Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function.

abstract：:This work investigates the effect of arterial bifurcation angulation on atherosclerosis development through in-silico simulations of coupled cell dynamics. The computational model presented here combines cellular pathways, fluid dynamics, and physiologically-realistic vessel geometries as observed in the human vascula...

journal_title：Frontiers in physiology

authors： Dowding S,Zakkaroff C,Moore S,David T

更新日期：2018-10-31 00:00:00

abstract：Introduction:Hypothermia has notable effects on platelets, platelet function, fibrinogen, and coagulation factors. Common laboratory techniques cannot identify those effects, because blood samples are usually warmed to 37°C before analysis and do not fully reflect the in vivo situation. Multiple aspects of the pathophy...

journal_title：Frontiers in physiology

authors： Wallner B,Schenk B,Hermann M,Paal P,Falk M,Strapazzon G,Martini WZ,Brugger H,Fries D

更新日期：2020-07-14 00:00:00

abstract：Purpose:To examine physiological and technical responses to repeated-sprint training in normobaric hypoxia at ∼3,000 m (RSH, n = 11) or in normoxia (RSN, n = 11) compared to a control group (CON, n = 8) in well-trained tennis players. Participants were 28.8 ± 5.9 years old without any previous experience of training in...

journal_title：Frontiers in physiology

authors： Brechbuhl C,Brocherie F,Willis SJ,Blokker T,Montalvan B,Girard O,Millet GP,Schmitt L

更新日期：2020-12-18 00:00:00

abstract：:Lineage fate decisions of hematopoietic cells depend on intrinsic factors and extrinsic signals provided by the bone marrow microenvironment, where they reside. Abnormalities in composition and function of hematopoietic niches have been proposed as key contributors of acute lymphoblastic leukemia (ALL) progression. Ou...

journal_title：Frontiers in physiology

authors： Enciso J,Mayani H,Mendoza L,Pelayo R

更新日期：2016-08-19 00:00:00

abstract：:Data-driven computational neural network models have been used to study mechanisms for generating the motor patterns for breathing and breathing related behaviors such as coughing. These models have commonly been evaluated in open loop conditions or with feedback of lung volume simply represented as a filtered version...

journal_title：Frontiers in physiology

authors： O'Connor R,Segers LS,Morris KF,Nuding SC,Pitts T,Bolser DC,Davenport PW,Lindsey BG

更新日期：2012-07-23 00:00:00

abstract：:The olfactory system serves a vital role in the evolution and survival of insects, being involved in behaviors such as host seeking, foraging, mating, and oviposition. Odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) are involved in the olfactory recognition process. In this study, BtabCSP11, a CSP11 g...

journal_title：Frontiers in physiology

authors： Zeng Y,Merchant A,Wu Q,Wang S,Kong L,Zhou X,Xie W,Zhang Y

更新日期：2020-06-30 00:00:00

abstract：:The analysis of neural systems leverages tools from many different fields. Drawing on techniques from the study of critical phenomena in statistical mechanics, several studies have reported signatures of criticality in neural systems, including power-law distributions, shape collapses, and optimized quantities under t...

journal_title：Frontiers in physiology

authors： Timme NM,Marshall NJ,Bennett N,Ripp M,Lautzenhiser E,Beggs JM

更新日期：2016-09-27 00:00:00

abstract：:Adipokinetic hormones (AKHs) are well known to mobilize lipids and carbohydrates for energy-consuming activities in insects. These neuropeptides exert their functions by interacting with AKH receptors (AKHRs) located on the plasma membrane of fat body cells, which regulates energy mobilization by stimulating lipolysis...

journal_title：Frontiers in physiology

authors： Lu K,Wang Y,Chen X,Zhang X,Li W,Cheng Y,Li Y,Zhou J,You K,Song Y,Zhou Q,Zeng R

更新日期：2019-01-08 00:00:00

abstract：:Cephalopod and vertebrate neural-systems are often highlighted as a traditional example of convergent evolution. Their large brains, relative to body size, and complexity of sensory-motor systems and behavioral repertoires offer opportunities for comparative analysis. Despite various attempts, questions on how cephalo...

journal_title：Frontiers in physiology

authors： Shigeno S,Andrews PLR,Ponte G,Fiorito G

更新日期：2018-07-20 00:00:00

abstract：:Fibrosis is intimately linked to wound healing and is one of the largest causes of wound-related morbidity. While scar formation is the normal and inevitable outcome of adult mammalian cutaneous wound healing, scarring varies widely between different anatomical sites. The spectrum of craniofacial wound healing spans a...

