Abstract:
:The analysis of neural systems leverages tools from many different fields. Drawing on techniques from the study of critical phenomena in statistical mechanics, several studies have reported signatures of criticality in neural systems, including power-law distributions, shape collapses, and optimized quantities under tuning. Independently, neural complexity-an information theoretic measure-has been introduced in an effort to quantify the strength of correlations across multiple scales in a neural system. This measure represents an important tool in complex systems research because it allows for the quantification of the complexity of a neural system. In this analysis, we studied the relationships between neural complexity and criticality in neural culture data. We analyzed neural avalanches in 435 recordings from dissociated hippocampal cultures produced from rats, as well as neural avalanches from a cortical branching model. We utilized recently developed maximum likelihood estimation power-law fitting methods that account for doubly truncated power-laws, an automated shape collapse algorithm, and neural complexity and branching ratio calculation methods that account for sub-sampling, all of which are implemented in the freely available Neural Complexity and Criticality MATLAB toolbox. We found evidence that neural systems operate at or near a critical point and that neural complexity is optimized in these neural systems at or near the critical point. Surprisingly, we found evidence that complexity in neural systems is dependent upon avalanche profiles and neuron firing rate, but not precise spiking relationships between neurons. In order to facilitate future research, we made all of the culture data utilized in this analysis freely available online.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Timme NM,Marshall NJ,Bennett N,Ripp M,Lautzenhiser E,Beggs JMdoi
10.3389/fphys.2016.00425subject
Has Abstractpub_date
2016-09-27 00:00:00pages
425issn
1664-042Xjournal_volume
7pub_type
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2019.00181
更新日期:2019-03-20 00:00:00
abstract::Phosphofructokinase deficiency is a very rare autosomal recessive disorder, which belongs to group of rare inborn errors of metabolism called glycogen storage disease. Here we report on a new mutation in the phosphofructokinase (PFK) gene PFKM identified in a 65-years-old woman who suffered from lifelong intermittent ...
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pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.00900
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pub_type: 杂志文章,评审
doi:10.3389/fphys.2019.01546
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.00348
更新日期:2020-05-08 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2016.00199
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00976
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00226
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abstract::Environmental hypoxia represents a major physiological challenge for Eriocheir sinensis and Palaemonetes sinensis and is a severe problem in aquaculture. Therefore, understanding the metabolic response mechanisms of E. sinensis and P. sinensis, which are economically important species, to environmental hypoxia and reo...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.01559
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abstract::Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. This phenomenon is known as the "m...
journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2018.01887
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abstract::Progressive aging induces several structural and functional alterations in the cardiovascular system, among whom particularly important are a reduced number of myocardial cells and increased interstitial collagen fibers, which result in impaired left ventricular diastolic function. Even in the absence of cardiovascula...
journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2014.00051
更新日期:2014-02-20 00:00:00
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pub_type: 杂志文章
doi:10.3389/fphys.2020.548055
更新日期:2020-09-24 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.00211
更新日期:2020-03-20 00:00:00
abstract::Liver cirrhosis (LC) is the final usual outcome of liver damage induced by various chronic liver diseases. Because of asymptomatic nature of LC, it is usually diagnosed at late and advanced stages, and patients are easy to miss the best timing for treatment. Thus, the early detection of LC is needed. In the prospectiv...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.01421
更新日期:2019-11-19 00:00:00
abstract::Background and Objective: It is widely accepted that there is an association between chronic obstructive pulmonary disease (COPD) and periodontitis. However, whether the periodontal status of the COPD patients is worse than that of the non-COPD subjects is seldom assessed. The findings currently available are inconsis...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.00033
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journal_title:Frontiers in physiology
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2019.01463
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pub_type: 杂志文章
doi:10.3389/fphys.2018.00346
更新日期:2018-04-10 00:00:00
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pub_type: 杂志文章
doi:10.3389/fphys.2020.00048
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00760
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pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.00202
更新日期:2019-03-05 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2014.00330
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pub_type: 杂志文章
doi:10.3389/fphys.2018.01505
更新日期:2018-10-25 00:00:00
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pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.00883
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