The power of boolean implication networks.

abstract：:Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

journal_title：Frontiers in physiology

authors： Perillo M,Folker ES

更新日期：2018-11-01 00:00:00

abstract：:Actual theaters of operations require fast actions from special operations units with a high level of readiness and survival. Mission accomplishment depends on their psychological and physiological performance. The aim of the present study was to analyze: (1) the physical parameters related with success in a special o...

journal_title：Frontiers in physiology

authors： Hormeño-Holgado AJ,Nikolaidis PT,Clemente-Suárez VJ

更新日期：2019-07-10 00:00:00

abstract：:We previously demonstrated that ureteral obstruction is associated with a urinary concentrating defect and reduced expression of renal aquaporins (AQPs), in which the renin-angiotensin system (RAS) may play an important role. The aims of the present study were to examine whether the renin inhibitor aliskiren could pre...

journal_title：Frontiers in physiology

authors： Hu S,Xie H,Luo R,Feng P,Liu Q,Han M,Kong Y,Zou X,Wang W,Li C

更新日期：2019-09-13 00:00:00

abstract：:Secretory glands including salivary glands by many hormonal inputs produce and secrete biological fluids determined by variety of ion transporters. Spinophilin is a multifunctional scaffolding protein, which involved in receptor signaling and regulation of anion exchangers AE2 activity. We found that spinophilin expre...

journal_title：Frontiers in physiology

authors： Lee D,Lee SA,Shin DM,Hong JH

更新日期：2018-07-19 00:00:00

abstract：:RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3. Homozygotes present with a phenotype characteristic of bone marrow failure that is accompanied by alternat...

journal_title：Frontiers in physiology

authors： Hartman ES,Brindley EC,Papoin J,Ciciotte SL,Zhao Y,Peters LL,Blanc L

更新日期：2018-06-05 00:00:00

abstract：:Nowadays, the common octopus (Octopus vulgaris) culture is hampered by massive mortalities occurring during early life-cycle stages (paralarvae). Despite the causes of the high paralarvae mortality are not yet well-defined and understood, the nutritional stress caused by inadequate diets is pointed out as one of the m...

journal_title：Frontiers in physiology

authors： Varó I,Cardenete G,Hontoria F,Monroig Ó,Iglesias J,Otero JJ,Almansa E,Navarro JC

更新日期：2017-05-17 00:00:00

abstract：:Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and non-excitable cells. With 40 known members in the human genome and a variety of homomeric and heteromeric pore-forming α subunit interactions, post-translational mod...

journal_title：Frontiers in physiology

authors： Kanda VA,Abbott GW

更新日期：2012-06-28 00:00:00

abstract：:There are animal species that have adapted to life at high altitude and hypobaric hypoxia conditions in the Andean highlands. One such species is the llama (Lama glama), which seem to have developed efficient protective mechanisms to avoid maladaptation resulting from chronic hypoxia, such as a resistance to the devel...

journal_title：Frontiers in physiology

authors： López V,Moraga FA,Llanos AJ,Ebensperger G,Taborda MI,Uribe E

更新日期：2018-05-29 00:00:00

abstract：:Background: Hypoxia represents both an outcome of cardiopulmonary diseases and a trigger for severe pulmonary complications as pulmonary hypertension. Because nitric oxide (NO) is a critical mediator in the development of pulmonary hypertension, the modulators of its downstream function may become target of pharmacolo...

journal_title：Frontiers in physiology

authors： Nydegger C,Martinelli C,Di Marco F,Bulfamante G,von Segesser L,Tozzi P,Samaja M,Milano G

更新日期：2018-03-27 00:00:00

abstract：:A Boolean model is a simple, discrete and dynamic model without the need to consider the effects at the intermediate levels. However, little effort has been made into constructing activation, inhibition, and protein decay networks, which could indicate the direct roles of a gene (or its synthesized protein) as an acti...

journal_title：Frontiers in physiology

authors： Chen L,Kulasiri D,Samarasinghe S

更新日期：2018-09-25 00:00:00

abstract：:A wide range of adipokines identified over the past years has allowed considering the white adipose tissue as a secretory organ closely integrated into overall physiological and metabolic control. Apelin, a ubiquitously expressed peptide was known to exert different physiological effects mainly on the cardiovascular s...

