Prediction of Druggable Proteins Using Machine Learning and Systems Biology: A Mini-Review.

abstract：:Exogenous dsRNA enters the insect body and can induce the RNAi effect only when it is cleaved into siRNA. However, what kinds of base composition are easier to cut and what kinds of siRNA will be produced in vivo is largely unknown. In this study, we found that dsRNA processing into siRNA has sequence preference and r...

journal_title：Frontiers in physiology

authors： Guan R,Hu S,Li H,Shi Z,Miao X

更新日期：2018-12-10 00:00:00

abstract：:The hypothesis of the present study is that apoptosis through an intrinsic mitochondrial pathway may mediate high fat diet (HFD)-induced changes in the metabolism of Pelteobagrus fulvidraco. To this end, we cloned the full-length cDNA sequences of Cycs, Apaf1, Casp9, Casp3a, and Casp3b involved in the mitochondria apo...

journal_title：Frontiers in physiology

authors： Li DD,Ling SC,Wu K,Luo Z

更新日期：2019-08-02 00:00:00

abstract：:The sense of taste is responsible for the detection and ingestion of food to cover energetic requirements in health and disease. The change in taste perception might lead to malnutrition that is usually one of the frequent causes of morbidity and mortality in patients with cancer. In this review, we summarize the mech...

journal_title：Frontiers in physiology

authors： Murtaza B,Hichami A,Khan AS,Ghiringhelli F,Khan NA

更新日期：2017-03-08 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) refers to the conversion of epithelial cells to mesenchymal phenotype, which endows the epithelial cells with enhanced migration, invasion, and extracellular matrix production abilities. These characteristics link EMT with the pathogenesis of organ fibrosis and cancer progressio...

journal_title：Frontiers in physiology

authors： Xu Z,Ding W,Deng X

更新日期：2019-11-29 00:00:00

abstract：:Circadian clocks consist of molecular negative feedback loops that coordinate physiological, neurological, and behavioral variables into "circa" 24-h rhythms. Rhythms in behavioral and other circadian outputs tend to weaken during aging, as evident in progressive disruptions of sleep-wake cycles in aging organisms. Ho...

journal_title：Frontiers in physiology

authors： Long DM,Giebultowicz JM

更新日期：2018-01-09 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) has been detected in various water bodies and caused harm to aquatic organisms. The aim of this study was to investigate the cytotoxicity and mechanism associated with autophagy and oxidative stress after exposure to PFOA (0, 1, 10, 100 μg/L) for 12 h on lymphocytes, which was isolated fr...

journal_title：Frontiers in physiology

authors： Tang J,Lu X,Chen F,Ye X,Zhou D,Yuan J,He J,Chen B,Shan X,Jiang J,Liu W,Zhang H

更新日期：2018-12-05 00:00:00

abstract：:This mini-review provides an updated summary of various analogs for adaptations of humans to the microgravity of space. Microgravity analogs discussed in this paper include dry immersion, wet immersion, unilateral lower-extremity limb suspension, head down tilt (HDT), and supine bed rest. All Earth-based analogs are i...

journal_title：Frontiers in physiology

authors： Pandiarajan M,Hargens AR

更新日期：2020-06-23 00:00:00

abstract：:Introduction: Tilt tables enable early mobilization of patients by providing verticalization. But there is a high risk of orthostatic hypotension provoked by verticalization, especially after neurological diseases such as spinal cord injury. Robot-assisted tilt tables might be an alternative as they add passive roboti...

journal_title：Frontiers in physiology

authors： Sarabadani Tafreshi A,Riener R,Klamroth-Marganska V

更新日期：2016-12-09 00:00:00

abstract：:Background: Chinese herbal medicine (CHM) has a good effect of alleviating symptoms and improving quality of life and exercise tolerance in patients with heart failure with preserved ejection fraction (HFpEF), but it wasn't sufficiently valued and promoted because of the lack of evidence-based medical evidence. Aim: T...

journal_title：Frontiers in physiology

authors： Wang J,Yang R,Zhang F,Jia C,Wang P,Liu J,Gao K,Xie H,Wang J,Zhao H,Chen J,Wang W

