Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts.

Abstract:

:Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological experiments and patient-specific data to analyze some aspects of the disease, particularly with regard to mechanical stimuli due to shear stresses on the vessel wall. By combining a biochemical model of cell growth and a patient-specific computational fluid dynamics analysis of blood flow in the lumen, remodeling of the blood vessel is studied by means of a novel computational framework. The framework was used to analyze two vein graft bypasses from one patient: a femoro-popliteal and a femoro-distal bypass. The remodeling of the vessel wall and analysis of the flow for each case was then compared to clinical data and discussed as a potential tool for a better understanding of the disease. Simulation results from this first computational approach showed an overall agreement on the locations of hyperplasia in these patients and demonstrated the potential of using new integrative modeling tools to understand disease progression.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Donadoni F,Pichardo-Almarza C,Bartlett M,Dardik A,Homer-Vanniasinkam S,Díaz-Zuccarini V

doi

10.3389/fphys.2017.00226

subject

Has Abstract

pub_date

2017-04-18 00:00:00

pages

226

issn

1664-042X

journal_volume

8

pub_type

杂志文章
  • On the Use of the Repeated-Sprint Training in Hypoxia in Tennis.

    abstract:Purpose:To examine physiological and technical responses to repeated-sprint training in normobaric hypoxia at ∼3,000 m (RSH, n = 11) or in normoxia (RSN, n = 11) compared to a control group (CON, n = 8) in well-trained tennis players. Participants were 28.8 ± 5.9 years old without any previous experience of training in...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.588821

    authors: Brechbuhl C,Brocherie F,Willis SJ,Blokker T,Montalvan B,Girard O,Millet GP,Schmitt L

    更新日期:2020-12-18 00:00:00

  • Polycystin-1 Downregulation Induced Vascular Smooth Muscle Cells Phenotypic Alteration and Extracellular Matrix Remodeling in Thoracic Aortic Dissection.

    abstract:Objective:Polycystin-1 (PC-1) is a protein encoded by the gene of polycystic kidney disease-1 (PKD-1). This study was designed to investigate the regulatory mechanisms of PC-1 on phenotypes of aortic vascular smooth muscle cells (VSMCs) and functions of extracellular matrix (ECM) in thoracic aortic dissection (TAD). M...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.548055

    authors: Zhang J,Liu F,He YB,Zhang W,Ma WR,Xing J,Wang LX

    更新日期:2020-09-24 00:00:00

  • Neurally Released GABA Acts via GABAC Receptors to Modulate Ca2+ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum.

    abstract::γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Nevertheless, a role for GABA in enteric synaptic transmission remains elusive. In this study, we characterized the expression and function of GABA in the myenteric plexus of the mouse ileum. A...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00097

    authors: Koussoulas K,Swaminathan M,Fung C,Bornstein JC,Foong JPP

    更新日期:2018-02-13 00:00:00

  • Effects of Water Acidification on Senegalese Sole Solea senegalensis Health Status and Metabolic Rate: Implications for Immune Responses and Energy Use.

    abstract::Increasing water CO2, aquatic hypercapnia, leads to higher physiological pCO2 levels in fish, resulting in an acidosis and compensatory acid-base regulatory response. Senegalese sole is currently farmed in super-intensive recirculating water systems where significant accumulation of CO2 in the water may occur. Moreove...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00026

    authors: Machado M,Arenas F,Svendsen JC,Azeredo R,Pfeifer LJ,Wilson JM,Costas B

    更新日期:2020-01-31 00:00:00

  • Sex-Specific Impact of Ischemic Preconditioning on Tissue Oxygenation and Maximal Concentric Force.

    abstract::Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs be...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00674

    authors: Paradis-Deschênes P,Joanisse DR,Billaut F

    更新日期:2017-01-05 00:00:00

  • Effects of Resistance Exercise and Nutritional Supplementation on Dynamic Cerebral Autoregulation in Head-Down Bed Rest.

    abstract::Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift and cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR, with or without countermeasures, affect cerebral autoregulation (CA). Twelve m...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01114

    authors: Kermorgant M,Nasr N,Custaud MA,Navasiolava N,Arbeille P,Guinet P,Labrunée M,Besnier F,Arvanitis DN,Czosnyka M,Senard JM,Pavy-Le Traon A