journal_title：Frontiers in physiology

authors： Bertrand C,Valet P,Castan-Laurell I

更新日期：2015-04-10 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) refers to the conversion of epithelial cells to mesenchymal phenotype, which endows the epithelial cells with enhanced migration, invasion, and extracellular matrix production abilities. These characteristics link EMT with the pathogenesis of organ fibrosis and cancer progressio...

journal_title：Frontiers in physiology

authors： Xu Z,Ding W,Deng X

更新日期：2019-11-29 00:00:00

abstract：:Xinnao shutong (XNST) capsules have been clinically used in China to treat cerebrovascular diseases. Previous studies have demonstrated that XNST has significant neuroprotective effects against acute cerebral ischemic stroke. The present study investigated the effects and mechanisms of XNST treatment following chronic...

journal_title：Frontiers in physiology

authors： Wang L,Wang R,Chen Z,Zhao H,Luo Y

更新日期：2018-05-15 00:00:00

abstract：Background:Perturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Previous reports indicate that CFTR activity upregulates endothelial barrier function, endoth...

journal_title：Frontiers in physiology

authors： Khalaf M,Scott-Ward T,Causer A,Saynor Z,Shepherd A,Górecki D,Lewis A,Laight D,Shute J

更新日期：2020-07-29 00:00:00

abstract：AIM:The aim of the present study was to analyze the response of vascular circulating microRNAs (miRNAs; miR-16, miR-21, miR-126) and the VEGF mRNA following an acute bout of HIIT and HVT in children. METHODS:Twelve healthy competitive young male cyclists (14.4 ± 0.8 years; 57.9 ± 9.4 ml·min(-1)·kg(-1) peak oxygen upta...

journal_title：Frontiers in physiology

authors： Kilian Y,Wehmeier UF,Wahl P,Mester J,Hilberg T,Sperlich B

更新日期：2016-03-14 00:00:00

abstract：:Anthropogenic climate change exposes marine organisms to CO2 induced ocean acidification (OA). Marine animals may make physiological and behavioral adaptations to cope with OA. Elevated pCO2 may affect metabolism, feeding, and energy partition of marine crabs, and thereby affect their predator-prey dynamics with musse...

journal_title：Frontiers in physiology

authors： Wang Y,Hu M,Wu F,Storch D,Pörtner HO

更新日期：2018-08-21 00:00:00

abstract：:We describe our development of the diffusion tensor imaging modality for the bovine ocular lens. Diffusion gradients were added to a spin-echo pulse sequence and the relevant parameters of the sequence were refined to achieve good diffusion weighting in the lens tissue, which demonstrated heterogeneous regions of diff...

journal_title：Frontiers in physiology

authors： Vaghefi E,Donaldson PJ

更新日期：2013-03-01 00:00:00

abstract：:Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological...

journal_title：Frontiers in physiology

authors： Donadoni F,Pichardo-Almarza C,Bartlett M,Dardik A,Homer-Vanniasinkam S,Díaz-Zuccarini V

更新日期：2017-04-18 00:00:00

abstract：:Pulpitis in primary teeth, a condition caused by presence of bacteria, is highly prevalent worldwide. The use of biocompatibility materials with anti-inflammatory, anti-bacterial, and regenerative properties is critical for prognosis of this endodontic disease. This study aimed to identify expression of human β defens...

journal_title：Frontiers in physiology

authors： Zhai Y,Wang Y,Rao N,Li J,Li X,Fang T,Zhao Y,Ge L

更新日期：2019-10-22 00:00:00

abstract：Background:Post-ligation cardiac syndrome (PLCS) is a common complication of patent ductus arteriosus (PDA) surgical closure in low birth weight infants. It has been associated with mortality, but there is a lack of information about the neurodevelopmental outcome of the survivors. We aimed to explore the prevalence of...

journal_title：Frontiers in physiology

authors： Bravo MC,Ybarra M,Madero R,Pellicer A

更新日期：2019-06-11 00:00:00

abstract：:Several clinical studies have investigated the potential benefits of endothelin receptor antagonism in chronic pathologies such as diabetic kidney disease. However, fluid retention and edema have been identified as major side effects of endothelin receptor antagonists. In the present study we hypothesized that avosent...

