Abstract：
:Planarians undergo continuous body size remodeling under starvation or during regeneration. This process likely involves autophagy and autophagic cell death, but this hypothesis is supported by few studies. To test this hypothesis, we cloned and characterized autophagy-related gene 7 (Atg7) from the planarian Dugesia japonica (DjAtg7). The full-length cDNA of DjAtg7 measures 2272 bp and includes a 2082-bp open reading frame encoding 693 amino acids with a molecular weight of 79.06 kDa. The deduced amino acid sequence of DjAtg7 contains a conserved ATP-binding site and a catalytic active site of an E1-like enzyme belonging to the ATG7 superfamily. DjAtg7 transcripts are mainly expressed in intestinal tissues of the intact animals. After amputation, DjAtg7 was highly expressed at the newly regenerated intestinal branch on days 3-7 of regeneration and in the old tissue of the distal intestinal branch on day 10 of regeneration. However, knockdown of DjAtg7 by RNAi did not affect planarian regeneration and did not block autophagosome formation, which indicates that autophagy is more complex than previously expected. Interestingly, TEM clearly confirmed that autophagy and autophagic cell death occurred in the old tissues of the newly regenerated planarians and clearly revealed that the dying cell released vesicles containing cellular cytoplasmic contents into the extracellular space. Therefore, the autophagy and autophagic cell death that occurred in the old tissue not only met the demand for body remodeling but also met the demand for energy supply during planarian regeneration. Collectively, our work contributes to the understanding of autophagy and autophagic cell death in planarian regeneration and body remodeling.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Ma K,Zhang Y,Song G,Wu M,Chen Gdoi
10.3389/fphys.2018.01223subject
Has Abstractpub_date
2018-09-04 00:00:00pages
1223issn
1664-042Xjournal_volume
9pub_type
杂志文章abstract：:It has been reported that nitric oxide (NO) is a negative regulator of aluminum (Al)-induced programmed cell death (PCD) in peanut root tips. However, the inhibiting mechanism of NO on Al-induced PCD is unclear. In order to investigate the mechanism by which NO inhibits Al-induced PCD, the effects of co-treatment Al w...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.01037
更新日期：2017-12-21 00:00:00
abstract：:A water surface acts not only as an optic mirror but also as an acoustic mirror. Echolocation calls emitted by bats at low heights above water are reflected away from the bat, and hence the background clutter is reduced. Moreover, targets on the surface create an enhanced echo. Here, we formally quantified the effect ...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2013.00065
更新日期：2013-04-05 00:00:00
abstract：:Human pluripotent stem cells (hPSCs) represent a new and exciting field in modern medicine, now the focus of many researchers and media outlets. The hype is well-earned because of the potential of stem cells to contribute to disease modeling, drug screening, and even therapeutic approaches. In this review, we focus fi...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2012.00047
更新日期：2012-03-19 00:00:00
abstract：:This study was designed to investigate the effects of a newly synthesized carboxymethyl-glucan (CM-G) on blood pressure (BP), baroreflex sensitivity (BRS) and sympathetic vascular modulation in renovascular hypertensive rats. Male Wistar rats were divided into four groups: Sham (n = 10); 2K1C (subjected to renal arter...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00607
更新日期：2018-05-23 00:00:00
abstract：:Coronary microembolization (CME) is an important clinical problem, and it is related to poor outcome. The specific molecular mechanisms of CME are not fully understood. In the present study, we established a mice model of CME. Isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography coupl...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.01318
更新日期：2018-09-19 00:00:00
abstract：:Physical exercise has been shown to modulate activity within the autonomic nervous system (ANS). Considering physical exercise as a holistic stimulus on the nervous system and specifically the ANS, uni- and multimodal analysis tools were applied to characterize centrally driven interactions and control of ANS function...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00240
更新日期：2019-03-29 00:00:00
abstract：:Yeast-like symbiotes (YLS), harbored in the abdomen fat-body cells of the rice brown planthopper (BPH), Nilaparvata lugens Stål (Hemiptera: Delphacidae), are vital to the growth and reproduction of their host. It is feasible to manipulate BPH infestation on rice by inhibiting YLS using fungicide. In this study, the fu...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00089
更新日期：2019-02-11 00:00:00
abstract：:Chronic kidney disease (CKD) caused by renal fibrosis is an important public health concern. It is therefore necessary to understand the molecular pathogenesis of renal fibrosis in order to develop novel therapeutic strategies. KLF4 is the most extensively studied factor among the various members of the Krüppel-like f...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2015.00327
更新日期：2015-11-12 00:00:00
abstract：:Background: Skeletal muscle aging is marked by the development of a sarcopenic phenotype, a global decline of muscle energetic capacities, and an intolerance to exercise. Among the metabolic disorders involved in this syndrome, NAD metabolism was shown to be altered in skeletalmuscle, with an important role for the NA...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.01290
更新日期：2018-09-19 00:00:00
abstract：:The brain-gut axis plays a critical role in the regulation of different diseases, many of which are characterized by sympathetic dysregulation. However, a direct link between sympathetic dysregulation and gut dysbiosis remains to be illustrated. Bone marrow (BM)-derived immune cells continuously interact with the gut ...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00220
更新日期：2017-04-12 00:00:00
abstract：:Polarized (POL) training intensity distribution (TID) emphasizes high-volume low-intensity exercise in zone (Z)1 (< first lactate threshold) with a greater proportion of high-intensity Z3 (>second lactate threshold) compared to Z2 (between first and second lactate threshold). In highly trained rowers there is a lack o...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00515
更新日期：2017-08-02 00:00:00
