History of Preeclampsia Adds to the Deleterious Effect of Chronic Stress on the Cardiac Ability to Flexibly Adapt to Challenge.

abstract：:Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information. Context specific reconstruction based on generic genome scale models like ReconX or HMR has the potential to become a diagnostic and treatment tool t...

journal_title：Frontiers in physiology

authors： Pacheco MP,Pfau T,Sauter T

更新日期：2016-01-22 00:00:00

abstract：OBJECTIVES:The dynamic interaction between blood pressure (BP) and cerebral blood flow velocity (CBFV) is not fully understood, especially for CBFV changes lasting longer than 50 s. The interaction between BP and CBFV is relatively well characterized for periods <50 s using transfer function (TF) estimations of phase, ...

journal_title：Frontiers in physiology

authors： Müller MW,Osterreich M

更新日期：2014-08-26 00:00:00

abstract：:This study aimed to test the hypothesis that branchial osmoregulatory acclimation involved increased apoptosis and replacement of mitochdonrion-rich cells (MRCs) in the climbing perch, Anabas testudineus, during a progressive acclimation from freshwater to seawater. A significant increase in branchial caspase-3/-7 act...

journal_title：Frontiers in physiology

authors： Ching B,Chen XL,Yong JH,Wilson JM,Hiong KC,Sim EW,Wong WP,Lam SH,Chew SF,Ip YK

更新日期：2013-06-07 00:00:00

abstract：:FXYD proteins are important regulators of Na+/K+-ATPase (NKA) activity in mammals. As an inhabitant of estuaries, the pufferfish (Tetraodon nigroviridis) responds to ambient salinity changes with efficient osmoregulation, including alterations in branchial, and renal NKA activities. Previous studies on teleostean FXYD...

journal_title：Frontiers in physiology

authors： Wang PJ,Yang WK,Lin CH,Hwang HH,Lee TH

更新日期：2017-08-08 00:00:00

abstract：:Alzheimer's disease (AD) is a major neurodegenerative disease and is one of the most common cause of dementia in older adults. Among several factors, neuroinflammation is known to play a critical role in the pathogenesis of chronic neurodegenerative diseases. In particular, studies of brains affected by AD show a clea...

journal_title：Frontiers in physiology

authors： Ravichandran S,Michelucci A,Del Sol A

更新日期：2018-03-02 00:00:00

abstract：:Physical exercise has been shown to modulate activity within the autonomic nervous system (ANS). Considering physical exercise as a holistic stimulus on the nervous system and specifically the ANS, uni- and multimodal analysis tools were applied to characterize centrally driven interactions and control of ANS function...

journal_title：Frontiers in physiology

authors： Vieluf S,Hasija T,Jakobsmeyer R,Schreier PJ,Reinsberger C

更新日期：2019-03-29 00:00:00

abstract：:Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca(2+)- and voltage-activated K(+) (BK or Slo1) channels at the single-channel level. It starts ...

journal_title：Frontiers in physiology

authors： Geng Y,Magleby KL

更新日期：2015-01-21 00:00:00

abstract：:Fatigue is one of the most debilitating symptoms of multiple sclerosis (MS), and the underlying mechanisms are poorly understood. When exposed to a physical or cognitive challenge, individuals with MS tend to exhibit greater declines in task performance (performance fatigability) and increased levels of self-reported ...

journal_title：Frontiers in physiology

authors： Gould JR,Reineberg AE,Cleland BT,Knoblauch KE,Clinton GK,Banich MT,Corboy JR,Enoka RM

更新日期：2018-10-17 00:00:00

abstract：:Crayfish are capable of two rapid, escape reflexes that are mediated by two pairs of giant interneurons, the lateral giants (LG) and the medial giants (MG), which respond to threats presented to the abdomen or head and thorax, respectively. The LG has been the focus of study for many decades and the role of GABAergic ...

journal_title：Frontiers in physiology

authors： Swierzbinski ME,Herberholz J

更新日期：2018-04-27 00:00:00

abstract：:Gene-targeted deletion of the potassium channel Kv1.3 (Kv1.3(-∕-)) results in "Super-smeller" mice with a sensory phenotype that includes an increased olfactory ability linked to changes in olfactory circuitry, increased abundance of olfactory cilia, and increased expression of odorant receptors and the G-protein, Gol...

