Dynamical Analysis of the Regulatory Network Controlling Natural Killer Cells Differentiation.

abstract：:F1F0-ATP synthase inhibitory factor 1 (IF1) inhibits the reverse mode of F1F0-ATP synthase, and therefore protects cellular ATP content at the expense of accelerated loss of mitochondrial membrane potential (ΔΨm). There is considerable variability in IF1 expression and its influence on bioenergetics between different ...

journal_title：Frontiers in physiology

authors： Tanton H,Voronina S,Evans A,Armstrong J,Sutton R,Criddle DN,Haynes L,Schmid MC,Campbell F,Costello E,Tepikin AV

更新日期：2018-07-11 00:00:00

abstract：:Pancreatic cancer is one of the deadliest human malignancies and little progress has been achieved in its treatment over the past decades. Advances in our understanding of the biology of this disease provide new potential opportunities for treatment. Pancreatic cancer is preceded by precursor lesions, the most common ...

journal_title：Frontiers in physiology

authors： Collins MA,Pasca di Magliano M

更新日期：2014-01-21 00:00:00

abstract：:Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, influencing multiple physiological processes. Among its many roles in insects are the initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory effects of OA on the components of the locust stomatogastric nervous s...

journal_title：Frontiers in physiology

authors： Rand D,Knebel D,Ayali A

更新日期：2012-07-20 00:00:00

abstract：:Skeletal muscle mass reflects a dynamic turnover between net protein synthesis and degradation. In addition, satellite cell inclusion may contribute to increase muscle mass while fiber loss results in a reduction of muscle mass. Since 2010, a few studies looked at the involvement of the newly discovered Hippo pathway ...

journal_title：Frontiers in physiology

authors： Gnimassou O,Francaux M,Deldicque L

更新日期：2017-03-29 00:00:00

abstract：:The physiological mechanisms related to cardio-vascular (CV), cardio-pulmonary (CP), and vasculo-pulmonary (VP) regulation may be probed through multivariate time series analysis tools. This study applied an information domain approach for the evaluation of non-linear causality to the beat-to-beat variability series o...

journal_title：Frontiers in physiology

authors： Faes L,Nollo G,Porta A

更新日期：2011-11-07 00:00:00

abstract：OBJECTIVES:The dynamic interaction between blood pressure (BP) and cerebral blood flow velocity (CBFV) is not fully understood, especially for CBFV changes lasting longer than 50 s. The interaction between BP and CBFV is relatively well characterized for periods <50 s using transfer function (TF) estimations of phase, ...

journal_title：Frontiers in physiology

authors： Müller MW,Osterreich M

更新日期：2014-08-26 00:00:00

abstract：:Bioenergetic profiling of cancer cells is of great potential because it can bring forward new and effective therapeutic strategies along with early diagnosis. Metabolic Control Analysis (MCA) is a methodology that enables quantification of the flux control exerted by different enzymatic steps in a metabolic network th...

journal_title：Frontiers in physiology

authors： Kaambre T,Chekulayev V,Shevchuk I,Tepp K,Timohhina N,Varikmaa M,Bagur R,Klepinin A,Anmann T,Koit A,Kaldma A,Guzun R,Valvere V,Saks V

更新日期：2013-06-28 00:00:00

abstract：:Gravity has remained constant during animal evolution and the neural sensory systems detecting acceleration forces have remained remarkably conserved among vertebrates. The utricular organ senses the sum of inertial force due to head translation and head tilt relative to gravitational vertical. Change in gravitational...

journal_title：Frontiers in physiology

authors： Boyle R,Popova Y,Varelas J

更新日期：2018-10-22 00:00:00

abstract：Background:Interleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise. We recently showed that an acute increase in IL-6 delayed gastric emptying rate and improved postprandial glycemia. Here we investigate whether r...

journal_title：Frontiers in physiology

authors： Lehrskov LL,Christensen RH,Wedell-Neergaard AS,Legaard GE,Dorph E,Larsen MK,Henneberg M,Launbo N,Fagerlind SR,Seide SK,Nymand S,Ball M,Vinum N,Dahl C,Wewer Albrechtsen NJ,Holst JJ,Ried-Larsen M,Rosenmeier JB,Krogh-Mad

更新日期：2019-10-04 00:00:00

abstract：:Atherosclerosis is the leading cause of death worldwide. Over the past two decades, it has been clearly recognized that atherosclerosis is an inflammatory disease of the arterial wall. Accumulating data from animal experiments have supported this hypothesis, however, clinical applications making use of this knowledge ...

