Ground-Based Analogs for Human Spaceflight.

Abstract:

:This mini-review provides an updated summary of various analogs for adaptations of humans to the microgravity of space. Microgravity analogs discussed in this paper include dry immersion, wet immersion, unilateral lower-extremity limb suspension, head down tilt (HDT), and supine bed rest. All Earth-based analogs are imperfect simulations of microgravity with their own advantages and disadvantages. This paper compares these five frequently used microgravity analogs to offer insights into their usefulness for various physiological systems. New developments for each human microgravity analog are explored and advantages of one analog are evaluated against other analogs. Furthermore, the newly observed risk of Spaceflight Associated Neuro-Ocular Syndrome (SANS) is included in this mini review with a discussion of the advantages and disadvantages of each method of simulation for the relatively new risk of SANS. Overall, the best and most integrated analog for Earth-based studies of the microgravity of space flight appears to be head-down tilt bed rest.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Pandiarajan M,Hargens AR

doi

10.3389/fphys.2020.00716

subject

Has Abstract

pub_date

2020-06-23 00:00:00

pages

716

issn

1664-042X

journal_volume

11

pub_type

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