A Dynamic Model for Prediction of Psoriasis Management by Blue Light Irradiation.

Abstract:

:Clinical investigations prove that blue light irradiation reduces the severity of psoriasis vulgaris. Nevertheless, the mechanisms involved in the management of this condition remain poorly defined. Despite the encouraging results of the clinical studies, no clear guidelines are specified in the literature for the irradiation scheme regime of blue light-based therapy for psoriasis. We investigated the underlying mechanism of blue light irradiation of psoriatic skin, and tested the hypothesis that regulation of proliferation is a key process. We implemented a mechanistic model of cellular epidermal dynamics to analyze whether a temporary decrease of keratinocytes hyper-proliferation can explain the outcome of phototherapy with blue light. Our results suggest that the main effect of blue light on keratinocytes impacts the proliferative cells. They show that the decrease in the keratinocytes proliferative capacity is sufficient to induce a transient decrease in the severity of psoriasis. To study the impact of the therapeutic regime on the efficacy of psoriasis treatment, we performed simulations for different combinations of the treatment parameters, i.e., length of treatment, fluence (also referred to as dose), and intensity. These simulations indicate that high efficacy is achieved by regimes with long duration and high fluence levels, regardless of the chosen intensity. Our modeling approach constitutes a framework for testing diverse hypotheses on the underlying mechanism of blue light-based phototherapy, and for designing effective strategies for the treatment of psoriasis.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Félix Garza ZC,Liebmann J,Born M,Hilbers PA,van Riel NA

doi

10.3389/fphys.2017.00028

subject

Has Abstract

pub_date

2017-01-26 00:00:00

pages

28

issn

1664-042X

journal_volume

8

pub_type

杂志文章
  • Mammalian STE20-Like Kinase 2 Promotes Lipopolysaccharides-Mediated Cardiomyocyte Inflammation and Apoptosis by Enhancing Mitochondrial Fission.

    abstract::In this study, we analyzed the role of mammalian STE20-like protein kinase 2 (Mst2), a serine-threonine protein kinase, in Lipopolysaccharides (LPS)-mediated inflammation and apoptosis in the H9C2 cardiomyocytes. Mst2 mRNA and protein levels were significantly upregulated in the LPS-treated H9C2 cardiomyocytes. LPS tr...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00897

    authors: Tian Y,Song H,Qin W,Ding Z,Zhang Y,Shan W,Jin D

    更新日期:2020-08-06 00:00:00

  • Specialized Positioning of Myonuclei Near Cell-Cell Junctions.

    abstract::Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01531

    authors: Perillo M,Folker ES

    更新日期:2018-11-01 00:00:00

  • Calcium-permeable ion channels in control of autophagy and cancer.

    abstract::Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis. Defects in autophagy are linked to a variety of pathological states, including cancer. Cancer is the d...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00272

    authors: Kondratskyi A,Yassine M,Kondratska K,Skryma R,Slomianny C,Prevarskaya N

    更新日期:2013-10-02 00:00:00

  • Nitric Oxide Inhibits Al-Induced Programmed Cell Death in Root Tips of Peanut (Arachis hypogaea L.) by Affecting Physiological Properties of Antioxidants Systems and Cell Wall.

    abstract::It has been reported that nitric oxide (NO) is a negative regulator of aluminum (Al)-induced programmed cell death (PCD) in peanut root tips. However, the inhibiting mechanism of NO on Al-induced PCD is unclear. In order to investigate the mechanism by which NO inhibits Al-induced PCD, the effects of co-treatment Al w...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.01037

    authors: Pan CL,Yao SC,Xiong WJ,Luo SZ,Wang YL,Wang AQ,Xiao D,Zhan J,He LF

    更新日期:2017-12-21 00:00:00

  • Comparative Susceptibility of Different Populations of Amblyomma sculptum to Rickettsia rickettsii.

    abstract::The bacterium Rickettsia rickettsii is the etiological agent of Brazilian spotted fever (BSF), which is transmitted in Brazil mainly by the tick Amblyomma sculptum. Herein, larvae and nymphs of six populations of A. sculptum were exposed to R. rickettsii by feeding on needle-inoculated guinea pigs, and thereafter rear...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00653

    authors: Gerardi M,Ramírez-Hernández A,Binder LC,Krawczak FS,Gregori F,Labruna MB

