A microCT Study of Three-Dimensional Patterns of Biomineralization in Pig Molars.

Abstract:

:Domestic pig molars provide an interesting system to study the biomineralization process. The large size, thick enamel and complex crown morphology make pig molars relatively similar to human molars. However, compared to human molars, pig molars develop considerably faster. Here we use microCT to image the developing pig molars and to decipher spatial patterns of biomineralization. We used mineral grains to calibrate individual microCT-scans, which allowed an accurate measure of the electron density of the developing molars. The microCT results show that unerupted molars that are morphologically at the same stage of development, can be at markedly different stage of enamel biomineralization. Erupted molars show increased electron density, suggesting that mineralization continues in oral cavity. Yet, our comparisons show that human enamel has slightly higher electron density than pig enamel. These results support the relatively low hardness values and calcium level values that have been reported earlier in literature for pig teeth. The mineral calibration was an efficient method for the microCT-absorption models, allowing a relatively robust way to detect scanning artifacts. In conclusions, whereas thin sections remain the preferred way to analyze enamel features, such as incremental lines and crystal orientation, the microCT allows efficient and non-destructive comparisons between different teeth and species.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Sova SS,Tjäderhane L,Heikkilä PA,Jernvall J

doi

10.3389/fphys.2018.00071

subject

Has Abstract

pub_date

2018-02-09 00:00:00

pages

71

issn

1664-042X

journal_volume

9

pub_type

杂志文章
  • Selenium-Containing Protein From Selenium-Enriched Spirulina platensis Attenuates High Glucose-Induced Calcification of MOVAS Cells by Inhibiting ROS-Mediated DNA Damage and Regulating MAPK and PI3K/AKT Pathways.

    abstract::Hyperglycemia is the main feature of diabetes and may increase the risk of vascular calcification (VC), which is an independent predictor for cardiovascular and cerebrovascular diseases (CCD). Selenium (Se) may decrease the risk of CCD, and previous studies confirmed that Se-containing protein from Se-enriched Spiruli...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00791

    authors: Lin C,Zhang LJ,Li B,Zhang F,Shen QR,Kong GQ,Wang XF,Cui SH,Dai R,Cao WQ,Zhang P

    更新日期:2020-07-09 00:00:00

  • Exercise-Induced Changes of Multimodal Interactions Within the Autonomic Nervous Network.

    abstract::Physical exercise has been shown to modulate activity within the autonomic nervous system (ANS). Considering physical exercise as a holistic stimulus on the nervous system and specifically the ANS, uni- and multimodal analysis tools were applied to characterize centrally driven interactions and control of ANS function...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00240

    authors: Vieluf S,Hasija T,Jakobsmeyer R,Schreier PJ,Reinsberger C

    更新日期:2019-03-29 00:00:00

  • Cellular cardiac electrophysiology modeling with Chaste and CellML.

    abstract::Chaste is an open-source C++ library for computational biology that has well-developed cardiac electrophysiology tissue simulation support. In this paper, we introduce the features available for performing cardiac electrophysiology action potential simulations using a wide range of models from the Physiome repository....

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00511

    authors: Cooper J,Spiteri RJ,Mirams GR

    更新日期:2015-01-06 00:00:00

  • Brain dysfunction as one cause of CFS symptoms including difficulty with attention and concentration.

    abstract::We have been able to reduce substantially patient pool heterogeneity by identifying phenotypic markers that allow the researcher to stratify chronic fatigue syndrome (CFS) patients into subgroups. To date, we have shown that stratifying based on the presence or absence of comorbid psychiatric diagnosis leads to a grou...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00109

    authors: Natelson BH

    更新日期:2013-05-20 00:00:00

  • Corrigendum: Partial Weight-Bearing in Female Rats: Proof of Concept in a Martian-Gravity Analog.

    abstract::[This corrects the article DOI: 10.3389/fphys.2020.00302.]. ...

    journal_title:Frontiers in physiology

    pub_type: 已发布勘误

    doi:10.3389/fphys.2020.00672

    authors: Semple C,Riveros D,Nagy JA,Rutkove SB,Mortreux M

    更新日期:2020-07-03 00:00:00

  • High Glucose Aggravates Cholesterol Accumulation in Glomerular Endothelial Cells Through the LXRs/LncRNAOR13C9/ABCA1 Regulatory Network.

