FXYD8, a Novel Regulator of Renal Na+/K+-ATPase in the Euryhaline Teleost, Tetraodon nigroviridis.

Abstract:

:FXYD proteins are important regulators of Na+/K+-ATPase (NKA) activity in mammals. As an inhabitant of estuaries, the pufferfish (Tetraodon nigroviridis) responds to ambient salinity changes with efficient osmoregulation, including alterations in branchial, and renal NKA activities. Previous studies on teleostean FXYDs have mainly focused on the expression and potential functions of FXYD proteins in gills. The goal of the present study was to elucidate the potential role of FXYD8, a member of the fish FXYD protein family, in the modulation of NKA activity in the kidneys of this euryhaline pufferfish by using molecular, biochemical, and physiological approaches. The results demonstrate that T. nigroviridis FXYD8 (TnFXYD8) interacts with NKA in renal tubules. Meanwhile, the protein expression of renal TnFXYD8 was found to be significantly upregulated in hyperosmotic seawater-acclimated pufferfish. Moreover, overexpression of TnFXYD8 in Xenopus oocytes decreased NKA activity. Our results suggest the FXYD8 is able to modulate NKA activity through inhibitory effects upon salinity challenge. The present study further extends our understanding of the functions of FXYD proteins, the regulators of NKA, in vertebrates.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Wang PJ,Yang WK,Lin CH,Hwang HH,Lee TH

doi

10.3389/fphys.2017.00576

subject

Has Abstract

pub_date

2017-08-08 00:00:00

pages

576

issn

1664-042X

journal_volume

8

pub_type

杂志文章
  • Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function.

    abstract::Inflammation is a process whose main function is to fight against invading pathogens or foreign agents. Nonetheless, it is widely accepted that inflammation takes part in multiple processes in a physiological or pathophysiological context. Among these processes the inflammation has been closely related to bone metabol...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.00504

    authors: Alonso-Pérez A,Franco-Trepat E,Guillán-Fresco M,Jorge-Mora A,López V,Pino J,Gualillo O,Gómez R

    更新日期:2018-05-08 00:00:00

  • Fractional Stability of Trunk Acceleration Dynamics of Daily-Life Walking: Toward a Unified Concept of Gait Stability.

    abstract::Over the last decades, various measures have been introduced to assess stability during walking. All of these measures assume that gait stability may be equated with exponential stability, where dynamic stability is quantified by a Floquet multiplier or Lyapunov exponent. These specific constructs of dynamic stability...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00516

    authors: Ihlen EAF,van Schooten KS,Bruijn SM,Pijnappels M,van Dieën JH

    更新日期:2017-08-29 00:00:00

  • The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release.

    abstract::The microbial community of the gut conveys significant benefits to host physiology. A clear relationship has now been established between gut bacteria and host metabolism in which microbial-mediated gut hormone release plays an important role. Within the gut lumen, bacteria produce a number of metabolites and contain ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00428

    authors: Martin AM,Sun EW,Rogers GB,Keating DJ

    更新日期:2019-04-16 00:00:00

  • Effects of Water Acidification on Senegalese Sole Solea senegalensis Health Status and Metabolic Rate: Implications for Immune Responses and Energy Use.

    abstract::Increasing water CO2, aquatic hypercapnia, leads to higher physiological pCO2 levels in fish, resulting in an acidosis and compensatory acid-base regulatory response. Senegalese sole is currently farmed in super-intensive recirculating water systems where significant accumulation of CO2 in the water may occur. Moreove...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00026

    authors: Machado M,Arenas F,Svendsen JC,Azeredo R,Pfeifer LJ,Wilson JM,Costas B

    更新日期:2020-01-31 00:00:00

  • Comparison of Left Ventricular Global Strain in Anterior and Non-anterior Wall Myocardial Infarction With CMR Tissue Tracking.

    abstract::Left ventricular (LV) myocardial dysfunction occurs after myocardial infarction (MI) is associated with the location, infarct size, and transmurality degrees of MI. The myocardial strain is a sensitive index used for the quantification of myocardium dysfunction. This study used Tissue-Tracking to evaluate whether the ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.530108

    authors: Li S,Zhao L,Lu A,Tian J,Gong L,Ma X

    更新日期:2020-12-10 00:00:00

  • Functional cardiac imaging by random access microscopy.