    更新日期:2019-05-28 00:00:00

  • ZOOMICS: Comparative Metabolomics of Red Blood Cells From Old World Monkeys and Humans.

    abstract::As part of the ZOOMICS project, we set out to investigate common and diverging metabolic traits in the blood metabolome across various species by taking advantage of recent developments in high-throughput metabolomics. Here we provide the first comparative metabolomics analysis of fresh and stored human (n = 21, 10 ma...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.593841

    authors: Bertolone L,Shin HK,Stefanoni D,Baek JH,Gao Y,Morrison EJ,Nemkov T,Thomas T,Francis RO,Hod EA,Zimring JC,Yoshida T,Karafin M,Schwartz J,Hudson KE,Spitalnik SL,Buehler PW,D'Alessandro A

    更新日期:2020-10-23 00:00:00

  • Fractal Analysis of BOLD Time Series in a Network Associated With Waiting Impulsivity.

    abstract::Fractal phenomena can be found in numerous scientific areas including neuroscience. Fractals are structures, in which the whole has the same shape as its parts. A specific structure known as pink noise (also called fractal or 1/f noise) is one key fractal manifestation, exhibits both stability and adaptability, and ca...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01378

    authors: Akhrif A,Romanos M,Domschke K,Schmitt-Boehrer A,Neufang S

    更新日期:2018-10-04 00:00:00

  • Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female Drosophila.

    abstract::Mild normobaric hypoxia (NH) and modest exercise have multiple beneficial effects on health, but the changes in physiological function induced by NH and/or exercise remain unclear. The purpose of this investigation was to examine the specific effects of NH and/or exercise on cardiac function and myocardial structure a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01610

    authors: Li QF,Wang H,Zheng L,Yang F,Li HZ,Li JX,Cheng D,Lu K,Liu Y

    更新日期:2020-01-21 00:00:00

  • Composite Measures of Physical Fitness to Discriminate Between Healthy Aging and Heart Failure: The COmPLETE Study.

    abstract:Background:Aging and changing age demographics represent critical problems of our time. Physiological functions decline with age, often ending in a systemic process that contributes to numerous impairments and age-related diseases including heart failure (HF). We aimed to analyze whether differences in composite measur...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.596240

    authors: Wagner J,Knaier R,Königstein K,Klenk C,Carrard J,Lichtenstein E,Scharnagl H,März W,Hanssen H,Hinrichs T,Schmidt-Trucksäss A,Arbeev K

    更新日期:2020-12-15 00:00:00

  • Effects of Apelin on Cardiovascular Aging.

    abstract::Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin-APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with high morbidity in ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.01035

    authors: Zhou Y,Wang Y,Qiao S,Yin L

    更新日期:2017-12-12 00:00:00

  • SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress.

    abstract::Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury. In endothelial cells, mitochondria regulate these inflammatory pathways ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2020.605908

    authors: Chang R,Mamun A,Dominic A,Le NT

    更新日期:2021-01-15 00:00:00

  • Viral Delivery of dsRNA for Control of Insect Agricultural Pests and Vectors of Human Disease: Prospects and Challenges.

    abstract::RNAi is applied as a new and safe method for pest control in agriculture but efficiency and specificity of delivery of dsRNA trigger remains a critical issue. Various agents have been proposed to augment dsRNA delivery, such as engineered micro-organisms and synthetic nanoparticles, but the use of viruses has received...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.00399

    authors: Kolliopoulou A,Taning CNT,Smagghe G,Swevers L

    更新日期:2017-06-14 00:00:00

  • Advanced Maternal Age Worsens Postpartum Vascular Function.

    abstract::The age at which women experience their first pregnancy has increased throughout the decades. Pregnancy has an important influence on maternal short- and long-term cardiovascular outcomes. Pregnancy at an advanced maternal age increases maternal risk of gestational diabetes, preeclampsia, placenta previa and caesarian...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00465

    authors: Morton JS,Care AS,Kirschenman R,Cooke CL,Davidge ST

    更新日期:2017-06-30 00:00:00

  • Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application?

    abstract::Optogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to electrical stimulation. In addition, cardiomyocyte-specific expres...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.00675

    authors: Sasse P,Funken M,Beiert T,Bruegmann T

    更新日期:2019-06-06 00:00:00

  • Recent advances in the involvement of long non-coding RNAs in neural stem cell biology and brain pathophysiology.

