Comparison of the Reverse-Remodeling Effect of Pharmacological Soluble Guanylate Cyclase Activation With Pressure Unloading in Pathological Myocardial Left Ventricular Hypertrophy.


:Background: Pressure unloading induces the regression of left ventricular myocardial hypertrophy (LVH). Recent findings indicate that pharmacological activation of the soluble guanylate cyclase (sGC) - cyclic guanosine monophosphate (cGMP) pathway may also exert reverse-remodeling properties in the myocardium. Therefore, we aimed to investigate the effects of the sGC activator cinaciguat in a rat model of LVH and compare it to the "gold standard" pressure unloading therapy. Methods: Abdominal aortic banding was performed for 6 or 12 weeks. Sham operated animals served as controls. Pressure unloading was induced by removing the aortic constriction after week 6. The animals were treated from week 7 to 12, with 10 mg/kg/day cinaciguat or with placebo p.o., respectively. Cardiac function and morphology were assessed by left ventricular pressure-volume analysis and echocardiography. Additionally, key markers of myocardial hypertrophy, fibrosis, nitro-oxidative stress, apoptosis and cGMP signaling were analyzed. Results: Pressure unloading effectively reversed LVH, decreased collagen accumulation and provided protection against oxidative stress and apoptosis. Regression of LVH was also associated with a full recovery of cardiac function. In contrast, chronic activation of the sGC enzyme by cinaciguat at sustained pressure overload only slightly influenced pre-established hypertrophy. However, it led to increased PKG activity and had a significant impact on interstitial fibrosis, nitro-oxidative stress and apoptosis. Amelioration of the pathological structural alterations prevented the deterioration of LV systolic function (contractility and ejection fraction) and improved myocardial stiffness. Conclusion: Our results indicate that both cinaciguat treatment and pressure unloading evoked anti-remodeling effects and improved LV function, however in a differing manners.


Front Physiol


Frontiers in physiology


Ruppert M,Korkmaz-Icöz S,Li S,Brlecic P,Németh BT,Oláh A,Horváth EM,Veres G,Pleger S,Grabe N,Merkely B,Karck M,Radovits T,Szabó G




Has Abstract


2019-01-08 00:00:00








  • Distal Arthrogryposis and Lethal Congenital Contracture Syndrome - An Overview.

    abstract::Distal arthrogryposis (DA) is a skeletal muscle disorder which can be classified under a broader term as Arthrogryposis multiplex contractures. DA is characterized by the presence of joint contractures at various parts of the body, particularly in distal extremities. It is identified as an autosomal dominant and a rar...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Desai D,Stiene D,Song T,Sadayappan S

    更新日期:2020-06-25 00:00:00

  • Molecular Characterization of a Novel Shell Matrix Protein With PDZ Domain From Mytilus coruscus.

    abstract::Mollusk shells are products of biomineralization and possess excellent mechanical properties, and shell matrix proteins (SMPs) have important functions in shell formation. A novel SMP with a PDZ domain (PDZ-domain-containing-protein-1, PDCP-1) was identified from the shell matrices of Mytilus coruscus. In this study, ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Sun Q,Jiang Y,Yan X,Fan M,Zhang X,Xu H,Liao Z

    更新日期:2020-10-02 00:00:00

  • Stiffness of the Gastrocnemius-Achilles Tendon Complex Between Amateur Basketball Players and the Non-athletic General Population.

    abstract::Muscle and tendon stiffness are related to sports performance, tendinopathy, and tendon degeneration. However, the effects of habitual loading on muscle and tendon mechanical properties are unclear. Using amateur basketball players as examples, we investigated the effects of mechanical loading on the stiffness of the ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chang TT,Li Z,Wang XQ,Zhang ZJ

    更新日期:2020-12-10 00:00:00

  • Salbutamol Worsens the Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease.

    abstract:Background:Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bokov P,El Jurdi H,Denjoy I,Peiffer C,Medjahdi N,Holvoet L,Benkerrou M,Delclaux C

    更新日期:2020-02-26 00:00:00

  • SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy.