journal_title：Frontiers in physiology

authors： Linden F,Domschke G,Erbel C,Akhavanpoor M,Katus HA,Gleissner CA

更新日期：2014-11-21 00:00:00

abstract：:Purpose: Blood biomarkers are a useful tool to study concussion. However, their interpretation is complicated by a number of potential biological confounds, including exercise. This is particularly relevant in military and athletic settings where injury commonly occurs during physical exertion. The impact of high-inte...

journal_title：Frontiers in physiology

authors： Di Battista AP,Moes KA,Shiu MY,Hutchison MG,Churchill N,Thomas SG,Rhind SG

更新日期：2018-09-28 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a "disease of the sarcomere." Despite the discovery of sarcomere protein mutations linked to HCM almost 30 years ago, the cellular mechanisms responsible for the deve...

journal_title：Frontiers in physiology

authors： Chowdhury SAK,Warren CM,Simon JN,Ryba DM,Batra A,Varga P,Kranias EG,Tardiff JC,Solaro RJ,Wolska BM

更新日期：2020-03-10 00:00:00

abstract：:Co-expressed genes often share similar functions, and gene co-expression networks have been widely used in studying the functionality of gene modules. Previous analysis indicated that genes are more likely to be co-expressed if they are either regulated by the same transcription factors, forming protein complexes or s...

journal_title：Frontiers in physiology

authors： Zhang C,Lee S,Mardinoglu A,Hua Q

更新日期：2016-05-02 00:00:00

abstract：:The development of durable ventricular assist devices (VADs) has improved mortality rates and quality of life in patients with end stage heart failure. While the use of VADs has increased dramatically in recent years, there is limited experience with VAD implantation in patients with complex congenital heart disease (...

journal_title：Frontiers in physiology

authors： Villa CR,Morales DLS

更新日期：2017-05-09 00:00:00

abstract：:Hypoxia has important effects on biological activity in crustaceans, and modulation of energy metabolism is a crucial aspect of crustaceans' ability to respond to hypoxia. The adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) enzyme is very important in cellular energy homeostasis; however, little infor...

journal_title：Frontiers in physiology

authors： Sun S,Gu Z,Fu H,Zhu J,Ge X,Wu X

更新日期：2018-06-14 00:00:00

abstract：:Neural crest (NC) cells are multipotent embryonic cells that form melanocytes, craniofacial bone and cartilage, and the peripheral nervous system in vertebrates. NC cells express many cadherin proteins, which control their specification, epithelial to mesenchymal transition (EMT), migration, and mesenchymal to epithel...

journal_title：Frontiers in physiology

authors： Manohar S,Camacho-Magallanes A,Echeverria C Jr,Rogers CD

更新日期：2020-10-30 00:00:00

abstract：:Recent efforts to ensure the reliability of computational model-based predictions in healthcare, such as the ASME V&V40 Standard, emphasize the importance of uncertainty quantification (UQ) and sensitivity analysis (SA) when evaluating computational models. UQ involves empirically determining the uncertainty in model ...

journal_title：Frontiers in physiology

authors： Pathmanathan P,Cordeiro JM,Gray RA

更新日期：2019-06-26 00:00:00

abstract：Purpose:The aim of this study was to verify whether physiological components [vertical jumps (Squat Jump - SJ and Countermovement Jump - CMJ), eccentric utilization ratio (EUR) of vertical jumps, running economy (RE), metabolic cost (C MET ), first and second ventilatory th...

journal_title：Frontiers in physiology

authors： Lanferdini FJ,Silva ES,Machado E,Fischer G,Peyré-Tartaruga LA

更新日期：2020-08-05 00:00:00

abstract：:Adipokinetic hormones (AKHs) are well known to mobilize lipids and carbohydrates for energy-consuming activities in insects. These neuropeptides exert their functions by interacting with AKH receptors (AKHRs) located on the plasma membrane of fat body cells, which regulates energy mobilization by stimulating lipolysis...

journal_title：Frontiers in physiology

authors： Lu K,Wang Y,Chen X,Zhang X,Li W,Cheng Y,Li Y,Zhou J,You K,Song Y,Zhou Q,Zeng R

更新日期：2019-01-08 00:00:00

abstract：:Introduction: It is well known that regular physical activity improves cardiovascular health, and higher baroreflex sensitivity and heart rate variability are associated with cardiovascular health. Adolescence is the age when an individual's behavior is easily modified; early intervention at this stage in terms of phy...

