the generation of NK cells, since they constitute the main immune barrier against cancer and intracellular pathogens such as viruses. Therefore, a predictive model for the development of NK cells would constitute a useful tool to test several hypotheses regarding the pr...

journal_title：Frontiers in physiology

authors： Liquitaya-Montiel AJ,Mendoza L

更新日期：2018-08-02 00:00:00

abstract：Background:More than 30-40% of uric acid is excreted via the intestine, and the dysfunction of intestinal epithelium disrupts uric acid excretion. The involvement of gut microbiota in hyperuricemia has been reported in previous studies, but the changes and mechanisms of intestinal immunity in hyperuricemia are still un...

journal_title：Frontiers in physiology

authors： Lv Q,Xu D,Zhang X,Yang X,Zhao P,Cui X,Liu X,Yang W,Yang G,Xing S

更新日期：2020-11-27 00:00:00

abstract：:Adaptation of arm reaching in a novel force field involves co-contraction of upper limb muscles, but it is not known how the co-ordination of multiple muscle activation is orchestrated. We have used intermuscular coherence (IMC) to test whether a coherent intermuscular coupling between muscle pairs is responsible for ...

journal_title：Frontiers in physiology

authors： Pizzamiglio S,De Lillo M,Naeem U,Abdalla H,Turner DL

更新日期：2017-01-09 00:00:00

abstract：:Malignant hypertension develops in some cases of hypertension but not in others. We hypothesized that an impaired neovascularization and a reduced capillary supply characterizes the malignant course of experimental hypertension. Two-kidney, one-clip renovascular hypertension was induced in rats; controls (sham) were s...

journal_title：Frontiers in physiology

authors： Hartner A,Jagusch L,Cordasic N,Amann K,Veelken R,Jacobi J,Hilgers KF

更新日期：2016-08-30 00:00:00

abstract：:Fibrosis is intimately linked to wound healing and is one of the largest causes of wound-related morbidity. While scar formation is the normal and inevitable outcome of adult mammalian cutaneous wound healing, scarring varies widely between different anatomical sites. The spectrum of craniofacial wound healing spans a...

journal_title：Frontiers in physiology

authors： desJardins-Park HE,Mascharak S,Chinta MS,Wan DC,Longaker MT

更新日期：2019-03-29 00:00:00

abstract：:The paper reports application of a Markov-like stochastic process agent-based model and a "virtual farm" concept for enhancement of site-specific Integrated Pest Management. Conceptually, the model represents a "bottom-up ethological" approach and emulates behavior of the "primary IPM actors"-large cohorts of individu...

journal_title：Frontiers in physiology

authors： Lux SA,Wnuk A,Vogt H,Belien T,Spornberger A,Studnicki M

更新日期：2016-08-23 00:00:00

abstract：:The arterial baroreflexes, located in the carotid sinus and along the arch of the aorta, are essential for the rapid short term autonomic regulation of blood pressure. In the past, they were believed to be inactivated during exercise because blood pressure, heart rate, and sympathetic activity were radically changed f...

journal_title：Frontiers in physiology

authors： Schwartz CE,Stewart JM

更新日期：2012-12-07 00:00:00

abstract：:Increased central sympathetic drive is a hallmark of several important clinical conditions including essential hypertension, heart failure, chronic kidney disease, and insulin resistance. Afferent signaling from the kidneys has been identified as an important contributor to elevated central sympathetic drive and incre...

journal_title：Frontiers in physiology

authors： Schlaich MP,Hering D,Sobotka P,Krum H,Lambert GW,Lambert E,Esler MD

更新日期：2012-02-02 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) represent a new and exciting field in modern medicine, now the focus of many researchers and media outlets. The hype is well-earned because of the potential of stem cells to contribute to disease modeling, drug screening, and even therapeutic approaches. In this review, we focus fi...

journal_title：Frontiers in physiology

authors： Martinez Y,Dubois-Dauphin M,Krause KH

更新日期：2012-03-19 00:00:00

abstract：:Cryptochromes (CRYs) are flavoproteins that are sensitive to blue light, first identified in Arabidopsis and then in Drosophila and mice. They are evolutionarily conserved and play fundamental roles in the circadian clock of living organisms, enabling them to adapt to the daily 24-h cycles. The role of CRYs in circadi...

journal_title：Frontiers in physiology

authors： Damulewicz M,Mazzotta GM

更新日期：2020-03-05 00:00:00

abstract：:Coronary microembolization (CME) is an important clinical problem, and it is related to poor outcome. The specific molecular mechanisms of CME are not fully understood. In the present study, we established a mice model of CME. Isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography coupl...

journal_title：Frontiers in physiology

authors： Chen A,Chen Z,Xia Y,Lu D,Jia J,Hu K,Sun A,Zou Y,Qian J,Ge J

更新日期：2018-09-19 00:00:00

abstract：:Introduction: Endothelial progenitor cells (EPCs) display a unique ability to promote angiogenesis and restore endothelial function in injured blood vessels. NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H2O2) serves as a signaling molecule and promotes endothelial cell proliferation and migration as well as prote...

journal_title：Frontiers in physiology

authors： Hakami NY,Ranjan AK,Hardikar AA,Dusting GJ,Peshavariya HM

更新日期：2017-03-23 00:00:00

abstract：Background:Aging and changing age demographics represent critical problems of our time. Physiological functions decline with age, often ending in a systemic process that contributes to numerous impairments and age-related diseases including heart failure (HF). We aimed to analyze whether differences in composite measur...

journal_title：Frontiers in physiology

authors： Wagner J,Knaier R,Königstein K,Klenk C,Carrard J,Lichtenstein E,Scharnagl H,März W,Hanssen H,Hinrichs T,Schmidt-Trucksäss A,Arbeev K

更新日期：2020-12-15 00:00:00

abstract：:Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce...

journal_title：Frontiers in physiology

authors： Zhang C,Hua Q

更新日期：2016-01-07 00:00:00

abstract：:This review details the manner in which the central nervous system regulates metabolic homeostasis in normal weight and obese rodents and humans. It includes a review of the homeostatic contributions of neurons located in the hypothalamus, the midbrain and limbic structures, the pons and the medullary area postrema, n...

journal_title：Frontiers in physiology

authors： Smith JK

更新日期：2018-05-17 00:00:00