Exercise, Obesity and CNS Control of Metabolic Homeostasis: A Review.

abstract：:Recently, we reported that Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats exhibit dyslipidemia and renal lipid accumulation independent of hyperglycemia that progresses to chronic kidney disease (CKD). Therefore, in the current study, we examined the effects of gemfibrozil, a lipid-lowering drug (200 m...

journal_title：Frontiers in physiology

authors： Shields CA,Poudel B,McPherson KC,Brown AK,Ekperikpe US,Browning E,Sutton L,Cornelius DC,Williams JM

更新日期：2020-09-18 00:00:00

abstract：:The importance of electrolyte concentrations for cardiac function is well established. Electrolyte variations can lead to arrhythmias onset, due to their important role in the action potential (AP) genesis and in maintaining cell homeostasis. However, most of the human AP computer models available in literature were d...

journal_title：Frontiers in physiology

authors： Bartolucci C,Passini E,Hyttinen J,Paci M,Severi S

更新日期：2020-04-15 00:00:00

abstract：Background:Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the a...

journal_title：Frontiers in physiology

authors： Bokov P,El Jurdi H,Denjoy I,Peiffer C,Medjahdi N,Holvoet L,Benkerrou M,Delclaux C

更新日期：2020-02-26 00:00:00

abstract：:The grand challenge to physiology, as was first described in an essay published in the inaugural issue of Frontiers in Physiology in 2010, remains to integrate function from molecules to intact organisms. In order to make sense of the vast volume of information derived from, and increasingly dependent upon, reductioni...

journal_title：Frontiers in physiology

authors： Billman GE

更新日期：2020-03-10 00:00:00

abstract：:The microbial community of the gut conveys significant benefits to host physiology. A clear relationship has now been established between gut bacteria and host metabolism in which microbial-mediated gut hormone release plays an important role. Within the gut lumen, bacteria produce a number of metabolites and contain ...

journal_title：Frontiers in physiology

authors： Martin AM,Sun EW,Rogers GB,Keating DJ

更新日期：2019-04-16 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is characterized by rapid wasting of skeletal muscle. Mitochondrial dysfunction is a well-known pathological feature of DMD. However, whether mitochondrial dysfunction occurs before muscle fiber damage in DMD pathology is not well known. Furthermore, the impact upon heterozygous femal...

journal_title：Frontiers in physiology

authors： Moore TM,Lin AJ,Strumwasser AR,Cory K,Whitney K,Ho T,Ho T,Lee JL,Rucker DH,Nguyen CQ,Yackly A,Mahata SK,Wanagat J,Stiles L,Turcotte LP,Crosbie RH,Zhou Z

更新日期：2020-06-19 00:00:00

abstract：:Anatomical evidence in several species shows highly heterogeneous fat distribution in the atrial and ventricular myocardium. Atrial appendages have fat deposits, and more so on the posterior left atrium. Although such fat distributions are considered normal, fatty infiltration is regarded arrhythmogenic, and various c...

journal_title：Frontiers in physiology

authors： Anumonwo JMB,Herron T

更新日期：2018-01-22 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) refers to the conversion of epithelial cells to mesenchymal phenotype, which endows the epithelial cells with enhanced migration, invasion, and extracellular matrix production abilities. These characteristics link EMT with the pathogenesis of organ fibrosis and cancer progressio...

journal_title：Frontiers in physiology

authors： Xu Z,Ding W,Deng X

更新日期：2019-11-29 00:00:00

abstract：:In the mammalian ear, transduction of sound stimuli is initiated by K+ entry through mechano-sensitive channels into inner hair cells. K+ entry is driven by a positive endocochlear potential that is maintained by the marginal cell layer of the stria vascularis. This process requires basolateral K+ import by NKCC1 Na+-...

journal_title：Frontiers in physiology

authors： Tan H,Bungert-Plümke S,Fahlke C,Stölting G

更新日期：2017-05-15 00:00:00

abstract：:Exogenous dsRNA enters the insect body and can induce the RNAi effect only when it is cleaved into siRNA. However, what kinds of base composition are easier to cut and what kinds of siRNA will be produced in vivo is largely unknown. In this study, we found that dsRNA processing into siRNA has sequence preference and r...