    abstract::Acute kidney injury (AKI), which involves the loss of kidney function caused by damage to renal tubular cells, is an important public health concern. We previously showed that sirtuin (SIRT)3 protects the kidneys against mitochondrial damage by inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NL...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Zhao W,Zhang L,Chen R,Lu H,Sui M,Zhu Y,Zeng L

    更新日期:2018-11-14 00:00:00

  • Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury.

    abstract::Obesity is a worldwide epidemic disease that induces important structural and functional changes to the heart and predisposes a patient to devastating cardiac complications. Sirtuin1 (SIRT1) has been found to have roles in regulating cardiac function, but whether it can help in cardioprotection is not clear. The aim o...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Favero G,Franco C,Stacchiotti A,Rodella LF,Rezzani R

    更新日期:2020-03-11 00:00:00

  • Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients.

    abstract::This paper introduces the use of low frequencies forced oscillation technique (FOT) in the presence of breathing signal. The hypothesis tested is to evaluate the sensitivity of FOT to various degrees of obstruction in COPD patients. The measurements were performed in the frequency range 0-2 Hz. The use of FOT to evalu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Ghita M,Copot D,Ghita M,Derom E,Ionescu C

    更新日期:2019-11-19 00:00:00

  • Altered Right Ventricular Mechanical Properties Are Afterload Dependent in a Rodent Model of Bronchopulmonary Dysplasia.

    abstract::Infants born premature are at increased risk for development of bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), and ultimately right ventricular (RV) dysfunction, which together carry a high risk of neonatal mortality. However, the role alveolar simplification and abnormal pulmonary microvascular develo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Patel JR,Barton GP,Braun RK,Goss KN,Haraldsdottir K,Hopp A,Diffee G,Hacker TA,Moss RL,Eldridge MW

    更新日期:2017-10-25 00:00:00

  • Verbal Encouragement and Between-Day Reliability During High-Intensity Functional Strength and Endurance Performance Testing.

    abstract::As verbal encouragement (VE) is used in high intensity functional exercise testing, this randomized controlled crossover study aimed at investigating whether VE affects high intensity functional strength and endurance performance testing. We further examined between-day variability of high intensity functional strengt...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Engel FA,Faude O,Kölling S,Kellmann M,Donath L

    更新日期:2019-04-25 00:00:00

  • Abdominal Binding Improves Neuromuscular Efficiency of the Human Diaphragm during Exercise.

    abstract::We tested the hypothesis that elastic binding of the abdomen (AB) would enhance neuromuscular efficiency of the human diaphragm during exercise. Twelve healthy non-obese men aged 24.8 ± 1.7 years (mean ± SE) completed a symptom-limited constant-load cycle endurance exercise test at 85% of their peak incremental power ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Abdallah SJ,Chan DS,Glicksman R,Mendonca CT,Luo Y,Bourbeau J,Smith BM,Jensen D

    更新日期:2017-05-31 00:00:00

  • Validity of the Catapult ClearSky T6 Local Positioning System for Team Sports Specific Drills, in Indoor Conditions.

    abstract::Aim: The aim of the present study was to determine the validity of position, distance traveled and instantaneous speed of team sport players as measured by a commercially available local positioning system (LPS) during indoor use. In addition, the study investigated how the placement of the field of play relative to t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Luteberget LS,Spencer M,Gilgien M

    更新日期:2018-04-04 00:00:00

  • Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects.

    abstract::Currently, schizophrenia is considered a multifactorial disease. Over the past 50 years, many investigators have considered the role of toxic free radicals in the etiology of schizophrenia. This is an area of active research which is still evolving. Here, we review the recent data and current concepts on the roles of ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Nasyrova RF,Ivashchenko DV,Ivanov MV,Neznanov NG

    更新日期:2015-05-11 00:00:00

  • TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma.

    abstract::The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca2+, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer's and Huntington's. Glaucomatous optic neuropathy - the world's le...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: McGrady NR,Risner ML,Vest V,Calkins DJ

    更新日期:2020-03-26 00:00:00

  • High Intensity High Volume Interval Training Improves Endurance Performance and Induces a Nearly Complete Slow-to-Fast Fiber Transformation on the mRNA Level.