    abstract::Advances in the development of voltage sensitive dyes and Ca(2+) sensors in combination with innovative microscopy techniques allowed researchers to perform functional measurements with an unprecedented spatial and temporal resolution. At the moment, one of the shortcomings of available technologies is their incapabil...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00403

    authors: Crocini C,Coppini R,Ferrantini C,Pavone FS,Sacconi L

    更新日期:2014-10-20 00:00:00

  • Resting state MEG oscillations show long-range temporal correlations of phase synchrony that break down during finger movement.

    abstract::The capacity of the human brain to interpret and respond to multiple temporal scales in its surroundings suggests that its internal interactions must also be able to operate over a broad temporal range. In this paper, we utilize a recently introduced method for characterizing the rate of change of the phase difference...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2015.00183

    authors: Botcharova M,Berthouze L,Brookes MJ,Barnes GR,Farmer SF

    更新日期:2015-06-17 00:00:00

  • Strength Training Improves Metabolic Health Markers in Older Individual Regardless of Training Frequency.

    abstract::The main purpose of the present study was to investigate the effect of frequency, thereby increasing training volume, of resistance training on body composition, inflammation markers, lipid and glycemic profile in healthy older individuals (age range 65-75 year). Ninety-two healthy participants were randomly assigned ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00032

    authors: Ihalainen JK,Inglis A,Mäkinen T,Newton RU,Kainulainen H,Kyröläinen H,Walker S

    更新日期:2019-02-01 00:00:00

  • Mechanosensitive Molecular Networks Involved in Transducing Resistance Exercise-Signals into Muscle Protein Accretion.

    abstract::Loss of skeletal muscle myofibrillar protein with disease and/or inactivity can severely deteriorate muscle strength and function. Strategies to counteract wasting of muscle myofibrillar protein are therefore desirable and invite for considerations on the potential superiority of specific modes of resistance exercise ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2016.00547

    authors: Rindom E,Vissing K

    更新日期:2016-11-17 00:00:00

  • HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1.

    abstract::Hyperglycemia induces vascular endothelial dysfunction, which contributes to the development of vascular complication of diabetes. A classic prescription of traditional medicine, HuangqiGuizhiWuwu Decoction (HGWWD) has been used for the treatment of various cardiovascular and cerebrovascular diseases, which all are re...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00201

    authors: Cheng H,Lu T,Wang J,Xia Y,Chai X,Zhang M,Yao Y,Zhou N,Zhou S,Chen X,Su W,Liu C,Yi W,Chen Y,Yao L

    更新日期:2020-03-25 00:00:00

  • Balanced Noise-Evoked Excitation and Inhibition in Awake Mice CA3.

    abstract::The hippocampus is known as a neuronal structure involved in learning, memory and spatial navigation using multi-sensory cues. However, the basic features of its response to acoustic stimuli without any behavioral tasks (conditioning) remains poorly studied. Here, we investigated the CA3 response to auditory stimuli u...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00931

    authors: Wang N,Gan X,Liu Y,Xiao Z

    更新日期:2017-11-21 00:00:00

  • Physiological Predictors of Maximal Incremental Running Performance.

    abstract:Purpose:The aim of this study was to verify whether physiological components [vertical jumps (Squat Jump - SJ and Countermovement Jump - CMJ), eccentric utilization ratio (EUR) of vertical jumps, running economy (RE), metabolic cost (C MET ), first and second ventilatory th...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00979

    authors: Lanferdini FJ,Silva ES,Machado E,Fischer G,Peyré-Tartaruga LA

    更新日期:2020-08-05 00:00:00

  • Bicuspid Aortic Valve: An Update in Morphology, Genetics, Biomarker, Complications, Imaging Diagnosis and Treatment.

    abstract::The bicuspid aortic valve, a kind of heart disease that comes from parents, has been paid attention around the world. Although most bicuspid aortic valve (BAV) patients will suffer from some complications including aortic stenosis, aortic regurgitation, endocarditis, and heart dysfunction in the late stage of the dise...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.01921

    authors: Liu T,Xie M,Lv Q,Li Y,Fang L,Zhang L,Deng W,Wang J

    更新日期:2019-01-30 00:00:00

  • Activation and Biological Properties of Human β Defensin 4 in Stem Cells Derived From Human Exfoliated Deciduous Teeth.