journal_title：Frontiers in physiology

authors： Subramanian SK,Sharma VK,Arunachalam V,Rajendran R,Gaur A

更新日期：2019-08-22 00:00:00

abstract：:In the mammalian ear, transduction of sound stimuli is initiated by K+ entry through mechano-sensitive channels into inner hair cells. K+ entry is driven by a positive endocochlear potential that is maintained by the marginal cell layer of the stria vascularis. This process requires basolateral K+ import by NKCC1 Na+-...

journal_title：Frontiers in physiology

authors： Tan H,Bungert-Plümke S,Fahlke C,Stölting G

更新日期：2017-05-15 00:00:00

abstract：:Background: Dental aberrations have been mentioned in relation to non-surgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP). However, a systematic review of dental characteristics have not been performed. The present systematic review describes the dental findings in patients with Ns-HypoPT and PH...

journal_title：Frontiers in physiology

authors： Hejlesen J,Underbjerg L,Gjørup H,Bloch-Zupan A,Sikjaer T,Rejnmark L,Haubek D

更新日期：2018-06-19 00:00:00

abstract：INTRODUCTION:Recently, three independent, intercorrelated biophysical measures have provided the first quantitative measures of a binary form of behavioral laterality called "Hemisity," a term referring to inherent opposite right or left brain-oriented differences in thinking and behavioral styles. Crucially, the right...

journal_title：Frontiers in physiology

authors： Morton BE

更新日期：2012-11-02 00:00:00

abstract：:The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications. The current study sought to investigate the antihypertensive effect of a newly synthesized pyrazole derivative ...

journal_title：Frontiers in physiology

authors： Trindade NR,Lopes PR,Naves LM,Fajemiroye JO,Alves PH,Amaral NO,Lião LM,Rebelo ACS,Castro CH,Braga VA,Menegatti R,Pedrino GR

更新日期：2018-08-07 00:00:00

abstract：:One of the key defining features of an endogenous circadian clock is that it can be entrained or set to local time. Though a number of cues can perform this role, light is the predominant environmental signal that acts to entrain circadian pacemakers in most species. For the past 20 years, a great deal of work has bee...

journal_title：Frontiers in physiology

authors： Steindal IAF,Whitmore D

更新日期：2020-08-14 00:00:00

abstract：:Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), and spinal-bulbar muscular atrophy (SBMA) are devastating diseases characterized by the degeneration of motor neurons. Although the molecular causes underlying these diseases differ, recent findings have highlighted the contribution of intrinsic skele...

journal_title：Frontiers in physiology

authors： Boyer JG,Ferrier A,Kothary R

更新日期：2013-12-18 00:00:00

abstract：Background:Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant hypertension, SHR kidneys remain relatively free of pathology due to having an augmented myogenic constriction (MC). We h...

journal_title：Frontiers in physiology

authors： Nademi S,Lu C,Dickhout JG

更新日期：2020-07-22 00:00:00

abstract：Introduction:MTHFR methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown. Objective:The aim of this study was to evaluate the influence of physical activity level and nutritional status on the methylation profile of the MTHFR gene in pati...

journal_title：Frontiers in physiology

authors： Diniz TG,Silva AS,Dos Santos Nunes MK,Ribeiro MD,Filho JM,do Nascimento RAF,Gomes CNAP,Evangelista IWQ,de Oliveira NFP,Persuhn DC

更新日期：2021-01-12 00:00:00

abstract：:Background: Skeletal muscle aging is marked by the development of a sarcopenic phenotype, a global decline of muscle energetic capacities, and an intolerance to exercise. Among the metabolic disorders involved in this syndrome, NAD metabolism was shown to be altered in skeletalmuscle, with an important role for the NA...

journal_title：Frontiers in physiology

authors： Deloux R,Tannous C,Ferry A,Li Z,Mericskay M

更新日期：2018-09-19 00:00:00

abstract：:The aim of this study was to analyze the relationship between alveolar bone deformation and β-catenin expression levels in response to the mechanical load changed by dental extraction in adult rats. Twenty-four male rats (Rattus norvegicus albinus), Wistar linage, at 2 months of age, were used. The right upper incisor...

journal_title：Frontiers in physiology

authors： Ferreira BC,Freire AR,Araujo R,do Amaral-Silva GK,Okamoto R,Prado FB,Rossi AC

更新日期：2020-06-05 00:00:00