The Role of Krüppel-like Factor 4 in Renal Fibrosis.

abstract：:Aim: To investigate whether housing temperature influences rat adiposity, and the extent it is modified by diet and/or pregnancy. Housing temperature impacts on brown adipose tissue, that possess a unique uncoupling protein (UCP) 1, which, when activated by reduced ambient temperature, enables rapid heat generation. M...

journal_title：Frontiers in physiology

authors： Albustanji L,Perez GS,AlHarethi E,Aldiss P,Bloor I,Barreto-Medeiros JM,Budge H,Symonds ME,Dellschaft N

更新日期：2019-03-06 00:00:00

abstract：:Comparison of genomic sequences from diverse vertebrate species has revealed numerous highly conserved regions that do not appear to encode proteins or functional RNAs. Often these "conserved non-coding elements," or CNEs, can direct gene expression to specific tissues in transgenic models, demonstrating they have reg...

journal_title：Frontiers in physiology

authors： Turner EE,Cox TC

更新日期：2014-01-21 00:00:00

abstract：:Currently, schizophrenia is considered a multifactorial disease. Over the past 50 years, many investigators have considered the role of toxic free radicals in the etiology of schizophrenia. This is an area of active research which is still evolving. Here, we review the recent data and current concepts on the roles of ...

journal_title：Frontiers in physiology

authors： Nasyrova RF,Ivashchenko DV,Ivanov MV,Neznanov NG

更新日期：2015-05-11 00:00:00

abstract：:Airway hyperresponsiveness (AHR), a characteristic of asthma that involves an excessive reduction in airway caliber, is a complex mechanism reflecting multiple processes that manifest over a large range of length and time scales. At one extreme, molecular interactions determine the force generated by airway smooth mus...

journal_title：Frontiers in physiology

authors： Lauzon AM,Bates JH,Donovan G,Tawhai M,Sneyd J,Sanderson MJ

更新日期：2012-06-11 00:00:00

abstract：:Current scientific debates center on the impact of lipids and mitochondrial function on diverse aspects of human health, nutrition and disease, among them the association of lipotoxicity with the onset of insulin resistance in skeletal muscle, and with heart dysfunction in obesity and diabetes. Mitochondria play a fun...

journal_title：Frontiers in physiology

authors： Aon MA,Bhatt N,Cortassa SC

更新日期：2014-07-31 00:00:00

abstract：:Ethylene is known to influence the cell cycle (CC) via poorly characterized roles whilst nitric oxide (NO) has well-established roles in the animal CC but analogous role(s) have not been reported for plants. As NO and ethylene signaling events often interact we examined their role in CC in cultured cells derived from ...

journal_title：Frontiers in physiology

authors： Novikova GV,Mur LA,Nosov AV,Fomenkov AA,Mironov KS,Mamaeva AS,Shilov ES,Rakitin VY,Hall MA

更新日期：2017-03-10 00:00:00

abstract：:Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertroph...

journal_title：Frontiers in physiology

authors： Pazó-Sayós L,González MC,Quintana-Villamandos B

更新日期：2020-08-26 00:00:00

abstract：:Aim: The aim of the present study was to determine the validity of position, distance traveled and instantaneous speed of team sport players as measured by a commercially available local positioning system (LPS) during indoor use. In addition, the study investigated how the placement of the field of play relative to t...

journal_title：Frontiers in physiology

authors： Luteberget LS,Spencer M,Gilgien M

更新日期：2018-04-04 00:00:00

abstract：:This study evaluated the effects of continuous and intermittent blood flow restriction (BFR) with 70% of full arterial occlusion pressure on bar velocity during the bench press exercise against a wide range of resistive loads. Eleven strength-trained males (age: 23.5 ± 1.4 years; resistance training experience: 2.8 ± ...

journal_title：Frontiers in physiology

authors： Wilk M,Gepfert M,Krzysztofik M,Stastny P,Zajac A,Bogdanis GC

更新日期：2020-11-27 00:00:00

abstract：:A Boolean model is a simple, discrete and dynamic model without the need to consider the effects at the intermediate levels. However, little effort has been made into constructing activation, inhibition, and protein decay networks, which could indicate the direct roles of a gene (or its synthesized protein) as an acti...

