Conjugating Existing Clinical Drugs With Gold Nanoparticles for Better Treatment of Heart Diseases.

abstract：Background:Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant hypertension, SHR kidneys remain relatively free of pathology due to having an augmented myogenic constriction (MC). We h...

journal_title：Frontiers in physiology

authors： Nademi S,Lu C,Dickhout JG

更新日期：2020-07-22 00:00:00

abstract：:The ubiquitin proteasome system (UPS) is a highly regulated mechanism of intracellular protein degradation and turnover. To evaluate the effect of crowding stress on the UPS in fish, grass carp (Ctenopharyngodon idellus) were randomly reared at low stocking density (LSD, 0.9 kg m-2) or high stocking density (HSD, 5.9 ...

journal_title：Frontiers in physiology

authors： Sun Y,Liang X,Chen J,Tang R,Li L,Li D

更新日期：2018-07-05 00:00:00

abstract：:With the advent of high-throughput technologies, the field of systems biology has amassed an abundance of "omics" data, quantifying thousands of cellular components across a variety of scales, ranging from mRNA transcript levels to metabolite quantities. Methods are needed to not only integrate this omics data but to ...

journal_title：Frontiers in physiology

authors： Blazier AS,Papin JA

更新日期：2012-08-06 00:00:00

abstract：:Long-duration spaceflight has been shown to negatively affect the lumbopelvic muscles of crewmembers. Through analysis of computed tomography scans of crewmembers on 4- to 6-month missions equipped with the interim resistive exercise device, the structural deterioration of the psoas, quadratus lumborum, and paraspinal...

journal_title：Frontiers in physiology

authors： McNamara KP,Greene KA,Moore AM,Lenchik L,Weaver AA

更新日期：2019-05-21 00:00:00

abstract：:Despite vast improvement in perinatal care during the 30 years, the incidence rate of neonatal encephalopathy remains unchanged without any further Progress towards preventive strategies for the clinical impasse. Antenatal brain injury including fetal intracranial hemorrhage caused by ischemia/reperfusion is known as ...

journal_title：Frontiers in physiology

authors： Funamoto K,Ito T,Funamoto K,Velayo CL,Kimura Y

更新日期：2017-05-24 00:00:00

abstract：:Skeletal muscle differentiation is an essential process for the maintenance of muscle development and homeostasis. Reactive oxygen species (ROS) are critical signaling molecules involved in muscle differentiation. Palmitoyl protein thioesterase 1 (PPT1), a lysosomal enzyme, is involved in removing thioester-linked fat...

journal_title：Frontiers in physiology

authors： Yun HR,Jo YH,Kim J,Nguyen NNY,Shin Y,Kim SS,Choi TG

更新日期：2020-10-15 00:00:00

abstract：:In aged subjects, late-onset Alzheimer's disease (LOAD) starts in the lateral entorhinal allocortex where a failure of clearance mechanisms triggers an accumulation of neurotoxic amyloid-β42 oligomers (Aβ42-os). In neurons and astrocytes, Aβ42-os enhance the transcription of Aβ precursor protein (APP) and β-secretase/...

journal_title：Frontiers in physiology

authors： Chiarini A,Armato U,Liu D,Dal Prà I

更新日期：2016-04-26 00:00:00

abstract：:Increased central sympathetic drive is a hallmark of several important clinical conditions including essential hypertension, heart failure, chronic kidney disease, and insulin resistance. Afferent signaling from the kidneys has been identified as an important contributor to elevated central sympathetic drive and incre...

journal_title：Frontiers in physiology

authors： Schlaich MP,Hering D,Sobotka P,Krum H,Lambert GW,Lambert E,Esler MD

更新日期：2012-02-02 00:00:00

abstract：:Mitochondrial redox imbalance has been implicated in mechanisms of aging, various degenerative diseases and drug-induced toxicity. Statins are safe and well-tolerated therapeutic drugs that occasionally induce myotoxicity such as myopathy and rhabdomyolysis. Previous studies indicate that myotoxicity caused by statins...

journal_title：Frontiers in physiology

authors： La Guardia PG,Alberici LC,Ravagnani FG,Catharino RR,Vercesi AE

更新日期：2013-05-15 00:00:00

abstract：:As verbal encouragement (VE) is used in high intensity functional exercise testing, this randomized controlled crossover study aimed at investigating whether VE affects high intensity functional strength and endurance performance testing. We further examined between-day variability of high intensity functional strengt...

