Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology.

abstract：:High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM). Adult male Munic...

journal_title：Frontiers in physiology

authors： Foresto-Neto O,Albino AH,Arias SCA,Faustino VD,Zambom FFF,Cenedeze MA,Elias RM,Malheiros DMAC,Camara NOS,Fujihara CK,Zatz R

更新日期：2020-02-11 00:00:00

abstract：:The aim of this study was to investigate the effects of two consecutive Crossfit® training sessions (24 h apart) designed to enhance work-capacity that involved both cardiovascular and muscular exercises on cytokines, muscle power, blood lactate and glucose. Nine male members of the CrossFit® community (age 26.7 ± 6.6...

journal_title：Frontiers in physiology

authors： Tibana RA,de Almeida LM,Frade de Sousa NM,Nascimento Dda C,Neto IV,de Almeida JA,de Souza VC,Lopes Mde F,Nobrega Ode T,Vieira DC,Navalta JW,Prestes J

更新日期：2016-06-28 00:00:00

abstract：:Purpose: To examine the effects of deceptively aggressive bike pacing on performance, pacing, and associated physiological and perceptual responses during simulated sprint-distance triathlon. Methods: Ten non-elite, competitive male triathletes completed three simulated sprint-distance triathlons (0.75 km swim, 500 kJ...

journal_title：Frontiers in physiology

authors： Taylor D,Smith MF

更新日期：2017-01-24 00:00:00

abstract：:Lepidopteran species detect CO2 via a specialized organ located on the peripheral segment of the labial palps, the labial palp pit organ (LPO). Based on tracing of LPO sensory neurons targeting one distinct antennal-lobe glomerulus, Kent and her colleagues described the projections originating from the LPO in the sphi...

journal_title：Frontiers in physiology

authors： Kc P,Chu X,Kvello P,Zhao XC,Wang GR,Berg BG

更新日期：2020-03-17 00:00:00

abstract：:Ethylene is known to influence the cell cycle (CC) via poorly characterized roles whilst nitric oxide (NO) has well-established roles in the animal CC but analogous role(s) have not been reported for plants. As NO and ethylene signaling events often interact we examined their role in CC in cultured cells derived from ...

journal_title：Frontiers in physiology

authors： Novikova GV,Mur LA,Nosov AV,Fomenkov AA,Mironov KS,Mamaeva AS,Shilov ES,Rakitin VY,Hall MA

更新日期：2017-03-10 00:00:00

abstract：Background:Interleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise. We recently showed that an acute increase in IL-6 delayed gastric emptying rate and improved postprandial glycemia. Here we investigate whether r...

journal_title：Frontiers in physiology

authors： Lehrskov LL,Christensen RH,Wedell-Neergaard AS,Legaard GE,Dorph E,Larsen MK,Henneberg M,Launbo N,Fagerlind SR,Seide SK,Nymand S,Ball M,Vinum N,Dahl C,Wewer Albrechtsen NJ,Holst JJ,Ried-Larsen M,Rosenmeier JB,Krogh-Mad

更新日期：2019-10-04 00:00:00

abstract：:Glucagon counterregulation (GCR) protects against hypoglycemia, but is impaired in type 1 diabetes (T1DM). A model-based analysis of in vivo animal data predicts that the GCR defects are linked to basal hyperglucagonemia. To test this hypothesis we studied the relationship between basal glucagon (BasG) and the GCR res...

journal_title：Frontiers in physiology

authors： Farhy LS,Chan A,Breton MD,Anderson SM,Kovatchev BP,McCall AL

更新日期：2012-02-28 00:00:00

abstract：:Melanization reflects not only body color variation but also environmental plasticity. It is a strategy that helps insects adapt to environmental change. Different color morphs may have distinct life history traits, e.g., development time, growth rate, and body weight. The green slender planthopper Saccharosydne proce...

journal_title：Frontiers in physiology

authors： Yin H,Shi Q,Shakeel M,Kuang J,Li J

更新日期：2016-09-12 00:00:00

abstract：Background:Angiotensin II (Ang II) could promote the development of atrial fibrosis in atrial fibrillation (AF). Apelin can inhibit the occurrence of myocardial fibrosis. However, the effect of apelin on Ang II-induced atrial fibrosis and subsequent AF still remains unknown. Objective:In the present study, we examined...

journal_title：Frontiers in physiology

authors： Lv W,Zhang L,Cheng X,Wang H,Qin W,Zhou X,Tang B

更新日期：2020-11-19 00:00:00

abstract：:In insects, locomotion is the result of rhythm generating thoracic circuits and their modulation by sensory reflexes and by inputs from the two head ganglia, the cerebral and the gnathal ganglia (GNG), which act as higher order neuronal centers playing different functions in the initiation, goal-direction, and mainten...