abstract：:Since the late 2010s, Transcranial Ultrasound Stimulation (TUS) has been used experimentally to carryout safe, non-invasive stimulation of the brain with better spatial resolution than Transcranial Magnetic Stimulation (TMS). This innovative stimulation method has emerged as a novel and valuable device for studying br...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.01042
更新日期：2020-08-19 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2014.00282
更新日期：2014-07-31 00:00:00
abstract：:Although interest in several areas of cephalopod research has emerged over the last decades (e.g., neurobiology, aquaculture, genetics, and welfare), especially following their 2010 inclusion in the EU Directive on the use of animals for experimental purposes, knowledge regarding the parasites of cephalopods is lackin...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.01573
更新日期：2018-11-20 00:00:00
abstract：:The sterile insect technique (SIT) may reduce pest populations by allowing sufficient amount of irradiation-induced sterile males to mate with wild females whilst maintaining mating ability comparable to wild males. Although the SIT methods are well understood, the optimal sterilizing dose and processing development s...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00118
更新日期：2018-02-20 00:00:00
abstract：:Previous studies assessing effect of ischemia on ventricular repolarization are mostly directed toward patients with coronary artery disease (CAD); however, similar reports on cardiac syndrome X (CSX) are scarce. Whether microvascular dysfunction of CSX and ischemia induced by CAD produce comparable effect on ventricu...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2016.00422
更新日期：2016-09-21 00:00:00
abstract：:Many cell division processes have been conserved throughout evolution and are being revealed by studies on model organisms such as bacteria, yeasts, and protozoa. Cellular membrane constriction is one of these processes, observed almost universally during cell division. It happens similarly in all organisms through a ...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00312
更新日期：2017-05-19 00:00:00
abstract：:The spawning migration of the European eel is an extensive journey over 5000 to 7000 km from the European coast to the Sargasso Sea. Eels do not feed during this journey and on-board fuels must be sufficient to support the journey of 3.5 to 6 month, as well as sexual maturation and the spawning activity. Swimming of e...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2014.00486
更新日期：2015-01-05 00:00:00
abstract：:A number of years ago we reported that ventral Lateral Neurons (LNvs), which are essential in the control of rest-activity cycles in Drosophila, undergo circadian remodeling of their axonal projections. This structural plasticity gives rise to changes in the degree of connectivity, which could provide a means of trans...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00918
更新日期：2017-11-14 00:00:00
abstract：:Data indicate endothelium-dependent dilation (EDD) may be preserved in the skeletal muscle microcirculation of young, obese adults. Preserved EDD might be mediated by compensatory mechanisms, impeding insight into preclinical vascular dysfunction. We aimed to determine the functional roles of nitric oxide synthase (NO...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2015.00387
更新日期：2015-12-22 00:00:00
abstract：:We have isolated dental pulp cells (DPCs) from three healthy (hDPCs) and three carious (cDPCs) donors and shown that compared to hDPCs cells isolated from superficial carious lesions show higher clonogenic potential; show an equivalent proportion of cells with putative stem cell surface markers; show enhanced matrix m...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00244
更新日期：2017-04-28 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2016.00349
更新日期：2016-08-19 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2013.00052
更新日期：2013-04-15 00:00:00
abstract：:Microvesicles (MVs) are released by most cell types in physiological conditions, but their number is often increased upon cellular activation or neoplastic transformation. This suggests that their detection may be helpful in pathological conditions to have information on activated cell types and, possibly, on the natu...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2012.00063
更新日期：2012-03-29 00:00:00
abstract：:Introduction: Endothelial progenitor cells (EPCs) display a unique ability to promote angiogenesis and restore endothelial function in injured blood vessels. NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H2O2) serves as a signaling molecule and promotes endothelial cell proliferation and migration as well as prote...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00150
更新日期：2017-03-23 00:00:00
abstract：:Introduction: Tilt tables enable early mobilization of patients by providing verticalization. But there is a high risk of orthostatic hypotension provoked by verticalization, especially after neurological diseases such as spinal cord injury. Robot-assisted tilt tables might be an alternative as they add passive roboti...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2016.00612
更新日期：2016-12-09 00:00:00
abstract：:We previously demonstrated that ureteral obstruction is associated with a urinary concentrating defect and reduced expression of renal aquaporins (AQPs), in which the renin-angiotensin system (RAS) may play an important role. The aims of the present study were to examine whether the renin inhibitor aliskiren could pre...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.01157
更新日期：2019-09-13 00:00:00
abstract：:Background: The short-term benefits of aerobic and resistance exercise in subjects affected by Peripheral Arterial Disease (PAD) are scarcely examined in interaction. This study aimed to identify the effects of combined aerobic and resistance exercise programs on walking performance compared with isolated aerobic exer...
journal_title：Frontiers in physiology
pub_type：
doi：10.3389/fphys.2019.01538
更新日期：2020-01-08 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00601
更新日期：2018-05-29 00:00:00
abstract：:The olfactory system serves a vital role in the evolution and survival of insects, being involved in behaviors such as host seeking, foraging, mating, and oviposition. Odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) are involved in the olfactory recognition process. In this study, BtabCSP11, a CSP11 g...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00709
更新日期：2020-06-30 00:00:00
