Modeling the Pro-inflammatory Tumor Microenvironment in Acute Lymphoblastic Leukemia Predicts a Breakdown of Hematopoietic-Mesenchymal Communication Networks.

abstract：:Recently, two alternative targets in insect periphery nerve system have been explored for environmentally-friendly approaches in insect pest management, namely odorant-binding proteins (OBPs) and odorant receptors (ORs). Located in insect antennae, OBPs are thought to be involved in the transport of odorants to ORs fo...

journal_title：Frontiers in physiology

authors： Venthur H,Zhou JJ

更新日期：2018-08-24 00:00:00

abstract：:Currently, neuropathic pain is an underestimated socioeconomic health problem affecting millions of people worldwide, which incidence may increase in the next years due to chronification of several diseases, such as cancer and diabetes. Growing evidence links neuropathic pain present in several disorders [i.e., spinal...

journal_title：Frontiers in physiology

authors： Carrasco C,Naziroǧlu M,Rodríguez AB,Pariente JA

更新日期：2018-02-14 00:00:00

abstract：:Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the native troponin complex in skinned trabecular fibers of guinea pigs ...

journal_title：Frontiers in physiology

authors： Groen M,López-Dávila AJ,Zittrich S,Pfitzer G,Stehle R

更新日期：2020-06-03 00:00:00

abstract：:Signaling pathways of red blood cells' (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool for correction of hemorheological disorders, which accompany a n...

journal_title：Frontiers in physiology

authors： Semenov AN,Shirshin EA,Muravyov AV,Priezzhev AV

更新日期：2019-08-14 00:00:00

abstract：:About 14% of veterans who suffer from Gulf war illness (GWI) complain of some form of gastrointestinal disorder but with no significant markers of clinical pathology. Our previous studies have shown that exposure to GW chemicals resulted in altered microbiome which was associated with damage associated molecular patte...

journal_title：Frontiers in physiology

authors： Kimono D,Sarkar S,Albadrani M,Seth R,Bose D,Mondal A,Li Y,Kar AN,Nagarkatti M,Nagarkatti P,Sullivan K,Janulewicz P,Lasley S,Horner R,Klimas N,Chatterjee S

更新日期：2019-10-14 00:00:00

abstract：:Many studies have investigated the physiological response to microgravity in both astronauts and animals. However, while space agencies have sought to deploy more women on their missions; animal models rarely include females studies or comparisons between males and females. Therefore, we exposed adult female rats to 2...

journal_title：Frontiers in physiology

authors： Semple C,Riveros D,Nagy JA,Rutkove SB,Mortreux M

更新日期：2020-04-03 00:00:00

abstract：:It has been proposed that group III and IV muscle afferents provide inhibitory feedback from locomotor muscles to the central nervous system, setting an absolute threshold for the development of peripheral fatigue during exercise. The aim of this study was to test the validity of this theory. Thus, we asked whether th...

journal_title：Frontiers in physiology

authors： Froyd C,Beltrami FG,Millet GY,Noakes TD

更新日期：2016-12-19 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) has been detected in various water bodies and caused harm to aquatic organisms. The aim of this study was to investigate the cytotoxicity and mechanism associated with autophagy and oxidative stress after exposure to PFOA (0, 1, 10, 100 μg/L) for 12 h on lymphocytes, which was isolated fr...

journal_title：Frontiers in physiology

authors： Tang J,Lu X,Chen F,Ye X,Zhou D,Yuan J,He J,Chen B,Shan X,Jiang J,Liu W,Zhang H

更新日期：2018-12-05 00:00:00

abstract：Context:Strength-endurance mainly depends on the power output, which is often expressed relative to the individual's maximal power capability (Pmax). However, an individual can develop the same power, but in different combinations of force and velocity (force-velocity condition). Also, at matched power output, changing...

journal_title：Frontiers in physiology

authors： Rivière JR,Peyrot N,Cross MR,Messonnier LA,Samozino P

更新日期：2020-10-09 00:00:00

abstract：:The brain-gut axis plays a critical role in the regulation of different diseases, many of which are characterized by sympathetic dysregulation. However, a direct link between sympathetic dysregulation and gut dysbiosis remains to be illustrated. Bone marrow (BM)-derived immune cells continuously interact with the gut ...

