Expression of the prostaglandin F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm labor.

abstract：:Objective: Unexpectedly wide distribution (<10 to >90%) of hemoglobin oxygen saturation (sO2) within red cell concentrates (RCCs) has recently been observed. Causes of such variability are not yet completely explained whereas the roles of oxygen and oxidative lesions during the storage of RCCs are known. The objective...

journal_title：Frontiers in physiology

authors： Bardyn M,Martin A,Dögnitz N,Abonnenc M,Dunham A,Yoshida T,Prudent M

更新日期：2020-12-23 00:00:00

abstract：:Secretory glands including salivary glands by many hormonal inputs produce and secrete biological fluids determined by variety of ion transporters. Spinophilin is a multifunctional scaffolding protein, which involved in receptor signaling and regulation of anion exchangers AE2 activity. We found that spinophilin expre...

journal_title：Frontiers in physiology

authors： Lee D,Lee SA,Shin DM,Hong JH

更新日期：2018-07-19 00:00:00

abstract：:Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-gly...

journal_title：Frontiers in physiology

authors： Tijardović M,Marijančević D,Bok D,Kifer D,Lauc G,Gornik O,Keser T

更新日期：2019-12-20 00:00:00

abstract：:Heart failure and frailty are clinical syndromes that present with overlapping phenotypic characteristics. Importantly, their co-presence is associated with increased mortality and morbidity. While mechanical and electrical device therapies for heart failure are vital for select patients with advanced stage disease, t...

journal_title：Frontiers in physiology

authors： Fung E,Hui E,Yang X,Lui LT,Cheng KF,Li Q,Fan Y,Sahota DS,Ma BHM,Lee JSW,Lee APW,Woo J

更新日期：2018-04-24 00:00:00

abstract：:Severely affected patients with autonomic failure require pressor agents to counteract the blood pressure fall and improve presyncopal symptoms upon standing. Previous studies suggest that combination ergotamine and caffeine may be effective in the treatment of autonomic failure, but the efficacy of this drug has not ...

journal_title：Frontiers in physiology

authors： Arnold AC,Ramirez CE,Choi L,Okamoto LE,Gamboa A,Diedrich A,Raj SR,Robertson D,Biaggioni I,Shibao CA

更新日期：2014-07-24 00:00:00

abstract：:Productivity in science has increased and it is becoming more important for scientists to publish, to publish frequently, and to accumulate citations to their work. However, the peer review system may not only promote and advance but also hinder, prevent, or delay publication. In this personal perspective, confirmator...

journal_title：Frontiers in physiology

authors： Coronel R

更新日期：2020-09-04 00:00:00

abstract：:Studies have revealed a robust and independent correlation between chronic kidney disease (CKD) and cardiovascular (CV) events, including death, heart failure, and myocardial infarction. Recent clinical trials extend this range of adverse CV events, including malignant ventricular arrhythmias and sudden cardiac death ...

journal_title：Frontiers in physiology

authors： Kiuchi MG,Ho JK,Nolde JM,Gavidia LML,Carnagarin R,Matthews VB,Schlaich MP

更新日期：2020-01-14 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2019.00621.]. ...

journal_title：Frontiers in physiology

authors： Russo R,Marra R,Andolfo I,De Rosa G,Rosato BE,Manna F,Gambale A,Raia M,Unal S,Barella S,Iolascon A

更新日期：2020-08-11 00:00:00

abstract：:The bicuspid aortic valve, a kind of heart disease that comes from parents, has been paid attention around the world. Although most bicuspid aortic valve (BAV) patients will suffer from some complications including aortic stenosis, aortic regurgitation, endocarditis, and heart dysfunction in the late stage of the dise...

journal_title：Frontiers in physiology

authors： Liu T,Xie M,Lv Q,Li Y,Fang L,Zhang L,Deng W,Wang J

更新日期：2019-01-30 00:00:00

abstract：:Systems biology approaches provide means to study the interplay between biological processes leading to the mechanistic understanding of the properties of complex biological systems. Here, we developed a vector format rule-based Boolean logic model of the yeast S. cerevisiae cAMP-PKA, Snf1, and the Snf3-Rgt2 pathway t...