journal_title：Frontiers in physiology

authors： Baltatu OC,Iliescu R,Zaugg CE,Reckelhoff JF,Louie P,Schumacher C,Campos LA

更新日期：2012-04-18 00:00:00

abstract：:Adipokinetic hormones (AKHs) are well known to mobilize lipids and carbohydrates for energy-consuming activities in insects. These neuropeptides exert their functions by interacting with AKH receptors (AKHRs) located on the plasma membrane of fat body cells, which regulates energy mobilization by stimulating lipolysis...

journal_title：Frontiers in physiology

authors： Lu K,Wang Y,Chen X,Zhang X,Li W,Cheng Y,Li Y,Zhou J,You K,Song Y,Zhou Q,Zeng R

更新日期：2019-01-08 00:00:00

abstract：:Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. This phenomenon is known as the "m...

journal_title：Frontiers in physiology

authors： Schwartz LM

更新日期：2019-01-25 00:00:00

abstract：:Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown. It was previously postulated that molecular switches responsible for cancer cell development, and for infiltration of inflammatory cells into cancer...

journal_title：Frontiers in physiology

authors： Liu ST,Pham H,Pandol SJ,Ptasznik A

更新日期：2014-01-16 00:00:00

abstract：:Mitochondrial redox imbalance has been implicated in mechanisms of aging, various degenerative diseases and drug-induced toxicity. Statins are safe and well-tolerated therapeutic drugs that occasionally induce myotoxicity such as myopathy and rhabdomyolysis. Previous studies indicate that myotoxicity caused by statins...

journal_title：Frontiers in physiology

authors： La Guardia PG,Alberici LC,Ravagnani FG,Catharino RR,Vercesi AE

更新日期：2013-05-15 00:00:00

abstract：:Animal studies have shown that very early life events may have programing effects on adult metabolism and health. In this study, we aim, for the first, time to elucidate the effects of embryonic thermal manipulation (TM) on the performance of overfed mule ducks, in particular for the production of foie gras (fatty liv...

journal_title：Frontiers in physiology

authors： Massimino W,Davail S,Bernadet MD,Pioche T,Tavernier A,Ricaud K,Gontier K,Bonnefont C,Manse H,Morisson M,Fauconneau B,Collin A,Panserat S,Houssier M

更新日期：2019-12-12 00:00:00

abstract：:Zinc-α2-glycoprotein (ZAG) plays an important role in the regulation of body weight, body fat, and glucose metabolism. In this study, we first measured ZAG levels in serum and ZAG mRNA levels in subcutaneous white adipose tissue (sWAT) among overweight/obese patients and lean control subjects. Second, we investigated ...

journal_title：Frontiers in physiology

authors： Liu M,Zhu H,Dai Y,Pan H,Li N,Wang L,Yang H,Yan K,Gong F

更新日期：2018-02-07 00:00:00

abstract：:Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from th...

journal_title：Frontiers in physiology

authors： Zhai C,Li R,Hou K,Chen J,Alzogool M,Hu Y,Zhang J,Zhang Y,Wang L,Zhang R,Cong H

更新日期：2020-08-14 00:00:00

abstract：:As part of the ZOOMICS project, we set out to investigate common and diverging metabolic traits in the blood metabolome across various species by taking advantage of recent developments in high-throughput metabolomics. Here we provide the first comparative metabolomics analysis of fresh and stored human (n = 21, 10 ma...

journal_title：Frontiers in physiology

authors： Bertolone L,Shin HK,Stefanoni D,Baek JH,Gao Y,Morrison EJ,Nemkov T,Thomas T,Francis RO,Hod EA,Zimring JC,Yoshida T,Karafin M,Schwartz J,Hudson KE,Spitalnik SL,Buehler PW,D'Alessandro A

更新日期：2020-10-23 00:00:00

abstract：:Background: Acute mountain sickness (AMS) is a common disabling condition in individuals experiencing high altitudes, which may progress to life-threatening high altitude cerebral edema. Today, no established biomarkers are available for prediction the susceptibility of AMS. MicroRNAs emerge as promising sensitive and...

journal_title：Frontiers in physiology

authors： Liu B,Huang H,Wu G,Xu G,Sun BD,Zhang EL,Chen J,Gao YQ

更新日期：2017-02-08 00:00:00