journal_title：Frontiers in physiology

authors： desJardins-Park HE,Mascharak S,Chinta MS,Wan DC,Longaker MT

更新日期：2019-03-29 00:00:00

abstract：:Dentin dysplasia (DD) and dentinogenesis imperfecta (DGI) patients have abnormal structure, morphology, and function of dentin. DD-II, DGI-II, and DGI-III are caused by heterozygous mutations in the dentin sialophosphoprotein (DSPP) gene in humans. Evidences have shown that loss of function of DSPP in Dspp knockout mi...

journal_title：Frontiers in physiology

authors： Shi C,Ma N,Zhang W,Ye J,Shi H,Xiang D,Wu C,Song L,Zhang N,Liu Q

更新日期：2020-11-09 00:00:00

abstract：:Cachexia, or wasting of skeletal muscle and fat, afflicts many patients with chronic diseases including cancer, organ failure, and AIDS. Muscle wasting reduces quality of life and decreases response to therapy. Cachexia is caused partly by elevated inflammatory cytokines, including interleukin-6 (IL-6). Others and we ...

journal_title：Frontiers in physiology

authors： Au ED,Desai AP,Koniaris LG,Zimmers TA

更新日期：2017-01-18 00:00:00

abstract：Background:The aim of presented cross-sectional study was to determine the association of different types of physical activity (PA) with metabolic control in people with type 1 diabetes. Materials and Methods:A total of 109 adult subjects with type 1 diabetes were asked to complete the non-exercise activity thermogene...

journal_title：Frontiers in physiology

authors： Štotl I,Kambič T,Hadžić V,Zdolšek A

更新日期：2019-09-24 00:00:00

abstract：:The paper reports application of a Markov-like stochastic process agent-based model and a "virtual farm" concept for enhancement of site-specific Integrated Pest Management. Conceptually, the model represents a "bottom-up ethological" approach and emulates behavior of the "primary IPM actors"-large cohorts of individu...

journal_title：Frontiers in physiology

authors： Lux SA,Wnuk A,Vogt H,Belien T,Spornberger A,Studnicki M

更新日期：2016-08-23 00:00:00

abstract：:Signal transduction and gene regulation determine a major reorganization of metabolic activities in order to support cell proliferation. Protein Kinase B (PKB), also known as Akt, participates in the PI3K/Akt/mTOR pathway, a master regulator of aerobic glycolysis and cellular biosynthesis, two activities shown by both...

journal_title：Frontiers in physiology

authors： Mosca E,Alfieri R,Maj C,Bevilacqua A,Canti G,Milanesi L

更新日期：2012-11-21 00:00:00

abstract：:Circadian rhythms are biological oscillations with a period of ~24 h. These rhythms are orchestrated by a circadian timekeeper in the suprachiasmatic nucleus of the hypothalamus, the circadian "master clock," which exactly adjusts clock outputs to solar time via photic synchronization. At the molecular level, circadia...

journal_title：Frontiers in physiology

authors： Chi-Castañeda D,Ortega A

更新日期：2018-02-12 00:00:00

abstract：:Animal experiments suggest that total liquid ventilation (TLV) induces less ventilator-induced lung injury (VILI) than conventional mechanical gas ventilation. However, TLV parameters that optimally minimize VILI in newborns remain unknown. Our objective was to compare lung inflammation between low (L-VT) and high (H-...

journal_title：Frontiers in physiology

authors： Sage M,See W,Nault S,Morin C,Michalski C,Chabot B,Marouan S,Lavoie PM,Micheau P,Praud JP,Fortin-Pellerin É

更新日期：2020-06-18 00:00:00

abstract：:Recent efforts to ensure the reliability of computational model-based predictions in healthcare, such as the ASME V&V40 Standard, emphasize the importance of uncertainty quantification (UQ) and sensitivity analysis (SA) when evaluating computational models. UQ involves empirically determining the uncertainty in model ...

journal_title：Frontiers in physiology

authors： Pathmanathan P,Cordeiro JM,Gray RA

更新日期：2019-06-26 00:00:00

abstract：:Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multiscale by nature, project work, and software tools usually focus on isolated aspects o...

journal_title：Frontiers in physiology

authors： Eissing T,Kuepfer L,Becker C,Block M,Coboeken K,Gaub T,Goerlitz L,Jaeger J,Loosen R,Ludewig B,Meyer M,Niederalt C,Sevestre M,Siegmund HU,Solodenko J,Thelen K,Telle U,Weiss W,Wendl T,Willmann S,Lippert J

