Ephrin regulation of palate development.

Abstract:

:Studies of palate development are motivated by the all too common incidence of cleft palate, a birth defect that imposes a tremendous health burden and can leave lasting disfigurement. Although, mechanistic studies of palate growth and fusion have focused on growth factors such as Transforming Growth Factor ß-3 (Tgfß3), recent studies have revealed that the ephrin family of membrane bound ligands and their receptors, the Ephs, play central roles in palatal morphogenesis, growth, and fusion. In this mini-review, we will discuss the recent findings by our group and others on the functions of ephrins in palatal development.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Benson MD,Serrano MJ

doi

10.3389/fphys.2012.00376

subject

Has Abstract

pub_date

2012-09-26 00:00:00

pages

376

issn

1664-042X

journal_volume

3

pub_type

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