    abstract::We present here a longitudinal study determining the effects of two 3 week-periods of high intensity high volume interval training (HIHVT) (90 intervals of 6 s cycling at 250% maximum power, Pmax/24 s) on a cycle ergometer. HIHVT was evaluated by comparing performance tests before and after the entire training (baseli...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Eigendorf J,May M,Friedrich J,Engeli S,Maassen N,Gros G,Meissner JD

    更新日期:2018-05-29 00:00:00

  • Quantifying Glioblastoma Drug Response Dynamics Incorporating Treatment Sensitivity and Blood Brain Barrier Penetrance From Experimental Data.

    abstract::Many drugs investigated for the treatment of glioblastoma (GBM) have had disappointing clinical trial results. Efficacy of these agents is dependent on adequate delivery to sensitive tumor cell populations, which is limited by the blood-brain barrier (BBB). Additionally, tumor heterogeneity can lead to subpopulations ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Massey SC,Urcuyo JC,Marin BM,Sarkaria JN,Swanson KR

    更新日期:2020-08-21 00:00:00

  • Atrial Rotor Dynamics Under Complex Fractional Order Diffusion.

    abstract::The mechanisms of atrial fibrillation (AF) are a challenging research topic. The rotor hypothesis states that the AF is sustained by a reentrant wave that propagates around an unexcited core. Cardiac tissue heterogeneities, both structural and cellular, play an important role during fibrillatory dynamics, so that the ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Ugarte JP,Tobón C,Lopes AM,Machado JAT

    更新日期:2018-07-24 00:00:00

  • Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.

    abstract::Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from th...

    journal_title:Frontiers in physiology



    authors: Zhai C,Li R,Hou K,Chen J,Alzogool M,Hu Y,Zhang J,Zhang Y,Wang L,Zhang R,Cong H

    更新日期:2020-08-14 00:00:00

  • Determination of the Maximum Velocity of Filaments in the in vitro Motility Assay.

    abstract::The in vitro motility assay (IVMA) is a powerful tool commonly used in basic muscle research and for drug screenings with the aim to find treatment options for neuromuscular disorders. In brief, the sliding movement of fluorescence-labeled actin filaments on myosin motor proteins is recorded, and the sliding velocity ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bopp N,Scheid LM,Fink RHA,Rohr K

    更新日期:2019-03-27 00:00:00

  • Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells.

    abstract::Preterm premature rupture of membranes is a leading cause of preterm births. Cytokine induced matrix metalloproteinase1 and interleukin 8 production from amnion mesenchymal cells may contribute to fetal membrane weakening and rupture. Progestins inhibit inflammation induced fetal membrane weakening but their effect on...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Marinello W,Feng L,Allen TK

    更新日期:2020-07-24 00:00:00

  • Inhibition of the NFATc4/ERK/AKT Pathway and Improvement of Thiol-Specific Oxidative Stress by Dronedarone Possibly Secondary to the Reduction of Blood Pressure in an Animal Model of Ventricular Hypertrophy.

    abstract::Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertroph...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Pazó-Sayós L,González MC,Quintana-Villamandos B

    更新日期:2020-08-26 00:00:00

  • Neuromuscular Adaptations to Multimodal Injury Prevention Programs in Youth Sports: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.

    abstract::Objective: Neuromuscular injury prevention programs (IPP) can reduce injury rate by about 40% in youth sport. Multimodal IPP include, for instance, balance, strength, power, and agility exercises. Our systematic review and meta-analysis aimed to evaluate the effects of multimodal IPP on neuromuscular performance in yo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Faude O,Rössler R,Petushek EJ,Roth R,Zahner L,Donath L

    更新日期:2017-10-12 00:00:00

  • Is central dogma a global property of cellular information flow?

    abstract::The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of Escherichia coli, Saccharomyces cerevisiae, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Piras V,Tomita M,Selvarajoo K

    更新日期:2012-11-23 00:00:00

  • Dynamical Landscape of Heart Rhythm in Long-Term Heart Transplant Recipients: A Way to Discern Erratic Rhythms.

