Mineralocorticoid Receptor-Dependent Impairment of Baroreflex Contributes to Hypertension in a Mouse Model of Primary Aldosteronism.

abstract：:Obstructive sleep apnea (OSA), manifested by exposure to chronic intermittent hypoxia (CIH) and excess production of reactive oxygen species (ROS) in the airways, is associated with hyperreactive airway diseases. ROS, particularly when created by NADPH oxidase, are known to sensitize lung vagal C fibers (LVCFs), which...

journal_title：Frontiers in physiology

authors： Yang CH,Zhuang WL,Shen YJ,Lai CJ,Kou YR

更新日期：2016-05-09 00:00:00

abstract：:In mammals, there are two types of urea transporters; urea transporter (UT)-A and UT-B. The UT-A transporters are mainly expressed in kidney epithelial cells while UT-B demonstrates a broader distribution in kidney, heart, brain, testis, urinary tract, and other tissues. Over the past few years, multiple urea transpor...

journal_title：Frontiers in physiology

authors： Li X,Chen G,Yang B

更新日期：2012-06-26 00:00:00

abstract：:A moderate hypoxic stimulus is considered a promising therapeutic modality for several pathological states including obesity. There is scientific evidence suggesting that when hypoxia and physical activity are combined, they could provide benefits for the obese population. The aim of the present study was to investiga...

journal_title：Frontiers in physiology

authors： Camacho-Cardenosa A,Camacho-Cardenosa M,Burtscher M,Martínez-Guardado I,Timon R,Brazo-Sayavera J,Olcina G

更新日期：2018-02-07 00:00:00

abstract：:Aim: The aim of the present study was to determine the validity of position, distance traveled and instantaneous speed of team sport players as measured by a commercially available local positioning system (LPS) during indoor use. In addition, the study investigated how the placement of the field of play relative to t...

journal_title：Frontiers in physiology

authors： Luteberget LS,Spencer M,Gilgien M

更新日期：2018-04-04 00:00:00

abstract：:Hypoxic environments at high altitude have significant effects on kidney injury. Following injury, renal primary cilia display length alterations. Primary cilia are mechanosensory organelles that regulate tubular architecture. The effect of hypoxia on cilia length is still controversial in cultured cells, and no corre...

journal_title：Frontiers in physiology

authors： Shamloo K,Chen J,Sardar J,Sherpa RT,Pala R,Atkinson KF,Pearce WJ,Zhang L,Nauli SM

更新日期：2017-09-20 00:00:00

abstract：:Introduction: In the chronic AV-block (CAVB) dog model, structural, contractile, and electrical remodeling occur, which predispose the heart to dofetilide-induced Torsade de Pointes (TdP) arrhythmias. Previous studies found a relation between electrical remodeling and inducibility of TdP, while structural remodeling i...

journal_title：Frontiers in physiology

authors： Sprenkeler DJ,Bossu A,Beekman JDM,Schoenmakers M,Vos MA

更新日期：2018-08-08 00:00:00

abstract：Background:The aim of this study is to report on the genetic composition of Brugada syndrome (BrS) patients undergoing genetic testing in Hong Kong. Methods:Patients with suspected BrS who presented to the Hospital Authority of Hong Kong between 1997 and 2019, and underwent genetic testing, were analyzed retrospective...

journal_title：Frontiers in physiology

authors： Tse G,Lee S,Liu T,Yuen HC,Wong ICK,Mak C,Mok NS,Wong WT

更新日期：2020-09-18 00:00:00

abstract：:When compared to the previous generations, younger generations have become sedentary on a global level. Physical activity positively contributes to human growth and development, causing, indeed, both physiological and psychological benefits. The aim of the current study was examining the relationship between physical ...

journal_title：Frontiers in physiology

authors： Padulo J,Bragazzi NL,De Giorgio A,Grgantov Z,Prato S,Ardigò LP

更新日期：2019-03-05 00:00:00

abstract：:Bioenergetic profiling of cancer cells is of great potential because it can bring forward new and effective therapeutic strategies along with early diagnosis. Metabolic Control Analysis (MCA) is a methodology that enables quantification of the flux control exerted by different enzymatic steps in a metabolic network th...

journal_title：Frontiers in physiology

authors： Kaambre T,Chekulayev V,Shevchuk I,Tepp K,Timohhina N,Varikmaa M,Bagur R,Klepinin A,Anmann T,Koit A,Kaldma A,Guzun R,Valvere V,Saks V