journal_title：Frontiers in physiology

authors： Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J

更新日期：2017-04-12 00:00:00

abstract：:The need for radiotherapy personalization is now widely recognized, however, it would require considerations not only on the probability of control and survival of the tumor, but also on the possible toxic effects, on the quality of the expected life and the economic efficiency of the treatment. In this paper, we prop...

journal_title：Frontiers in physiology

authors： Belfatto A,Jereczek-Fossa BA,Baroni G,Cerveri P

更新日期：2018-10-15 00:00:00

abstract：Background:Post-ligation cardiac syndrome (PLCS) is a common complication of patent ductus arteriosus (PDA) surgical closure in low birth weight infants. It has been associated with mortality, but there is a lack of information about the neurodevelopmental outcome of the survivors. We aimed to explore the prevalence of...

journal_title：Frontiers in physiology

authors： Bravo MC,Ybarra M,Madero R,Pellicer A

更新日期：2019-06-11 00:00:00

abstract：:Pancreatic cancer shows a characteristic tissue structure called desmoplasia, which consists of dense fibrotic stroma surrounding cancer cells. Interactions between pancreatic cancer cells and stromal cells promote invasive growth of cancer cells and establish a specific microenvironment such as hypoxia which further ...

journal_title：Frontiers in physiology

authors： Hamada S,Masamune A,Shimosegawa T

更新日期：2013-11-01 00:00:00

abstract：:When compared to the previous generations, younger generations have become sedentary on a global level. Physical activity positively contributes to human growth and development, causing, indeed, both physiological and psychological benefits. The aim of the current study was examining the relationship between physical ...

journal_title：Frontiers in physiology

authors： Padulo J,Bragazzi NL,De Giorgio A,Grgantov Z,Prato S,Ardigò LP

更新日期：2019-03-05 00:00:00

abstract：:Animal experiments suggest that total liquid ventilation (TLV) induces less ventilator-induced lung injury (VILI) than conventional mechanical gas ventilation. However, TLV parameters that optimally minimize VILI in newborns remain unknown. Our objective was to compare lung inflammation between low (L-VT) and high (H-...

journal_title：Frontiers in physiology

authors： Sage M,See W,Nault S,Morin C,Michalski C,Chabot B,Marouan S,Lavoie PM,Micheau P,Praud JP,Fortin-Pellerin É

更新日期：2020-06-18 00:00:00

abstract：:Since the late 2010s, Transcranial Ultrasound Stimulation (TUS) has been used experimentally to carryout safe, non-invasive stimulation of the brain with better spatial resolution than Transcranial Magnetic Stimulation (TMS). This innovative stimulation method has emerged as a novel and valuable device for studying br...

journal_title：Frontiers in physiology

authors： Pouget P,Frey S,Ahnine H,Attali D,Claron J,Constans C,Aubry JF,Arcizet F

更新日期：2020-08-19 00:00:00

abstract：:While many effectors have been identified in enamel matrix and cells via genetic studies, physiological networks underlying their expression levels and thus the natural spectrum of enamel thickness and degree of mineralization are now just emerging. Several transcription factors are candidates for enamel gene expressi...

journal_title：Frontiers in physiology

authors： Babajko S,de La Dure-Molla M,Jedeon K,Berdal A

更新日期：2015-01-05 00:00:00

abstract：:Most insect species exhibit characteristic behavioral changes after mating. Typical post-mating behaviors in female insects include noticeable increases in food intake, elevated oviposition rates, lowered receptivity to courting males, and enhanced immune response. Although it has been reported that mated females of s...

journal_title：Frontiers in physiology

authors： Tsukamoto Y,Kataoka H,Nagasawa H,Nagata S

更新日期：2014-03-13 00:00:00

abstract：:Purpose: Few large-scale population-based studies have adequately examined the relationships between steroid hormones, health status and physical fitness. The purpose of the study was to describe the relationship of serum basal endogenous steroid hormones (testosterone, TES; empirical free testosterone, EFT; cortisol,...

journal_title：Frontiers in physiology

authors： Gagnon SS,Nindl BC,Vaara JP,Santtila M,Häkkinen K,Kyröläinen H

更新日期：2018-07-27 00:00:00

abstract：:The use of anesthesia is a common practice in aquaculture to sedate fish and mitigate handling stress. Although the employ of anesthesia is considered beneficial for fish, as it reduces stress and improves welfare, at the same time it may induce hazardous side-effects. The aim of the present study was to investigate t...

