Robustness of Nutrient Signaling Is Maintained by Interconnectivity Between Signal Transduction Pathways.

abstract：:Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological...

journal_title：Frontiers in physiology

authors： Donadoni F,Pichardo-Almarza C,Bartlett M,Dardik A,Homer-Vanniasinkam S,Díaz-Zuccarini V

更新日期：2017-04-18 00:00:00

abstract：:Skeletal muscle is a plastic tissue that undergoes cellular and metabolic adaptations under conditions of increased contractile activity such as exercise. Using adult zebrafish as an exercise model, we previously demonstrated that swimming training stimulates hypertrophy and vascularization of fast muscle fibers, cons...

journal_title：Frontiers in physiology

authors： Rovira M,Arrey G,Planas JV

更新日期：2017-12-18 00:00:00

abstract：:The paired cranial sensory organs and peripheral nervous system of vertebrates arise from a thin strip of cells immediately adjacent to the developing neural plate. The neural plate border region comprises progenitors for four key populations of cells: neural plate cells, neural crest cells, the cranial placodes, and ...

journal_title：Frontiers in physiology

authors： Thawani A,Groves AK

更新日期：2020-12-07 00:00:00

abstract：:Acute kidney injury (AKI), which involves the loss of kidney function caused by damage to renal tubular cells, is an important public health concern. We previously showed that sirtuin (SIRT)3 protects the kidneys against mitochondrial damage by inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NL...

journal_title：Frontiers in physiology

authors： Zhao W,Zhang L,Chen R,Lu H,Sui M,Zhu Y,Zeng L

更新日期：2018-11-14 00:00:00

abstract：:The non-selective mechanosensitive ion channel PIEZO1 controls erythrocyte volume homeostasis. Different missense gain-of-function mutations in PIEZO1 gene have been identified that cause Hereditary Xerocytosis (HX), a rare autosomal dominant haemolytic anemia. PIEZO1 expression is not limited to erythrocytes and expr...

journal_title：Frontiers in physiology

authors： Aglialoro F,Hofsink N,Hofman M,Brandhorst N,van den Akker E

更新日期：2020-07-31 00:00:00

abstract：:This study aimed to test the hypothesis that branchial osmoregulatory acclimation involved increased apoptosis and replacement of mitochdonrion-rich cells (MRCs) in the climbing perch, Anabas testudineus, during a progressive acclimation from freshwater to seawater. A significant increase in branchial caspase-3/-7 act...

journal_title：Frontiers in physiology

authors： Ching B,Chen XL,Yong JH,Wilson JM,Hiong KC,Sim EW,Wong WP,Lam SH,Chew SF,Ip YK

更新日期：2013-06-07 00:00:00

abstract：:The analysis of human brain functional networks is achieved by computing functional connectivity indices reflecting phase coupling and interactions between remote brain regions. In magneto- and electroencephalography, the most frequently used functional connectivity indices are constructed based on Fourier-based cross...

journal_title：Frontiers in physiology

authors： La Rocca D,Wendt H,van Wassenhove V,Ciuciu P,Abry P

更新日期：2021-01-07 00:00:00

abstract：:Hemoglobin (Hb) continuously undergoes autoxidation producing superoxide which dismutates into hydrogen peroxide (H2O2) and is a potential source for subsequent oxidative reactions. Autoxidation is most pronounced under hypoxic conditions in the microcirculation and for unstable dimers formed at reduced Hb concentrati...

journal_title：Frontiers in physiology

authors： Rifkind JM,Mohanty JG,Nagababu E

更新日期：2015-01-14 00:00:00

abstract：:The upcoming exploration missions will imply a much longer duration than any of the missions flown so far. In these missions, physiological adaptation to the new environment leads to changes in different body systems, such as the cardiovascular and musculoskeletal systems, metabolic and neurobehavioral health and immu...

journal_title：Frontiers in physiology

authors： Turroni S,Magnani M,Kc P,Lesnik P,Vidal H,Heer M

更新日期：2020-09-08 00:00:00

abstract：:The central purpose of this study was to evaluate the fiber type-specific satellite cell and myonuclear responses of endurance-trained cyclists to a block of intensified training, when supplementing with carbohydrate (CHO) vs. carbohydrate-protein (PRO). In a crossover design, endurance-trained cyclists (n = 8) perfor...