journal_title：Frontiers in physiology

authors： Chen L,Kulasiri D,Samarasinghe S

更新日期：2018-09-25 00:00:00

abstract：:While many effectors have been identified in enamel matrix and cells via genetic studies, physiological networks underlying their expression levels and thus the natural spectrum of enamel thickness and degree of mineralization are now just emerging. Several transcription factors are candidates for enamel gene expressi...

journal_title：Frontiers in physiology

authors： Babajko S,de La Dure-Molla M,Jedeon K,Berdal A

更新日期：2015-01-05 00:00:00

abstract：:Short bowel syndrome (SBS) is characterized by severe intestinal malabsorption following restrictive surgery. The objective of this study was to determine the functional contribution of SBS-microbiota after resection. It is well-known that SBS-microbiota displayed specific features with a prevalence of Lactobacillus, ...

journal_title：Frontiers in physiology

authors： Gillard L,Mayeur C,Robert V,Pingenot I,Le Beyec J,Bado A,Lepage P,Thomas M,Joly F

更新日期：2017-04-19 00:00:00

abstract：:Realistic electrocardiogram (ECG) simulation with numerical models is important for research linking cellular and molecular physiology to clinically observable signals, and crucial for patient tailoring of numerical heart models. However, ECG simulation with a realistic torso model is computationally much harder than ...

journal_title：Frontiers in physiology

authors： Potse M

更新日期：2018-04-20 00:00:00

abstract：:Wound healing is delayed frequently in patients with diabetes. Proper keratinocyte migration is an essential step during re-epithelialization. Impaired keratinocyte migration is a critical underlying factor responsible for the deficiency of diabetic wound healing, which is mainly attributed to the hyperglycemic state....

journal_title：Frontiers in physiology

authors： Li L,Zhang J,Zhang Q,Zhang D,Xiang F,Jia J,Wei P,Zhang J,Hu J,Huang Y

更新日期：2019-01-28 00:00:00

abstract：:Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-systemic chronic illness of unknown etiology, classified as a neurological disorder by the World Health Organization (WHO). The symptomatology of the condition appears to emanate from a variety of sources of chronic neurological distur...

journal_title：Frontiers in physiology

authors： Glassford JA

更新日期：2017-02-17 00:00:00

abstract：:Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucidated the acute (1-2 days) and 2-week effects of blocking ACVR2 ligand...

journal_title：Frontiers in physiology

authors： Hentilä J,Nissinen TA,Korkmaz A,Lensu S,Silvennoinen M,Pasternack A,Ritvos O,Atalay M,Hulmi JJ

更新日期：2019-01-18 00:00:00

abstract：:Primary aldosteronism (PA) is the most common cause of secondary hypertension. The paucity of good animal models hinders our understanding of the pathophysiology of PA and the hypertensive mechanism of PA remains incompletely known. It was recently reported that genetic deletion of TWIK-related acid-sensitive potassiu...

journal_title：Frontiers in physiology

authors： Shi L,Yuan F,Wang X,Wang R,Liu K,Tian Y,Guo Z,Zhang X,Wang S

更新日期：2019-11-22 00:00:00

abstract：:RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3. Homozygotes present with a phenotype characteristic of bone marrow failure that is accompanied by alternat...

journal_title：Frontiers in physiology

authors： Hartman ES,Brindley EC,Papoin J,Ciciotte SL,Zhao Y,Peters LL,Blanc L

更新日期：2018-06-05 00:00:00

abstract：:Mucolipins (TRPML) are endosome/lysosome Ca2+ permeable channels belonging to the family of transient receptor potential channels. In mammals, there are three TRPML proteins, TRPML1, 2, and 3, encoded by MCOLN1-3 genes. Among these channels, TRPML1 is a reactive oxygen species sensor localized on the lysosomal membran...

journal_title：Frontiers in physiology

authors： Santoni G,Maggi F,Amantini C,Marinelli O,Nabissi M,Morelli MB

更新日期：2020-03-24 00:00:00

abstract：:Domestic pig molars provide an interesting system to study the biomineralization process. The large size, thick enamel and complex crown morphology make pig molars relatively similar to human molars. However, compared to human molars, pig molars develop considerably faster. Here we use microCT to image the developing ...

journal_title：Frontiers in physiology

authors： Sova SS,Tjäderhane L,Heikkilä PA,Jernvall J

更新日期：2018-02-09 00:00:00

abstract：:Productivity in science has increased and it is becoming more important for scientists to publish, to publish frequently, and to accumulate citations to their work. However, the peer review system may not only promote and advance but also hinder, prevent, or delay publication. In this personal perspective, confirmator...

