Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease.

abstract：:A new concept of non-rapid eye movement (NREM) and rapid eye movement (REM) sleep is proposed, that of multi-component integrative states that define stable and unstable sleep, respectively, NREMS, NREMUS REMS, and REMUS. Three complementary data sets are used: obstructive sleep apnea (20), healthy subjects (11), and ...

journal_title：Frontiers in physiology

authors： Wood C,Bianchi MT,Yun CH,Shin C,Thomas RJ

更新日期：2020-12-03 00:00:00

abstract：:The use of intravenous vitamin C (IVC) for cancer therapy has long been an area of intense controversy. Despite this, high dose IVC has been administered for decades by complementary health care practitioners and physicians, with little evidence base resulting in inconsistent clinical practice. In this review we pose ...

journal_title：Frontiers in physiology

authors： Carr AC,Cook J

更新日期：2018-08-23 00:00:00

abstract：:Intravascular hemolysis occurs in hereditary, acquired, and iatrogenic hemolytic conditions but it could be also a normal physiological process contributing to intercellular signaling. New evidence suggests that intravascular hemolysis and the associated release of adenosine triphosphate (ATP) may be an important mech...

journal_title：Frontiers in physiology

authors： Grygorczyk R,Orlov SN

更新日期：2017-12-22 00:00:00

abstract：:A wide range of adipokines identified over the past years has allowed considering the white adipose tissue as a secretory organ closely integrated into overall physiological and metabolic control. Apelin, a ubiquitously expressed peptide was known to exert different physiological effects mainly on the cardiovascular s...

journal_title：Frontiers in physiology

authors： Bertrand C,Valet P,Castan-Laurell I

更新日期：2015-04-10 00:00:00

abstract：:Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-gly...

journal_title：Frontiers in physiology

authors： Tijardović M,Marijančević D,Bok D,Kifer D,Lauc G,Gornik O,Keser T

更新日期：2019-12-20 00:00:00

abstract：:The RR-interval time series or tachograms obtained from electrocardiograms have been widely studied since they reflect the cardiac variability, and this is an indicative of the health status of a person. The tachogram can be seen as a highly non-linear and complex time series, and therefore, should be analyzed with no...

journal_title：Frontiers in physiology

authors： Solís-Montufar EE,Gálvez-Coyt G,Muñoz-Diosdado A

更新日期：2020-08-12 00:00:00

abstract：:Several Octopodidae species have a great potential for the diversification of worldwide aquaculture. Unfortunately, the lack of stress-related biomarkers in this taxon results an obstacle for its maintenance in conditions where animal welfare is of paramount relevance. In this study, we made a first approach to uncove...

journal_title：Frontiers in physiology

authors： Barragán-Méndez C,Sobrino I,Marín-Rincón A,Fernández-Boo S,Costas B,Mancera JM,Ruiz-Jarabo I

更新日期：2019-06-25 00:00:00

abstract：:Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells th...

journal_title：Frontiers in physiology

authors： Chistiakov DA,Sobenin IA,Orekhov AN,Bobryshev YV

更新日期：2014-05-27 00:00:00

abstract：:Different from other epithelia, the intestinal epithelium has the complex task of providing a barrier impeding the entry of toxins, food antigens, and microbes, while at the same time allowing for the transfer of nutrients, electrolytes, water, and microbial metabolites. These molecules/organisms are transported eithe...

journal_title：Frontiers in physiology

authors： Tang L,Cheng CY,Sun X,Pedicone AJ,Mohamadzadeh M,Cheng SX

更新日期：2016-06-21 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2016.00260.]. ...

journal_title：Frontiers in physiology

authors： Tibana RA,de Almeida LM,Frade de Sousa NM,Nascimento DDC,Neto IVS,de Almeida JA,de Souza VC,Lopes MFTPL,Nobrega OT,Vieira DCL,Navalta JW,Prestes J

更新日期：2018-07-16 00:00:00

abstract：:The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbor connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43. Connexins give rise to hemichannels, which dock with counterparts on adjacent cells to form gap junctions. Both hemichannel...

journal_title：Frontiers in physiology

authors： Maes M,Decrock E,Cogliati B,Oliveira AG,Marques PE,Dagli ML,Menezes GB,Mennecier G,Leybaert L,Vanhaecke T,Rogiers V,Vinken M