journal_title：Frontiers in physiology

authors： Guan R,Hu S,Li H,Shi Z,Miao X

更新日期：2018-12-10 00:00:00

abstract：:Glucagon counterregulation (GCR) protects against hypoglycemia, but is impaired in type 1 diabetes (T1DM). A model-based analysis of in vivo animal data predicts that the GCR defects are linked to basal hyperglucagonemia. To test this hypothesis we studied the relationship between basal glucagon (BasG) and the GCR res...

journal_title：Frontiers in physiology

authors： Farhy LS,Chan A,Breton MD,Anderson SM,Kovatchev BP,McCall AL

更新日期：2012-02-28 00:00:00

abstract：:Basketball is a team sport, where fundamental skills - fundamentals - are key determinants for success. Jump-shot (JS) is a basketball fundamental used frequently during game. It is interesting to spread light on the relationship between effort intensity and JS ability. Study aim was to investigate different heart rat...

journal_title：Frontiers in physiology

authors： Padulo J,Nikolaidis PT,Cular D,Dello Iacono A,Vando S,Galasso M,Lo Storto D,Ardigò LP

更新日期：2018-08-03 00:00:00

abstract：:Antibiotic resistance is a major issue in animal industries and antibiotic-free alternatives are needed to treat infectious diseases and improve performance of pigs. Plant extracts have been suggested as a potential solution. The present study was conducted to investigate the effects of Astragalus polysaccharides (Aps...

journal_title：Frontiers in physiology

authors： Yang CM,Han QJ,Wang KL,Xu YL,Lan JH,Cao GT

更新日期：2019-04-12 00:00:00

abstract：:Gravity has remained constant during animal evolution and the neural sensory systems detecting acceleration forces have remained remarkably conserved among vertebrates. The utricular organ senses the sum of inertial force due to head translation and head tilt relative to gravitational vertical. Change in gravitational...

journal_title：Frontiers in physiology

authors： Boyle R,Popova Y,Varelas J

更新日期：2018-10-22 00:00:00

abstract：:The goal here is to describe our current understanding of heme metabolism and the deleterious effects of "free" heme on immunological processes, endothelial function, systemic inflammation, and various end-organ tissues (e.g., kidney, lung, liver, etc.), with particular attention paid to the role of hemopexin (HPX). B...

journal_title：Frontiers in physiology

authors： Smith A,McCulloh RJ

更新日期：2015-06-30 00:00:00

abstract：:Background: In an aging population, regular physical activity (PA) and exercise have been recognized as important factors in maintaining physical function and thereby preventing loss of independence and disability. However, (older) adults spent the majority of their day sedentary and therefore insight into the consequ...

journal_title：Frontiers in physiology

authors： van der Velde JHPM,Savelberg HHCM,van der Berg JD,Sep SJS,van der Kallen CJH,Dagnelie PC,Schram MT,Henry RMA,Reijven PLM,van Geel TACM,Stehouwer CDA,Koster A,Schaper NC

更新日期：2017-04-25 00:00:00

abstract：:Local purinergic signals modulate renal tubular transport. Acute activation of renal epithelial P2 receptors causes inhibition of epithelial transport and thus, should favor increased water and salt excretion by the kidney. So far only a few studies have addressed the effects of extracellular nucleotides on ion transp...

journal_title：Frontiers in physiology

authors： Marques RD,Praetorius HA,Leipziger J

更新日期：2013-10-09 00:00:00

abstract：:The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in a patient-specific environment. Given the recent advances in medical imaging, computational power and mathematical algorithms, patient-specific cardiac models ...

journal_title：Frontiers in physiology

authors： Zhong L,Zhang JM,Su B,Tan RS,Allen JC,Kassab GS

更新日期：2018-06-26 00:00:00

abstract：:Cryptochromes (CRYs) are flavoproteins that are sensitive to blue light, first identified in Arabidopsis and then in Drosophila and mice. They are evolutionarily conserved and play fundamental roles in the circadian clock of living organisms, enabling them to adapt to the daily 24-h cycles. The role of CRYs in circadi...

journal_title：Frontiers in physiology

authors： Damulewicz M,Mazzotta GM

更新日期：2020-03-05 00:00:00

abstract：:Background and Objective: It is widely accepted that there is an association between chronic obstructive pulmonary disease (COPD) and periodontitis. However, whether the periodontal status of the COPD patients is worse than that of the non-COPD subjects is seldom assessed. The findings currently available are inconsis...