    abstract::Pulpitis in primary teeth, a condition caused by presence of bacteria, is highly prevalent worldwide. The use of biocompatibility materials with anti-inflammatory, anti-bacterial, and regenerative properties is critical for prognosis of this endodontic disease. This study aimed to identify expression of human β defens...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01304

    authors: Zhai Y,Wang Y,Rao N,Li J,Li X,Fang T,Zhao Y,Ge L

    更新日期:2019-10-22 00:00:00

  • Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses.

    abstract:Background:Perturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Previous reports indicate that CFTR activity upregulates endothelial barrier function, endoth...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00879

    authors: Khalaf M,Scott-Ward T,Causer A,Saynor Z,Shepherd A,Górecki D,Lewis A,Laight D,Shute J

    更新日期:2020-07-29 00:00:00

  • Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy.

    abstract::Corpus luteum (CL) is a transient endocrine tissue that produces progesterone for maintaining pregnancy in mammals. In addition, the regression of CL is necessary for the initiation of the estrous cycle. Extensive research has shown that the prostaglandin F2α (PGF2α) induces the regression of CL in ruminants. However,...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00868

    authors: Wen X,Liu L,Li S,Lin P,Chen H,Zhou D,Tang K,Wang A,Jin Y

    更新日期:2020-09-11 00:00:00

  • Salbutamol Worsens the Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease.

    abstract:Background:Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00031

    authors: Bokov P,El Jurdi H,Denjoy I,Peiffer C,Medjahdi N,Holvoet L,Benkerrou M,Delclaux C

    更新日期:2020-02-26 00:00:00

  • Effects of the Order of Physical Exercises on Body Composition, Physical Fitness, and Cardiometabolic Risk in Adolescents Participating in an Interdisciplinary Program Focusing on the Treatment of Obesity.

    abstract::The main objective of this study was to investigate the effects of the order of physical exercises on body composition, physical fitness, and cardiometabolic risk in adolescents participating in an interdisciplinary program focusing on the treatment of obesity. The final 12-week analyses involved 33 female adolescents...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01013

    authors: Branco BHM,Valladares D,de Oliveira FM,Carvalho IZ,Marques DC,Coelho AA,de Oliveira LP,Bertolini SMMG

    更新日期:2019-08-06 00:00:00

  • Dual Substance Use of Electronic Cigarettes and Alcohol.

    abstract::Electronic cigarettes (ECs) are a modern nicotine delivery system that rapidly grew in widespread use, particularly in younger populations. Given the long history of the comorbidity of alcohol and nicotine use, the rising prevalence of ECs raises the question as to their role in the consumption of alcohol. Of the nume...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2020.593803

    authors: Wetzel TJ,Wyatt TA

    更新日期:2020-11-02 00:00:00

  • Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression.

    abstract::Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence ratio. Traditional therapeutic approaches such as surgery in combination with chemo- or radiotherapy have had limited efficacy in improving the outcome of this disease. Up until just under a decade ago, the prominent desmoplast...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00052

    authors: Wilson JS,Pirola RC,Apte MV

    更新日期:2014-02-14 00:00:00

  • EPCR Gene Ser219Gly Polymorphism and Venous Thromboembolism: A Meta-Analysis of 9,494 Subjects.

    abstract::Background: Although endothelial cell protein C receptor (EPCR) gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached. Objective and methods: A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidat...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00339

    authors: Li YY,Wu JJ,Yang XX,Geng HY,Gong G,Kim HJ

    更新日期:2017-05-26 00:00:00

  • Viral Delivery of dsRNA for Control of Insect Agricultural Pests and Vectors of Human Disease: Prospects and Challenges.

    abstract::RNAi is applied as a new and safe method for pest control in agriculture but efficiency and specificity of delivery of dsRNA trigger remains a critical issue. Various agents have been proposed to augment dsRNA delivery, such as engineered micro-organisms and synthetic nanoparticles, but the use of viruses has received...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.00399

    authors: Kolliopoulou A,Taning CNT,Smagghe G,Swevers L

    更新日期:2017-06-14 00:00:00

  • Heart Failure and Frailty in the Community-Living Elderly Population: What the UFO Study Will Tell Us.

