EPCR Gene Ser219Gly Polymorphism and Venous Thromboembolism: A Meta-Analysis of 9,494 Subjects.

Abstract:

:Background: Although endothelial cell protein C receptor (EPCR) gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached. Objective and methods: A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidate the potential relationship between the EPCR gene Ser219Gly polymorphism and VTE. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed or random effect models. Results: The current meta-analysis suggested that there was a significant association between EPCR gene Ser219Gly polymorphism and VTE under allelic (OR: 1.42, 95% CI: 1.21-1.66, P = 1.30 × 10-5), recessive (OR: 2.02, 95% CI: 1.44-2.85, P = 5.35 × 10-5), homozygous (OR: 2.24, 95% CI: 1.59-3.16, P = 3.66 × 10-6), and additive genetic models (OR: 1.63, 95% CI: 1.30-2.04, P = 2.24 × 10-5). Conclusions:EPCR gene Ser219Gly polymorphism was associated with an elevated risk of VTE and the Gly residue carriers of the EPCR gene might be predisposed to VTE.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Li YY,Wu JJ,Yang XX,Geng HY,Gong G,Kim HJ

doi

10.3389/fphys.2017.00339

subject

Has Abstract

pub_date

2017-05-26 00:00:00

pages

339

issn

1664-042X

journal_volume

8

pub_type

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