    更新日期:2019-08-27 00:00:00

  • Criticality Maximizes Complexity in Neural Tissue.

    abstract::The analysis of neural systems leverages tools from many different fields. Drawing on techniques from the study of critical phenomena in statistical mechanics, several studies have reported signatures of criticality in neural systems, including power-law distributions, shape collapses, and optimized quantities under t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00425

    authors: Timme NM,Marshall NJ,Bennett N,Ripp M,Lautzenhiser E,Beggs JM

    更新日期:2016-09-27 00:00:00

  • Different Types of Physical Activity and Metabolic Control in People With Type 1 Diabetes Mellitus.

    abstract:Background:The aim of presented cross-sectional study was to determine the association of different types of physical activity (PA) with metabolic control in people with type 1 diabetes. Materials and Methods:A total of 109 adult subjects with type 1 diabetes were asked to complete the non-exercise activity thermogene...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01210

    authors: Štotl I,Kambič T,Hadžić V,Zdolšek A

    更新日期:2019-09-24 00:00:00

  • Inhibition of miR-27b Regulates Lipid Metabolism in Skeletal Muscle of Obese Rats During Hypoxic Exercise by Increasing PPARγ Expression.

    abstract::Hypoxic exercise may represent a novel therapeutic strategy to reduce and prevent obesity through the regulation of lipid metabolism. During hypoxic exercise, the targeting of peroxisome proliferator-activated receptor gamma (PPARγ) by miR-27b has been proposed to be one of the mechanisms involved in the modulation of...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.01090

    authors: Wang X,Lu Y,Zhu L,Zhang H,Feng L

    更新日期:2020-08-31 00:00:00

  • Computerized Morphometric Analysis of Eryptosis.

    abstract::Eryptosis is the suicidal destruction-process of erythrocytes, much like apoptosis of nucleated cells, in the course of which the stressed red cell undergoes cell-shrinkage, vesiculation and externalization of membrane phosphatidylserine. Currently, there exist numerous methods to detect eryptosis, both morphometrical...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01230

    authors: Jacob SS,Prasad K,Rao P,Kamath A,Hegde RB,Baby PM,Rao RK

    更新日期:2019-09-24 00:00:00

  • Computational modeling of the metabolic States regulated by the kinase akt.

    abstract::Signal transduction and gene regulation determine a major reorganization of metabolic activities in order to support cell proliferation. Protein Kinase B (PKB), also known as Akt, participates in the PI3K/Akt/mTOR pathway, a master regulator of aerobic glycolysis and cellular biosynthesis, two activities shown by both...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00418

    authors: Mosca E,Alfieri R,Maj C,Bevilacqua A,Canti G,Milanesi L

    更新日期:2012-11-21 00:00:00

  • Osthole Ameliorates Renal Fibrosis in Mice by Suppressing Fibroblast Activation and Epithelial-Mesenchymal Transition.

    abstract::Renal fibrosis is a common pathway of virtually all progressive kidney diseases. Osthole (OST, 7-Methoxy-8-(3-methylbut-2-enyl)-2-chromenone), a derivative of coumarin mainly found in plants of the Apiaceae family, has shown inhibitory effects on inflammation, oxidative stress, fibrosis and tumor progression. The pres...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01650

    authors: Zhang S,Huang Q,Cai X,Jiang S,Xu N,Zhou Q,Cao X,Hultström M,Tian J,Lai EY

    更新日期:2018-11-21 00:00:00

  • Dietary Effect on the Proteome of the Common Octopus (Octopus vulgaris) Paralarvae.

    abstract::Nowadays, the common octopus (Octopus vulgaris) culture is hampered by massive mortalities occurring during early life-cycle stages (paralarvae). Despite the causes of the high paralarvae mortality are not yet well-defined and understood, the nutritional stress caused by inadequate diets is pointed out as one of the m...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00309

    authors: Varó I,Cardenete G,Hontoria F,Monroig Ó,Iglesias J,Otero JJ,Almansa E,Navarro JC

    更新日期:2017-05-17 00:00:00

  • Impact of new electrocardiographic criteria in arrhythmogenic cardiomyopathy.