journal_title：Frontiers in physiology

authors： Engel FA,Faude O,Kölling S,Kellmann M,Donath L

更新日期：2019-04-25 00:00:00

abstract：:Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, ...

journal_title：Frontiers in physiology

authors： Larsson S,Åkerström B,Gram M,Lohmander LS,Struglics A

更新日期：2018-11-16 00:00:00

abstract：:Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors by sensing and inter...

journal_title：Frontiers in physiology

authors： Kurtz R,Steinberg LG,Betcher M,Fowler D,Shepard BD

更新日期：2020-10-06 00:00:00

abstract：:Hypoxic exercise may represent a novel therapeutic strategy to reduce and prevent obesity through the regulation of lipid metabolism. During hypoxic exercise, the targeting of peroxisome proliferator-activated receptor gamma (PPARγ) by miR-27b has been proposed to be one of the mechanisms involved in the modulation of...

journal_title：Frontiers in physiology

authors： Wang X,Lu Y,Zhu L,Zhang H,Feng L

更新日期：2020-08-31 00:00:00

abstract：:Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological...

journal_title：Frontiers in physiology

authors： Donadoni F,Pichardo-Almarza C,Bartlett M,Dardik A,Homer-Vanniasinkam S,Díaz-Zuccarini V

更新日期：2017-04-18 00:00:00

abstract：:Drosophila melanogaster has served as an excellent genetic model to decipher the molecular basis of the circadian clock. Two key proteins, PERIOD (PER) and TIMELESS (TIM), are particularly well explored and a number of various arrhythmic, slow, and fast clock mutants have been identified in classical genetic screens. ...

journal_title：Frontiers in physiology

authors： Singh S,Giesecke A,Damulewicz M,Fexova S,Mazzotta GM,Stanewsky R,Dolezel D

更新日期：2019-12-03 00:00:00

abstract：:The large amount of energy expended during flapping flight is associated with heat generated through the increased work of the flight muscles. This increased muscle work rate can manifest itself in core body temperature (Tb) increase of 1-2°C in birds during flight. Therefore, episodic body cooling may be mandatory in...

journal_title：Frontiers in physiology

authors： Guillemette M,Polymeropoulos ET,Portugal SJ,Pelletier D

更新日期：2017-07-25 00:00:00

abstract：:The emergence of -omics technologies has allowed the collection of vast amounts of data on biological systems. Although, the pace of such collection has been exponential, the impact of these data remains small on many critical biomedical applications such as drug development. Limited resources, high costs, and low hit...

journal_title：Frontiers in physiology

authors： Kandoi G,Acencio ML,Lemke N

更新日期：2015-12-08 00:00:00

abstract：:DNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespread DNA methylation whereas invertebrate genomes are less methylated, predominantly within gene bodies. DNA methylation in invertebrates is associated with transcription level, alternative splicing, and genome evolution, but functional outco...

journal_title：Frontiers in physiology

authors： Rivière G

更新日期：2014-04-07 00:00:00

abstract：:While many effectors have been identified in enamel matrix and cells via genetic studies, physiological networks underlying their expression levels and thus the natural spectrum of enamel thickness and degree of mineralization are now just emerging. Several transcription factors are candidates for enamel gene expressi...

journal_title：Frontiers in physiology

authors： Babajko S,de La Dure-Molla M,Jedeon K,Berdal A

更新日期：2015-01-05 00:00:00

abstract：:It has been proposed that group III and IV muscle afferents provide inhibitory feedback from locomotor muscles to the central nervous system, setting an absolute threshold for the development of peripheral fatigue during exercise. The aim of this study was to test the validity of this theory. Thus, we asked whether th...

journal_title：Frontiers in physiology

authors： Froyd C,Beltrami FG,Millet GY,Noakes TD

更新日期：2016-12-19 00:00:00

abstract：:Carbon monoxide (CO) that is produced in a number of different mammalian tissues is now known to have significant effects on the cardiovascular system. These include: (i) vasodilation, (ii) changes in heart rate and strength of contractions, and (iii) modulation of autonomic nervous system input to both the primary pa...

