Membrane lipid unsaturation as physiological adaptation to animal longevity.

abstract：:Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs be...

journal_title：Frontiers in physiology

authors： Paradis-Deschênes P,Joanisse DR,Billaut F

更新日期：2017-01-05 00:00:00

abstract：:Delivery of exogenous high mobility group box 1 (HMGB1) may exert a beneficial effect on myocardial ischemia-reperfusion (I/R) injury. Since the expression of vascular endothelial growth factor (VEGF) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) in the myocardium mediates the cardioprotective function...

journal_title：Frontiers in physiology

authors： Zhou YH,Han QF,Gao L,Sun Y,Tang ZW,Wang M,Wang W,Yao HC

更新日期：2020-01-29 00:00:00

abstract：:Leucine-rich repeat containing protein 10 (LRRC10) is a cardiomyocyte-specific member of the Leucine-rich repeat containing (LRRC) protein superfamily with critical roles in cardiac function and disease pathogenesis. Recent studies have identified LRRC10 mutations in human idiopathic dilated cardiomyopathy (DCM) and L...

journal_title：Frontiers in physiology

authors： Brody MJ,Lee Y

更新日期：2016-08-03 00:00:00

abstract：:This review details the manner in which the central nervous system regulates metabolic homeostasis in normal weight and obese rodents and humans. It includes a review of the homeostatic contributions of neurons located in the hypothalamus, the midbrain and limbic structures, the pons and the medullary area postrema, n...

journal_title：Frontiers in physiology

authors： Smith JK

更新日期：2018-05-17 00:00:00

abstract：:Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human ventricular myocytes (HVMs) were investigated using the mathematical model developed by ten Tusscher and Panfilov (Am J Physiol Heart Circ Physiol 2...

journal_title：Frontiers in physiology

authors： Kurata Y,Tsumoto K,Hayashi K,Hisatome I,Kuda Y,Tanida M

更新日期：2020-01-10 00:00:00

abstract：Background:Nav1.5 cardiac Na+ channel mutations can cause arrhythmogenic syndromes. Some of these mutations exert a dominant negative effect on wild-type channels. Recent studies showed that Na+ channels can dimerize, allowing coupled gating. This leads to the hypothesis that allosteric interactions between Na+ channel...

journal_title：Frontiers in physiology

authors： Hichri E,Selimi Z,Kucera JP

更新日期：2020-11-05 00:00:00

abstract：:Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellu...

journal_title：Frontiers in physiology

authors： Moullé VS,Cansell C,Luquet S,Cruciani-Guglielmacci C

更新日期：2012-09-28 00:00:00

abstract：:This study was designed to investigate whether oxidative stress, nitric oxide (NO) deficiency and/or endothelial dysfunction (ED) are present in young borderline hypertensive rats (BHR) and whether these pathologies can be causally involved in the initiation of blood pressure (BP) increases. Additionally, we tested th...

journal_title：Frontiers in physiology

authors： Bernatova I,Puzserova A,Balis P,Sestakova N,Horvathova M,Kralovicova Z,Zitnanova I

更新日期：2018-08-29 00:00:00

abstract：:Animal studies have shown that very early life events may have programing effects on adult metabolism and health. In this study, we aim, for the first, time to elucidate the effects of embryonic thermal manipulation (TM) on the performance of overfed mule ducks, in particular for the production of foie gras (fatty liv...

journal_title：Frontiers in physiology

authors： Massimino W,Davail S,Bernadet MD,Pioche T,Tavernier A,Ricaud K,Gontier K,Bonnefont C,Manse H,Morisson M,Fauconneau B,Collin A,Panserat S,Houssier M

更新日期：2019-12-12 00:00:00

abstract：PURPOSE:The aim of present investigation was to evaluate marginal bone level after 5-year follow-up of implants placed in healed ridges and fresh extraction sockets in maxilla with immediate loading protocol. MATERIALS AND METHODS:Thirty-six patients in need of a single-tooth replacement in the anterior maxilla receiv...