journal_title：Frontiers in physiology

authors： Emanuel S,Kaiser M,Pflueger HJ,Libersat F

更新日期：2020-02-21 00:00:00

abstract：:Basketball is a team sport, where fundamental skills - fundamentals - are key determinants for success. Jump-shot (JS) is a basketball fundamental used frequently during game. It is interesting to spread light on the relationship between effort intensity and JS ability. Study aim was to investigate different heart rat...

journal_title：Frontiers in physiology

authors： Padulo J,Nikolaidis PT,Cular D,Dello Iacono A,Vando S,Galasso M,Lo Storto D,Ardigò LP

更新日期：2018-08-03 00:00:00

abstract：:Studies of palate development are motivated by the all too common incidence of cleft palate, a birth defect that imposes a tremendous health burden and can leave lasting disfigurement. Although, mechanistic studies of palate growth and fusion have focused on growth factors such as Transforming Growth Factor ß-3 (Tgfß3...

journal_title：Frontiers in physiology

authors： Benson MD,Serrano MJ

更新日期：2012-09-26 00:00:00

abstract：:The effect of training status on post-exercise flow-mediated dilation (FMD) is not well characterized. We tested the hypothesis that the more trained the subjects, the lower the reduction in FMD after an acute bout of aerobic exercise. Forty-seven men (mean ± SD, age: 20.1 ± 1.2 years, body mass: 75.5 ± 5.1 kg, height...

journal_title：Frontiers in physiology

authors： Kapilevich LV,Kologrivova VV,Zakharova AN,Mourot L

更新日期：2020-05-08 00:00:00

abstract：:The upcoming exploration missions will imply a much longer duration than any of the missions flown so far. In these missions, physiological adaptation to the new environment leads to changes in different body systems, such as the cardiovascular and musculoskeletal systems, metabolic and neurobehavioral health and immu...

journal_title：Frontiers in physiology

authors： Turroni S,Magnani M,Kc P,Lesnik P,Vidal H,Heer M

更新日期：2020-09-08 00:00:00

abstract：:Background: Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) is highly effective in alleviating motor symptoms of Parkinson's disease (PD) which are not optimally controlled by dopamine replacement therapy. Clinical studies and reports suggest that STN-DBS may result in increased impulsivity and de novo impulse co...

journal_title：Frontiers in physiology

authors： Mandali A,Chakravarthy VS,Rajan R,Sarma S,Kishore A

更新日期：2016-11-29 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) not only play essential roles in bone development but also are involved in embryonic growth, organogenesis cell proliferation and differentiation. However, the previous studies on the functions of shellfish BMPs genes are still very limited. To better understand its molecular structu...

journal_title：Frontiers in physiology

authors： Zhao J,Cui B,Yao H,Lin Z,Dong Y

更新日期：2020-08-28 00:00:00

abstract：:The goal here is to describe our current understanding of heme metabolism and the deleterious effects of "free" heme on immunological processes, endothelial function, systemic inflammation, and various end-organ tissues (e.g., kidney, lung, liver, etc.), with particular attention paid to the role of hemopexin (HPX). B...

journal_title：Frontiers in physiology

authors： Smith A,McCulloh RJ

更新日期：2015-06-30 00:00:00

abstract：:Sepsis is a systemic inflammatory disease with infection, and autophagy has been shown to play an important role in sepsis. This review summarizes the main regulatory mechanisms of autophagy in sepsis and its latest research. Recent studies have shown that autophagy can regulate innate immune processes and acquired im...

journal_title：Frontiers in physiology

authors： Yin X,Xin H,Mao S,Wu G,Guo L

更新日期：2019-08-23 00:00:00

abstract：:Adipose tissue is recognized as an important organ with metabolic, regulatory, and plastic roles. Adipose tissue-derived stem cells (ASCs) with self-renewal properties localize in the stromal vascular fraction (SVF) being present in a vascular niche, thereby, contributing to local regulation of angiogenesis and vessel...

journal_title：Frontiers in physiology

authors： Panina YA,Yakimov AS,Komleva YK,Morgun AV,Lopatina OL,Malinovskaya NA,Shuvaev AN,Salmin VV,Taranushenko TE,Salmina AB

更新日期：2018-11-26 00:00:00

abstract：:The main purpose of the present study was to investigate the effect of frequency, thereby increasing training volume, of resistance training on body composition, inflammation markers, lipid and glycemic profile in healthy older individuals (age range 65-75 year). Ninety-two healthy participants were randomly assigned ...

