MSX2 in ameloblast cell fate and activity.

abstract：:Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, ...

journal_title：Frontiers in physiology

authors： Larsson S,Åkerström B,Gram M,Lohmander LS,Struglics A

更新日期：2018-11-16 00:00:00

abstract：:Regulation of energy homeostasis is fundamental for life. In animal species and humans, the Central Nervous System (CNS) plays a critical role in such regulation by integrating peripheral signals and modulating behavior and the activity of peripheral organs. A precise interplay between CNS and peripheral signals is ne...

journal_title：Frontiers in physiology

authors： Kim JD,Leyva S,Diano S

更新日期：2014-12-09 00:00:00

abstract：:Productivity in science has increased and it is becoming more important for scientists to publish, to publish frequently, and to accumulate citations to their work. However, the peer review system may not only promote and advance but also hinder, prevent, or delay publication. In this personal perspective, confirmator...

journal_title：Frontiers in physiology

authors： Coronel R

更新日期：2020-09-04 00:00:00

abstract：Background:There is an increasing interest in the use of eccentric muscle exercise to improve physical condition, especially with regards to its health-related benefits. However, it is known that unaccustomed eccentric exercise causes muscle damage and delayed pain, commonly defined as "delayed onset muscle soreness" (...

journal_title：Frontiers in physiology

authors： Dominguez-Balmaseda D,Diez-Vega I,Larrosa M,San Juan AF,Issaly N,Moreno-Pérez D,Burgos S,Sillero-Quintana M,Gonzalez C,Bas A,Roller M,Pérez-Ruiz M

更新日期：2020-07-21 00:00:00

abstract：:The senescence of vascular smooth muscle cells (VSMCs) has been implicated as a causal pro-inflammatory mechanism for cardiovascular disease development and progression of atherosclerosis, the instigator of ischemic heart disease. Contemporary limitations related to studying this cellular population and senescence-rel...

journal_title：Frontiers in physiology

authors： Stojanović SD,Fuchs M,Kunz M,Xiao K,Just A,Pich A,Bauersachs J,Fiedler J,Sedding D,Thum T

更新日期：2020-05-25 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2019.00116.]. ...

journal_title：Frontiers in physiology

authors： Satti R,Abid NU,Bottaro M,De Rui M,Garrido M,Raoufy MR,Montagnese S,Mani AR

更新日期：2019-05-28 00:00:00

abstract：:Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in all cells by a highly regulated pathway that involves a mitochondrial multiprotein complex. Defects in either the structural and/or regulatory...

journal_title：Frontiers in physiology

authors： Hernández-Camacho JD,Bernier M,López-Lluch G,Navas P

更新日期：2018-02-05 00:00:00

abstract：:Na(+)/Ca(2+) exchanger (NCX) proteins extrude Ca(2+) from the cell to maintain cellular homeostasis. Since NCX proteins contribute to numerous physiological and pathophysiological events, their pharmacological targeting has been desired for a long time. This intervention remains challenging owing to our poor understan...

journal_title：Frontiers in physiology

authors： Giladi M,Tal I,Khananshvili D

更新日期：2016-02-09 00:00:00

abstract：:Background: Non-invasive cardiac mapping-also known as Electrocardiographic imaging (ECGi)-is a novel, painless and relatively economic method to map the electrical activation and repolarization patterns of the heart, providing a valuable tool for early identification and diagnosis of conduction abnormalities and arrh...

journal_title：Frontiers in physiology

authors： Perez Alday EA,Whittaker DG,Benson AP,Colman MA

更新日期：2019-04-05 00:00:00

abstract：:Preeclampsia, a pregnancy-specific disorder, presents a major health problem during gestation, but is also associated with increased risk for cardiovascular complications in later life. We aimed to investigate whether chronic stress experience and preeclampsia may have additive adverse effects on the cardiac ability t...

journal_title：Frontiers in physiology

authors： Lackner HK,Moertl MG,Schmid-Zalaudek K,Lucovnik M,Weiss EM,Kolovetsiou-Kreiner V,Papousek I

更新日期：2018-09-03 00:00:00

abstract：:Background: Measuring the extent to which renal artery stenosis (RAS) alters renal haemodynamics may permit precision medicine by physiologically guided revascularization. This currently requires invasive intra-arterial pressure measurement with associated risks and is rarely performed. The present proof-of-concept st...