journal_title：Frontiers in physiology

authors： Welkenhuysen N,Schnitzer B,Österberg L,Cvijovic M

更新日期：2019-01-21 00:00:00

abstract：PURPOSE:While the intention of endurance athletes undertaking short term heat training protocols is to rapidly gain meaningful physical adaption prior to competition in the heat, it is currently unclear whether or not this process also presents an overt, acute challenge to the immune system. The aim of this study was t...

journal_title：Frontiers in physiology

authors： Guy JH,Pyne DB,Deakin GB,Miller CM,Edwards AM

更新日期：2016-07-29 00:00:00

abstract：:The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific challenges. Endogenous continuous ("tonic") neuromodulation can regula...

journal_title：Frontiers in physiology

authors： Peña-Ortega F

更新日期：2012-07-20 00:00:00

abstract：:Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, ...

journal_title：Frontiers in physiology

authors： Larsson S,Åkerström B,Gram M,Lohmander LS,Struglics A

更新日期：2018-11-16 00:00:00

abstract：:Human diseases have been investigated in the context of single genes as well as complex networks of genes. Though single gene approaches have been extremely successful in the past, most human diseases are complex and better characterized by multiple interacting genes commonly known as networks or pathways. With the ad...

journal_title：Frontiers in physiology

authors： Sahoo D

更新日期：2012-07-23 00:00:00

abstract：:Background: Nrg4 expression has been linked to brown adipose tissue activity and browning of white adipocytes in mice. Here, we aimed to investigate whether these observations could be translated to humans by investigating NRG4 mRNA and markers of brown/beige adipocytes in human visceral (VAT) and subcutaneous adipose...

journal_title：Frontiers in physiology

authors： Comas F,Martínez C,Sabater M,Ortega F,Latorre J,Díaz-Sáez F,Aragonés J,Camps M,Gumà A,Ricart W,Fernández-Real JM,Moreno-Navarrete JM

更新日期：2019-01-31 00:00:00

abstract：:Denervation induces skeletal muscle atrophy, accompanied by complex biochemical and physiological changes, with potentially devastating outcomes even an increased mortality. Currently, however, there remains a paucity of effective strategies to treat skeletal muscle atrophy. Therefore, it is required to understand the...

journal_title：Frontiers in physiology

authors： Shen Y,Zhang R,Xu L,Wan Q,Zhu J,Gu J,Huang Z,Ma W,Shen M,Ding F,Sun H

更新日期：2019-10-11 00:00:00

abstract：:Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and non-excitable cells. With 40 known members in the human genome and a variety of homomeric and heteromeric pore-forming α subunit interactions, post-translational mod...

journal_title：Frontiers in physiology

authors： Kanda VA,Abbott GW

更新日期：2012-06-28 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity accounting for 50% of all diagnosed heart failure and that has claimed its own dignity being markedly different from heart failure with reduced EF in terms of etiology and natural history (Graziani et al., 2018). Recently, a growi...

journal_title：Frontiers in physiology

authors： D'Amario D,Migliaro S,Borovac JA,Restivo A,Vergallo R,Galli M,Leone AM,Montone RA,Niccoli G,Aspromonte N,Crea F

更新日期：2019-11-05 00:00:00

abstract：:Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues. The rate of secretion of salivary substances, ions, and water follows a circadian rhythm, h...

journal_title：Frontiers in physiology

authors： Satou R,Sato M,Kimura M,Ishizuka Y,Tazaki M,Sugihara N,Shibukawa Y

更新日期：2017-05-23 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is the most common mendelian heart disease, with a prevalence of 1/500. HCM is a primary cause of sudden death, due to an heightened risk of ventricular tachyarrhythmias that often occur in young asymptomatic patients. HCM can slowly progress toward heart failure, either with preserve...

journal_title：Frontiers in physiology

authors： Coppini R,Ferrantini C,Mugelli A,Poggesi C,Cerbai E

更新日期：2018-10-16 00:00:00

abstract：:Chronic kidney disease (CKD) caused by renal fibrosis is an important public health concern. It is therefore necessary to understand the molecular pathogenesis of renal fibrosis in order to develop novel therapeutic strategies. KLF4 is the most extensively studied factor among the various members of the Krüppel-like f...

