More than a bystander: the contributions of intrinsic skeletal muscle defects in motor neuron diseases.

abstract：:Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAII and aquaporin-1 are expressed in the thin descending limb (TDL); however, the ...

journal_title：Frontiers in physiology

authors： Krishnan D,Pan W,Beggs MR,Trepiccione F,Chambrey R,Eladari D,Cordat E,Dimke H,Alexander RT

更新日期：2018-01-05 00:00:00

abstract：:We describe a new nonlinear dynamic model of insect phototransduction using a NLN (nonlinear, linear, nonlinear) block structure. The first nonlinear stage provides a single exponential decline in gain and mean following the start of light stimulation. The linear stage uses a two-parameter log-normal convolution model...

journal_title：Frontiers in physiology

authors： French AS,Immonen EV,Frolov RV

更新日期：2016-10-25 00:00:00

abstract：:Skeletal muscle makes up approximately 40% of the total body mass, providing structural support and enabling the body to maintain posture, to control motor movements and to store energy. It therefore plays a vital role in whole body metabolism. Skeletal muscle displays remarkable plasticity and is able to alter its si...

journal_title：Frontiers in physiology

authors： Zacharewicz E,Lamon S,Russell AP

更新日期：2013-09-30 00:00:00

abstract：:Nowadays, the common octopus (Octopus vulgaris) culture is hampered by massive mortalities occurring during early life-cycle stages (paralarvae). Despite the causes of the high paralarvae mortality are not yet well-defined and understood, the nutritional stress caused by inadequate diets is pointed out as one of the m...

journal_title：Frontiers in physiology

authors： Varó I,Cardenete G,Hontoria F,Monroig Ó,Iglesias J,Otero JJ,Almansa E,Navarro JC

更新日期：2017-05-17 00:00:00

abstract：:Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized medicine. Computational models can be used to interpret experimental findings in iPSC-CMs, provide mechanistic insights, and translate these findings to adult cardi...

journal_title：Frontiers in physiology

authors： Lei CL,Wang K,Clerx M,Johnstone RH,Hortigon-Vinagre MP,Zamora V,Allan A,Smith GL,Gavaghan DJ,Mirams GR,Polonchuk L

更新日期：2017-12-12 00:00:00

abstract：:Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors by sensing and inter...

journal_title：Frontiers in physiology

authors： Kurtz R,Steinberg LG,Betcher M,Fowler D,Shepard BD

更新日期：2020-10-06 00:00:00

abstract：:The mouse is one of the most important model organisms for understanding human genetic function and disease. This includes characterization of the factors that influence energy expenditure and dysregulation of energy balance leading to obesity and its sequelae. Measuring energy metabolism in the mouse presents a chall...

journal_title：Frontiers in physiology

authors： Speakman JR

更新日期：2013-03-14 00:00:00

abstract：:The ketogenic diet (KD) has been utilized as a dietary therapeutic for nearly a century. One experimental model particularly responsive to the KD is the BTBRT+tf/j (BTBR) mouse, which displays phenotypic characteristics of autism spectrum disorder (ASD) and insulin resistance. Recently, the study of impaired mitochond...

journal_title：Frontiers in physiology

authors： Newell C,Shutt TE,Ahn Y,Hittel DS,Khan A,Rho JM,Shearer J

更新日期：2016-12-27 00:00:00

abstract：:Purpose: To determine if acute slow breathing at 6 breaths/min would improve baroreflex sensitivity (BRS) and heart rate variability (HRV), and lower blood pressure (BP) in adults after stroke. Methods: Twelve individuals completed two randomized study visits where they performed a 15-min bout of breathing exercises a...

journal_title：Frontiers in physiology

authors： Larson M,Chantigian DP,Asirvatham-Jeyaraj N,Van de Winckel A,Keller-Ross ML

更新日期：2020-10-30 00:00:00

abstract：:Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from th...

journal_title：Frontiers in physiology

authors： Zhai C,Li R,Hou K,Chen J,Alzogool M,Hu Y,Zhang J,Zhang Y,Wang L,Zhang R,Cong H

更新日期：2020-08-14 00:00:00

abstract：Objective:Develop an automated approach to detect flash (<1.0 s) or prolonged (>2.0 s) capillary refill time (CRT) that correlates with clinician judgment by applying several supervised machine learning (ML) techniques to pulse oximeter plethysmography data. Materials and Methods:Data was collected in the Pediatric In...