    abstract::Exploration of non-coding genome has recently uncovered a growing list of formerly unknown regulatory long non-coding RNAs (lncRNAs) with important functions in stem cell pluripotency, development and homeostasis of several tissues. Although thousands of lncRNAs are expressed in mammalian brain in a highly patterned m...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00155

    authors: Antoniou D,Stergiopoulos A,Politis PK

    更新日期:2014-04-22 00:00:00

  • Effects of Fungicide Propiconazole on the Yeast-Like Symbiotes in Brown Planthopper (BPH, Nilaparvata lugens Stål) and Its Role in Controlling BPH Infestation.

    abstract::Yeast-like symbiotes (YLS), harbored in the abdomen fat-body cells of the rice brown planthopper (BPH), Nilaparvata lugens Stål (Hemiptera: Delphacidae), are vital to the growth and reproduction of their host. It is feasible to manipulate BPH infestation on rice by inhibiting YLS using fungicide. In this study, the fu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00089

    authors: Shentu X,Wang X,Xiao Y,Yu X

    更新日期:2019-02-11 00:00:00

  • The Averaged EMGs Recorded from the Arm Muscles During Bimanual "Rowing" Movements.

    abstract::The main purpose was to analyze quantitatively the the average surface EMGs of the muscles that function around the elbow and shoulder joints of both arms in bimanual "rowing" movements, which were produced under identical elastic loads applied to the levers ("oars"). The muscles of PM group ("pulling" muscles: elbow ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2015.00349

    authors: Tomiak T,Gorkovenko AV,Tal'nov AN,Abramovych TI,Mishchenko VS,Vereshchaka IV,Kostyukov AI

    更新日期:2015-11-27 00:00:00

  • Odorant Receptors and Odorant-Binding Proteins as Insect Pest Control Targets: A Comparative Analysis.

    abstract::Recently, two alternative targets in insect periphery nerve system have been explored for environmentally-friendly approaches in insect pest management, namely odorant-binding proteins (OBPs) and odorant receptors (ORs). Located in insect antennae, OBPs are thought to be involved in the transport of odorants to ORs fo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.01163

    authors: Venthur H,Zhou JJ

    更新日期:2018-08-24 00:00:00

  • Sex-Specific Impact of Ischemic Preconditioning on Tissue Oxygenation and Maximal Concentric Force.

    abstract::Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs be...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00674

    authors: Paradis-Deschênes P,Joanisse DR,Billaut F

    更新日期:2017-01-05 00:00:00

  • Photodynamic Physiology-Photonanomanipulations in Cellular Physiology with Protein Photosensitizers.

    abstract::Singlet oxygen generated in a type II photodynamic action, due to its limited lifetime (1 μs) and reactive distance (<10 nm), could regulate live cell function nanoscopically. The genetically-encoded protein photosensitizers (engineered fluorescent proteins such as KillerRed, TagRFP, and flavin-binding proteins such a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.00191

    authors: Jiang HN,Li Y,Cui ZJ

    更新日期:2017-04-04 00:00:00

  • Effects of Hypoxia on Erythrocyte Membrane Properties-Implications for Intravascular Hemolysis and Purinergic Control of Blood Flow.

    abstract::Intravascular hemolysis occurs in hereditary, acquired, and iatrogenic hemolytic conditions but it could be also a normal physiological process contributing to intercellular signaling. New evidence suggests that intravascular hemolysis and the associated release of adenosine triphosphate (ATP) may be an important mech...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.01110

    authors: Grygorczyk R,Orlov SN

    更新日期:2017-12-22 00:00:00

  • Compliant Titin Isoform Content Is Reduced in Left Ventricles of Sedentary Versus Active Rats.

    abstract::A sedentary lifestyle is associated with increased cardiovascular risk factors and reduced cardiac compliance when compared to a lifestyle that includes exercise training. Exercise training increases cardiac compliance in humans, but the mechanisms underlying this improvement are unknown. A major determinant of cardia...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00015

    authors: Chung CS,Hiske MA,Chadha A,Mueller PJ

    更新日期:2020-02-05 00:00:00

  • Social interactions affecting caste development through physiological actions in termites.