更新日期：2014-01-10 00:00:00

abstract：:Infants born premature are at increased risk for development of bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), and ultimately right ventricular (RV) dysfunction, which together carry a high risk of neonatal mortality. However, the role alveolar simplification and abnormal pulmonary microvascular develo...

journal_title：Frontiers in physiology

authors： Patel JR,Barton GP,Braun RK,Goss KN,Haraldsdottir K,Hopp A,Diffee G,Hacker TA,Moss RL,Eldridge MW

更新日期：2017-10-25 00:00:00

abstract：:Prone position can reduce mortality in acute respiratory distress syndrome (ARDS), but several studies found variable effects on oxygenation and lung mechanics. It is unclear whether different positive end-expiratory pressure (PEEP) titration techniques modify the effect of prone position. We tested, in an animal mode...

journal_title：Frontiers in physiology

authors： Scaramuzzo G,Ball L,Pino F,Ricci L,Larsson A,Guérin C,Pelosi P,Perchiazzi G

更新日期：2020-03-12 00:00:00

abstract：:Long-duration spaceflight has been shown to negatively affect the lumbopelvic muscles of crewmembers. Through analysis of computed tomography scans of crewmembers on 4- to 6-month missions equipped with the interim resistive exercise device, the structural deterioration of the psoas, quadratus lumborum, and paraspinal...

journal_title：Frontiers in physiology

authors： McNamara KP,Greene KA,Moore AM,Lenchik L,Weaver AA

更新日期：2019-05-21 00:00:00

abstract：:Sepsis is a systemic inflammatory disease with infection, and autophagy has been shown to play an important role in sepsis. This review summarizes the main regulatory mechanisms of autophagy in sepsis and its latest research. Recent studies have shown that autophagy can regulate innate immune processes and acquired im...

journal_title：Frontiers in physiology

authors： Yin X,Xin H,Mao S,Wu G,Guo L

更新日期：2019-08-23 00:00:00

abstract：Background/Aims:Enterochromaffin cells (EC cells) constitute the largest population of enteroendocrine cells and release serotonin (5-HT) in response to mechanical and chemical cues of the gastrointestinal tract (GIT). How EC cells respond to altered microbiota such as due to antibiotic treatments remain poorly underst...

journal_title：Frontiers in physiology

authors： Zhu C,Gong H,Luo P,Dong L,Zhang G,Shi X,Rong W

更新日期：2020-12-23 00:00:00

abstract：:Mature spermatozoa have highly condensed DNA that is essentially silent both transcriptionally and translationally. Therefore, post translational modifications are very important for regulating sperm motility, morphology, and for male fertility in general. Protein sumoylation was recently demonstrated in human and rod...

journal_title：Frontiers in physiology

authors： Brohi RD,Wang L,Hassine NB,Cao J,Talpur HS,Wu D,Huang CJ,Rehman ZU,Bhattarai D,Huo LJ

更新日期：2017-06-13 00:00:00

abstract：:Anthropogenic climate change exposes marine organisms to CO2 induced ocean acidification (OA). Marine animals may make physiological and behavioral adaptations to cope with OA. Elevated pCO2 may affect metabolism, feeding, and energy partition of marine crabs, and thereby affect their predator-prey dynamics with musse...

journal_title：Frontiers in physiology

authors： Wang Y,Hu M,Wu F,Storch D,Pörtner HO

更新日期：2018-08-21 00:00:00

abstract：:To determine the level of hypoxia from which muscle activation (MA) is reduced during incremental exercise to exhaustion (IE), and the role played by PIO2 in this process, ten volunteers (21 ± 2 years) performed four IE in severe acute hypoxia (SAH) (PIO2 = 73 mmHg). Upon exhaustion, subjects were asked to continue ex...

journal_title：Frontiers in physiology

authors： Torres-Peralta R,Losa-Reyna J,Morales-Alamo D,González-Izal M,Pérez-Suárez I,Ponce-González JG,Izquierdo M,Calbet JA

更新日期：2016-08-17 00:00:00

abstract：:Hemoglobin (Hb) continuously undergoes autoxidation producing superoxide which dismutates into hydrogen peroxide (H2O2) and is a potential source for subsequent oxidative reactions. Autoxidation is most pronounced under hypoxic conditions in the microcirculation and for unstable dimers formed at reduced Hb concentrati...