    abstract::Arrhythmogenic cardiomyopathy (AC) has originally been described as a disorder characterized by fibrofatty replacement of the myocardium, primarily of the right ventricle (RV), and ventricular tachyarrhythmias, sudden death, and at a late stage progressive heart failure. Arrhythmogenic right ventricular dysplasia or c...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00352

    authors: Hauer RN,Cox MG,Groeneweg JA

    更新日期:2012-09-17 00:00:00

  • AltitudeOmics: Spontaneous Baroreflex Sensitivity During Acclimatization to 5,260 m: A Comparison of Methods.

    abstract:Introduction:Baroreflex sensitivity (BRS) is essential to ensure rapid adjustment to variations in blood pressure (BP). Spontaneous baroreflex function can be assessed using continuous recordings of blood pressure. The goal of this study was to compare four methods for BRS quantification [the sequence, Bernardi's (BER)...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01505

    authors: Bourdillon N,Yazdani S,Vesin JM,Subudhi AW,Lovering AT,Roach RC,Kayser B

    更新日期:2019-12-10 00:00:00

  • Non-invasive Assessment of Systolic and Diastolic Cardiac Function During Rest and Stress Conditions Using an Integrated Image-Modeling Approach.

    abstract::Background: The possibility of non-invasively assessing load-independent parameters characterizing cardiac function is of high clinical value. Typically, these parameters are assessed during resting conditions. However, for diagnostic purposes, the parameter behavior across a physiologically relevant range of heart ra...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01515

    authors: Casas B,Viola F,Cedersund G,Bolger AF,Karlsson M,Carlhäll CJ,Ebbers T

    更新日期:2018-10-30 00:00:00

  • Identification of Halloween Genes and RNA Interference-Mediated Functional Characterization of a Halloween Gene shadow in Plutella xylostella.

    abstract::Ecdysteroids play an essential role in controlling insect development and reproduction. Their pathway is regulated by a group of enzymes called Halloween gene proteins. The relationship between the Halloween genes and ecdysteroid synthesis has yet to be clearly understood in diamondback moth, Plutella xylostella (L.),...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01120

    authors: Peng L,Wang L,Zou MM,Vasseur L,Chu LN,Qin YD,Zhai YL,You MS

    更新日期:2019-08-28 00:00:00

  • Functional cardiac imaging by random access microscopy.

    abstract::Advances in the development of voltage sensitive dyes and Ca(2+) sensors in combination with innovative microscopy techniques allowed researchers to perform functional measurements with an unprecedented spatial and temporal resolution. At the moment, one of the shortcomings of available technologies is their incapabil...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00403

    authors: Crocini C,Coppini R,Ferrantini C,Pavone FS,Sacconi L

    更新日期:2014-10-20 00:00:00

  • Molecular Characterization and Expression Profiling of Three Transformer-2 Splice Isoforms in the Redclaw Crayfish, Cherax quadricarinatus.

    abstract::Sex determination/sex differentiation is determined by genetics, environmental factors, or the interactions of the two. The Transformer-2 (Tra-2) gene plays an important role in the sex determination cascade signal pathway in insects. In this study, the Tra-2 gene was isolated and characterized from the cDNA library o...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00631

    authors: Cai L,Zheng J,Jia Y,Gu Z,Liu S,Chi M,Cheng S

    更新日期:2020-07-09 00:00:00

  • Perindopril and a Galectin-3 Inhibitor Improve Ischemic Heart Failure in Rabbits by Reducing Gal-3 Expression and Myocardial Fibrosis.

    abstract::Objective: Ventricular remodeling is considered the basis of heart failure and is involved in myocardial fibrosis. This study aimed to assess perindopril and a galectin-3 inhibitor (modified citrus pectin, MCP) for their effects on ventricular remodeling and myocardial fibrosis in rabbits with ischemic heart failure. ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00267

    authors: Li S,Li S,Hao X,Zhang Y,Deng W

    更新日期:2019-03-22 00:00:00

  • A trade-off study revealing nested timescales of constraint.

    abstract::This study investigates human performance in a cyclic Fitts task at three different scales of observation, either in the presence (difficult condition) or in the absence (easy condition) of a speed-accuracy trade-off. At the fastest scale, the harmonicity of the back and forth movements, which reflects the dissipation...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00116

    authors: Wijnants ML,Cox RF,Hasselman F,Bosman AM,Van Orden G

    更新日期:2012-05-23 00:00:00

  • Are We Ill Because We Age?