    abstract::Heart failure and frailty are clinical syndromes that present with overlapping phenotypic characteristics. Importantly, their co-presence is associated with increased mortality and morbidity. While mechanical and electrical device therapies for heart failure are vital for select patients with advanced stage disease, t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00347

    authors: Fung E,Hui E,Yang X,Lui LT,Cheng KF,Li Q,Fan Y,Sahota DS,Ma BHM,Lee JSW,Lee APW,Woo J

    更新日期:2018-04-24 00:00:00

  • Swimbladder function and the spawning migration of the European eel Anguilla anguilla.

    abstract::The spawning migration of the European eel is an extensive journey over 5000 to 7000 km from the European coast to the Sargasso Sea. Eels do not feed during this journey and on-board fuels must be sufficient to support the journey of 3.5 to 6 month, as well as sexual maturation and the spawning activity. Swimming of e...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00486

    authors: Pelster B

    更新日期:2015-01-05 00:00:00

  • Proteomics Analysis of Myocardial Tissues in a Mouse Model of Coronary Microembolization.

    abstract::Coronary microembolization (CME) is an important clinical problem, and it is related to poor outcome. The specific molecular mechanisms of CME are not fully understood. In the present study, we established a mice model of CME. Isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography coupl...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01318

    authors: Chen A,Chen Z,Xia Y,Lu D,Jia J,Hu K,Sun A,Zou Y,Qian J,Ge J

    更新日期:2018-09-19 00:00:00

  • Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits.

    abstract::We examined how systemic blockade of type 1 angiotensin (AT(1)-) receptors affects reflex control of the circulation and the kidney. In conscious rabbits, the effects of candesartan on responses of systemic and renal hemodynamics and renal excretory function to acute hypoxia, mild hemorrhage, and plasma volume expansi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2011.00040

    authors: Xu TB,Eppel GA,Head GA,Evans RG

    更新日期:2011-07-19 00:00:00

  • Functional Study of Cytochrome P450 Enzymes from the Brown Planthopper (Nilaparvata lugens Stål) to Analyze Its Adaptation to BPH-Resistant Rice.

    abstract::Plant-insect interactions constitute a complex of system, whereby plants synthesize toxic compounds as the main defense strategy to combat herbivore assault, and insects deploy detoxification systems to cope with toxic plant compounds. Cytochrom P450s are among the main detoxification enzymes employed by insects to co...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00972

    authors: Peng L,Zhao Y,Wang H,Song C,Shangguan X,Ma Y,Zhu L,He G

    更新日期:2017-11-30 00:00:00

  • Immunocytochemical localization of claudin-1 in the maturation ameloblasts of rat incisors.

    abstract::Claudin-1 is a tight junction transmembrane protein. Its localization in the maturation ameloblasts of rat incisors was examined by immunofluorescence microscopy. Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts (SA) and RAs stained positive ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2010.00150

    authors: Nishikawa S,Abe M

    更新日期:2010-11-16 00:00:00

  • Identification of Five Key Genes Involved in Intrinsic Apoptotic Pathway From Yellow Catfish Pelteobagrus fulvidraco and Their Transcriptional Responses to High Fat Diet (HFD).

    abstract::The hypothesis of the present study is that apoptosis through an intrinsic mitochondrial pathway may mediate high fat diet (HFD)-induced changes in the metabolism of Pelteobagrus fulvidraco. To this end, we cloned the full-length cDNA sequences of Cycs, Apaf1, Casp9, Casp3a, and Casp3b involved in the mitochondria apo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00921

    authors: Li DD,Ling SC,Wu K,Luo Z

    更新日期:2019-08-02 00:00:00

  • Two Sympatric Spodoptera Species Could Mutually Recognize Sex Pheromone Components for Behavioral Isolation.

    abstract::Spodoptera exigua and S. litura are two sympatric species in China and many other countries. Both moths employ a multiple component sex pheromone blend, including a common component Z9,E12-14:OAc, and two specific components Z9-14:OH and Z11-16:OAc for S. exigua, and one specific component Z9,E11-14:OAc for S. litura....

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01256

    authors: Yan Q,Liu XL,Wang YL,Tang XQ,Shen ZJ,Dong SL,Deng JY

    更新日期:2019-09-27 00:00:00