journal_title：Frontiers in physiology

authors： Berberi AN,Sabbagh JM,Aboushelib MN,Noujeim ZF,Salameh ZA

更新日期：2014-01-31 00:00:00

abstract：:Circadian clocks consist of molecular negative feedback loops that coordinate physiological, neurological, and behavioral variables into "circa" 24-h rhythms. Rhythms in behavioral and other circadian outputs tend to weaken during aging, as evident in progressive disruptions of sleep-wake cycles in aging organisms. Ho...

journal_title：Frontiers in physiology

authors： Long DM,Giebultowicz JM

更新日期：2018-01-09 00:00:00

abstract：:Ecdysteroids play an essential role in controlling insect development and reproduction. Their pathway is regulated by a group of enzymes called Halloween gene proteins. The relationship between the Halloween genes and ecdysteroid synthesis has yet to be clearly understood in diamondback moth, Plutella xylostella (L.),...

journal_title：Frontiers in physiology

authors： Peng L,Wang L,Zou MM,Vasseur L,Chu LN,Qin YD,Zhai YL,You MS

更新日期：2019-08-28 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：Background:Walking patterns can provide important indications of a person's health status and be beneficial in the early diagnosis of individuals with a potential walking disorder. For appropriate gait analysis, it is critical that natural functional walking characteristics are captured, rather than those experienced i...

journal_title：Frontiers in physiology

authors： Renggli D,Graf C,Tachatos N,Singh N,Meboldt M,Taylor WR,Stieglitz L,Schmid Daners M

更新日期：2020-02-20 00:00:00

abstract：:Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a variety of receptor mediated vasorelaxants. The Kv7.4 isoform, abundant within the vasculature, is key to these processes and was recently shown to have an obligatory requirement of G-protein βγ subunits for its voltage dependent ...

journal_title：Frontiers in physiology

authors： Greenwood IA,Stott JB

更新日期：2020-01-14 00:00:00

abstract：:Throughout evolution the foraging and echolocation behaviors as well as the motor systems of bats have been adapted to the tasks they have to perform while searching and acquiring food. When bats exploit the same class of environmental resources in a similar way, they perform comparable tasks and thus share similar ad...

journal_title：Frontiers in physiology

authors： Denzinger A,Schnitzler HU

更新日期：2013-07-03 00:00:00

abstract：:Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of multiple diverse ion channels. K+ channels, the largest family of chann...

journal_title：Frontiers in physiology

authors： Malysz J,Petkov GV

更新日期：2020-09-16 00:00:00

abstract：:Background: The possibility of non-invasively assessing load-independent parameters characterizing cardiac function is of high clinical value. Typically, these parameters are assessed during resting conditions. However, for diagnostic purposes, the parameter behavior across a physiologically relevant range of heart ra...

journal_title：Frontiers in physiology

authors： Casas B,Viola F,Cedersund G,Bolger AF,Karlsson M,Carlhäll CJ,Ebbers T

更新日期：2018-10-30 00:00:00

abstract：:Endothelial dysfunction has been considered as pivotal in the pathogenesis of decompression sickness (DCS) and contributes substantively to subsequent inflammatory responses. Escin is well known for its endothelial protection and anti-inflammatory properties, and its protection against DCS has been proved in a rat mod...

journal_title：Frontiers in physiology

authors： Qing L,Meng W,Zhang W,Yi HJ,Zhang K,Ariyadewa DK,Xu WG

更新日期：2019-05-21 00:00:00

abstract：:Background: For some time now, the effects of sound, noise, and music on the human body have been studied. However, despite research done through time, it is still not completely clear what influence, interaction, and effects sounds have on human body. That is why it is necessary to conduct new research on this topic....

journal_title：Frontiers in physiology

authors： Idrobo-Ávila EH,Loaiza-Correa H,van Noorden L,Muñoz-Bolaños FG,Vargas-Cañas R

更新日期：2018-05-22 00:00:00

abstract：:Forced sustained swimming exercise at optimal speed enhances growth in many fish species, particularly through hypertrophy of the white skeletal muscle. The exact mechanism of this effect has not been resolved yet. To explore the role of cortisol, we first subjected wild-type zebrafish to an exercise protocol validate...