    abstract:Background:The underlying mechanisms by which diabetes and dyslipidemia contribute to diabetic nephropathy (DN) are not fully understood. In this study, we aimed to investigate the role of high glucose (HG) on intracellular cholesterol accumulation in glomerular endothelial cells (GEnCs) and its potential mechanism. M...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.552483

    authors: Wang Y,Xiao S,Zhou S,Zhang R,Liu H,Lin Y,Yu P

    更新日期:2020-10-19 00:00:00

  • The Effects of Tai Chi Training in Patients with Heart Failure: A Systematic Review and Meta-Analysis.

    abstract::Heart Failure (HF) is associated with significantly high morbidity and mortality. We performed a meta-analysis and updated new evidences from randomized controlled trials (RCTs) to determine the effects of Tai Chi (TC) in patients with HF. Electronic literature search of Medline, PubMed, EMBASE, the Cochrane Library, ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00989

    authors: Ren X,Li Y,Yang X,Li J,Li H,Yuan Z,Sun Y,Shang H,Xing Y,Gao Y

    更新日期:2017-12-07 00:00:00

  • Age-Related Changes in the Expression of the Circadian Clock Protein PERIOD in Drosophila Glial Cells.

    abstract::Circadian clocks consist of molecular negative feedback loops that coordinate physiological, neurological, and behavioral variables into "circa" 24-h rhythms. Rhythms in behavioral and other circadian outputs tend to weaken during aging, as evident in progressive disruptions of sleep-wake cycles in aging organisms. Ho...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.01131

    authors: Long DM,Giebultowicz JM

    更新日期:2018-01-09 00:00:00

  • Enhanced Myogenic Constriction in the SHR Preglomerular Vessels Is Mediated by Thromboxane A2 Synthesis.

    abstract:Background:Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant hypertension, SHR kidneys remain relatively free of pathology due to having an augmented myogenic constriction (MC). We h...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00853

    authors: Nademi S,Lu C,Dickhout JG

    更新日期:2020-07-22 00:00:00

  • Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect.

    abstract::Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAII and aquaporin-1 are expressed in the thin descending limb (TDL); however, the ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.01108

    authors: Krishnan D,Pan W,Beggs MR,Trepiccione F,Chambrey R,Eladari D,Cordat E,Dimke H,Alexander RT

    更新日期:2018-01-05 00:00:00

  • Indexing Mental Workload During Simulated Air Traffic Control Tasks by Means of Dual Frequency Head Maps.

    abstract::In our digitized society, advanced information and communication technology and highly interactive work environments impose high demands on cognitive capacity. Optimal workload conditions are important for assuring employee's health and safety of other persons. This is particularly relevant in safety-critical occupati...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00300

    authors: Radüntz T,Fürstenau N,Mühlhausen T,Meffert B

    更新日期:2020-04-21 00:00:00

  • Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation.

    abstract::Mitochondrial redox imbalance has been implicated in mechanisms of aging, various degenerative diseases and drug-induced toxicity. Statins are safe and well-tolerated therapeutic drugs that occasionally induce myotoxicity such as myopathy and rhabdomyolysis. Previous studies indicate that myotoxicity caused by statins...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00103

    authors: La Guardia PG,Alberici LC,Ravagnani FG,Catharino RR,Vercesi AE

    更新日期:2013-05-15 00:00:00

  • Functional Study of Cytochrome P450 Enzymes from the Brown Planthopper (Nilaparvata lugens Stål) to Analyze Its Adaptation to BPH-Resistant Rice.

    abstract::Plant-insect interactions constitute a complex of system, whereby plants synthesize toxic compounds as the main defense strategy to combat herbivore assault, and insects deploy detoxification systems to cope with toxic plant compounds. Cytochrom P450s are among the main detoxification enzymes employed by insects to co...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00972

    authors: Peng L,Zhao Y,Wang H,Song C,Shangguan X,Ma Y,Zhu L,He G

    更新日期:2017-11-30 00:00:00

  • Effectiveness of a Novel Nutraceutical Compound Containing Red Yeast Rice, Polymethoxyflavones and Antioxidants in the Modulation of Cholesterol Levels in Subjects With Hypercholesterolemia and Low-Moderate Cardiovascular Risk: The NIRVANA Study.

    abstract::Background: Red yeast rice supplements are broadly accepted as treatment for dyslipidaemia in subjects without high cardiovascular (CV) risk. Their effect on lipid profile is well known, but few data are available on their effect on endothelial function. Objectives: To study the effect of a novel nutraceutical compoun...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00217

    authors: Cimaglia P,Vieceli Dalla Sega F,Vitali F,Lodolini V,Bernucci D,Passarini G,Fortini F,Marracino L,Aquila G,Rizzo P,Ferrari R,Campo G