journal_title：Frontiers in physiology

authors： Ke B,Zhang A,Wu X,Fang X

更新日期：2015-11-12 00:00:00

abstract：:In the last three decades, all efforts in bone tissue engineering were driven by the dogma that the ideal pore size in bone substitutes lies between 0.3 and 0.5 mm in diameter. Newly developed additive manufacturing methodologies for ceramics facilitate the total control over pore size, pore distribution, bottleneck s...

journal_title：Frontiers in physiology

authors： Ghayor C,Weber FE

更新日期：2018-07-19 00:00:00

abstract：:Crayfish are capable of two rapid, escape reflexes that are mediated by two pairs of giant interneurons, the lateral giants (LG) and the medial giants (MG), which respond to threats presented to the abdomen or head and thorax, respectively. The LG has been the focus of study for many decades and the role of GABAergic ...

journal_title：Frontiers in physiology

authors： Swierzbinski ME,Herberholz J

更新日期：2018-04-27 00:00:00

abstract：:Background: Pressure unloading induces the regression of left ventricular myocardial hypertrophy (LVH). Recent findings indicate that pharmacological activation of the soluble guanylate cyclase (sGC) - cyclic guanosine monophosphate (cGMP) pathway may also exert reverse-remodeling properties in the myocardium. Therefo...

journal_title：Frontiers in physiology

authors： Ruppert M,Korkmaz-Icöz S,Li S,Brlecic P,Németh BT,Oláh A,Horváth EM,Veres G,Pleger S,Grabe N,Merkely B,Karck M,Radovits T,Szabó G

更新日期：2019-01-08 00:00:00

abstract：:Many drugs investigated for the treatment of glioblastoma (GBM) have had disappointing clinical trial results. Efficacy of these agents is dependent on adequate delivery to sensitive tumor cell populations, which is limited by the blood-brain barrier (BBB). Additionally, tumor heterogeneity can lead to subpopulations ...

journal_title：Frontiers in physiology

authors： Massey SC,Urcuyo JC,Marin BM,Sarkaria JN,Swanson KR

更新日期：2020-08-21 00:00:00

abstract：:We tested the hypothesis that elastic binding of the abdomen (AB) would enhance neuromuscular efficiency of the human diaphragm during exercise. Twelve healthy non-obese men aged 24.8 ± 1.7 years (mean ± SE) completed a symptom-limited constant-load cycle endurance exercise test at 85% of their peak incremental power ...

journal_title：Frontiers in physiology

authors： Abdallah SJ,Chan DS,Glicksman R,Mendonca CT,Luo Y,Bourbeau J,Smith BM,Jensen D

更新日期：2017-05-31 00:00:00

abstract：Background:The aim of this study is to report on the genetic composition of Brugada syndrome (BrS) patients undergoing genetic testing in Hong Kong. Methods:Patients with suspected BrS who presented to the Hospital Authority of Hong Kong between 1997 and 2019, and underwent genetic testing, were analyzed retrospective...

journal_title：Frontiers in physiology

authors： Tse G,Lee S,Liu T,Yuen HC,Wong ICK,Mak C,Mok NS,Wong WT

更新日期：2020-09-18 00:00:00

abstract：Background:The aim of presented cross-sectional study was to determine the association of different types of physical activity (PA) with metabolic control in people with type 1 diabetes. Materials and Methods:A total of 109 adult subjects with type 1 diabetes were asked to complete the non-exercise activity thermogene...

journal_title：Frontiers in physiology

authors： Štotl I,Kambič T,Hadžić V,Zdolšek A

更新日期：2019-09-24 00:00:00

abstract：:Fractal phenomena can be found in numerous scientific areas including neuroscience. Fractals are structures, in which the whole has the same shape as its parts. A specific structure known as pink noise (also called fractal or 1/f noise) is one key fractal manifestation, exhibits both stability and adaptability, and ca...

journal_title：Frontiers in physiology

authors： Akhrif A,Romanos M,Domschke K,Schmitt-Boehrer A,Neufang S

更新日期：2018-10-04 00:00:00

abstract：:Many animals use a diverse repertoire of complex acoustic signals to convey different types of information to other animals. The information in each vocalization therefore must be coded by neurons in the auditory system. One way in which the auditory system may discriminate among different vocalizations is by having h...

journal_title：Frontiers in physiology

authors： Dimitrov AG,Cummins GI,Mayko ZM,Portfors CV

更新日期：2014-04-16 00:00:00