更新日期：2013-06-28 00:00:00

abstract：PURPOSE:While the intention of endurance athletes undertaking short term heat training protocols is to rapidly gain meaningful physical adaption prior to competition in the heat, it is currently unclear whether or not this process also presents an overt, acute challenge to the immune system. The aim of this study was t...

journal_title：Frontiers in physiology

authors： Guy JH,Pyne DB,Deakin GB,Miller CM,Edwards AM

更新日期：2016-07-29 00:00:00

abstract：:Hallucinations - compelling perceptions of stimuli that aren't really there - occur in many psychiatric and neurological disorders, and are triggered by certain drugs of abuse. Despite their clinical importance, the neuronal mechanisms giving rise to hallucinations are poorly understood, in large part due to the absen...

journal_title：Frontiers in physiology

authors： Lee AH,Brandon CL,Wang J,Frost WN

更新日期：2018-06-25 00:00:00

abstract：:Skeletal myofibers are injured due to mechanical stresses experienced during physical activity, or due to myofiber fragility caused by genetic diseases. The injured myofiber needs to be repaired or regenerated to restore the loss in muscle tissue function. Myofiber repair and regeneration requires coordinated action o...

journal_title：Frontiers in physiology

authors： Bittel DC,Jaiswal JK

更新日期：2019-07-18 00:00:00

abstract：:Hypoxic exercise may represent a novel therapeutic strategy to reduce and prevent obesity through the regulation of lipid metabolism. During hypoxic exercise, the targeting of peroxisome proliferator-activated receptor gamma (PPARγ) by miR-27b has been proposed to be one of the mechanisms involved in the modulation of...

journal_title：Frontiers in physiology

authors： Wang X,Lu Y,Zhu L,Zhang H,Feng L

更新日期：2020-08-31 00:00:00

abstract：:Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II enzymes that conjugate a variety of small lipophilic molecules with UDP sugars and alter them into more water-soluble metabolites. Therefore, glucosidation plays a major role in the inactivation and excretion of a great variety of both endogenous...

journal_title：Frontiers in physiology

authors： Pan Y,Tian F,Wei X,Wu Y,Gao X,Xi J,Shang Q

更新日期：2018-04-03 00:00:00

abstract：:The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in a patient-specific environment. Given the recent advances in medical imaging, computational power and mathematical algorithms, patient-specific cardiac models ...

journal_title：Frontiers in physiology

authors： Zhong L,Zhang JM,Su B,Tan RS,Allen JC,Kassab GS

更新日期：2018-06-26 00:00:00

abstract：:A wide range of adipokines identified over the past years has allowed considering the white adipose tissue as a secretory organ closely integrated into overall physiological and metabolic control. Apelin, a ubiquitously expressed peptide was known to exert different physiological effects mainly on the cardiovascular s...

journal_title：Frontiers in physiology

authors： Bertrand C,Valet P,Castan-Laurell I

更新日期：2015-04-10 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects. While brain-derived GLP-1 may participate in these central actions, evidence suggests that peripherally derived GLP-1 plays an important role and GLP-1 analogs are kno...

journal_title：Frontiers in physiology

authors： Fu Z,Gong L,Liu J,Wu J,Barrett EJ,Aylor KW,Liu Z

更新日期：2020-05-29 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) refers to the conversion of epithelial cells to mesenchymal phenotype, which endows the epithelial cells with enhanced migration, invasion, and extracellular matrix production abilities. These characteristics link EMT with the pathogenesis of organ fibrosis and cancer progressio...

journal_title：Frontiers in physiology

authors： Xu Z,Ding W,Deng X

更新日期：2019-11-29 00:00:00

abstract：:Dental and periodontal tissue development is a complex process involving various cell-types. A finely orchestrated network of communications between these cells is implicated. During early development, communications between cells from the oral epithelium and the underlying mesenchyme govern the dental morphogenesis w...

journal_title：Frontiers in physiology

authors： Gama A,Navet B,Vargas JW,Castaneda B,Lézot F

更新日期：2015-11-05 00:00:00

abstract：:Crayfish are capable of two rapid, escape reflexes that are mediated by two pairs of giant interneurons, the lateral giants (LG) and the medial giants (MG), which respond to threats presented to the abdomen or head and thorax, respectively. The LG has been the focus of study for many decades and the role of GABAergic ...

journal_title：Frontiers in physiology

authors： Swierzbinski ME,Herberholz J

更新日期：2018-04-27 00:00:00

abstract：:Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertroph...

