Abstract:
:We have isolated dental pulp cells (DPCs) from three healthy (hDPCs) and three carious (cDPCs) donors and shown that compared to hDPCs cells isolated from superficial carious lesions show higher clonogenic potential; show an equivalent proportion of cells with putative stem cell surface markers; show enhanced matrix mineralization capability; have enhanced angiogenic marker expression and retain the inflammatory phenotype in vitro characteristic of superficial caries lesions in vivo. Our findings suggest that cDPCs may be used for further investigation of the cross talk between inflammatory, angiogenic and mineralization pathways in repair of carious pulp. In addition cells derived from carious pulps (almost always discarded) may have potential for future applications in mineralized tissue repair and regeneration.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Alkharobi H,Beattie J,Meade J,Devine D,El-Gendy Rdoi
10.3389/fphys.2017.00244subject
Has Abstractpub_date
2017-04-28 00:00:00pages
244issn
1664-042Xjournal_volume
8pub_type
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