journal_title：Frontiers in physiology

authors： Kovach CP,Al Koborssy D,Huang Z,Chelette BM,Fadool JM,Fadool DA

更新日期：2016-05-19 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:Electronic cigarettes (ECs) are a modern nicotine delivery system that rapidly grew in widespread use, particularly in younger populations. Given the long history of the comorbidity of alcohol and nicotine use, the rising prevalence of ECs raises the question as to their role in the consumption of alcohol. Of the nume...

journal_title：Frontiers in physiology

authors： Wetzel TJ,Wyatt TA

更新日期：2020-11-02 00:00:00

abstract：:For many model organisms traditionally in use for cardiac electrophysiological studies, characterization of ion channel genes is lacking. We focused here on two genes encoding the inward rectifier current, KCNJ2 and KCNJ12, in the dog heart. A combination of RT-PCR, 5'-RACE, and 3'-RACE demonstrated the status of KCNJ...

journal_title：Frontiers in physiology

authors： Houtman MJ,Takanari H,Kok BG,van Eck M,Montagne DR,Vos MA,de Boer TP,van der Heyden MA

更新日期：2012-01-30 00:00:00

abstract：:The grand challenge to physiology, as was first described in an essay published in the inaugural issue of Frontiers in Physiology in 2010, remains to integrate function from molecules to intact organisms. In order to make sense of the vast volume of information derived from, and increasingly dependent upon, reductioni...

journal_title：Frontiers in physiology

authors： Billman GE

更新日期：2020-03-10 00:00:00

abstract：:The recognition of invading pathogens and endogenous molecules from damaged tissues by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However, excessive TLR activation disrupts the immune homeostasis by sustained pro-inflammatory cytokines and chemokines production and consequently contributes...

journal_title：Frontiers in physiology

authors： Gao W,Xiong Y,Li Q,Yang H

更新日期：2017-07-19 00:00:00

abstract：:Purpose: Few large-scale population-based studies have adequately examined the relationships between steroid hormones, health status and physical fitness. The purpose of the study was to describe the relationship of serum basal endogenous steroid hormones (testosterone, TES; empirical free testosterone, EFT; cortisol,...

journal_title：Frontiers in physiology

authors： Gagnon SS,Nindl BC,Vaara JP,Santtila M,Häkkinen K,Kyröläinen H

更新日期：2018-07-27 00:00:00

abstract：:Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder with polydactyly and syndactyly of the limbs and a broad spectrum of craniofacial abnormalities. Craniosynostosis of the metopic suture (interfrontal suture in mice) is an important but rare feature associated with GCPS. GCPS is caused by mu...

journal_title：Frontiers in physiology

authors： Veistinen L,Takatalo M,Tanimoto Y,Kesper DA,Vortkamp A,Rice DP

更新日期：2012-05-03 00:00:00

abstract：:Stable gait requires active control of the mediolateral (ML) kinematics of the body center of mass (CoM) and the base of support (BoS) in relation to each other. Stance leg hip abductor (HA) muscle spindle afference may be used to guide contralateral swing foot placement and adequately position the BoS in relation to ...

journal_title：Frontiers in physiology

authors： Arvin M,Hoozemans MJM,Pijnappels M,Duysens J,Verschueren SM,van Dieën JH

更新日期：2018-08-21 00:00:00

abstract：:Milk and dairy products are relevant components of daily diet and are part of dietary recommendation in many countries due to their content of key nutrients. However, the relatively high content of saturated fat of the milk and its extensive usage for every age group raises concerns about its potential negative health...

journal_title：Frontiers in physiology

authors： Trinchese G,Cavaliere G,Penna E,De Filippo C,Cimmino F,Catapano A,Musco N,Tudisco R,Lombardi P,Infascelli F,Messina G,Muredda L,Banni S,Monda M,Crispino M,Mollica MP

更新日期：2019-01-17 00:00:00

abstract：:Genetically modified mice provide a number of models for studying cardiac channelopathies related to cardiac Na(+) channel (SCN5A) abnormalities. We review key pathophysiological features in these murine models that may underlie clinical features observed in sinus node dysfunction and progressive cardiac conduction di...

journal_title：Frontiers in physiology

authors： Huang CL,Lei L,Matthews GD,Zhang Y,Lei M

更新日期：2012-07-06 00:00:00

abstract：:Background: The superior cervical ganglion (SCG) of the autonomic nervous system plays an important role in different cardiovascular diseases. In this study, we investigated the effects of ischemia and fluvastatin treatment on the ion channel characteristics of SCG neurons in a rabbit myocardial ischemia (MI) model. M...