journal_title：Frontiers in physiology

authors： Hunter RB,Jiang S,Nishisaki A,Nickel AJ,Napolitano N,Shinozaki K,Li T,Saeki K,Becker LB,Nadkarni VM,Masino AJ

更新日期：2020-10-06 00:00:00

abstract：:Animal experiments suggest that total liquid ventilation (TLV) induces less ventilator-induced lung injury (VILI) than conventional mechanical gas ventilation. However, TLV parameters that optimally minimize VILI in newborns remain unknown. Our objective was to compare lung inflammation between low (L-VT) and high (H-...

journal_title：Frontiers in physiology

authors： Sage M,See W,Nault S,Morin C,Michalski C,Chabot B,Marouan S,Lavoie PM,Micheau P,Praud JP,Fortin-Pellerin É

更新日期：2020-06-18 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:Southeast Asian Ovalocytosis results from a heterozygous deletion of 9 amino acids in the erythrocyte anion exchange protein AE1 (band 3). The report of the first successful birth of an individual homozygous for this mutation showed an association with severe dyserythropoietic anemia. Imaging of the proband's erythroc...

journal_title：Frontiers in physiology

authors： Flatt JF,Stevens-Hernandez CJ,Cogan NM,Eggleston DJ,Haines NM,Heesom KJ,Picard V,Thomas C,Bruce LJ

更新日期：2020-04-28 00:00:00

abstract：:Prescribing the proper resistance training (RT) program is critical to optimize skeletal muscle hypertrophy and strength. Periodization is a strategy that entails planned manipulations of training variables to maximize fitness adaptations while minimizing the risk of overtraining. Multiple meta-analyses have shown per...

journal_title：Frontiers in physiology

authors： Evans JW

更新日期：2019-01-23 00:00:00

abstract：:Background: Electrical cardioversion in patients with atrial fibrillation is followed by a transiently impaired atrial mechanical function, termed atrial stunning. During atrial stunning, a retained risk of left atrial thrombus formation exists, which may be attributed to abnormal left atrial blood flow patterns. 4D F...

journal_title：Frontiers in physiology

authors： Cibis M,Lindahl TL,Ebbers T,Karlsson LO,Carlhäll CJ

更新日期：2017-12-12 00:00:00

abstract：:To understand dynamic changes in polyamines (PAs) forms and components of polyamine metabolism in zoysiagrass (Zoysia japonica Steud.) response to salt stress with exogenous spermidine (Spd) application, two Chinese zoysia cultivars, z081 and z057, were exposed to sodium chloride stress for 2, 4, 6, and 8 days. The z0...

journal_title：Frontiers in physiology

authors： Li S,Cui L,Zhang Y,Wang Y,Mao P

更新日期：2017-04-06 00:00:00

abstract：:Hypoxia has important effects on biological activity in crustaceans, and modulation of energy metabolism is a crucial aspect of crustaceans' ability to respond to hypoxia. The adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) enzyme is very important in cellular energy homeostasis; however, little infor...

journal_title：Frontiers in physiology

authors： Sun S,Gu Z,Fu H,Zhu J,Ge X,Wu X

更新日期：2018-06-14 00:00:00

abstract：:Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

journal_title：Frontiers in physiology

authors： Perillo M,Folker ES

更新日期：2018-11-01 00:00:00

abstract：:Endothelial dysfunction has been considered as pivotal in the pathogenesis of decompression sickness (DCS) and contributes substantively to subsequent inflammatory responses. Escin is well known for its endothelial protection and anti-inflammatory properties, and its protection against DCS has been proved in a rat mod...

journal_title：Frontiers in physiology

authors： Qing L,Meng W,Zhang W,Yi HJ,Zhang K,Ariyadewa DK,Xu WG

更新日期：2019-05-21 00:00:00

abstract：:Molar hypomineralisation (MH) is becoming globally recognised as a significant public health problem linked to childhood tooth decay. However, with causation and pathogenesis unclear after 100 years of investigation, better pathological understanding is needed if MH is to become preventable. Our studies have implicate...