journal_title：Frontiers in physiology

authors： Coronel R

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:Human labor is a complex series of cellular and molecular events that occur at the materno-fetal and uterine levels. Many hypotheses have been proposed for the initiation of human labor, one hypothesis suggests that maturation of the fetus releases a signal in the amniotic fluid that will be transmitted to m...

journal_title：Frontiers in physiology

authors： Alzamil HA,Pawade J,Fortier MA,Bernal AL

更新日期：2014-07-30 00:00:00

abstract：UNLABELLED:Since Matrix metalloproteinases (MMPs) have been suggested to contribute to dentin caries progression, the hypothesis that MMP inhibition would affect the progression of dentin caries is clinically relevant. Grape seed extracts (GSE) have been previously reported to be natural inhibitors of MMPs. OBJECTIVE:...

journal_title：Frontiers in physiology

authors： Khaddam M,Salmon B,Le Denmat D,Tjaderhane L,Menashi S,Chaussain C,Rochefort GY,Boukpessi T

更新日期：2014-10-31 00:00:00

abstract：:Purpose: The mechanisms involved in the coordination of muscle activity are not completely known: to investigate adaptive changes in human motor cortex Transcranial magnetic stimulation (TMS) was often used. The sport models are frequently used to study how the training may affect the corticospinal system excitability...

journal_title：Frontiers in physiology

authors： Monda V,Valenzano A,Moscatelli F,Salerno M,Sessa F,Triggiani AI,Viggiano A,Capranica L,Marsala G,De Luca V,Cipolloni L,Ruberto M,Precenzano F,Carotenuto M,Zammit C,Gelzo M,Monda M,Cibelli G,Messina G,Messina A

更新日期：2017-09-12 00:00:00

abstract：:Huanglian Jiedu decoction (HLJDD) has been used in the clinical treatment of inflammatory conditions. To clarify the mechanism of its comprehensive anti-inflammatory activities, the correlation between lipid homeostasis and the TLR4/MyD88 signaling pathway in zebrafish was established in the present study. In the lipo...

journal_title：Frontiers in physiology

authors： Zhou J,Gu X,Fan X,Zhou Y,Wang H,Si N,Yang J,Bian B,Zhao H

更新日期：2019-09-26 00:00:00

abstract：INTRODUCTION:Gases, such as nitric oxide (NO), carbon monoxide (CO), or hydrogen sulfide (H2S), termed gasotransmitters, play an increasingly important role in understanding of how electrical signaling of cells is modulated. H2S is well-known to act on various ion channels and receptors. In a previous study we reported...

journal_title：Frontiers in physiology

authors： Sitdikova GF,Fuchs R,Kainz V,Weiger TM,Hermann A

更新日期：2014-11-12 00:00:00

abstract：:Claudin-1 is a tight junction transmembrane protein. Its localization in the maturation ameloblasts of rat incisors was examined by immunofluorescence microscopy. Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts (SA) and RAs stained positive ...

journal_title：Frontiers in physiology

authors： Nishikawa S,Abe M

更新日期：2010-11-16 00:00:00

abstract：:Many disease fighting strategies have focused on the generation of NK cells, since they constitute the main immune barrier against cancer and intracellular pathogens such as viruses. Therefore, a predictive model for the development of NK cells would constitute a useful tool to test several hypotheses regarding the pr...

journal_title：Frontiers in physiology

authors： Liquitaya-Montiel AJ,Mendoza L

更新日期：2018-08-02 00:00:00

abstract：:Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from th...

journal_title：Frontiers in physiology

authors： Zhai C,Li R,Hou K,Chen J,Alzogool M,Hu Y,Zhang J,Zhang Y,Wang L,Zhang R,Cong H

更新日期：2020-08-14 00:00:00

abstract：:Heat shock proteins are molecular chaperones that are involved in numerous normal cellular processes and stress responses, and heat shock factors are transcriptional activators of heat shock proteins. Heat shock factors and heat shock proteins are coordinated in various biological processes. The regulatory function of...

journal_title：Frontiers in physiology

authors： Jin J,Li Y,Zhou Z,Zhang H,Guo J,Wan F

更新日期：2020-09-15 00:00:00