journal_title：Frontiers in physiology

authors： McKenzie AI,D'Lugos AC,Saunders MJ,Gworek KD,Luden ND

更新日期：2016-11-16 00:00:00

abstract：:Percutaneous edge-to-edge mitral valve (MV) repair using MitraClip has been recently established as a treatment option for patients with heart failure and functional mitral regurgitation (MR), which significantly expands the number of patients that can be treated with this device. This study aimed to quantify the morp...

journal_title：Frontiers in physiology

authors： Caballero A,Mao W,McKay R,Hahn RT,Sun W

更新日期：2020-05-07 00:00:00

abstract：UNLABELLED:Limitations of current methods: Normalization of resting energy expenditure (REE) for body composition using the 2-compartment model fat mass (FM), and fat-free mass (FFM) has inherent limitations for the interpretation of REE and may lead to erroneous conclusions when comparing people with a wide range of a...

journal_title：Frontiers in physiology

authors： Bosy-Westphal A,Braun W,Schautz B,Müller MJ

更新日期：2013-03-25 00:00:00

abstract：:Animal studies have shown that very early life events may have programing effects on adult metabolism and health. In this study, we aim, for the first, time to elucidate the effects of embryonic thermal manipulation (TM) on the performance of overfed mule ducks, in particular for the production of foie gras (fatty liv...

journal_title：Frontiers in physiology

authors： Massimino W,Davail S,Bernadet MD,Pioche T,Tavernier A,Ricaud K,Gontier K,Bonnefont C,Manse H,Morisson M,Fauconneau B,Collin A,Panserat S,Houssier M

更新日期：2019-12-12 00:00:00

abstract：:There is compelling evidence that the "what it feels like" subjective experience of sensory stimuli arises in the cerebral cortex in both humans as well as mammalian experimental animal models. Humans are alone in their ability to verbally communicate their experience of the external environment. In other species, sen...

journal_title：Frontiers in physiology

authors： Key B,Brown D

更新日期：2018-08-02 00:00:00

abstract：:To excrete body nitrogen waste and regulate electrolyte and fluid balance, the kidney has developed into an energy factory with only second to the heart in mitochondrial content in the body to meet the high-energy demand and regulate homeostasis. Energy supply from the renal mitochondria majorly depends on lipid metab...

journal_title：Frontiers in physiology

authors： Lin PH,Duann P

更新日期：2020-09-03 00:00:00

abstract：:Cephalopod and vertebrate neural-systems are often highlighted as a traditional example of convergent evolution. Their large brains, relative to body size, and complexity of sensory-motor systems and behavioral repertoires offer opportunities for comparative analysis. Despite various attempts, questions on how cephalo...

journal_title：Frontiers in physiology

authors： Shigeno S,Andrews PLR,Ponte G,Fiorito G

更新日期：2018-07-20 00:00:00

abstract：:Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-gly...

journal_title：Frontiers in physiology

authors： Tijardović M,Marijančević D,Bok D,Kifer D,Lauc G,Gornik O,Keser T

更新日期：2019-12-20 00:00:00

abstract：:Swimming induced pulmonary edema (SIPE) is a complication that can occur during exercise with the possibility of misdiagnosis and can quickly become life threatening; however, medical literature infrequently describes SIPE. Therefore, the aim of this review was to analyse all individual cases diagnosed with SIPE as re...

journal_title：Frontiers in physiology

authors： Grünig H,Nikolaidis PT,Moon RE,Knechtle B

更新日期：2017-08-31 00:00:00

abstract：Background:Post-ligation cardiac syndrome (PLCS) is a common complication of patent ductus arteriosus (PDA) surgical closure in low birth weight infants. It has been associated with mortality, but there is a lack of information about the neurodevelopmental outcome of the survivors. We aimed to explore the prevalence of...

journal_title：Frontiers in physiology

authors： Bravo MC,Ybarra M,Madero R,Pellicer A

更新日期：2019-06-11 00:00:00

abstract：Objective:Varicose veins are a common problem worldwide and can cause significant impairments in health-related quality of life, but the etiology and pathogenesis remain not well defined. This study aims to elucidate transcriptomic regulations of varicose veins by detecting differentially expressed genes, pathways and ...

journal_title：Frontiers in physiology

authors： Zhang J,Nie Q,Si C,Wang C,Chen Y,Sun W,Pan L,Guo J,Kong J,Cui Y,Wang F,Fan X,Ye Z,Wen J,Liu P