journal_title：Frontiers in physiology

authors： Perez VA,Mangum JE,Hubbard MJ

更新日期：2020-09-30 00:00:00

abstract：:Circadian clocks are endogenous oscillators essential for orchestrating daily rhythms in physiology, metabolism and behavior. While mouse models have been instrumental to elucidate the molecular mechanism of circadian rhythm generation, our knowledge about the molecular makeup of circadian oscillators in humans is sti...

journal_title：Frontiers in physiology

authors： Börding T,Abdo AN,Maier B,Gabriel C,Kramer A

更新日期：2019-05-09 00:00:00

abstract：:Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an increasingly serious health and socioeconomic concern for modern societies. Science has made tremendous progress in the understanding of aging itself, which has helped medicine to extend life expectancies. With the increase of the l...

journal_title：Frontiers in physiology

authors： Fulop T,Larbi A,Khalil A,Cohen AA,Witkowski JM

更新日期：2019-12-18 00:00:00

abstract：:Aim: The hemodynamic response to mouse systemic anaphylaxis is characterized by an initial hypertension followed by sustained hypotension. However, the defense mechanisms of the sympathetic nervous system against this circulatory disturbance is not known. Here, we investigated the renal sympathetic nerve activity (RSN...

journal_title：Frontiers in physiology

authors： Zhang T,Tanida M,Uchida K,Suzuki Y,Yang W,Kuda Y,Kurata Y,Tominaga M,Shibamoto T

更新日期：2017-09-07 00:00:00

abstract：:Cardiac autonomic function can be quantified through mean heart rate (HR) or heart rate variability (HRV). Numerous studies have supported the utility of different HRV parameters as indicators of cardiorespiratory fitness (CRF). However, HR has recently shown to be a stronger predictor of CRF than HRV in healthy young...

journal_title：Frontiers in physiology

authors： Plaza-Florido A,Migueles JH,Mora-Gonzalez J,Molina-Garcia P,Rodriguez-Ayllon M,Cadenas-Sanchez C,Esteban-Cornejo I,Solis-Urra P,de Teresa C,Gutiérrez Á,Michels N,Sacha J,Ortega FB

更新日期：2019-05-07 00:00:00

abstract：:Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information. Context specific reconstruction based on generic genome scale models like ReconX or HMR has the potential to become a diagnostic and treatment tool t...

journal_title：Frontiers in physiology

authors： Pacheco MP,Pfau T,Sauter T

更新日期：2016-01-22 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2016.00260.]. ...

journal_title：Frontiers in physiology

authors： Tibana RA,de Almeida LM,Frade de Sousa NM,Nascimento DDC,Neto IVS,de Almeida JA,de Souza VC,Lopes MFTPL,Nobrega OT,Vieira DCL,Navalta JW,Prestes J

更新日期：2018-07-16 00:00:00

abstract：:Cachexia, or wasting of skeletal muscle and fat, afflicts many patients with chronic diseases including cancer, organ failure, and AIDS. Muscle wasting reduces quality of life and decreases response to therapy. Cachexia is caused partly by elevated inflammatory cytokines, including interleukin-6 (IL-6). Others and we ...

journal_title：Frontiers in physiology

authors： Au ED,Desai AP,Koniaris LG,Zimmers TA

更新日期：2017-01-18 00:00:00

abstract：:We recorded via telemetry the arterial blood pressure (BP) and heart rate (HR) response to classical conditioning following the spontaneous onset of autoimmune diabetes in BBDP/Wor rats vs. age-matched, diabetes-resistant control (BBDR/Wor) rats. Our purpose was to evaluate the autonomic regulatory responses to an acu...

journal_title：Frontiers in physiology

authors： Randall DC,Speakman RO,Silcox DL,Brown LV,Brown DR,Gong MC,Patwardhan A,Reynolds LR,Karounos DG,Burgess DE,Anigbogu CN

更新日期：2011-08-27 00:00:00

abstract：:In the quest for a viable non-gravity dependent method to "lift weights" in space, our laboratory introduced iso-inertial resistance (YoYo™) exercise using spinning flywheel(s), more than 25 years ago. After being thoroughly tested in individuals subjected to various established spaceflight analogs, a multi-mode YoYo™...

journal_title：Frontiers in physiology

authors： Tesch PA,Fernandez-Gonzalo R,Lundberg TR

更新日期：2017-04-27 00:00:00