journal_title：Frontiers in physiology

authors： Rifkind JM,Mohanty JG,Nagababu E

更新日期：2015-01-14 00:00:00

abstract：:Local purinergic signals modulate renal tubular transport. Acute activation of renal epithelial P2 receptors causes inhibition of epithelial transport and thus, should favor increased water and salt excretion by the kidney. So far only a few studies have addressed the effects of extracellular nucleotides on ion transp...

journal_title：Frontiers in physiology

authors： Marques RD,Praetorius HA,Leipziger J

更新日期：2013-10-09 00:00:00

abstract：:Muscle fatigue is the decline in performance of muscles observed during periods of intense activity. ATP consumption exceeds production during intense activity and there are multiple changes in intracellular metabolites which may contribute to the changes in crossbridge activity. It is also well-established that a red...

journal_title：Frontiers in physiology

authors： Allen DG,Trajanovska S

更新日期：2012-12-11 00:00:00

abstract：:Alcohol use disorder (AUD) is a major health, social and economic problem for which there are few effective treatments. The opiate antagonist naltrexone is currently prescribed clinically with mixed success. We have used naltrexone in an established behavioral assay (CAFE) in Drosophila melanogaster that measures the ...

journal_title：Frontiers in physiology

authors： Koyyada R,Latchooman N,Jonaitis J,Ayoub SS,Corcoran O,Casalotti SO

更新日期：2018-03-14 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects. While brain-derived GLP-1 may participate in these central actions, evidence suggests that peripherally derived GLP-1 plays an important role and GLP-1 analogs are kno...

journal_title：Frontiers in physiology

authors： Fu Z,Gong L,Liu J,Wu J,Barrett EJ,Aylor KW,Liu Z

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:The potential for cross acclimation between environmental stressors is not well understood. Thus, the aim of this investigation was to determine the effect of fixed-workload heat or hypoxic acclimation on cellular, physiological, and performance responses during post acclimation hypoxic exercise in humans. ...

journal_title：Frontiers in physiology

authors： Lee BJ,Miller A,James RS,Thake CD

更新日期：2016-03-08 00:00:00

abstract：:F1F0-ATP synthase inhibitory factor 1 (IF1) inhibits the reverse mode of F1F0-ATP synthase, and therefore protects cellular ATP content at the expense of accelerated loss of mitochondrial membrane potential (ΔΨm). There is considerable variability in IF1 expression and its influence on bioenergetics between different ...

journal_title：Frontiers in physiology

authors： Tanton H,Voronina S,Evans A,Armstrong J,Sutton R,Criddle DN,Haynes L,Schmid MC,Campbell F,Costello E,Tepikin AV

更新日期：2018-07-11 00:00:00

abstract：:The mechanisms of atrial fibrillation (AF) are a challenging research topic. The rotor hypothesis states that the AF is sustained by a reentrant wave that propagates around an unexcited core. Cardiac tissue heterogeneities, both structural and cellular, play an important role during fibrillatory dynamics, so that the ...

journal_title：Frontiers in physiology

authors： Ugarte JP,Tobón C,Lopes AM,Machado JAT

更新日期：2018-07-24 00:00:00

abstract：:Supplementation of omega-3 fatty acids (Ω-3) has been associated with a decreased cardiovascular risk, thereby concentrating attention on a potentially preventive effect regarding tachyarrhythmias and sudden cardiac death. However, recent randomized controlled trials challenge the efficacy of the additional applicatio...

journal_title：Frontiers in physiology

authors： Rauch B,Senges J

更新日期：2012-04-02 00:00:00

abstract：:Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs be...

journal_title：Frontiers in physiology

authors： Paradis-Deschênes P,Joanisse DR,Billaut F

更新日期：2017-01-05 00:00:00

abstract：:Aging is associated with a decline in cardiac function due to a decreased myocardial reserve. This adverse cardiac remodeling comprises of a variety of changes, including a reduction in mitochondrial function and a decline in the expression of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a...

journal_title：Frontiers in physiology

authors： Whitehead N,Gill JF,Brink M,Handschin C

更新日期：2018-03-21 00:00:00