journal_title：Frontiers in physiology

authors： Ihalainen JK,Inglis A,Mäkinen T,Newton RU,Kainulainen H,Kyröläinen H,Walker S

更新日期：2019-02-01 00:00:00

abstract：:This study investigates the complex interplay between the cardiac and respiratory systems in 268 healthy neonates born between 35 and 40 weeks of gestation. The aim is to provide a comprehensive description of the developing cardiorespiratory information transfer mechanisms as a function of gestational age (GA). This ...

journal_title：Frontiers in physiology

authors： Lucchini M,Pini N,Burtchen N,Signorini MG,Fifer WP

更新日期：2020-08-27 00:00:00

abstract：:Skeletal myofibers are injured due to mechanical stresses experienced during physical activity, or due to myofiber fragility caused by genetic diseases. The injured myofiber needs to be repaired or regenerated to restore the loss in muscle tissue function. Myofiber repair and regeneration requires coordinated action o...

journal_title：Frontiers in physiology

authors： Bittel DC,Jaiswal JK

更新日期：2019-07-18 00:00:00

abstract：:Extracellular vesicles (EVs) - including exosomes, microvesicles and apoptotic bodies - have received much scientific attention last decade as mediators of a newly discovered cell-to-cell communication system, acting at short and long distances. EVs carry biologically active molecules, thus providing signals that infl...

journal_title：Frontiers in physiology

authors： Rackov G,Garcia-Romero N,Esteban-Rubio S,Carrión-Navarro J,Belda-Iniesta C,Ayuso-Sacido A

更新日期：2018-06-05 00:00:00

abstract：:Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, influencing multiple physiological processes. Among its many roles in insects are the initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory effects of OA on the components of the locust stomatogastric nervous s...

journal_title：Frontiers in physiology

authors： Rand D,Knebel D,Ayali A

更新日期：2012-07-20 00:00:00

abstract：:Exercise and exogenous heat each stimulate multiple adaptations, but their roles are not well delineated, and that of the related stressor, dehydration, is largely unknown. While severe and prolonged hypohydration potentially "silences" the long-term heat acclimated phenotype, mild and transient dehydration may enhanc...

journal_title：Frontiers in physiology

authors： Akerman AP,Lucas SJE,Katare R,Cotter JD

更新日期：2017-10-09 00:00:00

abstract：:Currently, neuropathic pain is an underestimated socioeconomic health problem affecting millions of people worldwide, which incidence may increase in the next years due to chronification of several diseases, such as cancer and diabetes. Growing evidence links neuropathic pain present in several disorders [i.e., spinal...

journal_title：Frontiers in physiology

authors： Carrasco C,Naziroǧlu M,Rodríguez AB,Pariente JA

更新日期：2018-02-14 00:00:00

abstract：:Heart failure and frailty are clinical syndromes that present with overlapping phenotypic characteristics. Importantly, their co-presence is associated with increased mortality and morbidity. While mechanical and electrical device therapies for heart failure are vital for select patients with advanced stage disease, t...

journal_title：Frontiers in physiology

authors： Fung E,Hui E,Yang X,Lui LT,Cheng KF,Li Q,Fan Y,Sahota DS,Ma BHM,Lee JSW,Lee APW,Woo J

更新日期：2018-04-24 00:00:00

abstract：:Background: The short-term benefits of aerobic and resistance exercise in subjects affected by Peripheral Arterial Disease (PAD) are scarcely examined in interaction. This study aimed to identify the effects of combined aerobic and resistance exercise programs on walking performance compared with isolated aerobic exer...

journal_title：Frontiers in physiology

authors： Machado I,Sousa N,Paredes H,Ferreira J,Abrantes C

更新日期：2020-01-08 00:00:00

abstract：:Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts. We aimed to determine its existence, molecular nature in undiseased h...

journal_title：Frontiers in physiology

authors： Wen H,Zhao Z,Fefelova N,Xie LH

更新日期：2018-12-13 00:00:00

abstract：:Despite vast improvement in perinatal care during the 30 years, the incidence rate of neonatal encephalopathy remains unchanged without any further Progress towards preventive strategies for the clinical impasse. Antenatal brain injury including fetal intracranial hemorrhage caused by ischemia/reperfusion is known as ...

journal_title：Frontiers in physiology

authors： Funamoto K,Ito T,Funamoto K,Velayo CL,Kimura Y

更新日期：2017-05-24 00:00:00