更新日期：2019-03-19 00:00:00

abstract：:Circadian rhythms are biological oscillations with a period of ~24 h. These rhythms are orchestrated by a circadian timekeeper in the suprachiasmatic nucleus of the hypothalamus, the circadian "master clock," which exactly adjusts clock outputs to solar time via photic synchronization. At the molecular level, circadia...

journal_title：Frontiers in physiology

authors： Chi-Castañeda D,Ortega A

更新日期：2018-02-12 00:00:00

abstract：:This study investigates the complex interplay between the cardiac and respiratory systems in 268 healthy neonates born between 35 and 40 weeks of gestation. The aim is to provide a comprehensive description of the developing cardiorespiratory information transfer mechanisms as a function of gestational age (GA). This ...

journal_title：Frontiers in physiology

authors： Lucchini M,Pini N,Burtchen N,Signorini MG,Fifer WP

更新日期：2020-08-27 00:00:00

abstract：:Introduction: Baroreflex sensitivity (BRS) is essential to ensure rapid adjustment to variations in blood pressure (BP). Little is known concerning the adaptive responses of BRS during acclimatization to high altitude at rest and during exercise. Methods: Twenty-one healthy sea-level residents were tested near sea lev...

journal_title：Frontiers in physiology

authors： Bourdillon N,Yazdani S,Subudhi AW,Lovering AT,Roach RC,Vesin JM,Kayser B

更新日期：2018-06-21 00:00:00

abstract：:Dentin dysplasia (DD) and dentinogenesis imperfecta (DGI) patients have abnormal structure, morphology, and function of dentin. DD-II, DGI-II, and DGI-III are caused by heterozygous mutations in the dentin sialophosphoprotein (DSPP) gene in humans. Evidences have shown that loss of function of DSPP in Dspp knockout mi...

journal_title：Frontiers in physiology

authors： Shi C,Ma N,Zhang W,Ye J,Shi H,Xiang D,Wu C,Song L,Zhang N,Liu Q

更新日期：2020-11-09 00:00:00

abstract：:Congenital haemolytic anaemias are inherited disorders caused by red blood cell membrane and cytoskeletal protein defects, deviant hemoglobin synthesis and metabolic enzyme deficiencies. In many cases, although the causing mutation might be known, the pathophysiology and the connection between the particular mutation ...

journal_title：Frontiers in physiology

authors： Petkova-Kirova P,Hertz L,Danielczok J,Huisjes R,Makhro A,Bogdanova A,Mañú-Pereira MDM,Vives Corrons JL,van Wijk R,Kaestner L

更新日期：2019-04-16 00:00:00

abstract：:As arteries become stiffer with aging, reflected waves move faster and augment late systolic pressure. Few studies have described the age-related changes in both peripheral and central systolic blood pressures in populations. We investigated the age dependency of peripheral (pSBP) and central (cSBP) systolic pressure ...

journal_title：Frontiers in physiology

authors： Wojciechowska W,Li Y,Stolarz-Skrzypek K,Kawecka-Jaszcz K,Staessen JA,Wang JG,European Project on Genes in Hypertension and the JingNing Study Investigators.

更新日期：2012-06-15 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellu...

journal_title：Frontiers in physiology

authors： Moullé VS,Cansell C,Luquet S,Cruciani-Guglielmacci C

更新日期：2012-09-28 00:00:00

abstract：:Background: Dental aberrations have been mentioned in relation to non-surgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP). However, a systematic review of dental characteristics have not been performed. The present systematic review describes the dental findings in patients with Ns-HypoPT and PH...

journal_title：Frontiers in physiology

authors： Hejlesen J,Underbjerg L,Gjørup H,Bloch-Zupan A,Sikjaer T,Rejnmark L,Haubek D

更新日期：2018-06-19 00:00:00

abstract：:Yellow genes are thought to be involved in the melanin biosynthetic pathway and play a crucial role in pigmentation reactions in insects. However, little research has been done on yellow genes in lepidopteran pests. To clarify the function of one of the yellow genes (yellow-y) in Spodoptera litura, we cloned the full-...

journal_title：Frontiers in physiology

authors： Liu XL,Han WK,Ze LJ,Peng YC,Yang YL,Zhang J,Yan Q,Dong SL

更新日期：2020-12-17 00:00:00