更新日期：2018-10-26 00:00:00

abstract：:Hypoxic exercise may represent a novel therapeutic strategy to reduce and prevent obesity through the regulation of lipid metabolism. During hypoxic exercise, the targeting of peroxisome proliferator-activated receptor gamma (PPARγ) by miR-27b has been proposed to be one of the mechanisms involved in the modulation of...

journal_title：Frontiers in physiology

authors： Wang X,Lu Y,Zhu L,Zhang H,Feng L

更新日期：2020-08-31 00:00:00

abstract：:Muscle strain is one of the most frequent sports injuries, having the rectus femoris (RF) muscle as the reported preferred site of quadriceps muscle strain. The decrease muscle stiffness could be an effective RF muscle strain prevention. In recent studies, a high-intensity static stretching intervention decreased pass...

journal_title：Frontiers in physiology

authors： Nakamura M,Sato S,Murakami Y,Kiyono R,Yahata K,Sanuki F,Yoshida R,Fukaya T,Takeuchi K

更新日期：2021-01-13 00:00:00

abstract：:The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in a patient-specific environment. Given the recent advances in medical imaging, computational power and mathematical algorithms, patient-specific cardiac models ...

journal_title：Frontiers in physiology

authors： Zhong L,Zhang JM,Su B,Tan RS,Allen JC,Kassab GS

更新日期：2018-06-26 00:00:00

abstract：:Insecticidal effects of Bacillus thuringiensis Cry toxins in hemocoel of larvae have not been properly evaluated. In the present study, hemocoelic injection of four representative Cry toxins i.e., Cry1Aa, Cry1Ab, Cry1Ac, and DOR5 to an economically important lepidopteran insect pest Achaea janata, induced larval morta...

journal_title：Frontiers in physiology

authors： Ningshen TJ,Chauhan VK,Dhania NK,Dutta-Gupta A

更新日期：2017-05-10 00:00:00

abstract：:Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by ...

journal_title：Frontiers in physiology

authors： Tao J,Lan Z,Wang Y,Hei H,Tian L,Pan W,Zhang X,Peng W

更新日期：2016-06-21 00:00:00

abstract：:Genome-wide association studies and physiological investigations have linked alterations in acid-base transporters to hypertension. Accordingly, Na(+)-coupled HCO(-) 3-transporters, Na(+)/H(+)-exchangers, and anion-exchangers have emerged as putative mechanistic components in blood pressure disturbances. Even though h...

journal_title：Frontiers in physiology

authors： Boedtkjer E,Aalkjaer C

更新日期：2013-12-24 00:00:00

abstract：:Ocean acidification (OA) and warming seas are significant concerns for coastal systems and species. The Atlantic longfin squid, Doryteuthis pealeii, a core component of the Northwest Atlantic trophic web, has demonstrated impacts, such as reduced growth and delayed development, under high chronic exposure to acidifica...

journal_title：Frontiers in physiology

authors： Zakroff CJ,Mooney TA

更新日期：2020-05-20 00:00:00

abstract：:This study aimed to investigate the influence of different exercise training modalities [(i) a concurrent training based on physical activity recommendation from the World Health Organization group (PAR group), (ii) a high intensity interval training group (HIIT group), and (iii) a high intensity interval training add...

journal_title：Frontiers in physiology

authors： Amaro-Gahete FJ,De-la-O A,Jurado-Fasoli L,Dote-Montero M,Gutiérrez Á,Ruiz JR,Castillo MJ

更新日期：2019-04-24 00:00:00

abstract：:The bicuspid aortic valve, a kind of heart disease that comes from parents, has been paid attention around the world. Although most bicuspid aortic valve (BAV) patients will suffer from some complications including aortic stenosis, aortic regurgitation, endocarditis, and heart dysfunction in the late stage of the dise...

journal_title：Frontiers in physiology

authors： Liu T,Xie M,Lv Q,Li Y,Fang L,Zhang L,Deng W,Wang J

更新日期：2019-01-30 00:00:00

abstract：:Pulmonary edema (PE) is an issue widely noted in acute exposure to hypoxia as seen in high altitude climbers, yet the etiology of this is not defined. Previous studies in rats showed that both hypoxia and strong sympathetic activation may induce PE. As acute exposure to hypoxia is accompanied by sympathetic activation...

