Abstract:
:Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and non-excitable cells. With 40 known members in the human genome and a variety of homomeric and heteromeric pore-forming α subunit interactions, post-translational modifications, cellular locations, and expression patterns, the functional repertoire of the Kv α subunit family is monumental. This versatility is amplified by a host of interacting proteins, including the single membrane-spanning KCNE ancillary subunits. Here, examining both the secretory and the endocytic pathways, we review recent findings illustrating the surprising virtuosity of the KCNE proteins in orchestrating not just the function, but also the composition, diaspora and retrieval of channels formed by their Kv α subunit partners.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Kanda VA,Abbott GWdoi
10.3389/fphys.2012.00231subject
Has Abstractpub_date
2012-06-28 00:00:00pages
231issn
1664-042Xjournal_volume
3pub_type
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journal_title:Frontiers in physiology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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abstract::[This corrects the article DOI: 10.3389/fphys.2019.00313.]. ...
journal_title:Frontiers in physiology
pub_type: 已发布勘误
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更新日期:2020-02-25 00:00:00
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pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.00925
更新日期:2019-07-30 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.574339
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pub_type: 杂志文章
doi:10.3389/fphys.2017.00006
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pub_type: 杂志文章,评审
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2013.00151
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Frontiers in physiology
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