    abstract::Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an increasingly serious health and socioeconomic concern for modern societies. Science has made tremendous progress in the understanding of aging itself, which has helped medicine to extend life expectancies. With the increase of the l...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.01508

    authors: Fulop T,Larbi A,Khalil A,Cohen AA,Witkowski JM

    更新日期:2019-12-18 00:00:00

  • Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects.

    abstract::Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells th...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00196

    authors: Chistiakov DA,Sobenin IA,Orekhov AN,Bobryshev YV

    更新日期:2014-05-27 00:00:00

  • Core Matrisome Protein Signature During Periodontal Ligament Maturation From Pre-occlusal Eruption to Occlusal Function.

    abstract::The pre-occlusal eruption brings the molars into functional occlusion and initiates tensional strains during mastication. We hypothesized that upon establishment of occlusal contact, the periodontal ligament (PDL) undergoes cell and extracellular matrix maturation to adapt to this mechanical function. The PDL of 12 Wi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00174

    authors: Denes BJ,Ait-Lounis A,Wehrle-Haller B,Kiliaridis S

    更新日期:2020-03-05 00:00:00

  • MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b.

    abstract::Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequen...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00281

    authors: Ding HL,Hooper JE,Batzel P,Eames BF,Postlethwait JH,Artinger KB,Clouthier DE

    更新日期:2016-07-14 00:00:00

  • Fractal complexity in spontaneous EEG metastable-state transitions: new vistas on integrated neural dynamics.

    abstract::Resting-state EEG signals undergo rapid transition processes (RTPs) that glue otherwise stationary epochs. We study the fractal properties of RTPs in space and time, supporting the hypothesis that the brain works at a critical state. We discuss how the global intermittent dynamics of collective excitations is linked t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2010.00128

    authors: Allegrini P,Paradisi P,Menicucci D,Gemignani A

    更新日期:2010-09-15 00:00:00

  • Corrigendum: The Spectrum of SPTA1-Associated Hereditary Spherocytosis.

    abstract::[This corrects the article DOI: 10.3389/fphys.2019.00815.]. ...

    journal_title:Frontiers in physiology

    pub_type: 已发布勘误

    doi:10.3389/fphys.2019.01331

    authors: Chonat S,Risinger M,Sakthivel H,Niss O,Rothman JA,Hsieh L,Chou ST,Kwiatkowski JL,Khandros E,Gorman MF,Wells DT,Maghathe T,Dagaonkar N,Seu KG,Zhang K,Zhang W,Kalfa TA

    更新日期:2019-10-18 00:00:00

  • Membrane lipid unsaturation as physiological adaptation to animal longevity.

    abstract::The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems. The evolution of using oxygen for efficient energy production served as a driving fo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2013.00372

    authors: Naudí A,Jové M,Ayala V,Portero-Otín M,Barja G,Pamplona R

    更新日期:2013-12-17 00:00:00

  • The Extracellular Calcium-Sensing Receptor in the Intestine: Evidence for Regulation of Colonic Absorption, Secretion, Motility, and Immunity.

    abstract::Different from other epithelia, the intestinal epithelium has the complex task of providing a barrier impeding the entry of toxins, food antigens, and microbes, while at the same time allowing for the transfer of nutrients, electrolytes, water, and microbial metabolites. These molecules/organisms are transported eithe...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2016.00245

    authors: Tang L,Cheng CY,Sun X,Pedicone AJ,Mohamadzadeh M,Cheng SX

    更新日期:2016-06-21 00:00:00

  • Paradigm Shifts in Voluntary Force Control and Motor Unit Behaviors with the Manipulated Size of Visual Error Perception.

    abstract::The detection of error information is an essential prerequisite of a feedback-based movement. This study investigated the differential behavior and neurophysiological mechanisms of a cyclic force-tracking task using error-reducing and error-enhancing feedback. The discharge patterns of a relatively large number of mot...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00140

    authors: Chen YC,Lin YT,Chang GC,Hwang IS

    更新日期:2017-03-13 00:00:00