journal_title：Frontiers in physiology

authors： Trenor B,Cardona K,Saiz J,Rajamani S,Belardinelli L,Giles WR

更新日期：2013-10-17 00:00:00

abstract：:We describe a new nonlinear dynamic model of insect phototransduction using a NLN (nonlinear, linear, nonlinear) block structure. The first nonlinear stage provides a single exponential decline in gain and mean following the start of light stimulation. The linear stage uses a two-parameter log-normal convolution model...

journal_title：Frontiers in physiology

authors： French AS,Immonen EV,Frolov RV

更新日期：2016-10-25 00:00:00

abstract：:The fluid transport and mixing induced by beating cilia, present in the bronchial airways, are studied using a coupled lattice Boltzmann-Immersed Boundary solver. This solver allows the simulation of both single and multi-component fluid flows around moving solid boundaries. The cilia are modeled by a set of Lagrangia...

journal_title：Frontiers in physiology

authors： Chateau S,D'Ortona U,Poncet S,Favier J

更新日期：2018-03-06 00:00:00

abstract：:While isolation of the pulmonary veins is firmly established as effective treatment for the majority of paroxysmal atrial fibrillation (AF) patients, there is recognition that patients with persistent AF have substrate for perpetuation of arrhythmia existing outside of the pulmonary veins. Various computational approa...

journal_title：Frontiers in physiology

authors： Stiles MK,Sanders P,Lau DH

更新日期：2018-09-18 00:00:00

abstract：:Hemoglobin (Hb) is a highly conserved molecule present in all life forms and functionally tied to the complexity of aerobic organisms on earth in utilizing oxygen from the atmosphere and delivering to cells and tissues. This primary function sustains the energy requirements of cells and maintains cellular homeostasis....

journal_title：Frontiers in physiology

authors： Quaye IK

更新日期：2015-04-20 00:00:00

abstract：:The sense of taste is responsible for the detection and ingestion of food to cover energetic requirements in health and disease. The change in taste perception might lead to malnutrition that is usually one of the frequent causes of morbidity and mortality in patients with cancer. In this review, we summarize the mech...

journal_title：Frontiers in physiology

authors： Murtaza B,Hichami A,Khan AS,Ghiringhelli F,Khan NA

更新日期：2017-03-08 00:00:00

abstract：:Exhaled breath carbon monoxide (eCO) is a candidate biomarker for non-invasive assessment of oxidative stress and respiratory diseases. Standard end-tidal CO analysis, however, cannot distinguish, whether eCO reflects endogenous CO production, lung diffusion properties or exogenous sources, and is unable to resolve a ...

journal_title：Frontiers in physiology

authors： Ghorbani R,Blomberg A,Schmidt FM

更新日期：2018-07-30 00:00:00

abstract：:Botrytis-induced kinase1 (BIK1), a receptor-like cytoplasmic kinase, plays an important role in resistance against pathogens and insects in Arabidopsis thaliana. However, it remains unknown whether BIK1 functions against Plasmodiophora brassicae, an obligate biotrophic protist that attacks cruciferous plants and induc...

journal_title：Frontiers in physiology

authors： Chen T,Bi K,He Z,Gao Z,Zhao Y,Fu Y,Cheng J,Xie J,Jiang D

更新日期：2016-09-13 00:00:00

abstract：UNLABELLED:Oxycodone (OXY) is one of the most commonly abused opiates during pregnancy. Perinatal opiate exposure (POE) is associated with neurobehavioral and hormone changes. Little is known about the effects of perinatal OXY on the cardiovascular (CV) responses to stress. OBJECTIVES:to determine the effects of POE o...

journal_title：Frontiers in physiology

authors： Sithisarn T,Bada HS,Charnigo RJ,Legan SJ,Randall DC

更新日期：2013-04-24 00:00:00

abstract：:Introduction: Endothelial progenitor cells (EPCs) display a unique ability to promote angiogenesis and restore endothelial function in injured blood vessels. NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H2O2) serves as a signaling molecule and promotes endothelial cell proliferation and migration as well as prote...

journal_title：Frontiers in physiology

authors： Hakami NY,Ranjan AK,Hardikar AA,Dusting GJ,Peshavariya HM

更新日期：2017-03-23 00:00:00