journal_title：Frontiers in physiology

authors： Cheng L,Wang X,Liu T,Tse G,Fu H,Li G

更新日期：2018-09-10 00:00:00

abstract：:Erythropoietin (Epo) is an indispensable erythropoietic hormone primarily produced from renal Epo-producing cells (REPs). Epo production in REPs is tightly regulated in a hypoxia-inducible manner to maintain tissue oxygen homeostasis. Insufficient Epo production by REPs causes renal anemia and anemia associated with c...

journal_title：Frontiers in physiology

authors： Souma T,Suzuki N,Yamamoto M

更新日期：2015-06-03 00:00:00

abstract：:The aim of this study is to detect the effects of C60 fullerenes, which possess pronounced antioxidant properties, in comparison with the actions of the known exogenous antioxidants N-acetylcysteine (NAC) and β-Alanine in terms of exercise tolerance and contractile property changes of the m. triceps surae (TS) during ...

journal_title：Frontiers in physiology

authors： Vereshchaka IV,Bulgakova NV,Maznychenko AV,Gonchar OO,Prylutskyy YI,Ritter U,Moska W,Tomiak T,Nozdrenko DM,Mishchenko IV,Kostyukov AI

更新日期：2018-05-15 00:00:00

abstract：Background:There is an increasing interest in the use of eccentric muscle exercise to improve physical condition, especially with regards to its health-related benefits. However, it is known that unaccustomed eccentric exercise causes muscle damage and delayed pain, commonly defined as "delayed onset muscle soreness" (...

journal_title：Frontiers in physiology

authors： Dominguez-Balmaseda D,Diez-Vega I,Larrosa M,San Juan AF,Issaly N,Moreno-Pérez D,Burgos S,Sillero-Quintana M,Gonzalez C,Bas A,Roller M,Pérez-Ruiz M

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:In patients with arterial hypertension, increased blood pressure (BP) variability contributes to end organ damage independently from mean levels of arterial BP. Increased BP variability has been linked to alterations in autonomic function including sympathetic overdrive. We hypothesized that catheter-based r...

journal_title：Frontiers in physiology

authors： Zuern CS,Rizas KD,Eick C,Stoleriu C,Bunk L,Barthel P,Balletshofer B,Gawaz M,Bauer A

更新日期：2012-05-10 00:00:00

abstract：Background:Walking patterns can provide important indications of a person's health status and be beneficial in the early diagnosis of individuals with a potential walking disorder. For appropriate gait analysis, it is critical that natural functional walking characteristics are captured, rather than those experienced i...

journal_title：Frontiers in physiology

authors： Renggli D,Graf C,Tachatos N,Singh N,Meboldt M,Taylor WR,Stieglitz L,Schmid Daners M

更新日期：2020-02-20 00:00:00

abstract：:Insect β-1,3-glucanases belong to Glycoside Hydrolase Family 16 (GHF16) and are involved in digestion of detritus and plant hemicellulose. In this work, we investigated the role of GHF16 genes in Aedes aegypti larvae, due to their detritivore diet. Aedes aegypti genome has six genes belonging to GHF16 (Aae GH16.1 - Aa...

journal_title：Frontiers in physiology

authors： Souza RS,Gama MDVF,Schama R,Lima JBP,Diaz-Albiter HM,Genta FA

更新日期：2019-02-28 00:00:00

abstract：:Hypoxia has important effects on biological activity in crustaceans, and modulation of energy metabolism is a crucial aspect of crustaceans' ability to respond to hypoxia. The adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) enzyme is very important in cellular energy homeostasis; however, little infor...

journal_title：Frontiers in physiology

authors： Sun S,Gu Z,Fu H,Zhu J,Ge X,Wu X

更新日期：2018-06-14 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2020.00697.]. ...

journal_title：Frontiers in physiology

authors： Roumbedakis K,Alexandre MN,Puch JA,Martins ML,Pascual C,Rosas C

更新日期：2020-10-07 00:00:00

abstract：:Realistic electrocardiogram (ECG) simulation with numerical models is important for research linking cellular and molecular physiology to clinically observable signals, and crucial for patient tailoring of numerical heart models. However, ECG simulation with a realistic torso model is computationally much harder than ...

journal_title：Frontiers in physiology

authors： Potse M

更新日期：2018-04-20 00:00:00