journal_title：Frontiers in physiology

authors： Pazó-Sayós L,González MC,Quintana-Villamandos B

更新日期：2020-08-26 00:00:00

abstract：:Several clinical studies have investigated the potential benefits of endothelin receptor antagonism in chronic pathologies such as diabetic kidney disease. However, fluid retention and edema have been identified as major side effects of endothelin receptor antagonists. In the present study we hypothesized that avosent...

journal_title：Frontiers in physiology

authors： Baltatu OC,Iliescu R,Zaugg CE,Reckelhoff JF,Louie P,Schumacher C,Campos LA

更新日期：2012-04-18 00:00:00

abstract：:Red blood cell (RBC) deformability is an important determinant of the microcirculation. It is influenced by various hematological parameters but also by nitric oxide (NO) which is produced in RBC from L-arginine by RBC-NO synthase. Longitudinal studies on blood profile, deformability at rest and NO levels but also dif...

journal_title：Frontiers in physiology

authors： Grau M,Cremer JM,Schmeichel S,Kunkel M,Bloch W

更新日期：2018-12-19 00:00:00

abstract：:Microbiopsies of human skeletal muscle are increasingly adopted by physiologists for a variety of experimental assays given the reduced invasiveness of this procedure compared to the classic Bergstrom percutaneous biopsy technique. However, a recent report demonstrated lower mitochondrial respiration in saponin-permea...

journal_title：Frontiers in physiology

authors： Hughes MC,Ramos SV,Turnbull PC,Nejatbakhsh A,Baechler BL,Tahmasebi H,Laham R,Gurd BJ,Quadrilatero J,Kane DA,Perry CG

更新日期：2015-12-18 00:00:00

abstract：:Tree pandemics are a major cause of economic and ecological loss in forest and urban ecosystems. They often depend on the introduction of a non-native pathogen, which is occupying the niche of a native, non-aggressive organism. Complex interactions with native insects carrying fungi and nematodes can be established ba...

journal_title：Frontiers in physiology

authors： Santini A,Battisti A

更新日期：2019-05-08 00:00:00

abstract：:Respiratory sensory gating function has been found decreased by induced negative emotion in healthy adults. The increased ratio of the respiratory-related evoked potential (RREP) N1 peak amplitude for the second occlusion (S2) vs. the first occlusion (S1), S2/S1, is indicative of such decreased respiratory sensory gat...

journal_title：Frontiers in physiology

authors： Chan PY,Cheng CH,Jhu YJ,Chen CL,von Leupoldt A

更新日期：2016-02-16 00:00:00

abstract：:The mDurance® system is an innovative digital tool that combines wearable surface electromyography (sEMG), mobile computing and cloud analysis to streamline and automatize the assessment of muscle activity. The tool is particularly devised to support clinicians and sport professionals in their daily routines, as an as...

journal_title：Frontiers in physiology

authors： Molina-Molina A,Ruiz-Malagón EJ,Carrillo-Pérez F,Roche-Seruendo LE,Damas M,Banos O,García-Pinillos F

更新日期：2020-11-27 00:00:00

abstract：:Consumption of acidic foods and drinks and other factors that cause enamel wear are responsible for the daily enamel loss and degradation. Use of some toothpastes that have been showed to possess different properties of remineralisation and/or repair of the enamel surface may help to protect tooth enamel. The aim of t...

journal_title：Frontiers in physiology

authors： Lelli M,Putignano A,Marchetti M,Foltran I,Mangani F,Procaccini M,Roveri N,Orsini G

更新日期：2014-09-05 00:00:00

abstract：:Currently, schizophrenia is considered a multifactorial disease. Over the past 50 years, many investigators have considered the role of toxic free radicals in the etiology of schizophrenia. This is an area of active research which is still evolving. Here, we review the recent data and current concepts on the roles of ...

journal_title：Frontiers in physiology

authors： Nasyrova RF,Ivashchenko DV,Ivanov MV,Neznanov NG

更新日期：2015-05-11 00:00:00

abstract：:The impact of peritoneal dialysis (PD) associated peritonitis on peritoneal membrane integrity is incompletely understood. Children are particularly suited to address this question, since they are largely devoid of preexisting tissue damage and life-style related alterations. Within the International Peritoneal Bioban...

journal_title：Frontiers in physiology

authors： Bartosova M,Schaefer B,Vondrak K,Sallay P,Taylan C,Cerkauskiene R,Dzierzega M,Milosevski-Lomic G,Büscher R,Zaloszyc A,Romero P,Lasitschka F,Warady BA,Schaefer F,Ujszaszi A,Schmitt CP

更新日期：2019-04-02 00:00:00