journal_title：Frontiers in physiology

authors： Teles M,Oliveira M,Jerez-Cepa I,Franco-Martínez L,Tvarijonaviciute A,Tort L,Mancera JM

更新日期：2019-05-03 00:00:00

abstract：:The grand challenge to physiology, as was first described in an essay published in the inaugural issue of Frontiers in Physiology in 2010, remains to integrate function from molecules to intact organisms. In order to make sense of the vast volume of information derived from, and increasingly dependent upon, reductioni...

journal_title：Frontiers in physiology

authors： Billman GE

更新日期：2020-03-10 00:00:00

abstract：:Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells th...

journal_title：Frontiers in physiology

authors： Chistiakov DA,Sobenin IA,Orekhov AN,Bobryshev YV

更新日期：2014-05-27 00:00:00

abstract：:Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown. It was previously postulated that molecular switches responsible for cancer cell development, and for infiltration of inflammatory cells into cancer...

journal_title：Frontiers in physiology

authors： Liu ST,Pham H,Pandol SJ,Ptasznik A

更新日期：2014-01-16 00:00:00

abstract：:Hemoglobin (Hb) continuously undergoes autoxidation producing superoxide which dismutates into hydrogen peroxide (H2O2) and is a potential source for subsequent oxidative reactions. Autoxidation is most pronounced under hypoxic conditions in the microcirculation and for unstable dimers formed at reduced Hb concentrati...

journal_title：Frontiers in physiology

authors： Rifkind JM,Mohanty JG,Nagababu E

更新日期：2015-01-14 00:00:00

abstract：:Oxidative modification of proteins in photosystem II (PSII) exposed to high light has been studied for a few decades, but the characterization of protein radicals formed by protein oxidation is largely unknown. Protein oxidation is induced by the direct reaction of proteins with reactive oxygen species known to form h...

journal_title：Frontiers in physiology

authors： Kumar A,Prasad A,Sedlářová M,Pospíšil P

更新日期：2019-08-13 00:00:00

abstract：:Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play an important role in cellular communication during skeletal growth and homeostasis. Bioactive molecules carried by EVs are transported to neighboring and distant cells to trigger a series of signaling cascades influencing bone ...

journal_title：Frontiers in physiology

authors： Yuan FL,Wu QY,Miao ZN,Xu MH,Xu RS,Jiang DL,Ye JX,Chen FH,Zhao MD,Wang HJ,Li X

更新日期：2018-05-30 00:00:00

abstract：:The paper reports application of a Markov-like stochastic process agent-based model and a "virtual farm" concept for enhancement of site-specific Integrated Pest Management. Conceptually, the model represents a "bottom-up ethological" approach and emulates behavior of the "primary IPM actors"-large cohorts of individu...

journal_title：Frontiers in physiology

authors： Lux SA,Wnuk A,Vogt H,Belien T,Spornberger A,Studnicki M

更新日期：2016-08-23 00:00:00

abstract：:A recent experiment proves the therapeutic effect of arm-in-arm walking, showing that if an aged participant walks in close synchrony with a young companion, the complexity matching effect results in the restoration of complexity in the former. A clear manifestation of complexity restoration is a perfect synchronizati...

journal_title：Frontiers in physiology

authors： Mahmoodi K,West BJ,Grigolini P

更新日期：2020-09-30 00:00:00

abstract：:Intravascular hemolysis occurs in hereditary, acquired, and iatrogenic hemolytic conditions but it could be also a normal physiological process contributing to intercellular signaling. New evidence suggests that intravascular hemolysis and the associated release of adenosine triphosphate (ATP) may be an important mech...

journal_title：Frontiers in physiology

authors： Grygorczyk R,Orlov SN

更新日期：2017-12-22 00:00:00

abstract：:Background: The purpose of this study was to investigate the acute effects of a single oral administration of an essential amino acids enriched mixture (EAA) on myoelectric descriptors of fatigue and maximal force production after a resistance exercise protocol (REP). Methods: Twenty adult males (age: 27 ± 6 years; bo...

journal_title：Frontiers in physiology

authors： Negro M,Segreto V,Barbero M,Cescon C,Castelli L,Calanni L,D'Antona G

更新日期：2018-08-17 00:00:00