    abstract::A colony of social insects is not only an aggregation of individuals but also a functional unit. To achieve adaptive social behavior in fluctuating environmental conditions, in addition to coordination of physiological status in each individual, the whole colony is coordinated by interactions among colony members. The...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00127

    authors: Watanabe D,Gotoh H,Miura T,Maekawa K

    更新日期:2014-04-09 00:00:00

  • Assessing the Temporal Organization of Walking Variability: A Systematic Review and Consensus Guidelines on Detrended Fluctuation Analysis.

    abstract::Human physiological signals are inherently rhythmic and have a hallmark feature in that even distant intrasignal measurements are related to each other. This relationship is termed long-range correlation and has been recognized as an indicator of the optimal state of the observed physiological systems, among which the...

    journal_title:Frontiers in physiology

    pub_type:

    doi:10.3389/fphys.2020.00562

    authors: Ravi DK,Marmelat V,Taylor WR,Newell KM,Stergiou N,Singh NB

    更新日期:2020-06-23 00:00:00

  • Modulation of Ion Channels in the Superior Cervical Ganglion Neurons by Myocardial Ischemia and Fluvastatin Treatment.

    abstract::Background: The superior cervical ganglion (SCG) of the autonomic nervous system plays an important role in different cardiovascular diseases. In this study, we investigated the effects of ischemia and fluvastatin treatment on the ion channel characteristics of SCG neurons in a rabbit myocardial ischemia (MI) model. M...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01157

    authors: Cheng L,Wang X,Liu T,Tse G,Fu H,Li G

    更新日期:2018-09-10 00:00:00

  • A unified point process probabilistic framework to assess heartbeat dynamics and autonomic cardiovascular control.

    abstract::In recent years, time-varying inhomogeneous point process models have been introduced for assessment of instantaneous heartbeat dynamics as well as specific cardiovascular control mechanisms and hemodynamics. Assessment of the model's statistics is established through the Wiener-Volterra theory and a multivariate auto...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00004

    authors: Chen Z,Purdon PL,Brown EN,Barbieri R

    更新日期:2012-02-01 00:00:00

  • Fractional Stability of Trunk Acceleration Dynamics of Daily-Life Walking: Toward a Unified Concept of Gait Stability.

    abstract::Over the last decades, various measures have been introduced to assess stability during walking. All of these measures assume that gait stability may be equated with exponential stability, where dynamic stability is quantified by a Floquet multiplier or Lyapunov exponent. These specific constructs of dynamic stability...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00516

    authors: Ihlen EAF,van Schooten KS,Bruijn SM,Pijnappels M,van Dieën JH

    更新日期:2017-08-29 00:00:00

  • Clinical Applications of Iso-Inertial, Eccentric-Overload (YoYo™) Resistance Exercise.

    abstract::In the quest for a viable non-gravity dependent method to "lift weights" in space, our laboratory introduced iso-inertial resistance (YoYo™) exercise using spinning flywheel(s), more than 25 years ago. After being thoroughly tested in individuals subjected to various established spaceflight analogs, a multi-mode YoYo™...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.00241

    authors: Tesch PA,Fernandez-Gonzalo R,Lundberg TR

    更新日期:2017-04-27 00:00:00

  • Have we missed that neural vasodilator mechanisms may contribute to exercise hyperemia at onset of voluntary exercise?

    abstract::Whether neurally-mediated vasodilatation may contribute to exercise hyperemia has not been completely understood. Bülbring and Burn (1935) found for the first time the existence of sympathetic cholinergic nerve to skeletal muscle contributing to vasodilatation in animals. Blair et al. (1959) reported that atropine-sen...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00023

    authors: Matsukawa K,Ishii K,Liang N,Endo K

    更新日期:2013-02-15 00:00:00

  • High Glucose Aggravates Cholesterol Accumulation in Glomerular Endothelial Cells Through the LXRs/LncRNAOR13C9/ABCA1 Regulatory Network.

    abstract:Background:The underlying mechanisms by which diabetes and dyslipidemia contribute to diabetic nephropathy (DN) are not fully understood. In this study, we aimed to investigate the role of high glucose (HG) on intracellular cholesterol accumulation in glomerular endothelial cells (GEnCs) and its potential mechanism. M...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.552483

    authors: Wang Y,Xiao S,Zhou S,Zhang R,Liu H,Lin Y,Yu P

    更新日期:2020-10-19 00:00:00