    abstract::It is commonly believed that higher values of heart rate variability (HRV) indices account for better organization of the network of feedback reflexes driving an organism's response to actual bodily needs. In order to evaluate this organization in heart transplant (HTX) recipients, 58 nocturnal Holter signals of 14 HT...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Wdowczyk J,Makowiec D,Gruchała M,Wejer D,Struzik ZR

    更新日期:2018-04-09 00:00:00

  • Mitochondrial Reactive Oxygen Species and Kidney Hypoxia in the Development of Diabetic Nephropathy.

    abstract::The underlying mechanisms in the development of diabetic nephropathy are currently unclear and likely consist of a series of dynamic events from the early to late stages of the disease. Diabetic nephropathy is currently without curative treatments and it is acknowledged that even the earliest clinical manifestation of...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Schiffer TA,Friederich-Persson M

    更新日期:2017-04-11 00:00:00

  • Influence of Magnitude and Duration of Altered Gravity and Readaptation to 1 g on the Structure and Function of the Utricle in Toadfish, Opsanus tau.

    abstract::Gravity has remained constant during animal evolution and the neural sensory systems detecting acceleration forces have remained remarkably conserved among vertebrates. The utricular organ senses the sum of inertial force due to head translation and head tilt relative to gravitational vertical. Change in gravitational...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Boyle R,Popova Y,Varelas J

    更新日期:2018-10-22 00:00:00

  • Expression of South East Asian Ovalocytic Band 3 Disrupts Erythroblast Cytokinesis and Reticulocyte Maturation.

    abstract::Southeast Asian Ovalocytosis results from a heterozygous deletion of 9 amino acids in the erythrocyte anion exchange protein AE1 (band 3). The report of the first successful birth of an individual homozygous for this mutation showed an association with severe dyserythropoietic anemia. Imaging of the proband's erythroc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Flatt JF,Stevens-Hernandez CJ,Cogan NM,Eggleston DJ,Haines NM,Heesom KJ,Picard V,Thomas C,Bruce LJ

    更新日期:2020-04-28 00:00:00

  • Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia: A Brief Up-Dated Description of Concurrent Exercise and Leucine-Based Multimodal Intervention.

    abstract::Sarcopenia is defined as the progressive loss of muscle mass with age, and poses a serious threat to the physiological and psychological health of the elderly population with consequential economic and social burdens. Chronic low-grade inflammation plays a central role in the development of sarcopenia such that it alt...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Xia Z,Cholewa J,Zhao Y,Shang HY,Yang YQ,Araújo Pessôa K,Su QS,Lima-Soares F,Zanchi NE

    更新日期:2017-06-22 00:00:00

  • Modulation of Ion Channels in the Superior Cervical Ganglion Neurons by Myocardial Ischemia and Fluvastatin Treatment.

    abstract::Background: The superior cervical ganglion (SCG) of the autonomic nervous system plays an important role in different cardiovascular diseases. In this study, we investigated the effects of ischemia and fluvastatin treatment on the ion channel characteristics of SCG neurons in a rabbit myocardial ischemia (MI) model. M...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Cheng L,Wang X,Liu T,Tse G,Fu H,Li G

    更新日期:2018-09-10 00:00:00

  • Physical Activity Level Influences MTHFR Gene Methylation Profile in Diabetic Patients.

    abstract:Introduction:MTHFR methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown. Objective:The aim of this study was to evaluate the influence of physical activity level and nutritional status on the methylation profile of the MTHFR gene in pati...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Diniz TG,Silva AS,Dos Santos Nunes MK,Ribeiro MD,Filho JM,do Nascimento RAF,Gomes CNAP,Evangelista IWQ,de Oliveira NFP,Persuhn DC

    更新日期:2021-01-12 00:00:00

  • How to assess performance in cycling: the multivariate nature of influencing factors and related indicators.

    abstract::Finding an optimum for the cycling performance is not a trivial matter, since the literature shows the presence of many controversial aspects. In order to quantify different levels of performance, several indexes have been defined and used in many studies, reflecting variations in physiological and biomechanical facto...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Castronovo AM,Conforto S,Schmid M,Bibbo D,D'Alessio T

    更新日期:2013-05-21 00:00:00