Dental Pulp Cells Isolated from Teeth with Superficial Caries Retain an Inflammatory Phenotype and Display an Enhanced Matrix Mineralization Potential.

Abstract:

:We have isolated dental pulp cells (DPCs) from three healthy (hDPCs) and three carious (cDPCs) donors and shown that compared to hDPCs cells isolated from superficial carious lesions show higher clonogenic potential; show an equivalent proportion of cells with putative stem cell surface markers; show enhanced matrix mineralization capability; have enhanced angiogenic marker expression and retain the inflammatory phenotype in vitro characteristic of superficial caries lesions in vivo. Our findings suggest that cDPCs may be used for further investigation of the cross talk between inflammatory, angiogenic and mineralization pathways in repair of carious pulp. In addition cells derived from carious pulps (almost always discarded) may have potential for future applications in mineralized tissue repair and regeneration.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Alkharobi H,Beattie J,Meade J,Devine D,El-Gendy R

doi

10.3389/fphys.2017.00244

subject

Has Abstract

pub_date

2017-04-28 00:00:00

pages

244

issn

1664-042X

journal_volume

8

pub_type

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