journal_title：Frontiers in physiology

authors： Shi Q,Zhang B,Xing H,Yang S,Xu J,Liu H

更新日期：2018-01-25 00:00:00

abstract：:In juvenile rats, the carotid body (CB) is the primary sensor of oxygen (O2) and a secondary sensor of carbon dioxide (CO2) in the blood. The CB communicates to the respiratory pattern generator via the carotid sinus nerve, which terminates within the commissural nucleus tractus solitarius (cNTS). While this is not th...

journal_title：Frontiers in physiology

authors： Getsy PM,Coffee GA,Lewis SJ

更新日期：2020-12-17 00:00:00

abstract：:Heart failure and frailty are clinical syndromes that present with overlapping phenotypic characteristics. Importantly, their co-presence is associated with increased mortality and morbidity. While mechanical and electrical device therapies for heart failure are vital for select patients with advanced stage disease, t...

journal_title：Frontiers in physiology

authors： Fung E,Hui E,Yang X,Lui LT,Cheng KF,Li Q,Fan Y,Sahota DS,Ma BHM,Lee JSW,Lee APW,Woo J

更新日期：2018-04-24 00:00:00

abstract：:Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence ratio. Traditional therapeutic approaches such as surgery in combination with chemo- or radiotherapy have had limited efficacy in improving the outcome of this disease. Up until just under a decade ago, the prominent desmoplast...

journal_title：Frontiers in physiology

authors： Wilson JS,Pirola RC,Apte MV

更新日期：2014-02-14 00:00:00

abstract：:Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy metabolism is unclear. The aim of the present study was to inves...

journal_title：Frontiers in physiology

authors： Lavoie S,Steullet P,Kulak A,Preitner F,Do KQ,Magistretti PJ

更新日期：2016-04-21 00:00:00

abstract：:To understand dynamic changes in polyamines (PAs) forms and components of polyamine metabolism in zoysiagrass (Zoysia japonica Steud.) response to salt stress with exogenous spermidine (Spd) application, two Chinese zoysia cultivars, z081 and z057, were exposed to sodium chloride stress for 2, 4, 6, and 8 days. The z0...

journal_title：Frontiers in physiology

authors： Li S,Cui L,Zhang Y,Wang Y,Mao P

更新日期：2017-04-06 00:00:00

abstract：:Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized medicine. Computational models can be used to interpret experimental findings in iPSC-CMs, provide mechanistic insights, and translate these findings to adult cardi...

journal_title：Frontiers in physiology

authors： Lei CL,Wang K,Clerx M,Johnstone RH,Hortigon-Vinagre MP,Zamora V,Allan A,Smith GL,Gavaghan DJ,Mirams GR,Polonchuk L

更新日期：2017-12-12 00:00:00

abstract：:Background: Chronic infection with HBV (CHB) or HCV (CHC) is the most common chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma in humans, their infections have distinct pathogenic processes, however, little is known about the difference of glycoprotein glycopatterns in serum between hepat...

journal_title：Frontiers in physiology

authors： Qin X,Guo Y,Du H,Zhong Y,Zhang J,Li X,Yu H,Zhang Z,Jia Z,Li Z

更新日期：2017-08-21 00:00:00

abstract：:Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, are chronic inflammatory disorders that can affect the whole gastrointestinal tract or the colonic mucosal layer. Current therapies aiming to suppress the exaggerated immune response in IBD largely rely on compounds with non-satis...

journal_title：Frontiers in physiology

authors： Schreiber D,Marx L,Felix S,Clasohm J,Weyland M,Schäfer M,Klotz M,Lilischkis R,Erkel G,Schäfer KH

更新日期：2017-08-07 00:00:00

abstract：:Previous studies assessing effect of ischemia on ventricular repolarization are mostly directed toward patients with coronary artery disease (CAD); however, similar reports on cardiac syndrome X (CSX) are scarce. Whether microvascular dysfunction of CSX and ischemia induced by CAD produce comparable effect on ventricu...

journal_title：Frontiers in physiology

authors： Lutfi MF

更新日期：2016-09-21 00:00:00

abstract：:Eryptosis is the suicidal destruction-process of erythrocytes, much like apoptosis of nucleated cells, in the course of which the stressed red cell undergoes cell-shrinkage, vesiculation and externalization of membrane phosphatidylserine. Currently, there exist numerous methods to detect eryptosis, both morphometrical...

journal_title：Frontiers in physiology

authors： Jacob SS,Prasad K,Rao P,Kamath A,Hegde RB,Baby PM,Rao RK

更新日期：2019-09-24 00:00:00