    更新日期:2019-03-11 00:00:00

  • Dental Pulp Cells Isolated from Teeth with Superficial Caries Retain an Inflammatory Phenotype and Display an Enhanced Matrix Mineralization Potential.

    abstract::We have isolated dental pulp cells (DPCs) from three healthy (hDPCs) and three carious (cDPCs) donors and shown that compared to hDPCs cells isolated from superficial carious lesions show higher clonogenic potential; show an equivalent proportion of cells with putative stem cell surface markers; show enhanced matrix m...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00244

    authors: Alkharobi H,Beattie J,Meade J,Devine D,El-Gendy R

    更新日期:2017-04-28 00:00:00

  • The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.

    abstract::Different from other epithelia, the intestinal epithelium has the complex task of providing a barrier impeding the entry of toxins, food antigens, and microbes, while at the same time allowing for the transfer of nutrients, electrolytes, water, and microbial metabolites. These molecules/organisms are transported eithe...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2016.00245

    authors: Tang L,Cheng CY,Sun X,Pedicone AJ,Mohamadzadeh M,Cheng SX

    更新日期:2016-06-21 00:00:00

  • Regulation of arterial pressure by the paraventricular nucleus in conscious rats: interactions among glutamate, GABA, and nitric oxide.

    abstract::The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic and neuroendocrine regulation. Experiments in anesthetized animals and in vitro indicate an interaction among gamma-aminobutyric acid (GABA), nitric oxide (NO), and glutamate in the PVN. The cardiovascular role of the PVN and inte...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00490

    authors: Martins-Pinge MC,Mueller PJ,Foley CM,Heesch CM,Hasser EM

    更新日期:2013-01-09 00:00:00

  • Embryonic Exposure to Valproic Acid Affects Social Predispositions for Dynamic Cues of Animate Motion in Newly-Hatched Chicks.

    abstract::Early predispositions to preferentially orient toward cues associated with social partners have been documented in several vertebrate species including human neonates and domestic chicks. Human newborns at high familiar risk of Autism Spectrum Disorder (ASD) show differences in their attention toward these predisposed...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00501

    authors: Lorenzi E,Pross A,Rosa-Salva O,Versace E,Sgadò P,Vallortigara G

    更新日期:2019-04-30 00:00:00

  • The multiple roles of fatty acid handling proteins in brain.

    abstract::Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00385

    authors: Moullé VS,Cansell C,Luquet S,Cruciani-Guglielmacci C

    更新日期:2012-09-28 00:00:00

  • Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.

    abstract::Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from th...

    journal_title:Frontiers in physiology

    pub_type:

    doi:10.3389/fphys.2020.00691

    authors: Zhai C,Li R,Hou K,Chen J,Alzogool M,Hu Y,Zhang J,Zhang Y,Wang L,Zhang R,Cong H

    更新日期:2020-08-14 00:00:00

  • Renal Hemodynamics During Sympathetic Activation Following Aerobic and Anaerobic Exercise.

    abstract::We tested the hypotheses that prior aerobic (Study 1) or anaerobic (Study 2) exercise attenuates the increase in renal vascular resistance (RVR) during sympathetic stimulation. Ten healthy young adults (5 females) participated in both Study 1 (aerobic exercise) and Study 2 (anaerobic exercise). In Study 1, subjects co...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01928

    authors: Schlader ZJ,Chapman CL,Benati JM,Gideon EA,Vargas NT,Lema PC,Johnson BD

    更新日期:2019-01-10 00:00:00

  • Ratings of Perceived Exertion Misclassify Intensities for Sedentary Older Adults During Graded Cycling Test: Effect of Supramaximal High-Intensity Interval Training.

    abstract::The present study aims (1) to evaluate ratings of perceived exertion (RPE) and corresponding intensities during a maximal graded cycling test and (2) to determine the effects of 6 weeks of supramaximal cycling exercise (SCE) intervention on RPE and associated physiological factors in young and older sedentary groups. ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01505

    authors: Jabbour G,Majed L

    更新日期:2018-10-25 00:00:00

  • Fatty Infiltration of the Myocardium and Arrhythmogenesis: Potential Cellular and Molecular Mechanisms.