journal_title：Frontiers in physiology

authors： Bölter C,Gabriel P,Appelt P,Salameh A,Schierle K,Rassler B

更新日期：2019-07-05 00:00:00

abstract：:Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, ...

journal_title：Frontiers in physiology

authors： Larsson S,Åkerström B,Gram M,Lohmander LS,Struglics A

更新日期：2018-11-16 00:00:00

abstract：:Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

journal_title：Frontiers in physiology

authors： Perillo M,Folker ES

更新日期：2018-11-01 00:00:00

abstract：:Catheter ablation therapy for persistent atrial fibrillation (AF) typically includes pulmonary vein isolation (PVI) and may include additional ablation lesions that target patient-specific anatomical, electrical, or structural features. Clinical centers employ different ablation strategies, which use imaging data toge...

journal_title：Frontiers in physiology

authors： Roney CH,Beach ML,Mehta AM,Sim I,Corrado C,Bendikas R,Solis-Lemus JA,Razeghi O,Whitaker J,O'Neill L,Plank G,Vigmond E,Williams SE,O'Neill MD,Niederer SA

更新日期：2020-09-16 00:00:00

abstract：:Many natural phenomena display "self-organized criticality" (SOC), (Bak et al., 1987). This refers to spatially extended systems for which patterns of activity characterized by different lengthscales can occur with a probability density that follows a power law with pattern size. Differently from power laws at phase t...

journal_title：Frontiers in physiology

authors： Lopez L,Piegari E,Sigaut L,Ponce Dawson S

更新日期：2012-09-03 00:00:00

abstract：:A colony of social insects is not only an aggregation of individuals but also a functional unit. To achieve adaptive social behavior in fluctuating environmental conditions, in addition to coordination of physiological status in each individual, the whole colony is coordinated by interactions among colony members. The...

journal_title：Frontiers in physiology

authors： Watanabe D,Gotoh H,Miura T,Maekawa K

更新日期：2014-04-09 00:00:00

abstract：:Aphidius gifuensis is one of the most important aphid natural enemies and has been successfully used to control Myzys persicae and other aphid species. High temperature in summer is one of the key barriers for the application of A. gifuensis in the field and greenhouse. In this work, we investigated the biological per...

journal_title：Frontiers in physiology

authors： Kang ZW,Liu FH,Liu X,Yu WB,Tan XL,Zhang SZ,Tian HG,Liu TX

更新日期：2017-11-28 00:00:00

abstract：:The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca2+, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer's and Huntington's. Glaucomatous optic neuropathy - the world's le...

journal_title：Frontiers in physiology

authors： McGrady NR,Risner ML,Vest V,Calkins DJ

更新日期：2020-03-26 00:00:00

abstract：:Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both...

journal_title：Frontiers in physiology

authors： Nomikos NN,Nikolaidis PT,Sousa CV,Papalois AE,Rosemann T,Knechtle B

更新日期：2018-12-18 00:00:00

abstract：:The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic and neuroendocrine regulation. Experiments in anesthetized animals and in vitro indicate an interaction among gamma-aminobutyric acid (GABA), nitric oxide (NO), and glutamate in the PVN. The cardiovascular role of the PVN and inte...

journal_title：Frontiers in physiology

authors： Martins-Pinge MC,Mueller PJ,Foley CM,Heesch CM,Hasser EM

更新日期：2013-01-09 00:00:00

abstract：:Airway hyperresponsiveness (AHR), a characteristic of asthma that involves an excessive reduction in airway caliber, is a complex mechanism reflecting multiple processes that manifest over a large range of length and time scales. At one extreme, molecular interactions determine the force generated by airway smooth mus...

journal_title：Frontiers in physiology

authors： Lauzon AM,Bates JH,Donovan G,Tawhai M,Sneyd J,Sanderson MJ

更新日期：2012-06-11 00:00:00

abstract：:Many studies have investigated the physiological response to microgravity in both astronauts and animals. However, while space agencies have sought to deploy more women on their missions; animal models rarely include females studies or comparisons between males and females. Therefore, we exposed adult female rats to 2...

journal_title：Frontiers in physiology

authors： Semple C,Riveros D,Nagy JA,Rutkove SB,Mortreux M

更新日期：2020-04-03 00:00:00