更新日期：2011-02-24 00:00:00

abstract：:The complex interactions that give rise to heart rate variability (HRV) involve coupled physiological oscillators operating over a wide range of different frequencies and length-scales. Based on the premise that interactions are key to the functioning of complex systems, the time-dependent deterministic coupling param...

journal_title：Frontiers in physiology

authors： Ticcinelli V,Stankovski T,Iatsenko D,Bernjak A,Bradbury AE,Gallagher AR,Clarkson PBM,McClintock PVE,Stefanovska A

更新日期：2017-10-13 00:00:00

abstract：:A sedentary lifestyle is associated with increased cardiovascular risk factors and reduced cardiac compliance when compared to a lifestyle that includes exercise training. Exercise training increases cardiac compliance in humans, but the mechanisms underlying this improvement are unknown. A major determinant of cardia...

journal_title：Frontiers in physiology

authors： Chung CS,Hiske MA,Chadha A,Mueller PJ

更新日期：2020-02-05 00:00:00

abstract：:Mouse Embryonic Stem Cells (ESCs) are pluripotent mammalian cells derived from the Inner Cell Mass (ICM) of mouse blastocysts, which give rise to all three embryonic germ layers both in vivo and in vitro. Mouse ESCs have a distinct epigenetic landscape and a more decondensed chromatin compared to differentiated cells....

journal_title：Frontiers in physiology

authors： Karnavas T,Pintonello L,Agresti A,Bianchi ME

更新日期：2014-08-28 00:00:00

abstract：:Muscle fatigue is the decline in performance of muscles observed during periods of intense activity. ATP consumption exceeds production during intense activity and there are multiple changes in intracellular metabolites which may contribute to the changes in crossbridge activity. It is also well-established that a red...

journal_title：Frontiers in physiology

authors： Allen DG,Trajanovska S

更新日期：2012-12-11 00:00:00

abstract：:Polarized (POL) training intensity distribution (TID) emphasizes high-volume low-intensity exercise in zone (Z)1 (< first lactate threshold) with a greater proportion of high-intensity Z3 (>second lactate threshold) compared to Z2 (between first and second lactate threshold). In highly trained rowers there is a lack o...

journal_title：Frontiers in physiology

authors： Treff G,Winkert K,Sareban M,Steinacker JM,Becker M,Sperlich B

更新日期：2017-08-02 00:00:00

abstract：:This study investigates the complex interplay between the cardiac and respiratory systems in 268 healthy neonates born between 35 and 40 weeks of gestation. The aim is to provide a comprehensive description of the developing cardiorespiratory information transfer mechanisms as a function of gestational age (GA). This ...

journal_title：Frontiers in physiology

authors： Lucchini M,Pini N,Burtchen N,Signorini MG,Fifer WP

更新日期：2020-08-27 00:00:00

abstract：:The emergence of -omics technologies has allowed the collection of vast amounts of data on biological systems. Although, the pace of such collection has been exponential, the impact of these data remains small on many critical biomedical applications such as drug development. Limited resources, high costs, and low hit...

journal_title：Frontiers in physiology

authors： Kandoi G,Acencio ML,Lemke N

更新日期：2015-12-08 00:00:00

abstract：:It has been reported that nitric oxide (NO) is a negative regulator of aluminum (Al)-induced programmed cell death (PCD) in peanut root tips. However, the inhibiting mechanism of NO on Al-induced PCD is unclear. In order to investigate the mechanism by which NO inhibits Al-induced PCD, the effects of co-treatment Al w...

journal_title：Frontiers in physiology

authors： Pan CL,Yao SC,Xiong WJ,Luo SZ,Wang YL,Wang AQ,Xiao D,Zhan J,He LF

更新日期：2017-12-21 00:00:00

abstract：:Canonical functions of mitochondria include the regulation of cellular survival, orchestration of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling. Recent discoveries, nevertheless, have demonstrated that mitochondria are also critical elements to stimulate innate immune signaling ca...

journal_title：Frontiers in physiology

authors： Chen Y,Zhou Z,Min W

更新日期：2018-10-18 00:00:00

abstract：:Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

journal_title：Frontiers in physiology

authors： Perillo M,Folker ES

更新日期：2018-11-01 00:00:00

abstract：:In our digitized society, advanced information and communication technology and highly interactive work environments impose high demands on cognitive capacity. Optimal workload conditions are important for assuring employee's health and safety of other persons. This is particularly relevant in safety-critical occupati...

journal_title：Frontiers in physiology

authors： Radüntz T,Fürstenau N,Mühlhausen T,Meffert B

更新日期：2020-04-21 00:00:00