    abstract::Anatomical evidence in several species shows highly heterogeneous fat distribution in the atrial and ventricular myocardium. Atrial appendages have fat deposits, and more so on the posterior left atrium. Although such fat distributions are considered normal, fatty infiltration is regarded arrhythmogenic, and various c...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.00002

    authors: Anumonwo JMB,Herron T

    更新日期:2018-01-22 00:00:00

  • Limb-Specific Features and Asymmetry of Nerve Conduction Velocity and Nerve Trunk Size in Human.

    abstract::This study aimed to simultaneously examine the differences of human nerve conduction velocity (NCV) and nerve cross-sectional area (nCSA) between the upper and lower limbs and between different regions of the upper and lower limbs. Thirty healthy subjects volunteered for the study. NCV and nCSA of the ulnar and tibial...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.609006

    authors: Nobue A,Kunimasa Y,Tsuneishi H,Sano K,Oda H,Ishikawa M

    更新日期:2020-12-03 00:00:00

  • High Altitude Affects Nocturnal Non-linear Heart Rate Variability: PATCH-HA Study.

    abstract::Background: High altitude (HA) exposure can lead to changes in resting heart rate variability (HRV), which may be linked to acute mountain sickness (AMS) development. Compared with traditional HRV measures, non-linear HRV appears to offer incremental and prognostic data, yet its utility and relationship to AMS have be...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00390

    authors: Boos CJ,Bye K,Sevier L,Bakker-Dyos J,Woods DR,Sullivan M,Quinlan T,Mellor A

    更新日期:2018-04-16 00:00:00

  • Antagonistic Interactions and Clutch-Dependent Sensitivity Induce Variable Responses to Ocean Acidification and Warming in Squid (Doryteuthis pealeii) Embryos and Paralarvae.

    abstract::Ocean acidification (OA) and warming seas are significant concerns for coastal systems and species. The Atlantic longfin squid, Doryteuthis pealeii, a core component of the Northwest Atlantic trophic web, has demonstrated impacts, such as reduced growth and delayed development, under high chronic exposure to acidifica...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00501

    authors: Zakroff CJ,Mooney TA

    更新日期:2020-05-20 00:00:00

  • Heart Rate Variability (HRV) and Pulse Rate Variability (PRV) for the Assessment of Autonomic Responses.

    abstract::Introduction: Heart Rate Variability (HRV) and Pulse Rate Variability (PRV), are non-invasive techniques for monitoring changes in the cardiac cycle. Both techniques have been used for assessing the autonomic activity. Although highly correlated in healthy subjects, differences in HRV and PRV have been observed under ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00779

    authors: Mejía-Mejía E,Budidha K,Abay TY,May JM,Kyriacou PA

    更新日期:2020-07-23 00:00:00

  • Corrigendum: The Spectrum of SPTA1-Associated Hereditary Spherocytosis.

    abstract::[This corrects the article DOI: 10.3389/fphys.2019.00815.]. ...

    journal_title:Frontiers in physiology

    pub_type: 已发布勘误

    doi:10.3389/fphys.2019.01331

    authors: Chonat S,Risinger M,Sakthivel H,Niss O,Rothman JA,Hsieh L,Chou ST,Kwiatkowski JL,Khandros E,Gorman MF,Wells DT,Maghathe T,Dagaonkar N,Seu KG,Zhang K,Zhang W,Kalfa TA

    更新日期:2019-10-18 00:00:00

  • Utility of a Novel Biofeedback Device for Within-Breath Modulation of Heart Rate in Rats: A Quantitative Comparison of Vagus Nerve vs. Right Atrial Pacing.

    abstract::In an emerging bioelectronics era, there is a clinical need for physiological devices incorporating biofeedback that permits natural and demand-dependent control in real time. Here, we describe a novel device termed a central pattern generator (CPG) that uses cutting edge analog circuitry producing temporally controll...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00027

    authors: O'Callaghan EL,Chauhan AS,Zhao L,Lataro RM,Salgado HC,Nogaret A,Paton JF

    更新日期:2016-02-04 00:00:00

  • F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation.

    abstract::F1F0-ATP synthase inhibitory factor 1 (IF1) inhibits the reverse mode of F1F0-ATP synthase, and therefore protects cellular ATP content at the expense of accelerated loss of mitochondrial membrane potential (ΔΨm). There is considerable variability in IF1 expression and its influence on bioenergetics between different ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00833

    authors: Tanton H,Voronina S,Evans A,Armstrong J,Sutton R,Criddle DN,Haynes L,Schmid MC,Campbell F,Costello E,Tepikin AV

    更新日期:2018-07-11 00:00:00