journal_title：Frontiers in physiology

authors： Palstra AP,Mendez S,Dirks RP,Schaaf MJM

更新日期：2019-01-14 00:00:00

abstract：:Nicotinamide nucleotide transhydrogenase (TH) is an enzyme complex in animal mitochondria and bacteria that utilizes the electrochemical proton gradient across membranes to drive the production of NADPH. The enzyme plays an important role in maintaining the redox balance of cells with implications in aging and a numbe...

journal_title：Frontiers in physiology

authors： Zhang Q,Padayatti PS,Leung JH

更新日期：2017-12-19 00:00:00

abstract：:Planarians undergo continuous body size remodeling under starvation or during regeneration. This process likely involves autophagy and autophagic cell death, but this hypothesis is supported by few studies. To test this hypothesis, we cloned and characterized autophagy-related gene 7 (Atg7) from the planarian Dugesia ...

journal_title：Frontiers in physiology

authors： Ma K,Zhang Y,Song G,Wu M,Chen G

更新日期：2018-09-04 00:00:00

abstract：:Pluripotency in human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is regulated by three transcription factors-OCT3/4, SOX2, and NANOG. To fully exploit the therapeutic potential of these cells it is essential to have a good mechanistic understanding of the maintenance of self-renewal and pl...

journal_title：Frontiers in physiology

authors： Peterson H,Abu Dawud R,Garg A,Wang Y,Vilo J,Xenarios I,Adjaye J

更新日期：2013-10-28 00:00:00

abstract：:Cigarette smoking causes chronic lung inflammation that is mainly regulated by redox-sensitive pathways. Our previous studies have demonstrated that cigarette smoke (CS) activates reactive oxygen species (ROS)-sensitive mitogen-activated protein kinases (MAPKs)/nuclear factor-κB (NF-κB) signaling resulting in inductio...

journal_title：Frontiers in physiology

authors： Liu MH,Lin AH,Lu SH,Peng RY,Lee TS,Kou YR

更新日期：2014-11-14 00:00:00

abstract：:Theoretical cardiac electrophysiology focuses on the dynamics of the membrane and sarcoplasmic reticulum ion currents; however, passive (e.g., membrane capacitance) and quasi-active (response to small signals) properties of the cardiac sarcolemma, which are quantified by impedance, are also important in determining th...

journal_title：Frontiers in physiology

authors： Iravanian S,Herndon C,Langberg JJ,Fenton FH

更新日期：2019-07-09 00:00:00

abstract：BACKGROUND:Human labor is a complex series of cellular and molecular events that occur at the materno-fetal and uterine levels. Many hypotheses have been proposed for the initiation of human labor, one hypothesis suggests that maturation of the fetus releases a signal in the amniotic fluid that will be transmitted to m...

journal_title：Frontiers in physiology

authors： Alzamil HA,Pawade J,Fortier MA,Bernal AL

更新日期：2014-07-30 00:00:00

abstract：:Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated the complexity of the molecular changes in human or mouse paraspinal muscles exposed to microgravity. The aim of this study was to evaluate l...

journal_title：Frontiers in physiology

authors： Gambara G,Salanova M,Ciciliot S,Furlan S,Gutsmann M,Schiffl G,Ungethuem U,Volpe P,Gunga HC,Blottner D

更新日期：2017-05-05 00:00:00

abstract：:3-iodothyronamine (T1AM) is an endogenous amine, that has been detected in many rodent tissues, and in human blood. It has been hypothesized to derive from thyroid hormone metabolism, but this hypothesis still requires validation. T1AM is not a ligand for nuclear thyroid hormone receptors, but stimulates with nanomola...

journal_title：Frontiers in physiology

authors： Zucchi R,Accorroni A,Chiellini G

更新日期：2014-10-16 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2019.01574.]. ...

journal_title：Frontiers in physiology

authors： Figueroa VA,Jara O,Oliva CA,Ezquer M,Ezquer F,Retamal MA,Martínez AD,Altenberg GA,Vargas AA

更新日期：2020-02-11 00:00:00