journal_title：Frontiers in physiology

authors： Mandaltsi A,Grytsan A,Odudu A,Kadziela J,Morris PD,Witkowski A,Ellam T,Kalra P,Marzo A

更新日期：2018-08-17 00:00:00

abstract：:Global environmental change is leading to an increase in the frequency, intensity, and duration of extreme weather events, so effective environmental management requires an understanding not only of the physiological response of organisms to increased mean temperatures, but also to extreme environmental conditions. To...

journal_title：Frontiers in physiology

authors： Cooper CE,Withers PC,Hurley LL,Griffith SC

更新日期：2019-11-20 00:00:00

abstract：Objective:Polycystin-1 (PC-1) is a protein encoded by the gene of polycystic kidney disease-1 (PKD-1). This study was designed to investigate the regulatory mechanisms of PC-1 on phenotypes of aortic vascular smooth muscle cells (VSMCs) and functions of extracellular matrix (ECM) in thoracic aortic dissection (TAD). M...

journal_title：Frontiers in physiology

authors： Zhang J,Liu F,He YB,Zhang W,Ma WR,Xing J,Wang LX

更新日期：2020-09-24 00:00:00

abstract：:Sirtuins (SIRT) are ubiquitous histone and protein deacetylases and a member of this family, SIRT1, is the best-studied one. Its functions in endothelial cells encompass branching angiogenesis, activation of endothelial nitric oxide synthase, regulation of proapoptotic and proinflammatory pathways, among others. Defec...

journal_title：Frontiers in physiology

authors： Lipphardt M,Dihazi H,Müller GA,Goligorsky MS

更新日期：2018-09-21 00:00:00

abstract：:The complex interactions that give rise to heart rate variability (HRV) involve coupled physiological oscillators operating over a wide range of different frequencies and length-scales. Based on the premise that interactions are key to the functioning of complex systems, the time-dependent deterministic coupling param...

journal_title：Frontiers in physiology

authors： Ticcinelli V,Stankovski T,Iatsenko D,Bernjak A,Bradbury AE,Gallagher AR,Clarkson PBM,McClintock PVE,Stefanovska A

更新日期：2017-10-13 00:00:00

abstract：:Sarcomere lengths have been a crucial outcome measure for understanding and explaining basic muscle properties and muscle function. Sarcomere lengths for a given muscle are typically measured at a single spot, often in the mid-belly of the muscle, and at a given muscle length. It is then assumed implicitly that the sa...

journal_title：Frontiers in physiology

authors： Moo EK,Fortuna R,Sibole SC,Abusara Z,Herzog W

更新日期：2016-05-25 00:00:00

abstract：:Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an increasingly serious health and socioeconomic concern for modern societies. Science has made tremendous progress in the understanding of aging itself, which has helped medicine to extend life expectancies. With the increase of the l...

journal_title：Frontiers in physiology

authors： Fulop T,Larbi A,Khalil A,Cohen AA,Witkowski JM

更新日期：2019-12-18 00:00:00

abstract：:Leucine-rich repeat containing protein 10 (LRRC10) is a cardiomyocyte-specific member of the Leucine-rich repeat containing (LRRC) protein superfamily with critical roles in cardiac function and disease pathogenesis. Recent studies have identified LRRC10 mutations in human idiopathic dilated cardiomyopathy (DCM) and L...

journal_title：Frontiers in physiology

authors： Brody MJ,Lee Y

更新日期：2016-08-03 00:00:00

abstract：:Sensory receptors, including olfactory receptors (ORs), taste receptors (TRs), and opsins (Opns) have recently been found in a variety of non-sensory tissues where they have distinct physiological functions. As G protein-coupled receptors (GPCRs), these proteins can serve as important chemosensors by sensing and inter...

journal_title：Frontiers in physiology

authors： Kurtz R,Steinberg LG,Betcher M,Fowler D,Shepard BD

更新日期：2020-10-06 00:00:00

abstract：:Surface electromyography (sEMG) is a popular research tool in sport and rehabilitation sciences. Common study designs include the comparison of sEMG amplitudes collected from different muscles as participants perform various exercises and techniques under different loads. Based on such comparisons, researchers attempt...

journal_title：Frontiers in physiology

authors： Vigotsky AD,Halperin I,Lehman GJ,Trajano GS,Vieira TM

更新日期：2018-01-04 00:00:00

abstract：:We investigate analytically the production of entropy during a breathing cycle in healthy and diseased lungs. First, we calculate entropy production in healthy lungs by applying the laws of thermodynamics to the well-known transpulmonary pressure-volume (P-V) curves of the lung under the assumption that lung tissue be...

journal_title：Frontiers in physiology

authors： Oliveira CL,Araújo AD,Bates JH,Andrade JS Jr,Suki B

更新日期：2016-03-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is characterized by rapid wasting of skeletal muscle. Mitochondrial dysfunction is a well-known pathological feature of DMD. However, whether mitochondrial dysfunction occurs before muscle fiber damage in DMD pathology is not well known. Furthermore, the impact upon heterozygous femal...

journal_title：Frontiers in physiology

authors： Moore TM,Lin AJ,Strumwasser AR,Cory K,Whitney K,Ho T,Ho T,Lee JL,Rucker DH,Nguyen CQ,Yackly A,Mahata SK,Wanagat J,Stiles L,Turcotte LP,Crosbie RH,Zhou Z

更新日期：2020-06-19 00:00:00

abstract：UNLABELLED:Limitations of current methods: Normalization of resting energy expenditure (REE) for body composition using the 2-compartment model fat mass (FM), and fat-free mass (FFM) has inherent limitations for the interpretation of REE and may lead to erroneous conclusions when comparing people with a wide range of a...

journal_title：Frontiers in physiology

authors： Bosy-Westphal A,Braun W,Schautz B,Müller MJ

更新日期：2013-03-25 00:00:00

abstract：:Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs be...

journal_title：Frontiers in physiology

authors： Paradis-Deschênes P,Joanisse DR,Billaut F

更新日期：2017-01-05 00:00:00

abstract：:We tested the hypothesis that elastic binding of the abdomen (AB) would enhance neuromuscular efficiency of the human diaphragm during exercise. Twelve healthy non-obese men aged 24.8 ± 1.7 years (mean ± SE) completed a symptom-limited constant-load cycle endurance exercise test at 85% of their peak incremental power ...

journal_title：Frontiers in physiology

authors： Abdallah SJ,Chan DS,Glicksman R,Mendonca CT,Luo Y,Bourbeau J,Smith BM,Jensen D

更新日期：2017-05-31 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant Scutellaria baicalensis (colloquially known as skullcap), has previously been shown to have direct anti-inflammatory and antioxidative ...

journal_title：Frontiers in physiology

authors： Smith JF,Starr EG,Goodman MA,Hanson RB,Palmer TA,Woolstenhulme JB,Weyand JA,Marchant AD,Bueckers SL,Nelson TK,Sterling MT,Rose BJ,Porter JP,Eggett DL,Kooyman DL

更新日期：2020-02-18 00:00:00

abstract：:Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological...

journal_title：Frontiers in physiology

authors： Donadoni F,Pichardo-Almarza C,Bartlett M,Dardik A,Homer-Vanniasinkam S,Díaz-Zuccarini V

更新日期：2017-04-18 00:00:00

abstract：:Tree pandemics are a major cause of economic and ecological loss in forest and urban ecosystems. They often depend on the introduction of a non-native pathogen, which is occupying the niche of a native, non-aggressive organism. Complex interactions with native insects carrying fungi and nematodes can be established ba...

journal_title：Frontiers in physiology

authors： Santini A,Battisti A

更新日期：2019-05-08 00:00:00

abstract：:Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury. In endothelial cells, mitochondria regulate these inflammatory pathways ...

journal_title：Frontiers in physiology

authors： Chang R,Mamun A,Dominic A,Le NT

更新日期：2021-01-15 00:00:00

abstract：:Mild normobaric hypoxia (NH) and modest exercise have multiple beneficial effects on health, but the changes in physiological function induced by NH and/or exercise remain unclear. The purpose of this investigation was to examine the specific effects of NH and/or exercise on cardiac function and myocardial structure a...

journal_title：Frontiers in physiology

authors： Li QF,Wang H,Zheng L,Yang F,Li HZ,Li JX,Cheng D,Lu K,Liu Y

更新日期：2020-01-21 00:00:00